Cancer CRCdb

TF information

TF name:	MEF2D
TF family:	SRF
Ensembl gene ID:	ENSG00000116604
Ensembl protein ID:	ENSP00000477413, ENSP00000476788, ENSP00000353803, ENSP00000357223, ENSP00000271555
Entrez gene ID:	4209

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of MEF2D in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_021	Cell line	Colon	V429	0.074949553185356
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.60869565217391
Sample_02_164	Cell line	Lung	H2087_Parental	0.4
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.184
Sample_02_168	Cell line	Prostate	LNCaP	0.18250950570342
Sample_02_179	Cell line	Urinary bladder	T24	0.2183908045977
Sample_02_180	Cell line	Human melanoma	CJM	0.703125
Sample_02_181	Cell line	Human melanoma	COLO679	0.2896
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.19252873563218
Sample_02_184	Cell line	Skin	SKMEL30	0.48231511254019
Sample_02_197	Cell line	Stomach	SNU1750	0.22222222222222
Sample_02_204	Cell line	Stomach	IM95	0.090909090909091
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.3037037037037
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.17647058823529
Sample_02_220	Cell line	Brain	BE2C_1	0.62820512820513
Sample_02_237	Cell line	Colon	V389	0.49556414503957
Sample_02_241	Cell line	Colon	V456	0.20880361173815
Sample_02_242	Cell line	Colon	V481	0.13631993847337
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.73529411764706
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.28444444444444
Sample_02_268	Cell line	Kidney	A-498	0.26952187557689
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.41666666666667
Sample_02_304	Cell line	Neuroblastoma	N206	0.40353260869565
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.38028169014085
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.40625
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.14023591087811
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.53246753246753
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.51595744680851
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.38610038610039
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.31868131868132
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.21621621621622
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.23699421965318
Sample_02_338	Cell line	Neuroblastoma	BE2	0.63235294117647
Sample_02_358	Cell line	Colon	LS180	0.095181674565561
Sample_02_359	Cell line	Colon	Colo741	0.26204819277108
Sample_02_395	Cell line	Mammary Gland	BT-549	0.3034965034965
Sample_02_430	Cell line	Kidney	12364284	0.5

MEF2D distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_164	Lung	Cell line	H2087_Parental
Sample_02_180	Human melanoma	Cell line	CJM
Sample_02_184	Skin	Cell line	SKMEL30
Sample_02_220	Brain	Cell line	BE2C_1
Sample_02_237	Colon	Cell line	V389
Sample_02_254	Neuroblastoma	Cell line	IMR5-75
Sample_02_304	Neuroblastoma	Cell line	N206
Sample_02_307	Neuroblastoma	Cell line	SJNB12
Sample_02_308	Neuroblastoma	Cell line	SJNB1
Sample_02_311	Neuroblastoma	Cell line	SK-N-AS
Sample_02_312	Neuroblastoma	Cell line	SK-N-BE_2-C
Sample_02_316	Neuroblastoma	Cell line	CHP212
Sample_02_338	Neuroblastoma	Cell line	BE2

