Cancer CRCdb

TF information

TF name:	TBX2
TF family:	T-box
Ensembl gene ID:	ENSG00000121068
Ensembl protein ID:	ENSP00000404781, ENSP00000240328
Entrez gene ID:	6909

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of TBX2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.8
Sample_02_181	Cell line	Human melanoma	COLO679	0.25866666666667
Sample_02_184	Cell line	Skin	SKMEL30	0.45337620578778
Sample_02_220	Cell line	Brain	BE2C_1	0.48717948717949
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.64705882352941
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.327467482785
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.58904109589041
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.72661870503597
Sample_02_300	Cell line	Neuroblastoma	CLB-PE	0.28205128205128
Sample_02_302	Cell line	Neuroblastoma	IMR32	0.35714285714286
Sample_02_303	Cell line	Neuroblastoma	LAN1	0.54285714285714
Sample_02_304	Cell line	Neuroblastoma	N206	0.48505434782609
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.45070422535211
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.5
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.51184834123223
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.47771952817824
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.28571428571429
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.3936170212766
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.48262548262548
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.67283950617284
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.46703296703297
Sample_02_318	Cell line	Neuroblastoma	NB69	0.6640625
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.43352601156069
Sample_02_338	Cell line	Neuroblastoma	BE2	0.47058823529412
Sample_02_359	Cell line	Colon	Colo741	0.060240963855422

TBX2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_046	Mammary Gland	Cell line	MCF-7
Sample_02_220	Brain	Cell line	BE2C_1
Sample_02_254	Neuroblastoma	Cell line	IMR5-75
Sample_02_299	Neuroblastoma	Cell line	CLB-MA
Sample_02_302	Neuroblastoma	Cell line	IMR32
Sample_02_303	Neuroblastoma	Cell line	LAN1
Sample_02_307	Neuroblastoma	Cell line	SJNB12
Sample_02_308	Neuroblastoma	Cell line	SJNB1
Sample_02_309	Neuroblastoma	Cell line	SJNB6
Sample_02_310	Neuroblastoma	Cell line	SJNB8
Sample_02_314	Neuroblastoma	Cell line	SK-N-FI
Sample_02_318	Neuroblastoma	Cell line	NB69
Sample_02_319	Neuroblastoma	Cell line	NB-EBc1
Sample_02_338	Neuroblastoma	Cell line	BE2

