Cancer CRCdb

TF information

TF name:	TFAP2C
TF family:	AP-2
Ensembl gene ID:	ENSG00000087510
Ensembl protein ID:	ENSP00000201031
Entrez gene ID:	7022

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of TFAP2C in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.4
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.49922178988327
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	1
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.536
Sample_02_180	Cell line	Human melanoma	CJM	0.578125
Sample_02_183	Cell line	Skin	SKMEL2	0.76923076923077
Sample_02_184	Cell line	Skin	SKMEL30	0.4887459807074
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.20289855072464

TFAP2C distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_046	Mammary Gland	Cell line	MCF-7
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_183	Skin	Cell line	SKMEL2
Sample_02_184	Skin	Cell line	SKMEL30

TFAP2C distribution in all CRCs

Genomic distribution of SEs associated with TFAP2C

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Mutation of TFAP2C

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TFAP2C

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr20	55206867	55206867	G	A	exonic	TFAP2C	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr20	55206428	55206428	G	A	exonic	TFAP2C	synonymous	BLCA\|1\|396\|0.00253
-	chr20	55206907	55206907	G	A	exonic	TFAP2C	nonsynonymous	ESCA\|1\|185\|0.00541,UCEC\|1\|248\|0.00403
-	chr20	55206311	55206311	C	A	exonic	TFAP2C	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	55208437	55208437	G	T	exonic	TFAP2C	synonymous	LUAD\|1\|543\|0.00184
-	chr20	55211672	55211672	C	A	exonic	TFAP2C	nonsynonymous	UCEC\|1\|248\|0.00403
rs757551788	chr20	55211796	55211796	G	A	exonic	TFAP2C	nonsynonymous	COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613
-	chr20	55211767	55211767	C	T	exonic	TFAP2C	stopgain	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	55206292	55206292	C	T	exonic	TFAP2C	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	55206438	55206438	T	C	exonic	TFAP2C	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	55211688	55211688	G	A	exonic	TFAP2C	synonymous	SKCM\|1\|368\|0.00272
rs146916115	chr20	55208518	55208518	G	A	exonic	TFAP2C	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr20	55211713	55211713	G	A	exonic	TFAP2C	nonsynonymous	BLCA\|1\|396\|0.00253,SKCM\|1\|368\|0.00272
-	chr20	55212976	55212976	G	A	exonic	TFAP2C	synonymous	CESC\|1\|194\|0.00515
-	chr20	55206371	55206371	A	T	exonic	TFAP2C	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	55209242	55209242	G	A	exonic	TFAP2C	synonymous	BLCA\|1\|396\|0.00253
-	chr20	55206728	55206728	C	A	exonic	TFAP2C	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr20	55209280	55209280	G	A	exonic	TFAP2C	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	55211765	55211765	G	A	exonic	TFAP2C	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs769025070	chr20	55208570	55208570	C	T	exonic	TFAP2C	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
rs372281758	chr20	55211799	55211799	A	G	exonic	TFAP2C	synonymous	LUAD\|1\|543\|0.00184
-	chr20	55211734	55211734	G	A	exonic	TFAP2C	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr20	55206271	55206271	A	G	exonic	TFAP2C	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr20	55212940	55212940	G	T	exonic	TFAP2C	synonymous	BLCA\|1\|396\|0.00253
-	chr20	55208541	55208541	A	G	exonic	TFAP2C	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr20	55204644	55204644	G	C	exonic	TFAP2C	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	55206393	55206393	C	T	exonic	TFAP2C	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	55206380	55206380	G	A	exonic	TFAP2C	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	55206674	55206674	C	A	exonic	TFAP2C	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr20	55206867	55206867	G	T	exonic	TFAP2C	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr20	55206408	55206408	C	T	exonic	TFAP2C	stopgain	PAAD\|1\|185\|0.00541
-	chr20	55208539	55208539	-	T	exonic	TFAP2C	frameshift	HNSC\|1\|512\|0.00195
-	chr20	55208504	55208504	C	A	exonic	TFAP2C	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	55209258	55209258	G	C	exonic	TFAP2C	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	55208625	55208625	G	A	exonic	TFAP2C	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	55209229	55209229	G	T	exonic	TFAP2C	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr20	55206484	55206484	A	G	exonic	TFAP2C	nonsynonymous	BLCA\|1\|396\|0.00253
