Cancer CRCdb

TF information

TF name:	MEIS1
TF family:	Homeobox
Ensembl gene ID:	ENSG00000143995
Ensembl protein ID:	ENSP00000454209, ENSP00000475161, ENSP00000272369, ENSP00000440571, ENSP00000381518
Entrez gene ID:	4211

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of MEIS1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_078	Primary cell	Neuroblastoma	low-MYCN-Neuroblastoma-patient-cells	0.375
Sample_02_181	Cell line	Human melanoma	COLO679	0.3616
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.52941176470588
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.57230298393267
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.32876712328767
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.43405275779377
Sample_02_302	Cell line	Neuroblastoma	IMR32	0.25
Sample_02_304	Cell line	Neuroblastoma	N206	0.51358695652174
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.36619718309859
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.359375
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.46445497630332
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.58322411533421
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.62337662337662
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.48262548262548
Sample_02_318	Cell line	Neuroblastoma	NB69	0.4609375
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.1849710982659

MEIS1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_254	Neuroblastoma	Cell line	IMR5-75
Sample_02_296	Neuroblastoma	Cell line	CLB-BER-Lud
Sample_02_298	Neuroblastoma	Cell line	CLB-GA
Sample_02_299	Neuroblastoma	Cell line	CLB-MA
Sample_02_304	Neuroblastoma	Cell line	N206
Sample_02_307	Neuroblastoma	Cell line	SJNB12
Sample_02_309	Neuroblastoma	Cell line	SJNB6
Sample_02_310	Neuroblastoma	Cell line	SJNB8
Sample_02_311	Neuroblastoma	Cell line	SK-N-AS
Sample_02_318	Neuroblastoma	Cell line	NB69

MEIS1 distribution in all CRCs

Genomic distribution of SEs associated with MEIS1

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Mutation of MEIS1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MEIS1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	66670075	66670075	C	T	exonic	MEIS1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	66739354	66739354	T	C	exonic	MEIS1	synonymous	HNSC\|2\|512\|0.00391
-	chr2	66664996	66664996	C	G	exonic	MEIS1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	66796234	66796234	C	T	exonic	MEIS1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	66798424	66798424	G	A	UTR3	MEIS1	unknown	SKCM\|1\|368\|0.00272
-	chr2	66665039	66665039	C	T	exonic	MEIS1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	66775088	66775088	C	T	exonic	MEIS1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	66667042	66667042	G	A	exonic	MEIS1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	66667034	66667034	C	-	exonic	MEIS1	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr2	66668593	66668593	G	T	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66798467	66798467	C	-	UTR3	MEIS1	unknown	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	66667033	66667033	-	C	exonic	MEIS1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs376358636	chr2	66691269	66691269	C	T	exonic	MEIS1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	66664888	66664888	A	G	exonic	MEIS1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	66670112	66670112	G	T	exonic	MEIS1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	66667099	66667099	G	A	exonic	MEIS1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	66691322	66691322	T	C	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66664997	66664997	G	A	exonic	MEIS1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr2	66664875	66664875	G	A	exonic	MEIS1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	66664973	66664973	G	A	exonic	MEIS1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	66664922	66664922	G	A	exonic	MEIS1	synonymous	BLCA\|2\|396\|0.00505
-	chr2	66739376	66739376	C	T	exonic	MEIS1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	66667699	66667699	C	T	exonic	MEIS1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	66795861	66795861	C	T	exonic	MEIS1	stopgain	BLCA\|1\|396\|0.00253,SKCM\|2\|368\|0.00543
-	chr2	66667037	66667037	C	T	exonic	MEIS1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	66775136	66775136	T	G	exonic	MEIS1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	66795807	66795807	G	A	exonic	MEIS1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	66664921	66664921	C	T	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66670158	66670158	G	T	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66794708	66794708	G	T	intronic	MEIS1	unknown	CESC\|1\|194\|0.00515
-	chr2	66796210	66796210	G	T	exonic	MEIS1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	66664968	66664968	C	T	exonic	MEIS1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	66670133	66670133	A	G	exonic	MEIS1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	66795797	66795797	A	T	splicing	MEIS1	splicing	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr2	66798499	66798499	C	A	UTR3	MEIS1	unknown	LUAD\|1\|543\|0.00184
-	chr2	66664989	66664989	C	T	exonic	MEIS1	synonymous	CESC\|1\|194\|0.00515
-	chr2	66670040	66670040	G	T	exonic	MEIS1	stopgain	LUAD\|1\|543\|0.00184
-	chr2	66739408	66739408	G	C	exonic	MEIS1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	66667009	66667009	G	T	exonic	MEIS1	stopgain	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr2	66667712	66667712	C	T	exonic	MEIS1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	66739317	66739317	C	T	exonic	MEIS1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	66667002	66667002	G	A	exonic	MEIS1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	66665076	66665076	G	T	exonic	MEIS1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	66667704	66667704	A	-	exonic	MEIS1	frameshift	LIHC\|1\|373\|0.00268
-	chr2	66775128	66775128	C	T	exonic	MEIS1	synonymous	HNSC\|2\|512\|0.00391
-	chr2	66798629	66798629	A	G	UTR3	MEIS1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	66796231	66796231	C	G	exonic	MEIS1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs775405225	chr2	66670114	66670114	C	T	exonic	MEIS1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	66691293	66691293	C	A	exonic	MEIS1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	66798628	66798628	G	T	UTR3	MEIS1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	66795850	66795850	T	C	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66739331	66739331	G	T	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66670093	66670093	G	A	exonic	MEIS1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr2	66667041	66667041	C	T	exonic	MEIS1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66665007	66665007	C	A	exonic	MEIS1	nonsynonymous	LUAD\|1\|543\|0.00184
rs748700693	chr2	66739382	66739382	-	T	exonic	MEIS1	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr2	66796217	66796217	G	A	exonic	MEIS1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	66798424	66798424	G	T	UTR3	MEIS1	unknown	BRCA\|1\|982\|0.00102
-	chr2	66739342	66739342	G	T	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66691249	66691249	G	A	exonic	MEIS1	stopgain	HNSC\|1\|512\|0.00195
-	chr2	66739308	66739308	C	-	exonic	MEIS1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66667004	66667004	T	A	exonic	MEIS1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	66739364	66739364	C	T	exonic	MEIS1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	66798643	66798643	G	T	UTR3	MEIS1	unknown	LUAD\|1\|543\|0.00184
-	chr2	66667071	66667071	C	T	exonic	MEIS1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	66794614	66794614	A	T	exonic	MEIS1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	66775109	66775109	T	C	exonic	MEIS1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	66665001	66665001	C	T	exonic	MEIS1	stopgain	BLCA\|1\|396\|0.00253
-	chr2	66691284	66691284	C	T	exonic	MEIS1	nonsynonymous	HNSC\|1\|512\|0.00195
rs548020669	chr2	66798489	66798489	G	A	UTR3	MEIS1	unknown	BRCA\|1\|982\|0.00102
rs755601677	chr2	66739372	66739372	C	T	exonic	MEIS1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	66796256	66796256	C	T	UTR3	MEIS1	unknown	ESCA\|1\|185\|0.00541
-	chr2	66796185	66796185	C	A	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66665074	66665074	G	A	exonic	MEIS1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	66691305	66691305	C	T	exonic	MEIS1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	66664937	66664937	G	A	exonic	MEIS1	synonymous	BRCA\|1\|982\|0.00102
rs61752693	chr2	66739353	66739353	G	A	exonic	MEIS1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	66667100	66667100	C	A	exonic	MEIS1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	66691327	66691327	C	G	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs762712444	chr2	66798466	66798466	-	C	UTR3	MEIS1	unknown	BRCA\|2\|982\|0.00204,LUAD\|1\|543\|0.00184
rs756115124	chr2	66667033	66667033	A	C	exonic	MEIS1	nonsynonymous	BRCA\|1\|982\|0.00102,KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr2	66667693	66667693	G	T	splicing	MEIS1	splicing	LUAD\|1\|543\|0.00184
-	chr2	66664881	66664881	C	T	exonic	MEIS1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	66668595	66668595	A	C	exonic	MEIS1	nonsynonymous	LUSC\|1\|178\|0.00562

