TF information

TF name: PHOX2A
TF family: Homeobox
Ensembl gene ID: ENSG00000165462
Ensembl protein ID: ENSP00000298231, ENSP00000444845
Entrez gene ID: 401
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of PHOX2A in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_254Cell lineNeuroblastomaIMR5-750.67647058823529
Sample_02_296Cell lineNeuroblastomaCLB-BER-Lud0.26243305279265
Sample_02_298Cell lineNeuroblastomaCLB-GA0.42465753424658
Sample_02_299Cell lineNeuroblastomaCLB-MA0.24460431654676
Sample_02_300Cell lineNeuroblastomaCLB-PE0.52564102564103
Sample_02_302Cell lineNeuroblastomaIMR320.32142857142857
Sample_02_303Cell lineNeuroblastomaLAN10.65714285714286
Sample_02_304Cell lineNeuroblastomaN2060.36820652173913
Sample_02_307Cell lineNeuroblastomaSJNB120.084507042253521
Sample_02_308Cell lineNeuroblastomaSJNB10.40625
Sample_02_309Cell lineNeuroblastomaSJNB60.35071090047393
Sample_02_310Cell lineNeuroblastomaSJNB80.23787680209699
Sample_02_312Cell lineNeuroblastomaSK-N-BE_2-C0.51595744680851
Sample_02_313Cell lineNeuroblastomaSK-N-DZ0.30501930501931
Sample_02_314Cell lineNeuroblastomaSK-N-FI0.28395061728395
Sample_02_318Cell lineNeuroblastomaNB690.578125
Sample_02_319Cell lineNeuroblastomaNB-EBc10.31791907514451

PHOX2A distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_298NeuroblastomaCell lineCLB-GA
Sample_02_300NeuroblastomaCell lineCLB-PE
Sample_02_303NeuroblastomaCell lineLAN1
Sample_02_308NeuroblastomaCell lineSJNB1
Sample_02_312NeuroblastomaCell lineSK-N-BE_2-C
Sample_02_318NeuroblastomaCell lineNB69
Sample_02_319NeuroblastomaCell lineNB-EBc1

PHOX2A distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with PHOX2A
Download

Mutation of PHOX2A
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of PHOX2A

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr117195088471950884TCexonicPHOX2Anonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr117195124271951242CTexonicPHOX2Anonsynonymous ACC|1|90|0.01111
-chr117195233171952331GTexonicPHOX2Anonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr117195087171950871GAexonicPHOX2Asynonymous BLCA|1|396|0.00253
-chr117195217971952179CAexonicPHOX2Asynonymous LUAD|2|543|0.00368
rs758428790chr117195498371954983GAexonicPHOX2Asynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr117195495871954958CTexonicPHOX2Anonsynonymous UCS|1|57|0.01754
-chr117195230571952305GAexonicPHOX2Asynonymous ESCA|1|185|0.00541
-chr117195225371952253CTexonicPHOX2Anonsynonymous HNSC|1|512|0.00195,STAD|1|395|0.00253,STES|1|395|0.00253
-chr117195222371952223CTexonicPHOX2Anonsynonymous STAD|2|395|0.00506,STES|2|395|0.00506
-chr117195091571950915CTexonicPHOX2Anonsynonymous THCA|1|504|0.00198
-chr117195091171950911CTexonicPHOX2Anonsynonymous SKCM|1|368|0.00272
-chr117195081371950813GTexonicPHOX2Anonsynonymous HNSC|1|512|0.00195
-chr117195089371950893TCexonicPHOX2Anonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr117195225271952252GAexonicPHOX2Anonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr117195215371952153CTexonicPHOX2Anonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr117195228871952288CTexonicPHOX2Anonsynonymous LUAD|1|543|0.00184
-chr117195216071952160CTexonicPHOX2Anonsynonymous LUSC|1|178|0.00562
-chr117195081771950817G-exonicPHOX2Aframeshift LIHC|1|373|0.00268
rs182932220chr117195489371954893GAexonicPHOX2Asynonymous ACC|2|90|0.02222
-chr117195227971952279CGexonicPHOX2Anonsynonymous LUAD|1|543|0.00184

Disease information of PHOX2A
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
PHOX2A Congenital Fibrosis of the Extraocular Muscles C10;C11;C23 Disease or Syndrome ORPHANET
PHOX2A FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 2 C10;C11;C16;C23 Disease or Syndrome CTD_human;UNIPROT

Pathway associated with PHOX2A
pathway_ID pathway_name pathway_source gene_number edge_number

Go term information of PHOX2A
GO_term_name GO_term_type TF_name
GO_SPINAL_CORD_DEVELOPMENT BP PHOX2A
GO_METENCEPHALON_DEVELOPMENT BP PHOX2A
GO_CRANIAL_NERVE_MORPHOGENESIS BP PHOX2A
GO_CRANIAL_NERVE_DEVELOPMENT BP PHOX2A
GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD BP PHOX2A
GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION BP PHOX2A
GO_VENTRAL_SPINAL_CORD_DEVELOPMENT BP PHOX2A
GO_NEURAL_NUCLEUS_DEVELOPMENT BP PHOX2A
GO_PONS_DEVELOPMENT BP PHOX2A
GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT BP PHOX2A
GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT BP PHOX2A
GO_DOPAMINERGIC_NEURON_DIFFERENTIATION BP PHOX2A
GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT BP PHOX2A
GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE BP PHOX2A
GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING MF PHOX2A
GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY MF PHOX2A

Survival analysis of PHOX2A



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of PHOX2A