Cancer CRCdb

TF information

TF name:	MEIS2
TF family:	Homeobox
Ensembl gene ID:	ENSG00000134138
Ensembl protein ID:	ENSP00000453793, ENSP00000475899, ENSP00000380749, ENSP00000453497, ENSP00000341400, ENSP00000453390, ENSP00000404185, ENSP00000339549, ENSP00000380745, ENSP00000452693
Entrez gene ID:	4212

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of MEIS2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_069	Cell line	Brain	SF268	0.36641221374046
Sample_02_220	Cell line	Brain	BE2C_1	0.47435897435897
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.097777777777778
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.4238714613619
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.36986301369863
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.33333333333333
Sample_02_300	Cell line	Neuroblastoma	CLB-PE	0.43589743589744
Sample_02_303	Cell line	Neuroblastoma	LAN1	0.48571428571429
Sample_02_304	Cell line	Neuroblastoma	N206	0.43478260869565
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.39810426540284
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.37549148099607
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.23376623376623
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.92021276595745
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.23552123552124
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.20987654320988
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.26923076923077
Sample_02_318	Cell line	Neuroblastoma	NB69	0.25
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.19653179190751
Sample_02_338	Cell line	Neuroblastoma	BE2	0.52941176470588
Sample_02_413	Tissue	Brain	GBM_2493	0.3956043956044

MEIS2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_069	Brain	Cell line	SF268
Sample_02_220	Brain	Cell line	BE2C_1
Sample_02_303	Neuroblastoma	Cell line	LAN1
Sample_02_310	Neuroblastoma	Cell line	SJNB8
Sample_02_312	Neuroblastoma	Cell line	SK-N-BE_2-C
Sample_02_338	Neuroblastoma	Cell line	BE2
Sample_02_413	Brain	Tissue	GBM_2493

