Cancer CRCdb

TF information

TF name:	SOX9
TF family:	HMG
Ensembl gene ID:	ENSG00000125398
Ensembl protein ID:	ENSP00000495527, ENSP00000245479
Entrez gene ID:	6662

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SOX9 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_068	Cell line	Prostate: derived from metastatic site: vertebral metastasis	VCaP	0.46575342465753
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	1
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	1
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.34
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.10344827586207
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.92888888888889
Sample_02_268	Cell line	Kidney	A-498	0.024552335240908
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.24254016832441
Sample_02_303	Cell line	Neuroblastoma	LAN1	0.65714285714286
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.22972972972973
Sample_02_358	Cell line	Colon	LS180	0.16785150078989
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.85611510791367

SOX9 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_068	Prostate: derived from metastatic site: vertebral metastasis	Cell line	VCaP
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_258	Lung	Other	NCI-H1299_EGFP-NEO_reporter_cells_DMSO
Sample_02_317	Neuroblastoma	Cell line	GICAN
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2

SOX9 distribution in all CRCs

Genomic distribution of SEs associated with SOX9

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Mutation of SOX9

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SOX9

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr17	70119039	70119039	T	A	exonic	SOX9	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr17	70120479	70120479	G	A	exonic	SOX9	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr17	70119760	70119760	A	-	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70118922	70118922	A	G	exonic	SOX9	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70117594	70117594	C	-	exonic	SOX9	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70120135	70120135	G	T	exonic	SOX9	synonymous	BLCA\|1\|396\|0.00253
-	chr17	70120103	70120103	C	T	exonic	SOX9	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr17	70120097	70120097	C	A	exonic	SOX9	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70118950	70118950	C	A	exonic	SOX9	stopgain	ESCA\|1\|185\|0.00541
-	chr17	70119762	70119762	-	G	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70119947	70119947	G	T	exonic	SOX9	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	70119026	70119026	C	T	exonic	SOX9	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	70119859	70119859	G	T	exonic	SOX9	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	70119701	70119701	C	G	exonic	SOX9	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	70117782	70117782	T	G	exonic	SOX9	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr17	70120416	70120416	A	G	exonic	SOX9	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70120351	70120351	C	T	exonic	SOX9	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr17	70119088	70119088	-	T	exonic	SOX9	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70120094	70120094	C	-	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70117600	70117600	-	C	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119794	70119794	C	A	exonic	SOX9	nonsynonymous	SARC\|1\|247\|0.00405
-	chr17	70119734	70119734	C	T	exonic	SOX9	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120195	70120195	G	A	exonic	SOX9	synonymous	UCS\|1\|57\|0.01754
-	chr17	70120178	70120178	C	T	exonic	SOX9	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119869	70119869	-	CAA	exonic	SOX9	nonframeshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119895	70119895	G	A	exonic	SOX9	synonymous	BLCA\|1\|396\|0.00253
-	chr17	70119780	70119780	-	G	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70117939	70117939	G	A	exonic	SOX9	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	70117713	70117714	AA	-	exonic	SOX9	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70119040	70119040	C	T	exonic	SOX9	synonymous	BLCA\|1\|396\|0.00253
-	chr17	70120487	70120487	C	A	exonic	SOX9	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	70117789	70117789	G	A	exonic	SOX9	stopgain	PCPG\|1\|184\|0.00543
-	chr17	70119870	70119870	T	-	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70118931	70118931	A	G	exonic	SOX9	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120225	70120226	GC	-	exonic	SOX9	frameshift	PRAD\|1\|499\|0.00200
-	chr17	70120418	70120418	C	T	exonic	SOX9	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	70118865	70118865	T	-	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119112	70119112	G	-	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119913	70119913	-	T	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120204	70120204	G	C	exonic	SOX9	synonymous	BLCA\|1\|396\|0.00253
rs778335883	chr17	70119805	70119805	C	A	exonic	SOX9	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr17	70118926	70118926	G	C	exonic	SOX9	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	70120448	70120448	T	G	exonic	SOX9	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	70117638	70117638	C	T	exonic	SOX9	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr17	70120238	70120239	TC	-	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119696	70119696	-	C	exonic	SOX9	frameshift	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr17	70118952	70118952	A	C	exonic	SOX9	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs149355998	chr17	70119856	70119856	C	T	exonic	SOX9	synonymous	UCEC\|1\|248\|0.00403
