Cancer CRCdb

TF information

TF name:	NFIX
TF family:	CTF/NFI
Ensembl gene ID:	ENSG00000008441
Ensembl protein ID:	ENSP00000465094, ENSP00000353219, ENSP00000466735, ENSP00000351354, ENSP00000468794, ENSP00000465616, ENSP00000467512, ENSP00000467785, ENSP00000468707, ENSP00000380781, ENSP00000466389
Entrez gene ID:	4784

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NFIX in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.23002421307506
Sample_01_022	Cell line	Prostate	C4-2B	0.11904761904762
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.33307392996109
Sample_02_168	Cell line	Prostate	LNCaP	0.44106463878327
Sample_02_250	Tissue	Brain	tumormodel3691	0.125
Sample_02_395	Cell line	Mammary Gland	BT-549	0.16615384615385

NFIX distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

NFIX distribution in all CRCs

Genomic distribution of SEs associated with NFIX

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Mutation of NFIX

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NFIX

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs375287066	chr19	13201172	13201172	G	A	exonic	NFIX	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	13184726	13184726	T	-	exonic	NFIX	frameshift	LIHC\|1\|373\|0.00268
rs367955217	chr19	13192651	13192651	G	A	exonic	NFIX	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	13192588	13192589	CC	-	exonic	NFIX	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr19	13184243	13184243	A	G	exonic	NFIX	synonymous	UCEC\|1\|248\|0.00403
rs771724729	chr19	13136046	13136046	G	A	exonic	NFIX	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	13192537	13192537	G	A	exonic	NFIX	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs762562838	chr19	13189499	13189499	G	A	exonic	NFIX	nonsynonymous	PRAD\|1\|499\|0.00200,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr19	13183886	13183886	C	A	exonic	NFIX	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr19	13184252	13184252	G	A	exonic	NFIX	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr19	13192584	13192584	G	A	exonic	NFIX	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	13192531	13192531	C	T	exonic	NFIX	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr19	13186360	13186360	G	A	exonic	NFIX	nonsynonymous	UCEC\|1\|248\|0.00403
rs748315181	chr19	13135824	13135824	G	T	intronic	NFIX	unknown	BLCA\|1\|396\|0.00253,PAAD\|1\|185\|0.00541,TGCT\|1\|155\|0.00645
-	chr19	13184814	13184814	G	A	exonic	NFIX	synonymous	SKCM\|1\|368\|0.00272
-	chr19	13192670	13192670	G	T	splicing	NFIX	splicing	HNSC\|1\|512\|0.00195,TGCT\|1\|155\|0.00645
-	chr19	13136057	13136057	C	T	exonic	NFIX	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr19	13184813	13184813	G	A	exonic	NFIX	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|1\|368\|0.00272
rs774838479	chr19	13189497	13189497	G	A	exonic	NFIX	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	13184817	13184817	C	T	exonic	NFIX	synonymous	SKCM\|1\|368\|0.00272
-	chr19	13192511	13192511	G	T	exonic	NFIX	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr19	13184742	13184742	G	A	exonic	NFIX	synonymous	UCEC\|1\|248\|0.00403
-	chr19	13184288	13184288	G	A	exonic	NFIX	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr19	13186460	13186460	C	T	exonic	NFIX	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr19	13136140	13136140	G	A	exonic	NFIX	synonymous	HNSC\|1\|512\|0.00195,LUSC\|1\|178\|0.00562
-	chr19	13189451	13189451	G	A	exonic	NFIX	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	13201190	13201190	C	A	exonic	NFIX	nonsynonymous	BLCA\|1\|396\|0.00253
rs759364037	chr19	13201160	13201160	G	A	exonic	NFIX	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	13135903	13135903	C	T	exonic	NFIX	synonymous	SKCM\|1\|368\|0.00272
-	chr19	13186407	13186407	G	A	exonic	NFIX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	13192576	13192576	G	T	exonic	NFIX	synonymous	LUAD\|1\|543\|0.00184
-	chr19	13186466	13186466	G	T	exonic	NFIX	nonsynonymous	LUAD\|1\|543\|0.00184
rs755556407	chr19	13184812	13184812	C	T	exonic	NFIX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	13189483	13189483	C	T	exonic	NFIX	stopgain	BLCA\|1\|396\|0.00253
rs768217315	chr19	13192528	13192528	C	T	exonic	NFIX	synonymous	SKCM\|1\|368\|0.00272
