Cancer CRCdb

TF information

TF name:	EN1
TF family:	Homeobox
Ensembl gene ID:	ENSG00000163064
Ensembl protein ID:	ENSP00000295206
Entrez gene ID:	2019

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of EN1 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_069	Cell line	Brain	SF268	0.33587786259542
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.40077821011673
Sample_02_395	Cell line	Mammary Gland	BT-549	0.87496503496503

EN1 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_395	Mammary Gland	Cell line	BT-549

EN1 distribution in all CRCs

Genomic distribution of SEs associated with EN1

Download

Mutation of EN1

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of EN1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	119600613	119600613	T	A	exonic	EN1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	119600629	119600629	C	T	exonic	EN1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	119603905	119603905	C	T	exonic	EN1	nonsynonymous	ESCA\|1\|185\|0.00541
rs139806570	chr2	119600595	119600595	G	A	exonic	EN1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr2	119600699	119600699	G	T	exonic	EN1	synonymous	ESCA\|1\|185\|0.00541
-	chr2	119600786	119600786	C	G	exonic	EN1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	119604484	119604484	G	T	exonic	EN1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	119600587	119600587	G	A	exonic	EN1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	119604348	119604348	G	T	exonic	EN1	synonymous	LUSC\|1\|178\|0.00562
-	chr2	119604321	119604321	C	G	exonic	EN1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	119600757	119600757	G	A	exonic	EN1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	119603936	119603936	G	C	exonic	EN1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	119600774	119600774	G	A	exonic	EN1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	119600542	119600542	G	A	exonic	EN1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	119600630	119600630	G	A	exonic	EN1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	119604372	119604372	C	T	exonic	EN1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	119604286	119604286	C	G	exonic	EN1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	119604502	119604502	G	-	exonic	EN1	frameshift	LUSC\|1\|178\|0.00562
-	chr2	119600538	119600538	G	T	exonic	EN1	synonymous	HNSC\|1\|512\|0.00195
-	chr2	119600649	119600649	C	A	exonic	EN1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	119604338	119604338	C	T	exonic	EN1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	119604527	119604528	GC	-	exonic	EN1	frameshift	PRAD\|1\|499\|0.00200
-	chr2	119600567	119600567	C	T	exonic	EN1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	119600729	119600729	A	G	exonic	EN1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	119600798	119600799	TC	-	exonic	EN1	frameshift	ACC\|1\|90\|0.01111,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr2	119604365	119604365	G	A	exonic	EN1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	119600699	119600699	G	A	exonic	EN1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	119600586	119600586	C	A	exonic	EN1	synonymous	ACC\|2\|90\|0.02222
-	chr2	119600779	119600779	C	T	exonic	EN1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	119604241	119604241	G	A	exonic	EN1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	119604427	119604427	A	-	exonic	EN1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	119603946	119603946	C	T	exonic	EN1	synonymous	HNSC\|2\|512\|0.00391
-	chr2	119600673	119600673	G	A	exonic	EN1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	119604484	119604484	G	A	exonic	EN1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	119600674	119600674	A	T	exonic	EN1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	119604387	119604387	C	T	exonic	EN1	synonymous	SKCM\|1\|368\|0.00272
rs769343130	chr2	119600601	119600601	G	C	exonic	EN1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	119600674	119600674	A	C	exonic	EN1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr2	119600743	119600743	C	A	exonic	EN1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	119603980	119603980	G	A	exonic	EN1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	119604516	119604516	T	G	exonic	EN1	synonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs558210525	chr2	119604045	119604045	C	T	exonic	EN1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	119604405	119604405	C	T	exonic	EN1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	119604052	119604052	C	T	exonic	EN1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr2	119600619	119600619	G	A	exonic	EN1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	119600627	119600627	C	T	exonic	EN1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr2	119600717	119600717	G	A	exonic	EN1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr2	119604494	119604494	G	C	exonic	EN1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	119604508	119604508	G	T	exonic	EN1	nonsynonymous	LUAD\|1\|543\|0.00184,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	119600568	119600568	C	A	exonic	EN1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	119600593	119600593	C	T	exonic	EN1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	119600737	119600737	T	G	exonic	EN1	nonsynonymous	ESCA\|1\|185\|0.00541

