TF information

TF name: NR4A1
TF family: NGFIB-like
Ensembl gene ID: ENSG00000123358
Ensembl protein ID: ENSP00000353427, ENSP00000440864, ENSP00000243050, ENSP00000378301, ENSP00000457070, ENSP00000449587, ENSP00000378302, ENSP00000449539
Entrez gene ID: 3164
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of NR4A1 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_001Cell lineProstate22Rv10.28571428571429
Sample_01_022Cell lineProstateC4-2B0.38095238095238
Sample_01_068Cell lineProstate: derived from metastatic site: vertebral metastasisVCaP0.26027397260274
Sample_02_021Cell lineColonV4290.52868261746901
Sample_02_168Cell lineProstateLNCaP0.71863117870722
Sample_02_180Cell lineHuman melanomaCJM0.4296875
Sample_02_181Cell lineHuman melanomaCOLO6790.51893333333333
Sample_02_204Cell lineStomachIM950.45454545454545
Sample_02_236Cell lineColonV2060.2463768115942
Sample_02_237Cell lineColonV3890.37644027240935
Sample_02_241Cell lineColonV4560.42099322799097
Sample_02_242Cell lineColonV4810.64256873678139
Sample_02_359Cell lineColonColo7410.30120481927711

NR4A1 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_01_022ProstateCell lineC4-2B
Sample_02_021ColonCell lineV429
Sample_02_168ProstateCell lineLNCaP
Sample_02_181Human melanomaCell lineCOLO679
Sample_02_204StomachCell lineIM95
Sample_02_242ColonCell lineV481

NR4A1 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with NR4A1
Download

Mutation of NR4A1
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NR4A1

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr125245247552452475GCexonicNR4A1nonsynonymous LUAD|2|543|0.00368
rs764715159chr125245250252452502TGexonicNR4A1nonsynonymous LUSC|1|178|0.00562
-chr125244854952448549TGexonicNR4A1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr125244843552448435TGexonicNR4A1nonsynonymous PRAD|1|499|0.00200
-chr125244838252448382GAexonicNR4A1synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr125244822452448224GTexonicNR4A1nonsynonymous LUAD|1|543|0.00184
-chr125244845452448454C-exonicNR4A1frameshift SKCM|1|368|0.00272
-chr125245127452451274CTexonicNR4A1synonymous SKCM|1|368|0.00272
-chr125244989752449897GAexonicNR4A1synonymous KICH|1|66|0.01515,KIPAN|1|799|0.00125
-chr125244855652448556GTexonicNR4A1synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr125244837652448376ACexonicNR4A1synonymous LUAD|1|543|0.00184
-chr125244985052449850GTexonicNR4A1nonsynonymous LUSC|1|178|0.00562
-chr125244904752449047CTintronicNR4A1unknown CESC|1|194|0.00515
-chr125245122852451228GAexonicNR4A1nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr125244876852448768GTexonicNR4A1nonsynonymous LUAD|4|543|0.00737
rs564417773chr125244858652448586CTexonicNR4A1synonymous UCEC|1|248|0.00403
rs767819564chr125245131352451313CTexonicNR4A1synonymous UCEC|1|248|0.00403
-chr125243566152435661GAUTR5NR4A1unknown CESC|1|194|0.00515
-chr125245270452452704CAexonicNR4A1synonymous UCEC|1|248|0.00403
rs370471749chr125245094452450944CTexonicNR4A1nonsynonymous UCEC|1|248|0.00403
-chr125244871552448715CAexonicNR4A1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr125244889552448895TGexonicNR4A1synonymous BRCA|1|982|0.00102
-chr125245040052450400CTexonicNR4A1nonsynonymous PAAD|1|185|0.00541
rs375396767chr125244815652448156CTexonicNR4A1nonsynonymous LIHC|1|373|0.00268
-chr125244824952448249CTexonicNR4A1nonsynonymous LIHC|1|373|0.00268
-chr125245036352450363CTexonicNR4A1synonymous SKCM|1|368|0.00272
-chr125245114852451148CAexonicNR4A1synonymous HNSC|2|512|0.00391
-chr125244988452449884GAexonicNR4A1nonsynonymous BLCA|1|396|0.00253,BRCA|1|982|0.00102
-chr125244988052449880CTexonicNR4A1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr125244988352449883CTexonicNR4A1stopgain PAAD|1|185|0.00541
-chr125245101752451017GTexonicNR4A1nonsynonymous LUAD|1|543|0.00184
-chr125245124952451249CTexonicNR4A1nonsynonymous SKCM|2|368|0.00543
-chr125244844952448449CTexonicNR4A1nonsynonymous SKCM|1|368|0.00272
-chr125244858752448587GAexonicNR4A1nonsynonymous UCEC|1|248|0.00403
-chr125245128152451281TCexonicNR4A1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr125245123852451238CTexonicNR4A1synonymous SKCM|2|368|0.00543
-chr125244861052448610TGexonicNR4A1synonymous SKCM|1|368|0.00272
-chr125245028552450285AGexonicNR4A1synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr125245123052451230AGexonicNR4A1nonsynonymous UCEC|1|248|0.00403
-chr125244982152449821TAexonicNR4A1nonsynonymous LUSC|1|178|0.00562
-chr125245034752450347CAexonicNR4A1nonsynonymous UCEC|1|248|0.00403
rs770620910chr125245103152451031GAexonicNR4A1nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr125244896152448961AGexonicNR4A1synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr125244868452448684CTexonicNR4A1nonsynonymous SKCM|1|368|0.00272
-chr125245122052451220GAexonicNR4A1stopgain LUSC|1|178|0.00562
-chr125245116352451164CT-exonicNR4A1frameshift GBMLGG|2|820|0.00244,LGG|2|530|0.00377
-chr125245119852451198GAexonicNR4A1nonsynonymous BRCA|1|982|0.00102
rs759594053chr125245118152451181GAexonicNR4A1synonymous UCS|1|57|0.01754
-chr125243570952435709GCexonicNR4A1nonsynonymous LUAD|1|543|0.00184
-chr125245030452450304CTexonicNR4A1nonsynonymous BLCA|1|396|0.00253,PAAD|1|185|0.00541
-chr125245260052452600GCexonicNR4A1nonsynonymous LIHC|1|373|0.00268
-chr125244885152448851GAexonicNR4A1nonsynonymous KICH|1|66|0.01515,KIPAN|1|799|0.00125
-chr125245248552452485GAexonicNR4A1synonymous LIHC|1|373|0.00268
-chr125244982552449825GAexonicNR4A1synonymous LUAD|1|543|0.00184
-chr125245249352452493CTexonicNR4A1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr125245124352451243CGexonicNR4A1stopgain HNSC|1|512|0.00195
-chr125245042552450425CTexonicNR4A1nonsynonymous UCEC|1|248|0.00403
-chr125245036252450362TGexonicNR4A1nonsynonymous SKCM|1|368|0.00272
rs140430231chr125244992352449923CTexonicNR4A1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr125244888052448880GCexonicNR4A1synonymous HNSC|1|512|0.00195
rs2701124chr125244815752448157GAexonicNR4A1synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr125245030352450303GAexonicNR4A1synonymous UCEC|1|248|0.00403
-chr125243251352432513ATintronicNR4A1unknown STAD|1|395|0.00253,STES|1|395|0.00253
rs570850379chr125244879652448796GAexonicNR4A1synonymous BRCA|1|982|0.00102
-chr125244824852448248-CexonicNR4A1frameshift HNSC|1|512|0.00195
-chr125244856552448565CGexonicNR4A1synonymous BRCA|1|982|0.00102
rs377043577chr125244816452448164CTexonicNR4A1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr125244889452448894GAexonicNR4A1nonsynonymous UCS|1|57|0.01754
rs771251157chr125245261552452615CAexonicNR4A1nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr125244881252448812GCexonicNR4A1nonsynonymous ESCA|1|185|0.00541
rs545590997chr125245128352451283CTexonicNR4A1synonymous BRCA|1|982|0.00102

