TF information

TF name: NR2F6
TF family: RXR-like
Ensembl gene ID: ENSG00000160113
Ensembl protein ID: ENSP00000291442, ENSP00000471686
Entrez gene ID: 2063
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of NR2F6 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_095Cell lineMammary GlandMDA-MB-4680.089494163424125
Sample_02_280Cell lineMammary GlandSUM159_DMSO_24h0.9
Sample_02_285Cell lineLiverHuH7_untreat0.1602787456446
Sample_02_322Cell lineColonCaco-20.1628532974428
Sample_02_358Cell lineColonLS1800.1129541864139

NR2F6 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_280Mammary GlandCell lineSUM159_DMSO_24h

NR2F6 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with NR2F6
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Mutation of NR2F6
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NR2F6

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr191735584917355849CTexonicNR2F6nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr191734329017343290CTexonicNR2F6synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr191735150217351502GAexonicNR2F6synonymous SKCM|1|368|0.00272
-chr191735592417355924GAexonicNR2F6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr191734640017346400CTexonicNR2F6nonsynonymous STAD|2|395|0.00506,STES|2|395|0.00506
rs370347405chr191734317517343175CTexonicNR2F6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr191734635417346354GAexonicNR2F6synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
rs372090950chr191734323717343237GAexonicNR2F6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr191735584117355841CGexonicNR2F6synonymous BRCA|1|982|0.00102,CESC|1|194|0.00515
-chr191735157217351572GTexonicNR2F6nonsynonymous UCEC|1|248|0.00403
-chr191734336817343368GAexonicNR2F6synonymous ACC|1|90|0.01111
-chr191734318817343188GAexonicNR2F6synonymous UCEC|1|248|0.00403
-chr191734322717343227CAexonicNR2F6nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr191734325317343253GAexonicNR2F6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253,UCEC|1|248|0.00403
-chr191734327517343275GAexonicNR2F6synonymous BLCA|1|396|0.00253
rs369918989chr191734335317343353CTexonicNR2F6synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr191734321417343214CTexonicNR2F6nonsynonymous UCEC|1|248|0.00403
rs757103571chr191735157217351572GAexonicNR2F6nonsynonymous SKCM|1|368|0.00272
-chr191734632917346329CTexonicNR2F6nonsynonymous ESCA|1|185|0.00541
rs761684813chr191734343317343433CTexonicNR2F6nonsynonymous PAAD|1|185|0.00541
-chr191735153517351535GCexonicNR2F6nonsynonymous LIHC|1|373|0.00268
-chr191734635117346351CTexonicNR2F6synonymous LUAD|1|543|0.00184
rs146497684chr191734644117346441ATexonicNR2F6synonymous ACC|1|90|0.01111
rs752642391chr191734323617343236CTexonicNR2F6synonymous PRAD|1|499|0.00200
-chr191734631517346315GTexonicNR2F6nonsynonymous BLCA|1|396|0.00253
-chr191735155317351553GAexonicNR2F6synonymous BLCA|1|396|0.00253
-chr191734323517343235GAexonicNR2F6nonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr191735584917355849CGexonicNR2F6nonsynonymous LUSC|1|178|0.00562
-chr191734323217343232TCexonicNR2F6nonsynonymous LUAD|1|543|0.00184
-chr191734336017343360AGexonicNR2F6nonsynonymous HNSC|1|512|0.00195
rs200476767chr191735156717351567GAexonicNR2F6nonsynonymous UCEC|1|248|0.00403
-chr191734331117343311CTexonicNR2F6synonymous PRAD|1|499|0.00200

Disease information of NR2F6
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
NR2F6 Malignant neoplasm of breast C04;C17 Neoplastic Process CTD_human
NR2F6 Endometriosis C13 Disease or Syndrome CTD_human
NR2F6 Endometrioma C13 Neoplastic Process CTD_human
NR2F6 Breast Carcinoma C04;C17 Neoplastic Process CTD_human
NR2F6 Mammary Neoplasms, Human C04;C17 Neoplastic Process CTD_human
NR2F6 Mammary Neoplasms C04;C17 Neoplastic Process CTD_human

Pathway associated with NR2F6
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0001534 Nuclear Receptor transcription pathway reactome 51 284

Go term information of NR2F6
GO_term_name GO_term_type TF_name
GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS BP NR2F6
GO_PHOTOPERIODISM BP NR2F6
GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD BP NR2F6
GO_HORMONE_MEDIATED_SIGNALING_PATHWAY BP NR2F6
GO_DETECTION_OF_TEMPERATURE_STIMULUS BP NR2F6
GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK BP NR2F6
GO_DETECTION_OF_ABIOTIC_STIMULUS BP NR2F6
GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION BP NR2F6
GO_ENHANCER_BINDING MF NR2F6
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING MF NR2F6
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY MF NR2F6
GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING MF NR2F6

Survival analysis of NR2F6



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of NR2F6