TBX2 distribution in all CRCs

Genomic distribution of SEs associated with TBX2

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Mutation of TBX2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TBX2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr17	59479069	59479069	G	T	exonic	TBX2	synonymous	ESCA\|1\|185\|0.00541
rs373091690	chr17	59485586	59485586	C	T	exonic	TBX2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr17	59482612	59482612	G	C	exonic	TBX2	nonsynonymous	LUAD\|1\|543\|0.00184
rs147014278	chr17	59485538	59485538	G	A	exonic	TBX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	59479054	59479054	C	-	exonic	TBX2	frameshift	ESCA\|1\|185\|0.00541
rs764036287	chr17	59485535	59485535	G	A	exonic	TBX2	nonsynonymous	UCS\|1\|57\|0.01754
-	chr17	59482956	59482956	C	T	exonic	TBX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59479268	59479268	C	T	exonic	TBX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	59479301	59479301	A	G	exonic	TBX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59477918	59477918	C	T	exonic	TBX2	synonymous	SARC\|1\|247\|0.00405
-	chr17	59483009	59483009	C	A	exonic	TBX2	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr17	59482937	59482937	G	A	exonic	TBX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	59482604	59482604	G	C	exonic	TBX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	59481830	59481830	G	A	exonic	TBX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	59485543	59485543	C	T	exonic	TBX2	synonymous	SKCM\|1\|368\|0.00272
-	chr17	59477559	59477559	G	C	exonic	TBX2	nonsynonymous	PCPG\|1\|184\|0.00543
rs768086181	chr17	59485645	59485645	C	T	exonic	TBX2	synonymous	LIHC\|1\|373\|0.00268
-	chr17	59482908	59482908	C	T	exonic	TBX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59482827	59482827	C	T	exonic	TBX2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr17	59482066	59482066	C	T	exonic	TBX2	synonymous	HNSC\|1\|512\|0.00195
-	chr17	59480512	59480512	A	G	exonic	TBX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	59481839	59481839	A	T	exonic	TBX2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr17	59485551	59485551	G	A	exonic	TBX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	59479238	59479238	-	A	exonic	TBX2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59479234	59479234	G	-	exonic	TBX2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs548613583	chr17	59482792	59482792	C	T	exonic	TBX2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	59485488	59485488	C	T	exonic	TBX2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	59477583	59477583	T	A	exonic	TBX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	59480480	59480480	A	G	exonic	TBX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	59479196	59479196	C	A	exonic	TBX2	nonsynonymous	LUAD\|1\|543\|0.00184
rs754928776	chr17	59485435	59485435	C	T	exonic	TBX2	synonymous	UCEC\|1\|248\|0.00403
-	chr17	59479158	59479158	C	G	exonic	TBX2	nonsynonymous	LUAD\|1\|543\|0.00184
rs539363382	chr17	59486690	59486690	A	G	UTR3	TBX2	unknown	ESCA\|1\|185\|0.00541
rs34493156	chr17	59485721	59485721	C	T	exonic	TBX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59479160	59479160	C	T	exonic	TBX2	nonsynonymous	UCEC\|1\|248\|0.00403
rs768834035	chr17	59485479	59485479	C	T	exonic	TBX2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr17	59479173	59479173	C	T	exonic	TBX2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	59483116	59483116	C	A	exonic	TBX2	synonymous	LUSC\|1\|178\|0.00562
rs776891087	chr17	59485480	59485480	C	T	exonic	TBX2	synonymous	UCEC\|1\|248\|0.00403
-	chr17	59479294	59479294	C	T	exonic	TBX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59485578	59485578	C	T	exonic	TBX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	59480475	59480475	C	T	exonic	TBX2	synonymous	OV\|1\|469\|0.00213
-	chr17	59482616	59482616	G	T	exonic	TBX2	stopgain	LUAD\|1\|543\|0.00184
-	chr17	59479233	59479233	-	G	exonic	TBX2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59480452	59480452	C	T	exonic	TBX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs753105343	chr17	59479053	59479053	-	C	exonic	TBX2	frameshift	BRCA\|1\|982\|0.00102
-	chr17	59480532	59480532	C	T	exonic	TBX2	synonymous	SKCM\|1\|368\|0.00272
-	chr17	59482884	59482884	C	-	exonic	TBX2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59479224	59479224	G	T	exonic	TBX2	nonsynonymous	ACC\|1\|90\|0.01111
-	chr17	59485556	59485556	C	T	exonic	TBX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	59482854	59482854	C	T	exonic	TBX2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	59485425	59485425	T	G	exonic	TBX2	nonsynonymous	LUAD\|1\|543\|0.00184
rs1057987	chr17	59485555	59485555	C	T	exonic	TBX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59480532	59480532	C	A	exonic	TBX2	synonymous	LUSC\|1\|178\|0.00562
-	chr17	59485548	59485548	C	T	exonic	TBX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	59479063	59479063	C	T	exonic	TBX2	synonymous	BLCA\|1\|396\|0.00253
-	chr17	59479175	59479175	G	T	exonic	TBX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	59485703	59485703	C	G	exonic	TBX2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr17	59482855	59482855	G	A	exonic	TBX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59481813	59481813	T	C	exonic	TBX2	nonsynonymous	UCEC\|1\|248\|0.00403
rs3198587	chr17	59486624	59486624	G	C	UTR3	TBX2	unknown	BRCA\|1\|982\|0.00102
-	chr17	59477552	59477552	G	A	exonic	TBX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59482747	59482747	-	G	exonic	TBX2	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr17	59479209	59479209	A	G	exonic	TBX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	59482957	59482957	G	A	exonic	TBX2	synonymous	ESCA\|1\|185\|0.00541
-	chr17	59480559	59480559	G	C	exonic	TBX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	59479190	59479190	G	A	exonic	TBX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	59485544	59485544	C	G	exonic	TBX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	59482039	59482039	A	T	exonic	TBX2	synonymous	LUAD\|1\|543\|0.00184
rs767959344	chr17	59485716	59485716	C	T	exonic	TBX2	nonsynonymous	SKCM\|1\|368\|0.00272
rs200245762	chr17	59481989	59481989	C	T	exonic	TBX2	synonymous	SKCM\|1\|368\|0.00272
rs61756219	chr17	59485501	59485501	C	T	exonic	TBX2	synonymous	ESCA\|1\|185\|0.00541
-	chr17	59485728	59485728	T	A	exonic	TBX2	nonsynonymous	LUAD\|1\|543\|0.00184
rs140013823	chr17	59480547	59480547	C	T	exonic	TBX2	synonymous	DLBC\|1\|48\|0.02083
rs760368587	chr17	59479272	59479272	A	G	exonic	TBX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	59479058	59479058	C	T	exonic	TBX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	59482917	59482917	C	T	exonic	TBX2	nonsynonymous	LUSC\|1\|178\|0.00562
rs760711917	chr17	59485502	59485502	G	A	exonic	TBX2	nonsynonymous	THCA\|1\|504\|0.00198
-	chr17	59479191	59479191	A	G	exonic	TBX2	nonsynonymous	BLCA\|1\|396\|0.00253

Disease information of TBX2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with TBX2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001117	IL12 signaling mediated by STAT4	pid	33	229
pathway0001124	IL27-mediated signaling events	pid	26	217
pathway0002768	Hs_Heart_Development_WP1591_90186	wikipathways	28	78