rs111436406	chr20	55212940	55212940	G	A	exonic	TFAP2C	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	55206350	55206350	C	G	exonic	TFAP2C	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	55209319	55209319	T	C	exonic	TFAP2C	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr20	55209267	55209267	C	A	exonic	TFAP2C	nonsynonymous	LUAD\|1\|543\|0.00184
rs200017220	chr20	55206738	55206738	G	A	exonic	TFAP2C	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	55208585	55208594	GAATGCTTAA	-	exonic	TFAP2C	frameshift	PRAD\|1\|499\|0.00200
-	chr20	55208508	55208508	G	A	exonic	TFAP2C	nonsynonymous	SKCM\|1\|368\|0.00272
rs138750457	chr20	55212825	55212825	G	A	exonic	TFAP2C	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr20	55212796	55212796	A	G	exonic	TFAP2C	synonymous	SKCM\|1\|368\|0.00272
-	chr20	55209300	55209300	A	C	exonic	TFAP2C	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr20	55211787	55211787	G	A	exonic	TFAP2C	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs770130262	chr20	55209215	55209215	G	A	exonic	TFAP2C	synonymous	SKCM\|1\|368\|0.00272
-	chr20	55211768	55211768	G	A	exonic	TFAP2C	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	55206340	55206340	C	T	exonic	TFAP2C	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	55208476	55208476	G	A	exonic	TFAP2C	nonsynonymous	BRCA\|2\|982\|0.00204
rs760198839	chr20	55212870	55212870	A	G	exonic	TFAP2C	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	55212914	55212914	T	A	exonic	TFAP2C	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	55212957	55212957	A	C	exonic	TFAP2C	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	55212806	55212806	G	T	exonic	TFAP2C	stopgain	UCEC\|1\|248\|0.00403
-	chr20	55212788	55212788	C	A	exonic	TFAP2C	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	55206890	55206890	C	T	exonic	TFAP2C	synonymous	LIHC\|1\|373\|0.00268
-	chr20	55206327	55206327	C	G	exonic	TFAP2C	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	55206379	55206379	C	T	exonic	TFAP2C	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	55209278	55209278	G	A	exonic	TFAP2C	synonymous	LUAD\|1\|543\|0.00184
-	chr20	55204645	55204645	C	T	exonic	TFAP2C	synonymous	ESCA\|1\|185\|0.00541
-	chr20	55204608	55204608	G	A	exonic	TFAP2C	stopgain	SKCM\|1\|368\|0.00272
-	chr20	55212856	55212856	A	-	exonic	TFAP2C	frameshift	PAAD\|2\|185\|0.01081
-	chr20	55208488	55208488	G	A	exonic	TFAP2C	synonymous	UCEC\|1\|248\|0.00403
rs764761215	chr20	55208471	55208471	G	A	exonic	TFAP2C	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	55211736	55211736	A	G	exonic	TFAP2C	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	55206414	55206414	G	A	exonic	TFAP2C	nonsynonymous	ACC\|1\|90\|0.01111,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs563528822	chr20	55209305	55209305	C	T	exonic	TFAP2C	synonymous	SKCM\|1\|368\|0.00272
-	chr20	55211737	55211737	G	A	exonic	TFAP2C	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	55211758	55211758	C	T	exonic	TFAP2C	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	55206395	55206395	C	T	exonic	TFAP2C	synonymous	SKCM\|1\|368\|0.00272
-	chr20	55211794	55211794	A	G	exonic	TFAP2C	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr20	55206743	55206743	G	A	exonic	TFAP2C	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs773514336	chr20	55209228	55209228	C	T	exonic	TFAP2C	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	55212966	55212966	A	T	exonic	TFAP2C	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	55206427	55206427	C	T	exonic	TFAP2C	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	55208590	55208590	C	T	exonic	TFAP2C	synonymous	UCEC\|1\|248\|0.00403

Disease information of TFAP2C

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
TFAP2C	Malignant neoplasm of stomach	C04;C06	Neoplastic Process	CTD_human
TFAP2C	Stomach Neoplasms	C04;C06	Neoplastic Process	CTD_human
TFAP2C	Hereditary Diffuse Gastric Cancer	C04;C06	Neoplastic Process	CTD_human
TFAP2C	cocaine use		Mental or Behavioral Dysfunction	PSYGENET

Pathway associated with TFAP2C

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of TFAP2C

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GO_term_name	GO_term_type	TF_name
GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS	BP	TFAP2C
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	TFAP2C

Survival analysis of TFAP2C

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of TFAP2C

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)