TF name: | NR4A1 |
TF family: | NGFIB-like |
Ensembl gene ID: | ENSG00000123358 |
Ensembl protein ID: | ENSP00000353427, ENSP00000440864, ENSP00000243050, ENSP00000378301, ENSP00000457070, ENSP00000449587, ENSP00000378302, ENSP00000449539 |
Entrez gene ID: | 3164 |
Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
---|---|---|---|---|
Sample_01_001 | Cell line | Prostate | 22Rv1 | 0.28571428571429 |
Sample_01_022 | Cell line | Prostate | C4-2B | 0.38095238095238 |
Sample_01_068 | Cell line | Prostate: derived from metastatic site: vertebral metastasis | VCaP | 0.26027397260274 |
Sample_02_021 | Cell line | Colon | V429 | 0.52868261746901 |
Sample_02_168 | Cell line | Prostate | LNCaP | 0.71863117870722 |
Sample_02_180 | Cell line | Human melanoma | CJM | 0.4296875 |
Sample_02_181 | Cell line | Human melanoma | COLO679 | 0.51893333333333 |
Sample_02_204 | Cell line | Stomach | IM95 | 0.45454545454545 |
Sample_02_236 | Cell line | Colon | V206 | 0.2463768115942 |
Sample_02_237 | Cell line | Colon | V389 | 0.37644027240935 |
Sample_02_241 | Cell line | Colon | V456 | 0.42099322799097 |
Sample_02_242 | Cell line | Colon | V481 | 0.64256873678139 |
Sample_02_359 | Cell line | Colon | Colo741 | 0.30120481927711 |
Sample ID | Tissue type | Biosample type | Biosample name |
---|---|---|---|
Sample_01_022 | Prostate | Cell line | C4-2B |
Sample_02_021 | Colon | Cell line | V429 |
Sample_02_168 | Prostate | Cell line | LNCaP |
Sample_02_181 | Human melanoma | Cell line | COLO679 |
Sample_02_204 | Stomach | Cell line | IM95 |
Sample_02_242 | Colon | Cell line | V481 |
rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
---|---|---|---|---|---|---|---|---|---|
- | chr12 | 52452475 | 52452475 | G | C | exonic | NR4A1 | nonsynonymous | LUAD|2|543|0.00368 |
rs764715159 | chr12 | 52452502 | 52452502 | T | G | exonic | NR4A1 | nonsynonymous | LUSC|1|178|0.00562 |
- | chr12 | 52448549 | 52448549 | T | G | exonic | NR4A1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr12 | 52448435 | 52448435 | T | G | exonic | NR4A1 | nonsynonymous | PRAD|1|499|0.00200 |
- | chr12 | 52448382 | 52448382 | G | A | exonic | NR4A1 | synonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
- | chr12 | 52448224 | 52448224 | G | T | exonic | NR4A1 | nonsynonymous | LUAD|1|543|0.00184 |
- | chr12 | 52448454 | 52448454 | C | - | exonic | NR4A1 | frameshift | SKCM|1|368|0.00272 |
- | chr12 | 52451274 | 52451274 | C | T | exonic | NR4A1 | synonymous | SKCM|1|368|0.00272 |
- | chr12 | 52449897 | 52449897 | G | A | exonic | NR4A1 | synonymous | KICH|1|66|0.01515,KIPAN|1|799|0.00125 |
- | chr12 | 52448556 | 52448556 | G | T | exonic | NR4A1 | synonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
- | chr12 | 52448376 | 52448376 | A | C | exonic | NR4A1 | synonymous | LUAD|1|543|0.00184 |
- | chr12 | 52449850 | 52449850 | G | T | exonic | NR4A1 | nonsynonymous | LUSC|1|178|0.00562 |
- | chr12 | 52449047 | 52449047 | C | T | intronic | NR4A1 | unknown | CESC|1|194|0.00515 |
- | chr12 | 52451228 | 52451228 | G | A | exonic | NR4A1 | nonsynonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
- | chr12 | 52448768 | 52448768 | G | T | exonic | NR4A1 | nonsynonymous | LUAD|4|543|0.00737 |
rs564417773 | chr12 | 52448586 | 52448586 | C | T | exonic | NR4A1 | synonymous | UCEC|1|248|0.00403 |
rs767819564 | chr12 | 52451313 | 52451313 | C | T | exonic | NR4A1 | synonymous | UCEC|1|248|0.00403 |
- | chr12 | 52435661 | 52435661 | G | A | UTR5 | NR4A1 | unknown | CESC|1|194|0.00515 |
- | chr12 | 52452704 | 52452704 | C | A | exonic | NR4A1 | synonymous | UCEC|1|248|0.00403 |
rs370471749 | chr12 | 52450944 | 52450944 | C | T | exonic | NR4A1 | nonsynonymous | UCEC|1|248|0.00403 |