Disease information of EN1

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
EN1	Adenoid Cystic Carcinoma	C04	Neoplastic Process	CTD_human
EN1	Neoplasm Invasiveness	C04;C23	Pathologic Function	CTD_human
EN1	nervous system disorder	C10	Disease or Syndrome	CTD_human
EN1	Salivary Gland Neoplasms	C04;C07	Neoplastic Process	CTD_human
EN1	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
EN1	Malignant neoplasm of salivary gland	C04;C07	Neoplastic Process	CTD_human

Pathway associated with EN1

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000337	C. elegans Notch signaling pathway ( Notch signaling pathway Diagram )	inoh	8	25
pathway0000354	Canonical Notch signaling pathway ( Notch signaling pathway Diagram )	inoh	19	107
pathway0000355	Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram )	inoh	56	519
pathway0000356	Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram )	inoh	56	519
pathway0000357	Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram )	inoh	56	519
pathway0000358	Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )	inoh	56	519
pathway0000359	Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	56	519
pathway0000549	Deactivation of the beta-catenin transactivating complex	reactome	42	236
pathway0000780	FGF signaling pathway	pid	55	600
pathway0000990	HDR through MMEJ (alt-NHEJ)	reactome	10	40
pathway0001314	Mammalian Notch signaling pathway ( Notch signaling pathway Diagram )	inoh	15	71
pathway0001315	Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )	inoh	49	453
pathway0001372	Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	reactome	6	11
pathway0001467	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	reactome	15	52
pathway0001522	Notch signaling pathway	panther	27	135
pathway0001598	PCNA-Dependent Long Patch Base Excision Repair	reactome	19	158
pathway0001689	POLB-Dependent Long Patch Base Excision Repair	reactome	7	15
pathway0001714	Presenilin action in Notch and Wnt signaling	pid	46	287
pathway0001873	Removal of the Flap Intermediate	reactome	14	91
pathway0001874	Removal of the Flap Intermediate from the C-strand	reactome	10	45
pathway0001877	Resolution of D-loop Structures through Holliday Junction Intermediates	reactome	33	508
pathway0001895	RHO GTPases activate IQGAPs	reactome	13	49
pathway0002069	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	reactome	32	197
pathway0002145	Syndecan-3-mediated signaling events	pid	23	73
pathway0002198	TCF dependent signaling in response to WNT	reactome	31	189
pathway0002346	tRNA splicing	humancyc	5	6
pathway0002448	Wnt signaling network	pid	29	169
pathway0002458	Xenopus axis formation Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	28	125
pathway0002589	Notch signaling pathway	kegg	44	313
pathway0002680	Hs_Cell_Cycle_WP179_89516	wikipathways	33	97
pathway0002687	Hs_Osteoblast_Signaling_WP322_90527	wikipathways	10	8
pathway0002746	Hs_Dopaminergic_Neurogenesis_WP2855_87239	wikipathways	19	37

