TF information

TF name: TCF4
TF family: bHLH
Ensembl gene ID: ENSG00000196628
Ensembl protein ID: ENSP00000457649, ENSP00000456125, ENSP00000455179, ENSP00000381382, ENSP00000439656, ENSP00000348374, ENSP00000457765, ENSP00000490451, ENSP00000486072, ENSP00000490006, ENSP00000455984, ENSP00000490883, ENSP00000490832, ENSP00000455418, ENSP00000486670, ENSP00000457263
Entrez gene ID: 6925
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of TCF4 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_220Cell lineBrainBE2C_10.19230769230769
Sample_02_250TissueBraintumormodel36910.21875
Sample_02_298Cell lineNeuroblastomaCLB-GA0.35616438356164
Sample_02_300Cell lineNeuroblastomaCLB-PE0.3974358974359
Sample_02_309Cell lineNeuroblastomaSJNB60.29383886255924
Sample_02_310Cell lineNeuroblastomaSJNB80.12319790301442
Sample_02_311Cell lineNeuroblastomaSK-N-AS0.12987012987013
Sample_02_312Cell lineNeuroblastomaSK-N-BE_2-C0.34042553191489
Sample_02_314Cell lineNeuroblastomaSK-N-FI0.33333333333333
Sample_02_316Cell lineNeuroblastomaCHP2120.36263736263736
Sample_02_318Cell lineNeuroblastomaNB690.28125
Sample_02_338Cell lineNeuroblastomaBE20.22058823529412

TCF4 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_300NeuroblastomaCell lineCLB-PE

