Cancer CRCdb

TF information

TF name:	GATA2
TF family:	zf-GATA
Ensembl gene ID:	ENSG00000179348
Ensembl protein ID:	ENSP00000417074, ENSP00000345681, ENSP00000400259
Entrez gene ID:	2624

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of GATA2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_022	Cell line	Prostate	C4-2B	0.14285714285714
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.096026490066225
Sample_02_078	Primary cell	Neuroblastoma	low-MYCN-Neuroblastoma-patient-cells	0.5
Sample_02_220	Cell line	Brain	BE2C_1	0.29487179487179
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.20588235294118
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.15455241009946
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.24657534246575
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.15347721822542
Sample_02_303	Cell line	Neuroblastoma	LAN1	0.28571428571429
Sample_02_304	Cell line	Neuroblastoma	N206	0.20380434782609
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.26760563380282
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.296875
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.18009478672986
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.33766233766234
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.18085106382979
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.26254826254826
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.29012345679012
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.53296703296703
Sample_02_318	Cell line	Neuroblastoma	NB69	0.1640625
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.21387283236994
Sample_02_338	Cell line	Neuroblastoma	BE2	0.30882352941176

GATA2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_078	Neuroblastoma	Primary cell	low-MYCN-Neuroblastoma-patient-cells
Sample_02_254	Neuroblastoma	Cell line	IMR5-75
Sample_02_299	Neuroblastoma	Cell line	CLB-MA
Sample_02_316	Neuroblastoma	Cell line	CHP212