Go term information of EN1

Download

GO_term_name	GO_term_type	TF_name
GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY	BP	EN1
GO_MEMORY	BP	EN1
GO_SYNAPTIC_VESICLE_LOCALIZATION	BP	EN1
GO_HINDBRAIN_DEVELOPMENT	BP	EN1
GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY	BP	EN1
GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION	BP	EN1
GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY	BP	EN1
GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT	BP	EN1
GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS	BP	EN1
GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING	BP	EN1
GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION	BP	EN1
GO_DENDRITIC_CELL_DIFFERENTIATION	BP	EN1
GO_REGULATION_OF_PROTEIN_BINDING	BP	EN1
GO_SINGLE_ORGANISM_BEHAVIOR	BP	EN1
GO_CHEMICAL_HOMEOSTASIS	BP	EN1
GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS	BP	EN1
GO_REGULATION_OF_MAPK_CASCADE	BP	EN1
GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE	BP	EN1
GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY	BP	EN1
GO_RESPONSE_TO_PEPTIDE	BP	EN1
GO_REGULATION_OF_COAGULATION	BP	EN1
GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE	BP	EN1
GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC	BP	EN1
GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY	BP	EN1
GO_BETA_AMYLOID_METABOLIC_PROCESS	BP	EN1
GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS	BP	EN1
GO_REGULATION_OF_RECEPTOR_ACTIVITY	BP	EN1
GO_HISTONE_METHYLATION	BP	EN1
GO_TRNA_METABOLIC_PROCESS	BP	EN1
GO_NOTCH_RECEPTOR_PROCESSING	BP	EN1
GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT	BP	EN1
GO_REGULATION_OF_KINASE_ACTIVITY	BP	EN1
GO_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	EN1
GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION	BP	EN1
GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS	BP	EN1
GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE	BP	EN1
GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS	BP	EN1
GO_MITOCHONDRIAL_TRANSPORT	BP	EN1
GO_POSITIVE_REGULATION_OF_COAGULATION	BP	EN1
GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY	BP	EN1
GO_L_AMINO_ACID_TRANSPORT	BP	EN1
GO_THYMUS_DEVELOPMENT	BP	EN1
GO_NEUROTRANSMITTER_TRANSPORT	BP	EN1
GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY	BP	EN1
GO_NEURAL_TUBE_DEVELOPMENT	BP	EN1
GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS	BP	EN1
GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT	BP	EN1
GO_NEURAL_RETINA_DEVELOPMENT	BP	EN1
GO_FORELIMB_MORPHOGENESIS	BP	EN1
GO_LEUKOCYTE_DIFFERENTIATION	BP	EN1
GO_UV_PROTECTION	BP	EN1
GO_WNT_SIGNALING_PATHWAY	BP	EN1
GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS	BP	EN1
GO_DORSAL_VENTRAL_PATTERN_FORMATION	BP	EN1
GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS	BP	EN1
GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY	BP	EN1
GO_FOREBRAIN_CELL_MIGRATION	BP	EN1
GO_DECIDUALIZATION	BP	EN1
GO_PIGMENTATION	BP	EN1
GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION	BP	EN1
GO_PEPTIDYL_AMINO_ACID_MODIFICATION	BP	EN1
GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS	BP	EN1
GO_PROXIMAL_DISTAL_PATTERN_FORMATION	BP	EN1
GO_REGULATION_OF_SPINDLE_CHECKPOINT	BP	EN1
GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION	BP	EN1
GO_REGULATION_OF_HOMEOSTATIC_PROCESS	BP	EN1
GO_NCRNA_PROCESSING	BP	EN1
GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT	BP	EN1