MEF2D distribution in all CRCs

Genomic distribution of SEs associated with MEF2D

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Mutation of MEF2D

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MEF2D

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr1	156452281	156452281	T	C	exonic	MEF2D	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	156449095	156449095	G	A	exonic	MEF2D	synonymous	UCEC\|1\|248\|0.00403
-	chr1	156446853	156446853	T	C	exonic	MEF2D	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	156437921	156437921	G	A	exonic	MEF2D	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	156438046	156438046	G	A	exonic	MEF2D	synonymous	UCEC\|1\|248\|0.00403
-	chr1	156446980	156446980	T	C	exonic	MEF2D	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	156438615	156438615	G	A	exonic	MEF2D	stopgain	BLCA\|1\|396\|0.00253
-	chr1	156438006	156438006	G	A	exonic	MEF2D	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	156452386	156452386	T	G	exonic	MEF2D	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	156449440	156449440	-	G	exonic	MEF2D	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	156438753	156438753	-	C	exonic	MEF2D	frameshift	LUAD\|1\|543\|0.00184
-	chr1	156449449	156449449	A	G	exonic	MEF2D	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	156438708	156438708	G	A	exonic	MEF2D	stopgain	SKCM\|1\|368\|0.00272
-	chr1	156449488	156449488	G	T	exonic	MEF2D	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	156437998	156437998	A	G	exonic	MEF2D	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs755442532	chr1	156438637	156438637	A	G	exonic	MEF2D	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs767404406	chr1	156452269	156452269	T	C	exonic	MEF2D	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	156452272	156452272	T	C	exonic	MEF2D	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	156450690	156450690	G	C	exonic	MEF2D	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	156436093	156436093	A	-	UTR3	MEF2D	unknown	CESC\|1\|194\|0.00515
-	chr1	156446831	156446831	C	A	exonic	MEF2D	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	156437897	156437897	C	G	exonic	MEF2D	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	156437907	156437907	A	G	exonic	MEF2D	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	156438739	156438739	A	G	exonic	MEF2D	synonymous	PRAD\|1\|499\|0.00200
-	chr1	156438576	156438576	G	T	exonic	MEF2D	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	156446862	156446862	C	T	exonic	MEF2D	nonsynonymous	PRAD\|1\|499\|0.00200
rs762225408	chr1	156437799	156437799	G	A	exonic	MEF2D	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	156438605	156438605	G	A	exonic	MEF2D	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	156452286	156452286	G	A	exonic	MEF2D	synonymous	UCEC\|1\|248\|0.00403
rs200731594	chr1	156444988	156444988	C	T	exonic	MEF2D	synonymous	PRAD\|1\|499\|0.00200
-	chr1	156437912	156437912	C	T	exonic	MEF2D	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	156449104	156449104	G	A	exonic	MEF2D	synonymous	UCEC\|1\|248\|0.00403
rs572441372	chr1	156437937	156437937	C	T	exonic	MEF2D	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	156446973	156446973	C	T	exonic	MEF2D	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	156452247	156452247	G	T	exonic	MEF2D	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs760467482	chr1	156446904	156446904	G	A	exonic	MEF2D	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,SKCM\|1\|368\|0.00272
-	chr1	156437893	156437893	G	A	exonic	MEF2D	synonymous	SKCM\|1\|368\|0.00272
-	chr1	156444993	156444993	G	A	exonic	MEF2D	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	156446855	156446855	G	A	exonic	MEF2D	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	156437901	156437901	T	A	exonic	MEF2D	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	156450662	156450662	G	T	exonic	MEF2D	synonymous	HNSC\|1\|512\|0.00195
-	chr1	156437973	156437973	G	A	exonic	MEF2D	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	156438655	156438655	C	A	exonic	MEF2D	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	156450706	156450706	A	G	exonic	MEF2D	nonsynonymous	SKCM\|1\|368\|0.00272
rs767074542	chr1	156437954	156437954	G	A	exonic	MEF2D	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr1	156446840	156446840	G	A	exonic	MEF2D	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	156444933	156444933	G	A	exonic	MEF2D	nonsynonymous	SKCM\|1\|368\|0.00272
rs753692123	chr1	156437983	156437983	C	T	exonic	MEF2D	synonymous	ACC\|1\|90\|0.01111
-	chr1	156446948	156446948	C	A	exonic	MEF2D	synonymous	LUAD\|1\|543\|0.00184
rs771689492	chr1	156450650	156450650	G	A	exonic	MEF2D	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	156453069	156453069	T	C	exonic	MEF2D	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	156437234	156437234	C	T	UTR3	MEF2D	unknown	CESC\|1\|194\|0.00515
-	chr1	156446904	156446904	G	C	exonic	MEF2D	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	156452228	156452228	C	T	splicing	MEF2D	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs756430794	chr1	156452364	156452364	G	A	exonic	MEF2D	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	156446841	156446841	A	G	exonic	MEF2D	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	156437437	156437437	T	C	exonic	MEF2D	stoploss	BRCA\|1\|982\|0.00102
-	chr1	156450738	156450738	C	A	exonic	MEF2D	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	156445004	156445004	G	A	exonic	MEF2D	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	156444934	156444934	G	A	exonic	MEF2D	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr1	156450503	156450503	G	-	intronic	MEF2D	unknown	CESC\|1\|194\|0.00515
-	chr1	156450724	156450724	C	A	exonic	MEF2D	stopgain	LUSC\|1\|178\|0.00562
rs748923134	chr1	156438787	156438787	G	A	exonic	MEF2D	synonymous	BLCA\|1\|396\|0.00253
-	chr1	156452248	156452248	G	C	exonic	MEF2D	nonsynonymous	OV\|1\|469\|0.00213
rs774925958	chr1	156437951	156437951	C	T	exonic	MEF2D	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	156437841	156437841	C	T	exonic	MEF2D	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	156446809	156446809	G	A	exonic	MEF2D	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	156450644	156450644	C	T	exonic	MEF2D	synonymous	CHOL\|1\|35\|0.02857
rs138045281	chr1	156437994	156437994	G	A	exonic	MEF2D	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	156453070	156453070	C	A	exonic	MEF2D	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	156437976	156437976	G	A	exonic	MEF2D	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	156444934	156444934	G	C	exonic	MEF2D	synonymous	BLCA\|1\|396\|0.00253
-	chr1	156438036	156438036	G	-	exonic	MEF2D	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	156449123	156449123	C	-	exonic	MEF2D	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	156452388	156452388	A	G	exonic	MEF2D	synonymous	LUSC\|1\|178\|0.00562
-	chr1	156452378	156452378	C	T	exonic	MEF2D	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	156446854	156446854	C	A	exonic	MEF2D	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	156450735	156450735	C	T	exonic	MEF2D	nonsynonymous	LUSC\|1\|178\|0.00562

Disease information of MEF2D

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
MEF2D	Common Migraine	C10	Disease or Syndrome	CTD_human

Pathway associated with MEF2D

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000393	CDO in myogenesis	reactome	29	200
pathway0000430	Circadian Clock	reactome	49	389
pathway0001572	p38 MAPK pathway	panther	31	137
pathway0001935	Role of Calcineurin-dependent NFAT signaling in lymphocytes	pid	54	450
pathway0002035	Signaling events mediated by HDAC Class III	pid	41	421
pathway0002299	Transcriptional activation of mitochondrial biogenesis	reactome	43	230

Go term information of MEF2D

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GO_term_name	GO_term_type	TF_name
GO_CARTILAGE_DEVELOPMENT	BP	MEF2D
GO_REPLACEMENT_OSSIFICATION	BP	MEF2D
GO_CHONDROCYTE_DIFFERENTIATION	BP	MEF2D
GO_BONE_MORPHOGENESIS	BP	MEF2D
GO_ADULT_HEART_DEVELOPMENT	BP	MEF2D
GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION	BP	MEF2D
GO_ENDOCHONDRAL_BONE_MORPHOGENESIS	BP	MEF2D
GO_TRANSCRIPTION_FACTOR_BINDING	MF	MEF2D

Survival analysis of MEF2D

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of MEF2D

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)