Disease information of NR4A1
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
NR4A1 Endometriosis C13 Disease or Syndrome CTD_human
NR4A1 Insulin Resistance C18 Pathologic Function CTD_human
NR4A1 Kidney Diseases C12;C13 Disease or Syndrome CTD_human
NR4A1 Pancreatic Neoplasm C04;C06;C19 Neoplastic Process CTD_human
NR4A1 Proteinuria C12;C13;C23 Finding CTD_human
NR4A1 Myocardial Ischemia C14 Disease or Syndrome CTD_human
NR4A1 Endometrioma C13 Neoplastic Process CTD_human
NR4A1 Malignant neoplasm of pancreas C04;C06;C19 Neoplastic Process CTD_human
NR4A1 Insulin Sensitivity C18 Pathologic Function CTD_human

Pathway associated with NR4A1
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000118 AKT phosphorylates targets in the nucleus reactome 9 27
pathway0000479 Constitutive Signaling by AKT1 E17K in Cancer reactome 25 137
pathway0001534 Nuclear Receptor transcription pathway reactome 51 284
pathway0001935 Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54 450
pathway0001947 RXR and RAR heterodimerization with other nuclear receptor pid 26 164
pathway0002699 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 wikipathways 41 162
pathway0002709 Hs_MAPK_Signaling_Pathway_WP382_79951 wikipathways 58 180

Go term information of NR4A1
GO_term_name GO_term_type TF_name
GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS BP NR4A1
GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION BP NR4A1
GO_ENDOTHELIAL_CELL_MIGRATION BP NR4A1
GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION BP NR4A1
GO_SPROUTING_ANGIOGENESIS BP NR4A1
GO_RESPONSE_TO_HORMONE BP NR4A1
GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS BP NR4A1
GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY BP NR4A1
GO_CELLULAR_RESPONSE_TO_PEPTIDE BP NR4A1
GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION BP NR4A1
GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS BP NR4A1
GO_NUCLEAR_MEMBRANE CC NR4A1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING MF NR4A1
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY MF NR4A1

Survival analysis of NR4A1



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of NR4A1