TCF4 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with TCF4
Download

Mutation of TCF4
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TCF4

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr185292188052921880GTexonicTCF4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr185289624852896248CAexonicTCF4nonsynonymous UCEC|1|248|0.00403
rs373774656chr185325431253254312CTexonicTCF4synonymous SKCM|1|368|0.00272
-chr185294685652946856TCexonicTCF4nonsynonymous LUAD|1|543|0.00184
-chr185292182052921820CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185292720752927207GAexonicTCF4nonsynonymous BLCA|1|396|0.00253
-chr185289622852896228CAexonicTCF4stopgain LUAD|1|543|0.00184
rs121909121chr185289621852896218CTexonicTCF4nonsynonymous ESCA|1|185|0.00541
-chr185289983752899837CTexonicTCF4nonsynonymous CESC|1|194|0.00515,PAAD|1|185|0.00541
-chr185325254253252542ACexonicTCF4synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs869312695chr185293713452937134GAexonicTCF4nonsynonymous KICH|1|66|0.01515,KIPAN|1|799|0.00125
rs151203913chr185313133453131334CTexonicTCF4synonymous SKCM|1|368|0.00272
-chr185307073553070735CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185325433953254339GAexonicTCF4synonymous BLCA|1|396|0.00253
-chr185292873252928732GTexonicTCF4nonsynonymous HNSC|1|512|0.00195
-chr185289553452895534GAexonicTCF4synonymous LIHC|1|373|0.00268
rs587784469chr185292869752928697CTexonicTCF4synonymous BRCA|1|982|0.00102
-chr185307073153070731GTexonicTCF4stopgain BLCA|1|396|0.00253
-chr185289616052896160GAexonicTCF4synonymous BRCA|1|982|0.00102
-chr185293709252937092GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185289623352896233GAexonicTCF4nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr185325435953254359CGexonicTCF4nonsynonymous LUAD|1|543|0.00184
rs767178395chr185292875052928750CTexonicTCF4nonsynonymous UCEC|1|248|0.00403
-chr185289975452899754ACexonicTCF4synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr185290184752901847GTexonicTCF4nonsynonymous LUAD|2|543|0.00368
-chr185313136353131363CAexonicTCF4stopgain UCEC|1|248|0.00403
-chr185289618052896180GAexonicTCF4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr185289629752896297CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185292461452924614CAexonicTCF4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr185290191452901914CTexonicTCF4nonsynonymous LIHC|1|373|0.00268
-chr185289989452899894GAexonicTCF4nonsynonymous UCEC|1|248|0.00403
-chr185329616853296168-TCGACAGACTTCAAAAGAATTGAGAACACAATintronicTCF4unknown -
-chr185289982252899822GCexonicTCF4nonsynonymous BRCA|1|982|0.00102
-chr185290187452901874CAexonicTCF4nonsynonymous PAAD|1|185|0.00541
-chr185312831453128314CGexonicTCF4nonsynonymous LUAD|1|543|0.00184
-chr185289615952896159TCexonicTCF4nonsynonymous UCEC|1|248|0.00403
-chr185325434553254345CTexonicTCF4nonsynonymous UCEC|1|248|0.00403
rs774269559chr185292184552921845CAexonicTCF4nonsynonymous STAD|2|395|0.00506,STES|2|395|0.00506
-chr185292875552928755CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185289620252896202GAexonicTCF4synonymous BRCA|1|982|0.00102
-chr185289625152896251CTexonicTCF4nonsynonymous LUAD|2|543|0.00368
rs587781188chr185289547752895477CTexonicTCF4synonymous SKCM|1|368|0.00272
-chr185292177852921778CAexonicTCF4nonsynonymous LUAD|1|543|0.00184
-chr185292184352921843GAexonicTCF4nonsynonymous SARC|1|247|0.00405
-chr185289621252896212CAexonicTCF4nonsynonymous LUAD|3|543|0.00552
-chr185325255253252552T-exonicTCF4frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr185294688552946885GAexonicTCF4synonymous SKCM|1|368|0.00272
rs567398278chr185312833153128331TCexonicTCF4nonsynonymous LIHC|1|373|0.00268
-chr185292181252921812AGexonicTCF4synonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr185289611952896119-GexonicTCF4frameshift LAML|1|197|0.00508
-chr185301760953017609GTexonicTCF4nonsynonymous UCEC|1|248|0.00403
-chr185292180152921801TCexonicTCF4nonsynonymous LUAD|1|543|0.00184