-	chr17	70118998	70118998	G	A	exonic	SOX9	synonymous	SKCM\|1\|368\|0.00272
-	chr17	70119807	70119807	-	C	exonic	SOX9	frameshift	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs752697003	chr17	70119055	70119055	C	T	exonic	SOX9	synonymous	LIHC\|1\|373\|0.00268
-	chr17	70118882	70118882	C	T	exonic	SOX9	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	70119709	70119709	A	G	exonic	SOX9	synonymous	BLCA\|1\|396\|0.00253
-	chr17	70119814	70119814	-	T	exonic	SOX9	frameshift	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr17	70120258	70120258	C	T	exonic	SOX9	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70120244	70120244	C	T	exonic	SOX9	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120487	70120487	-	CT	exonic	SOX9	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70120330	70120330	C	A	exonic	SOX9	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	70120527	70120527	G	C	exonic	SOX9	stoploss	BRCA\|1\|982\|0.00102
-	chr17	70119772	70119772	C	A	exonic	SOX9	synonymous	LUAD\|1\|543\|0.00184
-	chr17	70120265	70120265	T	-	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120342	70120342	C	-	exonic	SOX9	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr17	70117876	70117876	G	A	exonic	SOX9	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120399	70120399	C	A	exonic	SOX9	synonymous	HNSC\|1\|512\|0.00195
-	chr17	70120194	70120194	-	G	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120527	70120527	G	A	exonic	SOX9	synonymous	HNSC\|1\|512\|0.00195
-	chr17	70120419	70120419	G	A	exonic	SOX9	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70120314	70120314	-	G	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120498	70120498	A	G	exonic	SOX9	synonymous	HNSC\|1\|512\|0.00195
-	chr17	70118942	70118942	T	C	exonic	SOX9	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120328	70120328	G	T	exonic	SOX9	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	70120376	70120376	A	C	exonic	SOX9	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	70117715	70117715	-	A	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70118882	70118883	CG	-	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs778047936	chr17	70119789	70119789	G	A	exonic	SOX9	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr17	70119866	70119866	G	A	exonic	SOX9	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	70120053	70120053	C	T	exonic	SOX9	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr17	70119683	70119683	G	A	splicing	SOX9	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119808	70119808	C	A	exonic	SOX9	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70117637	70117637	C	A	exonic	SOX9	stopgain	LUAD\|1\|543\|0.00184
-	chr17	70117755	70117755	G	A	exonic	SOX9	nonsynonymous	BRCA\|1\|982\|0.00102,LUAD\|2\|543\|0.00368
-	chr17	70120440	70120440	C	G	exonic	SOX9	nonsynonymous	LUAD\|1\|543\|0.00184
rs551719325	chr17	70120328	70120328	G	A	exonic	SOX9	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	70120345	70120345	-	CCT	exonic	SOX9	nonframeshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119768	70119768	G	A	exonic	SOX9	nonsynonymous	BLCA\|1\|396\|0.00253,UCEC\|1\|248\|0.00403
-	chr17	70119798	70119798	C	T	exonic	SOX9	nonsynonymous	LUAD\|1\|543\|0.00184
rs747366415	chr17	70119082	70119082	G	A	exonic	SOX9	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	70119832	70119832	G	A	exonic	SOX9	synonymous	BLCA\|1\|396\|0.00253
-	chr17	70117908	70117908	C	T	exonic	SOX9	stopgain	BRCA\|1\|982\|0.00102
-	chr17	70119038	70119038	-	AG	exonic	SOX9	stopgain	COADREAD\|2\|489\|0.00409,READ\|2\|122\|0.01639
-	chr17	70119864	70119864	-	C	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119050	70119050	C	T	exonic	SOX9	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70117873	70117873	T	C	exonic	SOX9	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr17	70118940	70118940	-	T	exonic	SOX9	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	70119068	70119068	T	C	exonic	SOX9	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	70120235	70120235	-	G	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119762	70119762	-	GGGC	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70120374	70120374	G	T	exonic	SOX9	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr17	70118979	70118979	A	T	exonic	SOX9	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	70118928	70118928	A	C	exonic	SOX9	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	70117761	70117761	G	T	exonic	SOX9	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70119910	70119910	G	-	exonic	SOX9	frameshift	BRCA\|1\|982\|0.00102,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	70120241	70120241	C	-	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70117604	70117604	C	G	exonic	SOX9	synonymous	LUAD\|1\|543\|0.00184
-	chr17	70120229	70120229	C	T	exonic	SOX9	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr17	70118957	70118957	C	T	exonic	SOX9	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	70117624	70117624	C	T	exonic	SOX9	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	70117912	70117912	A	G	exonic	SOX9	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr17	70118954	70118954	C	T	exonic	SOX9	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr17	70119806	70119806	T	A	exonic	SOX9	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr17	70118925	70118926	AG	-	exonic	SOX9	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr17	70120341	70120341	C	T	exonic	SOX9	nonsynonymous	HNSC\|2\|512\|0.00391
rs865810520	chr17	70119078	70119078	G	A	exonic	SOX9	nonsynonymous	HNSC\|1\|512\|0.00195,PRAD\|1\|499\|0.00200
-	chr17	70120131	70120131	-	G	exonic	SOX9	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204