GATA2 distribution in all CRCs

Genomic distribution of SEs associated with GATA2

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Mutation of GATA2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of GATA2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr3	128199894	128199894	G	-	exonic	GATA2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	128204623	128204623	C	-	exonic	GATA2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	128205212	128205212	C	T	splicing	GATA2	splicing	SKCM\|1\|368\|0.00272
-	chr3	128200151	128200151	G	A	exonic	GATA2	nonsynonymous	LAML\|1\|197\|0.00508
-	chr3	128205181	128205181	G	C	exonic	GATA2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	128200119	128200119	G	A	exonic	GATA2	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr3	128204752	128204752	C	T	exonic	GATA2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	128202809	128202809	G	T	exonic	GATA2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LAML\|1\|197\|0.00508
-	chr3	128200698	128200698	G	A	exonic	GATA2	synonymous	HNSC\|1\|512\|0.00195
-	chr3	128199829	128199829	G	A	UTR3	GATA2	unknown	CESC\|1\|194\|0.00515
rs569990126	chr3	128199937	128199937	C	T	exonic	GATA2	synonymous	ESCA\|1\|185\|0.00541
-	chr3	128205204	128205204	C	T	exonic	GATA2	synonymous	SKCM\|1\|368\|0.00272
-	chr3	128205070	128205070	G	A	exonic	GATA2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr3	128204928	128204928	G	A	exonic	GATA2	synonymous	SKCM\|2\|368\|0.00543
-	chr3	128202816	128202816	C	A	exonic	GATA2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	128200730	128200730	A	G	exonic	GATA2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	128200724	128200724	G	A	exonic	GATA2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr3	128202738	128202738	G	A	exonic	GATA2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs867160952	chr3	128200720	128200720	C	T	exonic	GATA2	nonsynonymous	BLCA\|1\|396\|0.00253,LUAD\|1\|543\|0.00184
-	chr3	128204912	128204912	G	A	exonic	GATA2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	128204627	128204627	C	T	exonic	GATA2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	128205185	128205185	G	-	exonic	GATA2	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	128200071	128200071	C	G	exonic	GATA2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	128200118	128200118	C	T	exonic	GATA2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	128205169	128205169	T	C	exonic	GATA2	nonsynonymous	LUAD\|1\|543\|0.00184
rs34799090	chr3	128204960	128204960	G	C	exonic	GATA2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr3	128204803	128204803	T	A	exonic	GATA2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	128204679	128204679	C	T	exonic	GATA2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	128205135	128205135	T	-	exonic	GATA2	frameshift	ESCA\|1\|185\|0.00541
-	chr3	128202703	128202703	C	T	exonic	GATA2	synonymous	HNSC\|1\|512\|0.00195
-	chr3	128200024	128200024	G	-	exonic	GATA2	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	128204917	128204917	G	A	exonic	GATA2	nonsynonymous	SKCM\|1\|368\|0.00272
rs2335052	chr3	128204951	128204951	C	T	exonic	GATA2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	128200907	128200907	G	T	intronic	GATA2	unknown	CESC\|1\|194\|0.00515
-	chr3	128199922	128199922	G	A	exonic	GATA2	synonymous	SKCM\|1\|368\|0.00272
rs770768777	chr3	128199973	128199973	C	T	exonic	GATA2	synonymous	LUSC\|1\|178\|0.00562,PAAD\|1\|185\|0.00541
-	chr3	128205213	128205213	T	A	splicing	GATA2	splicing	LIHC\|1\|373\|0.00268
-	chr3	128204728	128204728	G	A	exonic	GATA2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	128204775	128204775	C	T	exonic	GATA2	synonymous	LUAD\|1\|543\|0.00184
rs758912342	chr3	128200709	128200709	C	T	exonic	GATA2	nonsynonymous	SKCM\|2\|368\|0.00543
rs751577185	chr3	128200063	128200063	G	A	exonic	GATA2	synonymous	PAAD\|1\|185\|0.00541
-	chr3	128200752	128200752	-	T	exonic	GATA2	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	128204641	128204641	G	T	exonic	GATA2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr3	128205664	128205664	A	G	exonic	GATA2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr3	128199595	128199595	C	G	UTR3	GATA2	unknown	BRCA\|2\|982\|0.00204
-	chr3	128200738	128200738	G	T	exonic	GATA2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr3	128200028	128200028	G	A	exonic	GATA2	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr3	128200680	128200680	G	A	exonic	GATA2	synonymous	SKCM\|1\|368\|0.00272
-	chr3	128200008	128200008	G	A	exonic	GATA2	synonymous	PAAD\|1\|185\|0.00541
-	chr3	128199967	128199967	G	T	exonic	GATA2	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr3	128205845	128205845	C	G	exonic	GATA2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr3	128204702	128204702	G	C	exonic	GATA2	nonsynonymous	SKCM\|1\|368\|0.00272
rs570641046	chr3	128205201	128205201	G	A	exonic	GATA2	synonymous	SKCM\|1\|368\|0.00272
-	chr3	128200788	128200788	C	A	splicing	GATA2	splicing	LUAD\|1\|543\|0.00184
-	chr3	128199875	128199875	G	A	exonic	GATA2	nonsynonymous	SKCM\|1\|368\|0.00272
rs765163478	chr3	128200835	128200835	C	T	intronic	GATA2	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs758279649	chr3	128200779	128200779	G	A	exonic	GATA2	synonymous	LUAD\|1\|543\|0.00184
-	chr3	128204810	128204810	C	T	exonic	GATA2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs769419116	chr3	128199926	128199926	T	G	exonic	GATA2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	128204697	128204697	G	A	exonic	GATA2	synonymous	LUSC\|1\|178\|0.00562
-	chr3	128199886	128199886	G	A	exonic	GATA2	synonymous	SKCM\|1\|368\|0.00272
-	chr3	128204641	128204641	G	A	exonic	GATA2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	128200691	128200691	C	T	exonic	GATA2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	128205123	128205123	A	T	exonic	GATA2	synonymous	LUAD\|1\|543\|0.00184
-	chr3	128204630	128204630	G	A	exonic	GATA2	synonymous	LIHC\|1\|373\|0.00268
-	chr3	128205000	128205000	C	T	exonic	GATA2	synonymous	SKCM\|1\|368\|0.00272
-	chr3	128200016	128200016	G	T	exonic	GATA2	nonsynonymous	PAAD\|1\|185\|0.00541
rs769473824	chr3	128204753	128204753	G	A	exonic	GATA2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	128204842	128204842	C	-	exonic	GATA2	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	128202816	128202816	C	T	exonic	GATA2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	128200783	128200783	G	A	exonic	GATA2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	128200037	128200038	TC	-	exonic	GATA2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	128200114	128200114	G	T	exonic	GATA2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	128202738	128202738	G	T	exonic	GATA2	nonsynonymous	SARC\|1\|247\|0.00405
-	chr3	128204816	128204816	C	G	exonic	GATA2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	128204709	128204709	G	A	exonic	GATA2	synonymous	PAAD\|1\|185\|0.00541
-	chr3	128200101	128200101	T	G	exonic	GATA2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	128200129	128200129	C	T	exonic	GATA2	synonymous	CESC\|1\|194\|0.00515
rs770511115	chr3	128204626	128204626	C	T	exonic	GATA2	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	128202797	128202797	C	T	exonic	GATA2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs766740489	chr3	128200015	128200015	T	G	exonic	GATA2	synonymous	SKCM\|1\|368\|0.00272
-	chr3	128199961	128199961	G	A	exonic	GATA2	synonymous	SKCM\|1\|368\|0.00272
-	chr3	128200120	128200120	A	C	exonic	GATA2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs146814201	chr3	128200710	128200710	G	A	exonic	GATA2	synonymous	UCEC\|1\|248\|0.00403
rs534807053	chr3	128199904	128199904	G	A	exonic	GATA2	synonymous	BLCA\|1\|396\|0.00253,CESC\|1\|194\|0.00515,SKCM\|1\|368\|0.00272
-	chr3	128200786	128200786	G	A	exonic	GATA2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	128204731	128204731	C	A	exonic	GATA2	nonsynonymous	ESCA\|1\|185\|0.00541
rs148024280	chr3	128204594	128204594	G	A	exonic	GATA2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	128204653	128204653	C	T	exonic	GATA2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	128200153	128200153	C	T	exonic	GATA2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs370164300	chr3	128199957	128199957	C	T	exonic	GATA2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	128199879	128199879	C	T	exonic	GATA2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	128200750	128200750	C	A	exonic	GATA2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	128202736	128202736	C	A	exonic	GATA2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	128200003	128200003	A	T	exonic	GATA2	synonymous	LUAD\|1\|543\|0.00184