- | chr12 | 52448715 | 52448715 | C | A | exonic | NR4A1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr12 | 52448895 | 52448895 | T | G | exonic | NR4A1 | synonymous | BRCA|1|982|0.00102 |
- | chr12 | 52450400 | 52450400 | C | T | exonic | NR4A1 | nonsynonymous | PAAD|1|185|0.00541 |
rs375396767 | chr12 | 52448156 | 52448156 | C | T | exonic | NR4A1 | nonsynonymous | LIHC|1|373|0.00268 |
- | chr12 | 52448249 | 52448249 | C | T | exonic | NR4A1 | nonsynonymous | LIHC|1|373|0.00268 |
- | chr12 | 52450363 | 52450363 | C | T | exonic | NR4A1 | synonymous | SKCM|1|368|0.00272 |
- | chr12 | 52451148 | 52451148 | C | A | exonic | NR4A1 | synonymous | HNSC|2|512|0.00391 |
- | chr12 | 52449884 | 52449884 | G | A | exonic | NR4A1 | nonsynonymous | BLCA|1|396|0.00253,BRCA|1|982|0.00102 |
- | chr12 | 52449880 | 52449880 | C | T | exonic | NR4A1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
- | chr12 | 52449883 | 52449883 | C | T | exonic | NR4A1 | stopgain | PAAD|1|185|0.00541 |
- | chr12 | 52451017 | 52451017 | G | T | exonic | NR4A1 | nonsynonymous | LUAD|1|543|0.00184 |
- | chr12 | 52451249 | 52451249 | C | T | exonic | NR4A1 | nonsynonymous | SKCM|2|368|0.00543 |
- | chr12 | 52448449 | 52448449 | C | T | exonic | NR4A1 | nonsynonymous | SKCM|1|368|0.00272 |
- | chr12 | 52448587 | 52448587 | G | A | exonic | NR4A1 | nonsynonymous | UCEC|1|248|0.00403 |
- | chr12 | 52451281 | 52451281 | T | C | exonic | NR4A1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
- | chr12 | 52451238 | 52451238 | C | T | exonic | NR4A1 | synonymous | SKCM|2|368|0.00543 |
- | chr12 | 52448610 | 52448610 | T | G | exonic | NR4A1 | synonymous | SKCM|1|368|0.00272 |
- | chr12 | 52450285 | 52450285 | A | G | exonic | NR4A1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr12 | 52451230 | 52451230 | A | G | exonic | NR4A1 | nonsynonymous | UCEC|1|248|0.00403 |
- | chr12 | 52449821 | 52449821 | T | A | exonic | NR4A1 | nonsynonymous | LUSC|1|178|0.00562 |
- | chr12 | 52450347 | 52450347 | C | A | exonic | NR4A1 | nonsynonymous | UCEC|1|248|0.00403 |
rs770620910 | chr12 | 52451031 | 52451031 | G | A | exonic | NR4A1 | nonsynonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
- | chr12 | 52448961 | 52448961 | A | G | exonic | NR4A1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr12 | 52448684 | 52448684 | C | T | exonic | NR4A1 | nonsynonymous | SKCM|1|368|0.00272 |
- | chr12 | 52451220 | 52451220 | G | A | exonic | NR4A1 | stopgain | LUSC|1|178|0.00562 |
- | chr12 | 52451163 | 52451164 | CT | - | exonic | NR4A1 | frameshift | GBMLGG|2|820|0.00244,LGG|2|530|0.00377 |
- | chr12 | 52451198 | 52451198 | G | A | exonic | NR4A1 | nonsynonymous | BRCA|1|982|0.00102 |
rs759594053 | chr12 | 52451181 | 52451181 | G | A | exonic | NR4A1 | synonymous | UCS|1|57|0.01754 |
- | chr12 | 52435709 | 52435709 | G | C | exonic | NR4A1 | nonsynonymous | LUAD|1|543|0.00184 |
- | chr12 | 52450304 | 52450304 | C | T | exonic | NR4A1 | nonsynonymous | BLCA|1|396|0.00253,PAAD|1|185|0.00541 |
- | chr12 | 52452600 | 52452600 | G | C | exonic | NR4A1 | nonsynonymous | LIHC|1|373|0.00268 |
- | chr12 | 52448851 | 52448851 | G | A | exonic | NR4A1 | nonsynonymous | KICH|1|66|0.01515,KIPAN|1|799|0.00125 |
- | chr12 | 52452485 | 52452485 | G | A | exonic | NR4A1 | synonymous | LIHC|1|373|0.00268 |
- | chr12 | 52449825 | 52449825 | G | A | exonic | NR4A1 | synonymous | LUAD|1|543|0.00184 |
- | chr12 | 52452493 | 52452493 | C | T | exonic | NR4A1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr12 | 52451243 | 52451243 | C | G | exonic | NR4A1 | stopgain | HNSC|1|512|0.00195 |
- | chr12 | 52450425 | 52450425 | C | T | exonic | NR4A1 | nonsynonymous | UCEC|1|248|0.00403 |