Disease information of SOX9

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SOX9	Carcinoma	C04	Neoplastic Process	CTD_human
SOX9	Gonadal Dysgenesis, 46,XY	C12;C13;C16;C19	Disease or Syndrome	ORPHANET
SOX9	Congenital Hand Deformities	C05;C16	Congenital Abnormality	CTD_human
SOX9	Lung Neoplasms	C04;C08	Neoplastic Process	CTD_human
SOX9	Animal Mammary Neoplasms	C04;C22	Neoplastic Process	CTD_human
SOX9	Mammary Neoplasms, Experimental	C04	Experimental Model of Disease; Neoplastic Process	CTD_human
SOX9	Osteogenesis Imperfecta	C05;C16;C17	Congenital Abnormality; Disease or Syndrome	GENOMICS_ENGLAND
SOX9	Pierre Robin Syndrome	C05;C07;C16	Congenital Abnormality	CTD_human;ORPHANET
SOX9	Disorders of Sex Development	C12;C13;C16;C19	Congenital Abnormality	GENOMICS_ENGLAND
SOX9	Unipolar Depression	F03	Mental or Behavioral Dysfunction	PSYGENET
SOX9	Anaplastic carcinoma	C04	Neoplastic Process	CTD_human
SOX9	Carcinoma, Spindle-Cell	C04	Neoplastic Process	CTD_human
SOX9	Undifferentiated carcinoma	C04	Neoplastic Process	CTD_human
SOX9	Carcinomatosis	C04	Neoplastic Process	CTD_human
SOX9	Malignant neoplasm of lung	C04;C08	Neoplastic Process	CTD_human
SOX9	ANONYCHIA	C23	Congenital Abnormality	CTD_human
SOX9	True Hermaphroditism (disorder)	C12;C13;C16;C19	Congenital Abnormality	ORPHANET
SOX9	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
SOX9	XX males		Disease or Syndrome	ORPHANET
SOX9	Mammary Carcinoma, Animal	C04;C22	Neoplastic Process	CTD_human
SOX9	Major Depressive Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
SOX9	Autism Spectrum Disorders	F03	Mental or Behavioral Dysfunction	CTD_human
SOX9	CAMPOMELIC DYSPLASIA WITH AUTOSOMAL SEX REVERSAL	C05;C12;C13;C16;C19	Disease or Syndrome	UNIPROT
SOX9	CAMPOMELIC DYSPLASIA	C05;C16	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
SOX9	Acampomelic Campomelic Dysplasia	C05;C16	Disease or Syndrome	CTD_human;UNIPROT
SOX9	Ovotesticular Disorders of Sex Development	C12;C13;C16;C19	Congenital Abnormality	ORPHANET
SOX9	46, XX Testicular Disorders of Sex Development	C12;C13;C16;C19	Congenital Abnormality	ORPHANET
SOX9	Swyer Syndrome	C12;C13;C16;C19	Disease or Syndrome	ORPHANET
SOX9	ACAMPOMELIC CAMPOMELIC DYSPLASIA WITH AUTOSOMAL SEX REVERSAL		Disease or Syndrome	UNIPROT
SOX9	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
SOX9	46,XY SEX REVERSAL 10		Disease or Syndrome	CTD_human
SOX9	46,XY partial gonadal dysgenesis		Disease or Syndrome	ORPHANET