Disease information of MEIS1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
MEIS1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
MEIS1	Sleep Initiation and Maintenance Disorders	C10;F03	Disease or Syndrome	CTD_human
MEIS1	Primary Insomnia	C10;F03	Disease or Syndrome	CTD_human
MEIS1	Restless Legs Syndrome	C10;F03	Disease or Syndrome	CTD_human
MEIS1	Rebound Insomnia	C10;F03	Sign or Symptom	CTD_human
MEIS1	Nonorganic Insomnia	C10;F03	Disease or Syndrome	CTD_human
MEIS1	Transient Insomnia	C10;F03	Sign or Symptom	CTD_human
MEIS1	Early Awakening	C10;F03	Mental or Behavioral Dysfunction	CTD_human
MEIS1	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
MEIS1	Chronic Insomnia	C10;F03	Disease or Syndrome	CTD_human
MEIS1	Psychophysiological Insomnia	C10;F03	Disease or Syndrome	CTD_human
MEIS1	Secondary Insomnia	C10;F03	Sign or Symptom	CTD_human
MEIS1	Sleep Initiation Dysfunction	C10;F03	Disease or Syndrome	CTD_human
MEIS1	Sleeplessness	C10;F03	Sign or Symptom	CTD_human
MEIS1	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
MEIS1	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human

Pathway associated with MEIS1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of MEIS1

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GO_term_name	GO_term_type	TF_name
GO_MYELOID_CELL_DEVELOPMENT	BP	MEIS1
GO_BONE_CELL_DEVELOPMENT	BP	MEIS1
GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	MEIS1
GO_MEGAKARYOCYTE_DEVELOPMENT	BP	MEIS1
GO_NEUROGENESIS	BP	MEIS1
GO_VASCULATURE_DEVELOPMENT	BP	MEIS1
GO_MEGAKARYOCYTE_DIFFERENTIATION	BP	MEIS1
GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE	BP	MEIS1
GO_CELL_DEVELOPMENT	BP	MEIS1
GO_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	MEIS1
GO_DEFINITIVE_HEMOPOIESIS	BP	MEIS1
GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE	BP	MEIS1
GO_PROTEIN_HETERODIMERIZATION_ACTIVITY	MF	MEIS1

Survival analysis of MEIS1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of MEIS1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)