- | chr12 | 52450362 | 52450362 | T | G | exonic | NR4A1 | nonsynonymous | SKCM|1|368|0.00272 |
rs140430231 | chr12 | 52449923 | 52449923 | C | T | exonic | NR4A1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
- | chr12 | 52448880 | 52448880 | G | C | exonic | NR4A1 | synonymous | HNSC|1|512|0.00195 |
rs2701124 | chr12 | 52448157 | 52448157 | G | A | exonic | NR4A1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr12 | 52450303 | 52450303 | G | A | exonic | NR4A1 | synonymous | UCEC|1|248|0.00403 |
- | chr12 | 52432513 | 52432513 | A | T | intronic | NR4A1 | unknown | STAD|1|395|0.00253,STES|1|395|0.00253 |
rs570850379 | chr12 | 52448796 | 52448796 | G | A | exonic | NR4A1 | synonymous | BRCA|1|982|0.00102 |
- | chr12 | 52448248 | 52448248 | - | C | exonic | NR4A1 | frameshift | HNSC|1|512|0.00195 |
- | chr12 | 52448565 | 52448565 | C | G | exonic | NR4A1 | synonymous | BRCA|1|982|0.00102 |
rs377043577 | chr12 | 52448164 | 52448164 | C | T | exonic | NR4A1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr12 | 52448894 | 52448894 | G | A | exonic | NR4A1 | nonsynonymous | UCS|1|57|0.01754 |
rs771251157 | chr12 | 52452615 | 52452615 | C | A | exonic | NR4A1 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
- | chr12 | 52448812 | 52448812 | G | C | exonic | NR4A1 | nonsynonymous | ESCA|1|185|0.00541 |
rs545590997 | chr12 | 52451283 | 52451283 | C | T | exonic | NR4A1 | synonymous | BRCA|1|982|0.00102 |
TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
---|---|---|---|---|
NR4A1 | Endometriosis | C13 | Disease or Syndrome | CTD_human |
NR4A1 | Insulin Resistance | C18 | Pathologic Function | CTD_human |
NR4A1 | Kidney Diseases | C12;C13 | Disease or Syndrome | CTD_human |
NR4A1 | Pancreatic Neoplasm | C04;C06;C19 | Neoplastic Process | CTD_human |
NR4A1 | Proteinuria | C12;C13;C23 | Finding | CTD_human |
NR4A1 | Myocardial Ischemia | C14 | Disease or Syndrome | CTD_human |
NR4A1 | Endometrioma | C13 | Neoplastic Process | CTD_human |
NR4A1 | Malignant neoplasm of pancreas | C04;C06;C19 | Neoplastic Process | CTD_human |
NR4A1 | Insulin Sensitivity | C18 | Pathologic Function | CTD_human |
pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
---|---|---|---|---|
pathway0000118 | AKT phosphorylates targets in the nucleus | reactome | 9 | 27 |
pathway0000479 | Constitutive Signaling by AKT1 E17K in Cancer | reactome | 25 | 137 |
pathway0001534 | Nuclear Receptor transcription pathway | reactome | 51 | 284 |
pathway0001935 | Role of Calcineurin-dependent NFAT signaling in lymphocytes | pid | 54 | 450 |
pathway0001947 | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 | 164 |
pathway0002699 | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 | 162 |
pathway0002709 | Hs_MAPK_Signaling_Pathway_WP382_79951 | wikipathways | 58 | 180 |
GO_term_name | GO_term_type | TF_name |
---|---|---|
GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS | BP | NR4A1 |
GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION | BP | NR4A1 |
GO_ENDOTHELIAL_CELL_MIGRATION | BP | NR4A1 |
GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION | BP | NR4A1 |
GO_SPROUTING_ANGIOGENESIS | BP | NR4A1 |
GO_RESPONSE_TO_HORMONE | BP | NR4A1 |
GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS | BP | NR4A1 |
GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY | BP | NR4A1 |
GO_CELLULAR_RESPONSE_TO_PEPTIDE | BP | NR4A1 |
GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION | BP | NR4A1 |
GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS | BP | NR4A1 |
GO_NUCLEAR_MEMBRANE | CC | NR4A1 |
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING | MF | NR4A1 |
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY | MF | NR4A1 |