GO_LAGGING_STRAND_ELONGATION	BP	EN1
GO_REGULATION_OF_SYNAPTIC_PLASTICITY	BP	EN1
GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS	BP	EN1
GO_EMBRYONIC_FORELIMB_MORPHOGENESIS	BP	EN1
GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS	BP	EN1
GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY	BP	EN1
GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING	BP	EN1
GO_CANONICAL_WNT_SIGNALING_PATHWAY	BP	EN1
GO_MYELOID_LEUKOCYTE_ACTIVATION	BP	EN1
GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION	BP	EN1
GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY	BP	EN1
GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY	BP	EN1
GO_CEREBRAL_CORTEX_DEVELOPMENT	BP	EN1
GO_ENDOCRINE_PANCREAS_DEVELOPMENT	BP	EN1
GO_SOMITOGENESIS	BP	EN1
GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT	BP	EN1
GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION	BP	EN1
GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS	BP	EN1
GO_ORGAN_MORPHOGENESIS	BP	EN1
GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION	BP	EN1
GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION	BP	EN1
GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION	BP	EN1
GO_AMINO_ACID_TRANSPORT	BP	EN1
GO_REGULATION_OF_CELL_DIFFERENTIATION	BP	EN1
GO_REGULATION_OF_CENTROSOME_CYCLE	BP	EN1
GO_REGULATION_OF_CENTROSOME_DUPLICATION	BP	EN1
GO_ORGANIC_ANION_TRANSPORT	BP	EN1
GO_RESPONSE_TO_UV	BP	EN1
GO_DNA_STRAND_ELONGATION	BP	EN1
GO_DICARBOXYLIC_ACID_TRANSPORT	BP	EN1
GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS	BP	EN1
GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING	BP	EN1
GO_CALCIUM_ION_REGULATED_EXOCYTOSIS	BP	EN1
GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS	BP	EN1
GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS	BP	EN1
GO_CELLULAR_GLUCOSE_HOMEOSTASIS	BP	EN1
GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION	BP	EN1
GO_REGULATION_OF_JNK_CASCADE	BP	EN1
GO_ACIDIC_AMINO_ACID_TRANSPORT	BP	EN1
GO_NEURON_APOPTOTIC_PROCESS	BP	EN1
GO_CARBOHYDRATE_HOMEOSTASIS	BP	EN1
GO_NEGATIVE_REGULATION_OF_JNK_CASCADE	BP	EN1
GO_AMMONIUM_TRANSPORT	BP	EN1
GO_MITOTIC_RECOMBINATION	BP	EN1
GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS	BP	EN1
GO_CELL_FATE_COMMITMENT	BP	EN1
GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY	BP	EN1
GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY	BP	EN1
GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE	BP	EN1
GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS	BP	EN1
GO_RESPONSE_TO_GAMMA_RADIATION	BP	EN1
GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY	BP	EN1
GO_OSTEOBLAST_DEVELOPMENT	BP	EN1
GO_ENDOCRINE_SYSTEM_DEVELOPMENT	BP	EN1
GO_MEMBRANE_PROTEIN_PROTEOLYSIS	BP	EN1
GO_DOPAMINERGIC_NEURON_DIFFERENTIATION	BP	EN1
GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY	BP	EN1
GO_EPITHELIAL_CELL_PROLIFERATION	BP	EN1
GO_RECOMBINATIONAL_REPAIR	BP	EN1
GO_NEGATIVE_REGULATION_OF_OSSIFICATION	BP	EN1
GO_CELL_FATE_SPECIFICATION	BP	EN1
GO_CEREBRAL_CORTEX_CELL_MIGRATION	BP	EN1
GO_FEEDING_BEHAVIOR	BP	EN1
GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION	BP	EN1
GO_REGULATION_OF_RECEPTOR_RECYCLING	BP	EN1
GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY	BP	EN1
GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY	BP	EN1
GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY	BP	EN1
GO_NEURON_DEATH	BP	EN1
GO_RNA_CATABOLIC_PROCESS	BP	EN1
GO_MATERNAL_PLACENTA_DEVELOPMENT	BP	EN1
GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY	BP	EN1
GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT	BP	EN1
GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING	BP	EN1
GO_SOMITE_DEVELOPMENT	BP	EN1
GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION	BP	EN1
GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING	BP	EN1
GO_NEGATIVE_REGULATION_OF_NEURON_DEATH	BP	EN1
GO_REGULATION_OF_FILOPODIUM_ASSEMBLY	BP	EN1
GO_MYELOID_DENDRITIC_CELL_ACTIVATION	BP	EN1
GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY	BP	EN1
GO_SKELETAL_SYSTEM_MORPHOGENESIS	BP	EN1
GO_AUTOPHAGOSOME_ORGANIZATION	BP	EN1
GO_NEURAL_TUBE_PATTERNING	BP	EN1
GO_REGULATION_OF_TELOMERASE_ACTIVITY	BP	EN1
GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION	BP	EN1
GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT	BP	EN1
GO_MULTI_ORGANISM_BEHAVIOR	BP	EN1
GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY	BP	EN1
GO_ACTIVATION_OF_MAPKK_ACTIVITY	BP	EN1
GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION	BP	EN1
GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC	BP	EN1
GO_BRAIN_MORPHOGENESIS	BP	EN1
GO_AGGRESOME	CC	EN1
GO_CHROMOSOME	CC	EN1
GO_NUCLEAR_OUTER_MEMBRANE	CC	EN1
GO_SITE_OF_POLARIZED_GROWTH	CC	EN1
GO_INCLUSION_BODY	CC	EN1
GO_ROUGH_ENDOPLASMIC_RETICULUM	CC	EN1
GO_GOLGI_APPARATUS_PART	CC	EN1
GO_DENDRITIC_SHAFT	CC	EN1
GO_NUCLEAR_CHROMOSOME	CC	EN1
GO_NUCLEAR_CHROMATIN	CC	EN1
GO_CELL_DIVISION_SITE	CC	EN1
GO_SMOOTH_ENDOPLASMIC_RETICULUM	CC	EN1
GO_MITOCHONDRION	CC	EN1
GO_MEMBRANE_MICRODOMAIN	CC	EN1
GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE	CC	EN1
GO_OUTER_MEMBRANE	CC	EN1
GO_CHROMOSOME_TELOMERIC_REGION	CC	EN1
GO_LYTIC_VACUOLE_MEMBRANE	CC	EN1
GO_TELOMERE_CAP_COMPLEX	CC	EN1
GO_NUCLEAR_MEMBRANE	CC	EN1
GO_SYNAPSE_PART	CC	EN1
GO_VACUOLAR_MEMBRANE	CC	EN1
GO_5_3_EXONUCLEASE_ACTIVITY	MF	EN1
GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS	MF	EN1
GO_DNA_SECONDARY_STRUCTURE_BINDING	MF	EN1
GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY	MF	EN1
GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS	MF	EN1
GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY	MF	EN1
GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY	MF	EN1
GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS	MF	EN1
GO_R_SMAD_BINDING	MF	EN1
GO_DAMAGED_DNA_BINDING	MF	EN1
GO_NUCLEASE_ACTIVITY	MF	EN1
GO_EXONUCLEASE_ACTIVITY	MF	EN1
GO_BINDING_BRIDGING	MF	EN1
GO_TELOMERIC_DNA_BINDING	MF	EN1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	EN1
GO_ENDODEOXYRIBONUCLEASE_ACTIVITY	MF	EN1
GO_FOUR_WAY_JUNCTION_DNA_BINDING	MF	EN1
GO_DEOXYRIBONUCLEASE_ACTIVITY	MF	EN1
GO_ENDONUCLEASE_ACTIVITY	MF	EN1
GO_SINGLE_STRANDED_DNA_BINDING	MF	EN1
GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY	MF	EN1
GO_PDZ_DOMAIN_BINDING	MF	EN1
GO_ENDORIBONUCLEASE_ACTIVITY	MF	EN1
GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY	MF	EN1
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING	MF	EN1
GO_CADHERIN_BINDING	MF	EN1
GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS	MF	EN1
GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY	MF	EN1
GO_EXODEOXYRIBONUCLEASE_ACTIVITY	MF	EN1
GO_CATION_CHANNEL_ACTIVITY	MF	EN1
GO_STRUCTURE_SPECIFIC_DNA_BINDING	MF	EN1
GO_HISTONE_METHYLTRANSFERASE_ACTIVITY	MF	EN1

Survival analysis of EN1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of EN1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)