-	chr19	13186419	13186419	G	A	exonic	NFIX	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr19	13189498	13189498	C	T	exonic	NFIX	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr19	13184731	13184731	A	G	exonic	NFIX	nonsynonymous	THCA\|1\|504\|0.00198
-	chr19	13192536	13192536	C	T	exonic	NFIX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs753318918	chr19	13186359	13186359	C	T	exonic	NFIX	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr19	13201181	13201181	C	T	exonic	NFIX	synonymous	SKCM\|1\|368\|0.00272
-	chr19	13183866	13183866	G	A	exonic	NFIX	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr19	13192606	13192606	G	A	exonic	NFIX	synonymous	SKCM\|1\|368\|0.00272
-	chr19	13184238	13184238	C	T	exonic	NFIX	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr19	13192571	13192571	C	T	exonic	NFIX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	13192654	13192654	C	-	exonic	NFIX	frameshift	LIHC\|1\|373\|0.00268
-	chr19	13186433	13186433	C	G	exonic	NFIX	synonymous	BRCA\|1\|982\|0.00102
-	chr19	13201145	13201145	C	T	exonic	NFIX	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	13184830	13184830	C	T	exonic	NFIX	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	13192546	13192546	C	T	exonic	NFIX	synonymous	SKCM\|1\|368\|0.00272
-	chr19	13186483	13186483	C	A	exonic	NFIX	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr19	13184299	13184299	G	A	exonic	NFIX	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr19	13136046	13136046	G	T	exonic	NFIX	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr19	13186432	13186432	C	T	exonic	NFIX	nonsynonymous	SKCM\|1\|368\|0.00272
rs786205515	chr19	13136327	13136327	G	T	exonic	NFIX	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	13184823	13184823	C	A	exonic	NFIX	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr19	13183900	13183900	C	A	exonic	NFIX	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs780269313	chr19	13184760	13184760	G	A	exonic	NFIX	synonymous	UCEC\|1\|248\|0.00403
-	chr19	13184720	13184720	C	G	exonic	NFIX	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr19	13135864	13135864	G	A	exonic	NFIX	synonymous	BLCA\|1\|396\|0.00253
-	chr19	13201204	13201204	G	A	exonic	NFIX	synonymous	LUAD\|1\|543\|0.00184
-	chr19	13192533	13192533	C	T	exonic	NFIX	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	13186433	13186433	C	T	exonic	NFIX	synonymous	SKCM\|1\|368\|0.00272
-	chr19	13201123	13201123	G	A	exonic	NFIX	nonsynonymous	UCEC\|2\|248\|0.00806
-	chr19	13201202	13201202	C	G	exonic	NFIX	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355,LUAD\|1\|543\|0.00184
-	chr19	13136190	13136190	G	T	exonic	NFIX	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr19	13201132	13201132	C	T	exonic	NFIX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	13192667	13192667	C	T	exonic	NFIX	stopgain	UCEC\|1\|248\|0.00403
-	chr19	13192662	13192662	C	-	exonic	NFIX	frameshift	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs372257657	chr19	13201118	13201118	G	A	exonic	NFIX	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr19	13136064	13136064	A	T	exonic	NFIX	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr19	13136080	13136080	C	T	exonic	NFIX	synonymous	SKCM\|2\|368\|0.00543
-	chr19	13183882	13183882	C	G	exonic	NFIX	stopgain	DLBC\|1\|48\|0.02083
-	chr19	13136228	13136228	C	T	exonic	NFIX	nonsynonymous	SKCM\|1\|368\|0.00272

Disease information of NFIX

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
NFIX	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
NFIX	Marshall-Smith syndrome	C05;C10;C16	Disease or Syndrome	CTD_human;ORPHANET
NFIX	SOTOS SYNDROME 2		Disease or Syndrome	ORPHANET;UNIPROT
NFIX	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with NFIX

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001926	RNA Polymerase III Abortive And Retractive Initiation	reactome	41	663
pathway0001931	RNA Polymerase III Transcription Termination	reactome	23	245

Go term information of NFIX

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GO_term_name	GO_term_type	TF_name
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	NFIX

Survival analysis of NFIX

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NFIX

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)