Pathway associated with SOX9

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000549	Deactivation of the beta-catenin transactivating complex	reactome	42	236
pathway0002747	Hs_Neural_Crest_Differentiation_WP2064_79263	wikipathways	40	129
pathway0002791	Hs_Spinal_Cord_Injury_WP2431_87678	wikipathways	21	31

Go term information of SOX9

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GO_term_name	GO_term_type	TF_name
GO_METANEPHRIC_NEPHRON_MORPHOGENESIS	BP	SOX9
GO_DIGESTION	BP	SOX9
GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS	BP	SOX9
GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT	BP	SOX9
GO_URETER_DEVELOPMENT	BP	SOX9
GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE	BP	SOX9
GO_LUNG_EPITHELIUM_DEVELOPMENT	BP	SOX9
GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION	BP	SOX9
GO_MUSCLE_TISSUE_DEVELOPMENT	BP	SOX9
GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS	BP	SOX9
GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	SOX9
GO_CARTILAGE_DEVELOPMENT	BP	SOX9
GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1	BP	SOX9
GO_PROSTATE_GLAND_MORPHOGENESIS	BP	SOX9
GO_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	SOX9
GO_CELLULAR_RESPONSE_TO_LIPID	BP	SOX9
GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION	BP	SOX9
GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT	BP	SOX9
GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS	BP	SOX9
GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT	BP	SOX9
GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION	BP	SOX9
GO_ENDOCARDIAL_CUSHION_DEVELOPMENT	BP	SOX9
GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM	BP	SOX9
GO_LUNG_CELL_DIFFERENTIATION	BP	SOX9
GO_OTIC_VESICLE_DEVELOPMENT	BP	SOX9
GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT	BP	SOX9
GO_SERTOLI_CELL_DEVELOPMENT	BP	SOX9
GO_MALE_SEX_DETERMINATION	BP	SOX9
GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION	BP	SOX9
GO_LUNG_MORPHOGENESIS	BP	SOX9
GO_SEX_DETERMINATION	BP	SOX9
GO_DEVELOPMENTAL_INDUCTION	BP	SOX9
GO_CHONDROCYTE_DEVELOPMENT	BP	SOX9
GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY	BP	SOX9
GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS	BP	SOX9
GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR	BP	SOX9
GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	SOX9
GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION	BP	SOX9
GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT	BP	SOX9
GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY	BP	SOX9
GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION	BP	SOX9
GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY	BP	SOX9
GO_SEXUAL_REPRODUCTION	BP	SOX9
GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION	BP	SOX9
GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	SOX9
GO_REGULATION_OF_KIDNEY_DEVELOPMENT	BP	SOX9
GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT	BP	SOX9
GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION	BP	SOX9
GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID	BP	SOX9
GO_REGULATION_OF_HEART_MORPHOGENESIS	BP	SOX9
GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS	BP	SOX9
GO_ERBB_SIGNALING_PATHWAY	BP	SOX9
GO_ENDOCRINE_PANCREAS_DEVELOPMENT	BP	SOX9
GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING	BP	SOX9
GO_HEART_MORPHOGENESIS	BP	SOX9
GO_CELL_AGGREGATION	BP	SOX9
GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION	BP	SOX9
GO_PROTEIN_KINASE_B_SIGNALING	BP	SOX9
GO_RENAL_TUBULE_DEVELOPMENT	BP	SOX9
GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS	BP	SOX9
GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	SOX9
