Cancer CRCdb

TF information

TF name:	IRX5
TF family:	Homeobox
Ensembl gene ID:	ENSG00000176842
Ensembl protein ID:	ENSP00000378132, ENSP00000316250
Entrez gene ID:	10265

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of IRX5 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.45136186770428
Sample_02_394	Cell line	Mammary Gland	T-47D_2	0.42307692307692
Sample_02_395	Cell line	Mammary Gland	BT-549	0.32307692307692
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	0.60227272727273
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.84172661870504

IRX5 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_394	Mammary Gland	Cell line	T-47D_2
Sample_02_403	Mammary Gland	Cell line	T-47D_untreat
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2

IRX5 distribution in all CRCs

Genomic distribution of SEs associated with IRX5

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Mutation of IRX5

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of IRX5

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr16	54967483	54967483	C	G	exonic	IRX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	54966440	54966440	G	T	exonic	IRX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	54966719	54966719	G	A	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54966770	54966770	C	T	exonic	IRX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs373826345	chr16	54967587	54967587	C	T	exonic	IRX5	synonymous	UCEC\|1\|248\|0.00403
-	chr16	54967551	54967551	G	A	exonic	IRX5	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr16	54966798	54966798	C	T	exonic	IRX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr16	54966567	54966567	G	A	exonic	IRX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54966813	54966813	C	-	exonic	IRX5	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr16	54966652	54966652	C	T	exonic	IRX5	synonymous	BLCA\|2\|396\|0.00505,COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr16	54966805	54966805	C	T	exonic	IRX5	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222,UCEC\|1\|248\|0.00403
-	chr16	54966458	54966458	C	T	exonic	IRX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	54967424	54967424	G	A	exonic	IRX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr16	54966468	54966468	C	T	exonic	IRX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	54966502	54966502	A	G	exonic	IRX5	synonymous	PRAD\|2\|499\|0.00401
-	chr16	54967655	54967655	G	T	exonic	IRX5	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr16	54965177	54965177	T	C	exonic	IRX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54966704	54966704	C	T	exonic	IRX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	54967504	54967504	C	G	exonic	IRX5	nonsynonymous	LUAD\|2\|543\|0.00368
rs151037166	chr16	54966517	54966517	C	T	exonic	IRX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	54966623	54966623	A	G	exonic	IRX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	54966629	54966629	C	G	exonic	IRX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	54967364	54967364	C	T	exonic	IRX5	nonsynonymous	SKCM\|1\|368\|0.00272
rs369644274	chr16	54966406	54966406	G	A	intronic	IRX5	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54966680	54966680	G	-	exonic	IRX5	frameshift	HNSC\|1\|512\|0.00195
-	chr16	54966485	54966485	T	C	exonic	IRX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs373958797	chr16	54965171	54965171	C	T	exonic	IRX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	54965245	54965245	C	T	exonic	IRX5	synonymous	HNSC\|1\|512\|0.00195
-	chr16	54967537	54967537	C	G	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54966809	54966809	G	A	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54966777	54966777	A	G	exonic	IRX5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr16	54967405	54967405	C	T	exonic	IRX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	54966721	54966721	C	T	exonic	IRX5	synonymous	UCEC\|1\|248\|0.00403
-	chr16	54967645	54967645	C	T	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54966534	54966534	C	T	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54967389	54967389	C	G	exonic	IRX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs750934548	chr16	54966396	54966396	C	T	intronic	IRX5	unknown	BRCA\|1\|982\|0.00102
-	chr16	54967577	54967577	A	G	exonic	IRX5	nonsynonymous	ESCA\|1\|185\|0.00541
rs767836036	chr16	54966510	54966510	G	A	exonic	IRX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54967689	54967689	T	G	exonic	IRX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs781126921	chr16	54967637	54967637	C	T	exonic	IRX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs867067507	chr16	54966435	54966435	G	A	exonic	IRX5	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr16	54966798	54966798	C	G	exonic	IRX5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr16	54965166	54965166	C	T	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54967008	54967008	G	A	exonic	IRX5	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr16	54966722	54966722	G	A	exonic	IRX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr16	54966466	54966466	C	T	exonic	IRX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54966530	54966530	G	A	exonic	IRX5	nonsynonymous	LUSC\|1\|178\|0.00562
rs778623433	chr16	54966402	54966402	C	T	intronic	IRX5	unknown	SKCM\|1\|368\|0.00272
-	chr16	54967445	54967445	T	C	exonic	IRX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	54967711	54967711	T	C	exonic	IRX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54967457	54967457	G	-	exonic	IRX5	frameshift	LUAD\|1\|543\|0.00184
-	chr16	54967531	54967531	C	T	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54967668	54967668	C	T	exonic	IRX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54965318	54965318	G	C	exonic	IRX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr16	54966430	54966430	A	G	exonic	IRX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	54966628	54966628	C	T	exonic	IRX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54965328	54965329	CC	-	exonic	IRX5	frameshift	SARC\|1\|247\|0.00405
rs754238323	chr16	54967130	54967130	-	C	exonic	IRX5	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs377035980	chr16	54965210	54965210	G	A	exonic	IRX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr16	54965196	54965196	C	T	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54966715	54966715	C	T	exonic	IRX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	54967646	54967646	A	G	exonic	IRX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	54967505	54967505	C	T	exonic	IRX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr16	54967589	54967589	G	A	exonic	IRX5	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr16	54966749	54966749	G	C	exonic	IRX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr16	54966716	54966716	G	A	exonic	IRX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	54967712	54967712	T	C	exonic	IRX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	54967470	54967470	C	T	exonic	IRX5	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr16	54966800	54966800	G	A	exonic	IRX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	54966436	54966436	C	A	exonic	IRX5	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr16	54966694	54966694	G	T	exonic	IRX5	synonymous	LUAD\|1\|543\|0.00184
-	chr16	54967638	54967638	G	T	exonic	IRX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	54966471	54966471	C	T	exonic	IRX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr16	54966542	54966542	C	G	exonic	IRX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr16	54967655	54967655	G	C	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54965339	54965339	G	A	exonic	IRX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54966559	54966559	C	T	exonic	IRX5	synonymous	HNSC\|1\|512\|0.00195
rs767854433	chr16	54967521	54967521	G	A	exonic	IRX5	synonymous	LUSC\|1\|178\|0.00562
-	chr16	54967726	54967726	C	T	exonic	IRX5	stopgain	SKCM\|1\|368\|0.00272
-	chr16	54967412	54967412	C	T	exonic	IRX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	54966761	54966761	G	A	exonic	IRX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs866136053	chr16	54967744	54967744	G	A	exonic	IRX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr16	54967479	54967479	G	A	exonic	IRX5	synonymous	PAAD\|1\|185\|0.00541
-	chr16	54967643	54967643	C	G	exonic	IRX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	54967504	54967504	C	T	exonic	IRX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	54967571	54967571	C	T	exonic	IRX5	nonsynonymous	CESC\|1\|194\|0.00515,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	54966775	54966775	G	A	exonic	IRX5	synonymous	BLCA\|1\|396\|0.00253