-chr185301761453017614TCexonicTCF4synonymous ESCA|1|185|0.00541
-chr185294687452946874GCexonicTCF4stopgain BLCA|2|396|0.00505
rs777418647chr185289984452899844GAexonicTCF4synonymous PRAD|1|499|0.00200
-chr185325430753254307TCexonicTCF4nonsynonymous BLCA|1|396|0.00253
-chr185289608852896088CGexonicTCF4nonsynonymous BRCA|1|982|0.00102
-chr185289979352899793CTexonicTCF4synonymous LUAD|1|543|0.00184,SKCM|1|368|0.00272
-chr185312833953128339CGexonicTCF4nonsynonymous BRCA|1|982|0.00102
-chr185290180052901800GAexonicTCF4nonsynonymous SKCM|2|368|0.00543
-chr185307073153070731GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185293719552937195CAsplicingTCF4splicing LUAD|1|543|0.00184
-chr185301761053017610GAexonicTCF4nonsynonymous SKCM|2|368|0.00543
rs587784458chr185292454552924545CTsplicingTCF4splicing STAD|1|395|0.00253,STES|1|395|0.00253
-chr185294689952946899GCexonicTCF4nonsynonymous BLCA|2|396|0.00505
-chr185290178152901781CTexonicTCF4nonsynonymous PRAD|2|499|0.00401
-chr185289616952896169CAexonicTCF4nonsynonymous LUAD|1|543|0.00184
-chr185292191352921913GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185289626752896267CTexonicTCF4nonsynonymous BLCA|1|396|0.00253
-chr185325251353252513GAexonicTCF4nonsynonymous BRCA|1|982|0.00102
-chr185330305253303052TAexonicTCF4nonsynonymous LIHC|1|373|0.00268
rs770354308chr185292871252928712CTexonicTCF4synonymous SKCM|1|368|0.00272
-chr185292191952921919CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185289981352899813TCexonicTCF4nonsynonymous PAAD|1|185|0.00541
-chr185312827653128276GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185289623152896231GAexonicTCF4stopgain UCEC|1|248|0.00403
-chr185325433253254332GAexonicTCF4stopgain PAAD|1|185|0.00541
-chr185292725152927251GTexonicTCF4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr185292722952927229GTexonicTCF4nonsynonymous CESC|1|194|0.00515
rs747963568chr185294678952946789GAexonicTCF4synonymous SKCM|1|368|0.00272
-chr185289987552899875CAexonicTCF4nonsynonymous LUAD|1|543|0.00184
-chr185289984552899845GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185292180352921803AGexonicTCF4synonymous BRCA|1|982|0.00102
-chr185294678652946786CTexonicTCF4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr185301813053018130CAexonicTCF4nonsynonymous ESCA|1|185|0.00541
-chr185292187752921877GAexonicTCF4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr185301818753018187ACexonicTCF4synonymous UCEC|1|248|0.00403
-chr185301761953017619GAexonicTCF4stopgain UCEC|4|248|0.01613
-chr185325252153252521AGexonicTCF4synonymous UCEC|1|248|0.00403
-chr185312833753128337CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
rs867075569chr185294298152942981CTexonicTCF4nonsynonymous SKCM|2|368|0.00543
-chr185294296152942961ATexonicTCF4synonymous LUAD|1|543|0.00184
-chr185292459352924593CAexonicTCF4stopgain LUAD|1|543|0.00184
-chr185301813453018134CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185301822753018227AGexonicTCF4nonsynonymous LIHC|1|373|0.00268
-chr185292460852924608AGexonicTCF4nonsynonymous PAAD|1|185|0.00541
-chr185292869852928698GAexonicTCF4nonsynonymous BLCA|1|396|0.00253,COADREAD|1|489|0.00204,READ|1|122|0.00820
rs778907139chr185294688052946880GAexonicTCF4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253,UCEC|1|248|0.00403
-chr185292185952921859GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185301763053017632GTC-exonicTCF4nonframeshift ESCA|1|185|0.00541
-chr185292722452927224GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185292872152928721ATexonicTCF4nonsynonymous LUAD|1|543|0.00184
rs756279357chr185293709452937094GAexonicTCF4nonsynonymous LIHC|1|373|0.00268
-chr185301761453017614TGexonicTCF4nonsynonymous BRCA|1|982|0.00102
-chr185290186052901860GAexonicTCF4nonsynonymous LUAD|1|543|0.00184
-chr185294294352942943CTexonicTCF4synonymous SKCM|1|368|0.00272
-chr185293710052937100GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185290181952901819CTexonicTCF4synonymous SKCM|1|368|0.00272