Disease information of GATA2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
GATA2	Cartilage Diseases	C05;C17	Disease or Syndrome	CTD_human
GATA2	Leukemia, Myelocytic, Acute	C04	Neoplastic Process	CGI;CTD_human
GATA2	Lymphatic Diseases	C15	Disease or Syndrome	GENOMICS_ENGLAND
GATA2	Lymphedema	C15	Disease or Syndrome	CTD_human
GATA2	Myelodysplasia		Congenital Abnormality	ORPHANET
GATA2	Acute Myeloid Leukemia, M1	C04	Neoplastic Process	CTD_human
GATA2	Chondromalacia	C05;C17	Disease or Syndrome	CTD_human
GATA2	Cardiovascular Abnormalities	C14;C16	Congenital Abnormality	CTD_human
GATA2	Juvenile Myelomonocytic Leukemia	C04;C15	Neoplastic Process	CTD_human
GATA2	Hematologic Neoplasms	C04;C15	Neoplastic Process	GENOMICS_ENGLAND
GATA2	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
GATA2	Milroy Disease	C15	Disease or Syndrome	CTD_human
GATA2	Acute Myeloid Leukemia (AML-M2)	C04	Neoplastic Process	CTD_human
GATA2	Hematopoetic Myelodysplasia	C15	Pathologic Function	CTD_human
GATA2	Emberger syndrome		Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
GATA2	GATA2 Deficiency		Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
GATA2	MYELODYSPLASTIC SYNDROME	C15	Neoplastic Process	CTD_human;ORPHANET;UNIPROT

Pathway associated with GATA2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000187	AP-1 transcription factor network	pid	71	659
pathway0000747	Factors involved in megakaryocyte development and platelet production	reactome	111	689
pathway0001021	HIF-1-alpha transcription factor network	pid	67	420
pathway0001126	IL3	netpath	84	1284
pathway0001825	Regulation of Androgen receptor activity	pid	54	338
pathway0002033	Signaling events mediated by HDAC Class I	pid	89	1618
pathway0002034	Signaling events mediated by HDAC Class II	pid	58	627
pathway0002719	Hs_Apoptosis_WP254_88977	wikipathways	31	127

Go term information of GATA2

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	GATA2
GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE	BP	GATA2
GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION	BP	GATA2
GO_LEUKOCYTE_DEGRANULATION	BP	GATA2
GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	GATA2
GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION	BP	GATA2
GO_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	GATA2
GO_PITUITARY_GLAND_DEVELOPMENT	BP	GATA2
GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY	BP	GATA2
GO_LEUKOCYTE_MEDIATED_IMMUNITY	BP	GATA2
GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD	BP	GATA2
GO_FOREBRAIN_DEVELOPMENT	BP	GATA2
GO_GABAERGIC_NEURON_DIFFERENTIATION	BP	GATA2
GO_VENTRAL_SPINAL_CORD_DEVELOPMENT	BP	GATA2
GO_MAST_CELL_ACTIVATION	BP	GATA2
GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION	BP	GATA2
GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS	BP	GATA2
GO_LYSOSOME_LOCALIZATION	BP	GATA2
GO_CELL_DIFFERENTIATION_IN_HINDBRAIN	BP	GATA2
GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	GATA2
GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION	BP	GATA2
GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION	BP	GATA2
GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS	BP	GATA2
GO_MAINTENANCE_OF_CELL_NUMBER	BP	GATA2
GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	GATA2
GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION	BP	GATA2
GO_REGULATION_OF_PROTEIN_ACETYLATION	BP	GATA2
GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY	BP	GATA2
GO_GRANULOCYTE_DIFFERENTIATION	BP	GATA2
GO_CELL_FATE_DETERMINATION	BP	GATA2
GO_DIENCEPHALON_DEVELOPMENT	BP	GATA2
GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS	BP	GATA2
GO_MAST_CELL_MEDIATED_IMMUNITY	BP	GATA2
GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE	BP	GATA2
GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE	BP	GATA2
GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	GATA2
GO_REGULATION_OF_PHAGOCYTOSIS	BP	GATA2
GO_REGULATION_OF_MEMBRANE_INVAGINATION	BP	GATA2
GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	GATA2
GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION	BP	GATA2
GO_NEURON_FATE_COMMITMENT	BP	GATA2
GO_MYELOID_CELL_DIFFERENTIATION	BP	GATA2
GO_FOREBRAIN_NEURON_FATE_COMMITMENT	BP	GATA2
GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT	BP	GATA2
GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	GATA2
GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	GATA2
GO_DEFINITIVE_HEMOPOIESIS	BP	GATA2
GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS	BP	GATA2
GO_INNER_EAR_MORPHOGENESIS	BP	GATA2
GO_MAST_CELL_GRANULE	CC	GATA2
GO_C2H2_ZINC_FINGER_DOMAIN_BINDING	MF	GATA2
GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	GATA2
GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	GATA2

Survival analysis of GATA2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of GATA2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)