Disease information of IRX5

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
IRX5	Craniosynostosis	C05;C16	Disease or Syndrome	GENOMICS_ENGLAND
IRX5	Fracture	C26	Injury or Poisoning	CTD_human
IRX5	Sensorineural Hearing Loss (disorder)	C09;C10;C23	Disease or Syndrome	CTD_human
IRX5	Congenital Heart Defects	C14;C16	Congenital Abnormality	CTD_human
IRX5	Hypodontia	C07;C16	Congenital Abnormality	CTD_human
IRX5	Lacrimal Apparatus Diseases	C11	Disease or Syndrome	CTD_human
IRX5	Lung diseases	C08	Disease or Syndrome	CTD_human
IRX5	Myopia	C11	Disease or Syndrome	CTD_human
IRX5	Excessive tearing	C11	Disease or Syndrome	CTD_human
IRX5	Microcytic hypochromic anemia (disorder)	C15	Disease or Syndrome	CTD_human
IRX5	Fracture, spiral	C26	Injury or Poisoning	CTD_human
IRX5	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
IRX5	Developmental absence of tooth	C07;C16	Congenital Abnormality	CTD_human
IRX5	Sensory hearing loss	C09;C10;C23	Disease or Syndrome	CTD_human
IRX5	Frontonasal dysplasia	C05;C16	Congenital Abnormality	CTD_human
IRX5	Hypertelorism, Severe, With Midface Prominence, Myopia, Mental Retardation, And Bone Fragility	C05;C10;C11;C16;C23;F01;F03	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
IRX5	Tooth Agenesis, Familial	C07;C16	Congenital Abnormality	CTD_human
IRX5	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with IRX5

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of IRX5

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GO_term_name	GO_term_type	TF_name
GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT	BP	IRX5
GO_NEURON_MATURATION	BP	IRX5
GO_NEURAL_RETINA_DEVELOPMENT	BP	IRX5
GO_REGULATION_OF_HEART_RATE	BP	IRX5
GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT	BP	IRX5
GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE	BP	IRX5
GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS	BP	IRX5
GO_STEROID_BINDING	MF	IRX5
GO_VITAMIN_BINDING	MF	IRX5

Survival analysis of IRX5

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of IRX5

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)