TF information

TF name: TLX2
TF family: Homeobox
Ensembl gene ID: ENSG00000115297
Ensembl protein ID: ENSP00000233638
Entrez gene ID: 3196
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of TLX2 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_254Cell lineNeuroblastomaIMR5-750.38235294117647
Sample_02_296Cell lineNeuroblastomaCLB-BER-Lud0.24254016832441
Sample_02_298Cell lineNeuroblastomaCLB-GA0.35616438356164
Sample_02_299Cell lineNeuroblastomaCLB-MA0.29016786570743
Sample_02_300Cell lineNeuroblastomaCLB-PE0.37179487179487
Sample_02_302Cell lineNeuroblastomaIMR320.35714285714286
Sample_02_303Cell lineNeuroblastomaLAN10.34285714285714
Sample_02_304Cell lineNeuroblastomaN2060.22690217391304
Sample_02_307Cell lineNeuroblastomaSJNB120.29577464788732
Sample_02_308Cell lineNeuroblastomaSJNB10.359375
Sample_02_309Cell lineNeuroblastomaSJNB60.37914691943128
Sample_02_310Cell lineNeuroblastomaSJNB80.25360419397117
Sample_02_313Cell lineNeuroblastomaSK-N-DZ0.23552123552124
Sample_02_318Cell lineNeuroblastomaNB690.203125
Sample_02_319Cell lineNeuroblastomaNB-EBc10.2485549132948

TLX2 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_299NeuroblastomaCell lineCLB-MA
Sample_02_300NeuroblastomaCell lineCLB-PE
Sample_02_319NeuroblastomaCell lineNB-EBc1

TLX2 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with TLX2
Download

Mutation of TLX2
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TLX2

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr27474277874742778CTexonicTLX2nonsynonymous BRCA|1|982|0.00102
-chr27474204974742049GAexonicTLX2nonsynonymous BLCA|1|396|0.00253
-chr27474331174743311GTexonicTLX2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr27474276774742767CGexonicTLX2synonymous LUAD|1|543|0.00184
-chr27474206574742065T-exonicTLX2frameshift ACC|1|90|0.01111
-chr27474324474743244GTexonicTLX2synonymous TGCT|1|155|0.00645
-chr27474324374743243CTexonicTLX2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr27474316174743161CTexonicTLX2synonymous BLCA|1|396|0.00253
-chr27474201174742011CTexonicTLX2synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr27474279874742798CAexonicTLX2nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
rs371068999chr27474313974743139CTexonicTLX2synonymous ACC|1|90|0.01111
-chr27474278674742786CTexonicTLX2nonsynonymous BRCA|1|982|0.00102
-chr27474289274742892GAexonicTLX2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr27474296874742968GAexonicTLX2synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr27474293574742935GAexonicTLX2synonymous HNSC|1|512|0.00195
-chr27474297774742977GTexonicTLX2nonsynonymous UCEC|1|248|0.00403
-chr27474295274742952AGexonicTLX2nonsynonymous HNSC|1|512|0.00195
rs568571616chr27474295474742954GAexonicTLX2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr27474296874742968GCexonicTLX2synonymous BLCA|1|396|0.00253
-chr27474283974742839GAexonicTLX2synonymous BLCA|1|396|0.00253
-chr27474212074742120GAexonicTLX2nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr27474279074742790GAexonicTLX2nonsynonymous PRAD|1|499|0.00200
rs760313591chr27474281374742813CTexonicTLX2nonsynonymous PAAD|1|185|0.00541
rs750480020chr27474286374742863GAexonicTLX2synonymous PRAD|1|499|0.00200

Disease information of TLX2
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source

Pathway associated with TLX2
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000135 ALK1 signaling events pid 26 204
pathway0000136 ALK2 signaling events pid 11 35

Go term information of TLX2
GO_term_name GO_term_type TF_name
GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION BP TLX2
GO_FORMATION_OF_PRIMARY_GERM_LAYER BP TLX2
GO_REGULATION_OF_DENDRITE_MORPHOGENESIS BP TLX2
GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS BP TLX2
GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT BP TLX2
GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT BP TLX2
GO_MESODERM_MORPHOGENESIS BP TLX2
GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT BP TLX2
GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT BP TLX2
GO_MESODERM_DEVELOPMENT BP TLX2

Survival analysis of TLX2



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of TLX2