Go term information of TBX2

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GO_term_name	GO_term_type	TF_name
GO_CARDIAC_CHAMBER_DEVELOPMENT	BP	TBX2
GO_SPINAL_CORD_DEVELOPMENT	BP	TBX2
GO_REGULATION_OF_CELL_ACTIVATION	BP	TBX2
GO_MAMMARY_GLAND_MORPHOGENESIS	BP	TBX2
GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE	BP	TBX2
GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS	BP	TBX2
GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX2
GO_FORMATION_OF_PRIMARY_GERM_LAYER	BP	TBX2
GO_ENDOCARDIAL_CUSHION_DEVELOPMENT	BP	TBX2
GO_POSITIVE_REGULATION_OF_HEART_GROWTH	BP	TBX2
GO_ARTERY_DEVELOPMENT	BP	TBX2
GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS	BP	TBX2
GO_CELLULAR_SENESCENCE	BP	TBX2
GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY	BP	TBX2
GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS	BP	TBX2
GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION	BP	TBX2
GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS	BP	TBX2
GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX2
GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD	BP	TBX2
GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION	BP	TBX2
GO_ENDOCARDIAL_CUSHION_FORMATION	BP	TBX2
GO_AORTA_DEVELOPMENT	BP	TBX2
GO_SPECIFICATION_OF_SYMMETRY	BP	TBX2
GO_VENTRAL_SPINAL_CORD_DEVELOPMENT	BP	TBX2
GO_LATERAL_MESODERM_DEVELOPMENT	BP	TBX2
GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION	BP	TBX2
GO_CARDIAC_ATRIUM_DEVELOPMENT	BP	TBX2
GO_ATRIAL_SEPTUM_DEVELOPMENT	BP	TBX2
GO_PATTERNING_OF_BLOOD_VESSELS	BP	TBX2
GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT	BP	TBX2
GO_ARTERY_MORPHOGENESIS	BP	TBX2
GO_ATRIAL_SEPTUM_MORPHOGENESIS	BP	TBX2
GO_REGULATION_OF_HEART_MORPHOGENESIS	BP	TBX2
GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	TBX2
GO_REGULATION_OF_ORGAN_GROWTH	BP	TBX2
GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY	BP	TBX2
GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY	BP	TBX2
GO_MYOBLAST_DIFFERENTIATION	BP	TBX2
GO_HEART_MORPHOGENESIS	BP	TBX2
GO_CARDIAC_VENTRICLE_MORPHOGENESIS	BP	TBX2
GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET	BP	TBX2
GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS	BP	TBX2
GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY	BP	TBX2
GO_HEART_VALVE_FORMATION	BP	TBX2
GO_CARDIOBLAST_DIFFERENTIATION	BP	TBX2
GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX2
GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY	BP	TBX2
GO_NOTCH_SIGNALING_PATHWAY	BP	TBX2
GO_ECTODERMAL_PLACODE_DEVELOPMENT	BP	TBX2
GO_MAMMARY_GLAND_DEVELOPMENT	BP	TBX2
GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION	BP	TBX2
GO_NEURON_MIGRATION	BP	TBX2
GO_NEUROGENESIS	BP	TBX2
GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT	BP	TBX2
GO_REGULATION_OF_ISOTYPE_SWITCHING	BP	TBX2
GO_CELL_FATE_DETERMINATION	BP	TBX2
GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION	BP	TBX2
GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY	BP	TBX2
GO_PERICARDIUM_DEVELOPMENT	BP	TBX2
GO_MUSCLE_CELL_FATE_COMMITMENT	BP	TBX2
GO_HEART_VALVE_DEVELOPMENT	BP	TBX2
GO_CELL_AGING	BP	TBX2
GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE	BP	TBX2
GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS	BP	TBX2
GO_MESENCHYME_DEVELOPMENT	BP	TBX2
GO_ENDODERM_FORMATION	BP	TBX2
GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX2
GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION	BP	TBX2
GO_EMBRYONIC_EYE_MORPHOGENESIS	BP	TBX2
GO_REGULATION_OF_HEART_GROWTH	BP	TBX2
GO_LYMPHOCYTE_MIGRATION	BP	TBX2
GO_OUTFLOW_TRACT_MORPHOGENESIS	BP	TBX2
GO_CARDIAC_CHAMBER_FORMATION	BP	TBX2
GO_CARDIAC_SEPTUM_MORPHOGENESIS	BP	TBX2
GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT	BP	TBX2
GO_MESODERM_DEVELOPMENT	BP	TBX2
GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT	BP	TBX2
GO_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	TBX2
GO_MESENCHYME_MORPHOGENESIS	BP	TBX2
GO_AORTA_MORPHOGENESIS	BP	TBX2
GO_EMBRYONIC_ORGAN_DEVELOPMENT	BP	TBX2
GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH	BP	TBX2
GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS	BP	TBX2
GO_REGULATION_OF_ORGAN_MORPHOGENESIS	BP	TBX2
GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT	BP	TBX2
GO_BIOLOGICAL_ADHESION	BP	TBX2
GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE	BP	TBX2
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	TBX2
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	TBX2
GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	TBX2
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	TBX2
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	TBX2
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY	MF	TBX2
GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	TBX2
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	TBX2

Survival analysis of TBX2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of TBX2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)