-chr185325430053254300CGexonicTCF4synonymous BLCA|1|396|0.00253
-chr185293709152937091GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185294291352942913CAexonicTCF4nonsynonymous LUAD|1|543|0.00184
-chr185312826153128261GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185289554152895541TCexonicTCF4nonsynonymous LIHC|1|373|0.00268
-chr185294285852942858CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185289615752896157CGexonicTCF4nonsynonymous HNSC|1|512|0.00195
-chr185293715452937154ACexonicTCF4nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr185330297653302976CAexonicTCF4nonsynonymous ESCA|1|185|0.00541
-chr185292874652928746GAexonicTCF4nonsynonymous BRCA|2|982|0.00204
-chr185292182952921829CTexonicTCF4nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr185289622552896225GAexonicTCF4nonsynonymous UCEC|1|248|0.00403
rs762922637chr185290189452901894AGexonicTCF4synonymous DLBC|1|48|0.02083
-chr185290189952901899CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185289557152895571GTexonicTCF4nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr185292458052924580GAexonicTCF4nonsynonymous UCEC|1|248|0.00403
-chr185289616252896162GTexonicTCF4nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr185301822553018225GAexonicTCF4nonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr185293719052937190TCexonicTCF4nonsynonymous ESCA|1|185|0.00541
-chr185292177952921779CGexonicTCF4synonymous LUAD|1|543|0.00184
-chr185289975752899757ACexonicTCF4nonsynonymous UCEC|1|248|0.00403
-chr185289978652899786CGexonicTCF4nonsynonymous BLCA|1|396|0.00253,LUSC|1|178|0.00562
-chr185290179552901795G-exonicTCF4frameshift LUAD|1|543|0.00184
-chr185325427753254277GAexonicTCF4nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr185290184852901848GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185330306353303063ACexonicTCF4nonsynonymous PAAD|1|185|0.00541
-chr185289611652896116GAexonicTCF4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr185289613352896133GAexonicTCF4synonymous SKCM|1|368|0.00272
-chr185289614952896149TGexonicTCF4nonsynonymous UCS|1|57|0.01754
-chr185289552052895520G-exonicTCF4frameshift BRCA|1|982|0.00102,COAD|2|367|0.00545,COADREAD|2|489|0.00409,STAD|1|395|0.00253,STES|1|395|0.00253
-chr185289547852895478GTexonicTCF4stopgain CHOL|1|35|0.02857
rs370405835chr185289978152899781GAexonicTCF4synonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs868465337chr185301759853017598GAexonicTCF4nonsynonymous ESCA|1|185|0.00541
-chr185293709952937099GAexonicTCF4synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr185292456652924566CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185292718952927189AGexonicTCF4nonsynonymous LIHC|1|373|0.00268
-chr185290180952901809CAexonicTCF4nonsynonymous BRCA|1|982|0.00102
-chr185289548852895488CAexonicTCF4stopgain OV|1|469|0.00213
rs200096408chr185289557652895576CTexonicTCF4synonymous SKCM|1|368|0.00272
-chr185325428753254287CAexonicTCF4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr185292719052927190TCexonicTCF4synonymous UCEC|1|248|0.00403
-chr185289629252896292CTexonicTCF4synonymous PRAD|1|499|0.00200
-chr185301819853018198GTexonicTCF4nonsynonymous PAAD|1|185|0.00541
rs776644488chr185289608052896080CTexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185293717052937170CAexonicTCF4nonsynonymous BLCA|1|396|0.00253
-chr185292172752921727CTsplicingTCF4splicing SKCM|1|368|0.00272
-chr185289975052899750ATsplicingTCF4splicing STAD|1|395|0.00253,STES|1|395|0.00253
-chr185289554052895540CAexonicTCF4nonsynonymous STAD|2|395|0.00506,STES|2|395|0.00506
-chr185292458352924583GAexonicTCF4nonsynonymous LUSC|1|178|0.00562
rs774527851chr185289981152899811CTexonicTCF4synonymous BRCA|1|982|0.00102,SKCM|1|368|0.00272
-chr185330295853302958CTexonicTCF4synonymous UCEC|1|248|0.00403
-chr185292724852927248GAexonicTCF4nonsynonymous SKCM|1|368|0.00272
-chr185289547852895478GAexonicTCF4nonsynonymous UCEC|1|248|0.00403
-chr185301761853017618CTexonicTCF4nonsynonymous PAAD|1|185|0.00541,SKCM|1|368|0.00272