GO_HEART_VALVE_FORMATION	BP	SOX9
GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	SOX9
GO_EXOCRINE_SYSTEM_DEVELOPMENT	BP	SOX9
GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION	BP	SOX9
GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM	BP	SOX9
GO_MESONEPHRIC_TUBULE_MORPHOGENESIS	BP	SOX9
GO_ASTROCYTE_DIFFERENTIATION	BP	SOX9
GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	SOX9
GO_ORGAN_GROWTH	BP	SOX9
GO_SKIN_EPIDERMIS_DEVELOPMENT	BP	SOX9
GO_NOTCH_SIGNALING_PATHWAY	BP	SOX9
GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	SOX9
GO_METANEPHRIC_NEPHRON_DEVELOPMENT	BP	SOX9
GO_TRACHEA_DEVELOPMENT	BP	SOX9
GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	SOX9
GO_DIGESTIVE_SYSTEM_PROCESS	BP	SOX9
GO_EAR_MORPHOGENESIS	BP	SOX9
GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS	BP	SOX9
GO_TUBE_FORMATION	BP	SOX9
GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS	BP	SOX9
GO_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	SOX9
GO_RESPONSE_TO_GROWTH_FACTOR	BP	SOX9
GO_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	SOX9
GO_HEART_VALVE_DEVELOPMENT	BP	SOX9
GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS	BP	SOX9
GO_COCHLEA_DEVELOPMENT	BP	SOX9
GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS	BP	SOX9
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION	BP	SOX9
GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE	BP	SOX9
GO_EYE_DEVELOPMENT	BP	SOX9
GO_MESENCHYME_DEVELOPMENT	BP	SOX9
GO_GLIAL_CELL_FATE_COMMITMENT	BP	SOX9
GO_DEVELOPMENTAL_CELL_GROWTH	BP	SOX9
GO_RESPONSE_TO_RETINOIC_ACID	BP	SOX9
GO_COCHLEA_MORPHOGENESIS	BP	SOX9
GO_PROSTATE_GLAND_GROWTH	BP	SOX9
GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION	BP	SOX9
GO_ENDOCRINE_SYSTEM_DEVELOPMENT	BP	SOX9
GO_TUBE_MORPHOGENESIS	BP	SOX9
GO_GLIAL_CELL_DIFFERENTIATION	BP	SOX9
GO_NEGATIVE_REGULATION_OF_OSSIFICATION	BP	SOX9
GO_EPITHELIAL_STRUCTURE_MAINTENANCE	BP	SOX9
GO_ENDOCHONDRAL_BONE_MORPHOGENESIS	BP	SOX9
GO_NEPHRON_TUBULE_FORMATION	BP	SOX9
GO_PROSTATE_GLAND_DEVELOPMENT	BP	SOX9
GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE	BP	SOX9
GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	SOX9
GO_NOTOCHORD_DEVELOPMENT	BP	SOX9
GO_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	SOX9
GO_MESENCHYME_MORPHOGENESIS	BP	SOX9
GO_PROTEIN_LOCALIZATION_TO_NUCLEUS	BP	SOX9
GO_SERTOLI_CELL_DIFFERENTIATION	BP	SOX9
GO_AXIS_ELONGATION	BP	SOX9
GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	SOX9
GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING	BP	SOX9
GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS	BP	SOX9
GO_REGULATION_OF_ORGAN_MORPHOGENESIS	BP	SOX9
GO_CELL_GROWTH	BP	SOX9
GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	SOX9
GO_ERK1_AND_ERK2_CASCADE	BP	SOX9
GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT	BP	SOX9
GO_METANEPHROS_MORPHOGENESIS	BP	SOX9
GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE	BP	SOX9
GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS	BP	SOX9
GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS	BP	SOX9
GO_CAMP_MEDIATED_SIGNALING	BP	SOX9
GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX	CC	SOX9
GO_BETA_CATENIN_BINDING	MF	SOX9
GO_BHLH_TRANSCRIPTION_FACTOR_BINDING	MF	SOX9
GO_PROTEIN_KINASE_A_BINDING	MF	SOX9
GO_KINASE_ACTIVITY	MF	SOX9
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	SOX9
GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING	MF	SOX9
GO_CHROMATIN_BINDING	MF	SOX9
GO_PRE_MRNA_BINDING	MF	SOX9

Survival analysis of SOX9

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SOX9

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)