TF information

TF name: E2F2
TF family: E2F
Ensembl gene ID: ENSG00000007968
Ensembl protein ID: ENSP00000355249
Entrez gene ID: 1870
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of E2F2 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_095Cell lineMammary GlandMDA-MB-4680.040077821011673
Sample_02_179Cell lineUrinary bladderT240.42528735632184
Sample_02_237Cell lineColonV3890.45175777655071
Sample_02_242Cell lineColonV4810.55284240210216
Sample_02_254Cell lineNeuroblastomaIMR5-750.29411764705882
Sample_02_300Cell lineNeuroblastomaCLB-PE0.17948717948718
Sample_02_303Cell lineNeuroblastomaLAN10.22857142857143
Sample_02_311Cell lineNeuroblastomaSK-N-AS0.27272727272727
Sample_02_312Cell lineNeuroblastomaSK-N-BE_2-C0.090425531914894
Sample_02_314Cell lineNeuroblastomaSK-N-FI0.24691358024691
Sample_02_318Cell lineNeuroblastomaNB690.265625

E2F2 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_179Urinary bladderCell lineT24
Sample_02_237ColonCell lineV389
Sample_02_242ColonCell lineV481

E2F2 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with E2F2
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Mutation of E2F2
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of E2F2

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr12384752723847527CTexonicE2F2synonymous BRCA|1|982|0.00102
-chr12385727723857277TAexonicE2F2nonsynonymous HNSC|1|512|0.00195
-chr12384743723847437GAexonicE2F2synonymous CESC|1|194|0.00515
-chr12384840023848400GAexonicE2F2synonymous LUAD|1|543|0.00184
-chr12383658223836582CTexonicE2F2synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr12385713623857136CTexonicE2F2synonymous UVM|1|80|0.01250
-chr12384833623848336GAexonicE2F2stopgain SKCM|1|368|0.00272
-chr12384841923848419TCexonicE2F2nonsynonymous HNSC|1|512|0.00195
-chr12384833723848337GAexonicE2F2synonymous SKCM|1|368|0.00272
-chr12383660823836608GAexonicE2F2nonsynonymous SKCM|1|368|0.00272
-chr12384555223845552TCexonicE2F2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr12384747623847476CAexonicE2F2nonsynonymous LUAD|1|543|0.00184
-chr12383656523836565ATexonicE2F2nonsynonymous OV|1|469|0.00213
rs146034018chr12383639923836399GAexonicE2F2synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr12385703423857034CAexonicE2F2synonymous BRCA|1|982|0.00102
-chr12384842223848422A-exonicE2F2frameshift BLCA|1|396|0.00253
rs777714546chr12385703423857034CTexonicE2F2synonymous LUAD|1|543|0.00184
-chr12384289123842891GTexonicE2F2nonsynonymous ESCA|1|185|0.00541
-chr12384756423847564CTsplicingE2F2splicing BLCA|1|396|0.00253
-chr12384560323845603GAexonicE2F2stopgain LUAD|1|543|0.00184
rs188102614chr12385724423857244CTexonicE2F2synonymous BLCA|1|396|0.00253
-chr12384746623847466GAexonicE2F2stopgain COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs139052092chr12384556623845566GAexonicE2F2nonsynonymous DLBC|1|48|0.02083
rs756515833chr12384293423842934GAexonicE2F2nonsynonymous SKCM|1|368|0.00272
rs201302633chr12384292023842920GAexonicE2F2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr12385717923857179-GexonicE2F2frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr12384838423848384CAexonicE2F2nonsynonymous LUAD|1|543|0.00184
-chr12385088723850887GAexonicE2F2nonsynonymous SKCM|1|368|0.00272
-chr12384854823848548GAexonicE2F2nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr12384833723848337GCexonicE2F2nonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr12384748323847483GAexonicE2F2nonsynonymous UCEC|1|248|0.00403
-chr12383644723836447CAexonicE2F2synonymous OV|1|469|0.00213
-chr12384747323847473GAexonicE2F2synonymous SKCM|1|368|0.00272
-chr12384838423848384CTexonicE2F2nonsynonymous OV|1|469|0.00213
-chr12383653023836530CTexonicE2F2nonsynonymous UCEC|1|248|0.00403
-chr12385094523850945CGexonicE2F2nonsynonymous HNSC|2|512|0.00391
-chr12384850423848504CAexonicE2F2nonsynonymous LUAD|1|543|0.00184
-chr12384838323848383AGexonicE2F2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs757615854chr12384551923845519CTexonicE2F2nonsynonymous ESCA|1|185|0.00541
rs141515224chr12384553623845536GAexonicE2F2nonsynonymous UCEC|1|248|0.00403
-chr12383641623836416CTexonicE2F2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs765421608chr12384844723848447CTexonicE2F2nonsynonymous CESC|1|194|0.00515
-chr12385091423850914CTexonicE2F2nonsynonymous SKCM|1|368|0.00272
-chr12383644823836448AGexonicE2F2nonsynonymous COAD|2|367|0.00545,COADREAD|2|489|0.00409
-chr12385705923857059CTexonicE2F2nonsynonymous BLCA|1|396|0.00253
-chr12384554523845545GTexonicE2F2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs772518646chr12384840623848406CTexonicE2F2synonymous UCEC|1|248|0.00403
-chr12384838223848382CAexonicE2F2synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr12383658023836580TCexonicE2F2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr12384292923842929CTexonicE2F2nonsynonymous STAD|2|395|0.00506,STES|2|395|0.00506
-chr12384299923842999GTexonicE2F2synonymous LUAD|1|543|0.00184
-chr12384552523845525CTexonicE2F2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs754726067chr12383647123836471TCexonicE2F2synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr12384834223848342TCexonicE2F2nonsynonymous BLCA|1|396|0.00253
-chr12383644923836449GAexonicE2F2synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204

Disease information of E2F2
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source

Pathway associated with E2F2
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000225 Association of licensing factors with the pre-replicative complex reactome 15 58
pathway0000391 CDC6 association with the ORC:origin complex reactome 11 41
pathway0000517 Cyclin D associated events in G1 reactome 38 366
pathway0000648 E2F transcription factor network pid 77 897
pathway0001543 Oncogene Induced Senescence reactome 30 146
pathway0001559 Oxidative Stress Induced Senescence reactome 120 3580
pathway0001857 Regulation of retinoblastoma protein pid 67 718
pathway0002571 Cell cycle kegg 124 2334
pathway0002656 Pathways in cancer kegg 321 8293
pathway0002659 Pancreatic cancer kegg 70 835
pathway0002661 Glioma kegg 65 998
pathway0002662 Prostate cancer kegg 85 1261
pathway0002665 Melanoma kegg 69 1192
pathway0002666 Bladder cancer kegg 38 233
pathway0002667 Chronic myeloid leukemia kegg 69 881
pathway0002669 Small cell lung cancer kegg 83 807
pathway0002670 Non-small cell lung cancer kegg 54 623
pathway0002717 Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 wikipathways 36 226

Go term information of E2F2
GO_term_name GO_term_type TF_name
GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER BP E2F2
GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR BP E2F2
GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS BP E2F2
GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR BP E2F2

Survival analysis of E2F2



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of E2F2