Disease information of TCF4
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
TCF4 Bipolar Disorder F03 Mental or Behavioral Dysfunction PSYGENET
TCF4 Fuchs Endothelial Dystrophy C11;C16 Disease or Syndrome ORPHANET
TCF4 Heart Diseases C14 Disease or Syndrome CTD_human
TCF4 Jacksonian Seizure C10;C23 Disease or Syndrome CTD_human
TCF4 Liver Cirrhosis, Experimental C06 Experimental Model of Disease CTD_human
TCF4 Liver neoplasms C04;C06 Neoplastic Process CTD_human
TCF4 Microcephaly C05;C10;C16 Congenital Abnormality CTD_human;GENOMICS_ENGLAND
TCF4 Peripheral Neuropathy C10 Disease or Syndrome CTD_human
TCF4 Psychotic Disorders F03 Mental or Behavioral Dysfunction PSYGENET
TCF4 Schizophrenia F03 Mental or Behavioral Dysfunction PSYGENET
TCF4 Seizures C10;C23 Sign or Symptom CTD_human
TCF4 Complex partial seizures C10;C23 Disease or Syndrome CTD_human
TCF4 Generalized seizures C10;C23 Disease or Syndrome CTD_human
TCF4 Seizures, Clonic C10;C23 Disease or Syndrome CTD_human
TCF4 Visual seizure C10;C23 Disease or Syndrome CTD_human
TCF4 Tonic Seizures C10;C23 Sign or Symptom CTD_human
TCF4 Epileptic drop attack C10;C23 Disease or Syndrome CTD_human
TCF4 Malignant neoplasm of liver C04;C06 Neoplastic Process CTD_human
TCF4 Nonorganic psychosis Mental or Behavioral Dysfunction PSYGENET
TCF4 Craniofacial Abnormalities C05;C16 Congenital Abnormality CTD_human
TCF4 Seizures, Somatosensory C10;C23 Pathologic Function CTD_human
TCF4 Seizures, Auditory C10;C23 Pathologic Function CTD_human
TCF4 Olfactory seizure C10;C23 Disease or Syndrome CTD_human
TCF4 Gustatory seizure C10;C23 Sign or Symptom CTD_human
TCF4 Vertiginous seizure C10;C23 Disease or Syndrome CTD_human
TCF4 Tonic - clonic seizures C10;C23 Disease or Syndrome CTD_human
TCF4 Epileptic encephalopathy Disease or Syndrome GENOMICS_ENGLAND
TCF4 Primary sclerosing cholangitis C06 Disease or Syndrome ORPHANET
TCF4 Non-epileptic convulsion C10;C23 Sign or Symptom CTD_human
TCF4 Single Seizure C10;C23 Disease or Syndrome CTD_human
TCF4 Atonic Absence Seizures C10;C23 Disease or Syndrome CTD_human
TCF4 Convulsive Seizures C10;C23 Sign or Symptom CTD_human
TCF4 Seizures, Focal C10;C23 Disease or Syndrome CTD_human
TCF4 Seizures, Sensory C10;C23 Sign or Symptom CTD_human
TCF4 Paranoia F03 Mental or Behavioral Dysfunction PSYGENET
TCF4 Neurodevelopmental Disorders F03 Mental or Behavioral Dysfunction CTD_human
TCF4 Microlissencephaly C05;C10;C16 Disease or Syndrome CTD_human
TCF4 PITT-HOPKINS SYNDROME C08;C10;C23;F01;F03 Disease or Syndrome CTD_human;ORPHANET;UNIPROT
TCF4 CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 3 C11;C16 Disease or Syndrome CTD_human
TCF4 Nonepileptic Seizures C10;C23 Disease or Syndrome CTD_human
TCF4 Intellectual Disability C10;C23;F01;F03 Mental or Behavioral Dysfunction GENOMICS_ENGLAND
TCF4 Severe Congenital Microcephaly C05;C10;C16 Congenital Abnormality; Disease or Syndrome CTD_human
TCF4 Convulsions C10;C23 Sign or Symptom CTD_human
TCF4 Absence Seizures C10;C23 Sign or Symptom CTD_human
TCF4 Epileptic Seizures C10;C23 Disease or Syndrome CTD_human
TCF4 Myoclonic Seizures C10;C23 Sign or Symptom CTD_human
TCF4 Generalized Absence Seizures C10;C23 Disease or Syndrome CTD_human

Pathway associated with TCF4
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000393 CDO in myogenesis reactome 29 200
pathway0001078 ID netpath 38 213
pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 wikipathways 41 162

Go term information of TCF4
GO_term_name GO_term_type TF_name
GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION BP TCF4
GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER BP TCF4
GO_BHLH_TRANSCRIPTION_FACTOR_BINDING MF TCF4
GO_E_BOX_BINDING MF TCF4
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING MF TCF4
GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING MF TCF4
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING MF TCF4
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING MF TCF4

Survival analysis of TCF4



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of TCF4