MEIS2 distribution in all CRCs

Genomic distribution of SEs associated with MEIS2

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Mutation of MEIS2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MEIS2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr15	37388529	37388529	G	A	exonic	MEIS2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37186973	37186973	C	T	exonic	MEIS2	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	37184639	37184639	T	C	exonic	MEIS2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	37386766	37386766	T	C	exonic	MEIS2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr15	37390328	37390328	C	T	exonic	MEIS2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	37387790	37387790	G	A	exonic	MEIS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	37390266	37390266	C	T	exonic	MEIS2	synonymous	PAAD\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37375970	37375970	A	G	splicing	MEIS2	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37184640	37184640	C	T	exonic	MEIS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	37184518	37184518	T	A	exonic	MEIS2	synonymous	LUAD\|1\|543\|0.00184
-	chr15	37242597	37242597	G	T	exonic	MEIS2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	37188828	37188828	C	A	splicing	MEIS2	splicing	LUAD\|1\|543\|0.00184
-	chr15	37390358	37390358	C	G	exonic	MEIS2	nonsynonymous	OV\|1\|469\|0.00213
-	chr15	37187361	37187361	G	A	exonic	MEIS2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37385817	37385817	C	T	exonic	MEIS2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr15	37388589	37388589	G	A	exonic	MEIS2	synonymous	UCEC\|2\|248\|0.00806
-	chr15	37390245	37390245	C	T	exonic	MEIS2	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	37242602	37242602	C	T	splicing	MEIS2	splicing	LIHC\|1\|373\|0.00268
-	chr15	37388540	37388540	C	T	exonic	MEIS2	nonsynonymous	OV\|1\|469\|0.00213,UCEC\|1\|248\|0.00403
-	chr15	37184468	37184468	T	G	exonic	MEIS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	37187014	37187014	C	T	splicing	MEIS2	splicing	SKCM\|1\|368\|0.00272
-	chr15	37242593	37242593	G	A	exonic	MEIS2	synonymous	SKCM\|1\|368\|0.00272
-	chr15	37329090	37329090	T	-	exonic	MEIS2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37242598	37242598	G	A	exonic	MEIS2	nonsynonymous	SARC\|1\|247\|0.00405
-	chr15	37390202	37390202	C	T	exonic	MEIS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	37329042	37329042	C	T	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37390191	37390191	C	A	exonic	MEIS2	nonsynonymous	LUSC\|1\|178\|0.00562
rs200799360	chr15	37390311	37390311	G	A	exonic	MEIS2	synonymous	LUAD\|1\|543\|0.00184
-	chr15	37184416	37184416	A	T	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37329158	37329158	C	T	exonic	MEIS2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	37376025	37376025	C	A	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37390322	37390322	G	A	exonic	MEIS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	37188856	37188856	G	A	exonic	MEIS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	37184562	37184562	G	A	exonic	MEIS2	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr15	37187432	37187432	C	A	exonic	MEIS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	37187382	37187382	C	A	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37388629	37388629	T	G	exonic	MEIS2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr15	37390313	37390313	G	A	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184,SKCM\|1\|368\|0.00272
rs140890748	chr15	37390260	37390260	G	A	exonic	MEIS2	synonymous	UCEC\|1\|248\|0.00403
-	chr15	37329122	37329122	C	A	exonic	MEIS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	37329140	37329140	C	A	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37242539	37242539	G	A	exonic	MEIS2	synonymous	SKCM\|1\|368\|0.00272
-	chr15	37387812	37387812	G	A	exonic	MEIS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	37186983	37186983	C	T	exonic	MEIS2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	37186997	37186997	C	T	exonic	MEIS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	37184499	37184499	C	A	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37388489	37388489	C	A	splicing	MEIS2	splicing	HNSC\|1\|512\|0.00195
-	chr15	37388558	37388558	C	G	exonic	MEIS2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr15	37187407	37187407	C	A	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37187378	37187378	T	A	exonic	MEIS2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr15	37184422	37184422	A	G	exonic	MEIS2	synonymous	HNSC\|1\|512\|0.00195
-	chr15	37390309	37390309	G	-	exonic	MEIS2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37187433	37187433	C	T	exonic	MEIS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	37385801	37385801	G	A	exonic	MEIS2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	37390190	37390190	G	A	exonic	MEIS2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37390206	37390206	G	C	exonic	MEIS2	synonymous	LUAD\|1\|543\|0.00184
-	chr15	37390290	37390290	G	A	exonic	MEIS2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37388588	37388588	C	T	exonic	MEIS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	37184448	37184448	C	T	exonic	MEIS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	37188835	37188835	G	A	exonic	MEIS2	stopgain	COADREAD\|2\|489\|0.00409,PRAD\|1\|499\|0.00200,READ\|2\|122\|0.01639
-	chr15	37329146	37329146	T	G	exonic	MEIS2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	37184625	37184625	C	A	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37376049	37376049	G	C	exonic	MEIS2	stopgain	BRCA\|1\|982\|0.00102
-	chr15	37184493	37184493	T	G	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37184477	37184477	G	A	exonic	MEIS2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	37184601	37184601	C	T	exonic	MEIS2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr15	37184626	37184626	C	T	exonic	MEIS2	synonymous	LUAD\|1\|543\|0.00184
rs377204162	chr15	37385842	37385842	G	A	exonic	MEIS2	synonymous	BLCA\|1\|396\|0.00253
rs200863215	chr15	37183275	37183275	T	C	UTR3	MEIS2	unknown	CESC\|1\|194\|0.00515
-	chr15	37329079	37329079	T	C	exonic	MEIS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	37242588	37242588	G	A	exonic	MEIS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	37385787	37385787	C	A	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37385874	37385874	T	-	exonic	MEIS2	frameshift	PAAD\|1\|185\|0.00541
-	chr15	37329016	37329018	GTG	-	exonic	MEIS2	nonframeshift	BLCA\|1\|396\|0.00253
-	chr15	37188873	37188873	C	T	exonic	MEIS2	nonsynonymous	CESC\|1\|194\|0.00515
rs748942972	chr15	37184392	37184392	C	T	exonic	MEIS2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37329107	37329107	G	A	exonic	MEIS2	nonsynonymous	SKCM\|1\|368\|0.00272
rs372646327	chr15	37390246	37390246	G	A	exonic	MEIS2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	37387806	37387806	C	T	exonic	MEIS2	nonsynonymous	UCS\|1\|57\|0.01754
-	chr15	37388581	37388581	G	A	exonic	MEIS2	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr15	37390256	37390256	C	T	exonic	MEIS2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	37388508	37388508	G	A	exonic	MEIS2	synonymous	PRAD\|1\|499\|0.00200
-	chr15	37390284	37390284	C	T	exonic	MEIS2	synonymous	UCEC\|1\|248\|0.00403
rs767585793	chr15	37329088	37329088	C	T	exonic	MEIS2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	37390168	37390168	C	T	exonic	MEIS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	37385877	37385877	T	C	exonic	MEIS2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37186920	37186920	C	G	UTR3	MEIS2	unknown	BRCA\|1\|982\|0.00102
-	chr15	37390255	37390255	G	A	exonic	MEIS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	37391659	37391659	T	C	exonic	MEIS2	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs773159665	chr15	37390250	37390250	C	T	exonic	MEIS2	nonsynonymous	UCS\|1\|57\|0.01754
-	chr15	37329152	37329152	A	C	exonic	MEIS2	nonsynonymous	CHOL\|1\|35\|0.02857
-	chr15	37390181	37390181	C	T	exonic	MEIS2	nonsynonymous	OV\|1\|469\|0.00213
-	chr15	37184485	37184485	G	T	exonic	MEIS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	37184583	37184583	G	A	exonic	MEIS2	nonsynonymous	SKCM\|1\|368\|0.00272
rs760342372	chr15	37184403	37184403	C	T	exonic	MEIS2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs139991974	chr15	37184485	37184485	G	A	exonic	MEIS2	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr15	37187002	37187002	C	A	exonic	MEIS2	stopgain	SKCM\|1\|368\|0.00272
-	chr15	37385869	37385869	G	T	exonic	MEIS2	synonymous	SKCM\|1\|368\|0.00272
-	chr15	37390178	37390178	C	T	exonic	MEIS2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	37329148	37329148	T	A	exonic	MEIS2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr15	37184626	37184626	C	A	exonic	MEIS2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr15	37183628	37183628	A	T	UTR3	MEIS2	unknown	BRCA\|1\|982\|0.00102
-	chr15	37184630	37184630	G	T	exonic	MEIS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	37391664	37391664	C	T	exonic	MEIS2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr15	37390258	37390258	C	T	exonic	MEIS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204

Disease information of MEIS2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
MEIS2	Cardiac Malformation, Cleft Lip-Palate, Microcephaly and Digital Anomalies	C05;C07;C10;C14;C16	Disease or Syndrome	CTD_human
MEIS2	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
MEIS2	CHROMOSOME 15q14 DELETION SYNDROME		Disease or Syndrome	ORPHANET

Pathway associated with MEIS2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of MEIS2

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GO_term_name	GO_term_type	TF_name
GO_COGNITION	BP	MEIS2
GO_ASSOCIATIVE_LEARNING	BP	MEIS2
GO_PANCREAS_DEVELOPMENT	BP	MEIS2
GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS	BP	MEIS2
GO_VISUAL_BEHAVIOR	BP	MEIS2
GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	MEIS2

Survival analysis of MEIS2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of MEIS2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)