Cancer CRCdb

TF information

TF name:	ISL1
TF family:	Homeobox
Ensembl gene ID:	ENSG00000016082
Ensembl protein ID:	ENSP00000230658, ENSP00000422676
Entrez gene ID:	3670

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ISL1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_220	Cell line	Brain	BE2C_1	0.16666666666667
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.20811017597552
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.28767123287671
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.10551558752998
Sample_02_302	Cell line	Neuroblastoma	IMR32	0.25
Sample_02_304	Cell line	Neuroblastoma	N206	0.12771739130435
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.056872037914692
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.065530799475754
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.17021276595745
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.14671814671815
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.22222222222222
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.076923076923077
Sample_02_318	Cell line	Neuroblastoma	NB69	0.3046875
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.063583815028902
Sample_02_338	Cell line	Neuroblastoma	BE2	0.13235294117647

ISL1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_314	Neuroblastoma	Cell line	SK-N-FI

ISL1 distribution in all CRCs

Genomic distribution of SEs associated with ISL1

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Mutation of ISL1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ISL1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr5	50683378	50683378	C	A	exonic	ISL1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	50683519	50683519	G	T	exonic	ISL1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	50685661	50685661	C	T	exonic	ISL1	synonymous	HNSC\|1\|512\|0.00195
-	chr5	50685739	50685739	C	G	exonic	ISL1	synonymous	HNSC\|1\|512\|0.00195
-	chr5	50685526	50685526	C	T	exonic	ISL1	synonymous	SKCM\|1\|368\|0.00272
rs754879931	chr5	50687233	50687233	C	T	exonic	ISL1	synonymous	BRCA\|1\|982\|0.00102
-	chr5	50683505	50683505	G	A	exonic	ISL1	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr5	50685748	50685748	G	A	exonic	ISL1	synonymous	UCEC\|1\|248\|0.00403
-	chr5	50683518	50683518	G	T	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs768220738	chr5	50683467	50683467	C	T	exonic	ISL1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	50685761	50685761	A	G	exonic	ISL1	nonsynonymous	OV\|1\|469\|0.00213
-	chr5	50680467	50680467	G	A	exonic	ISL1	nonsynonymous	PAAD\|1\|185\|0.00541
rs768556500	chr5	50689434	50689434	T	C	exonic	ISL1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr5	50685530	50685530	C	T	exonic	ISL1	stopgain	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr5	50683546	50683546	C	T	exonic	ISL1	synonymous	BLCA\|1\|396\|0.00253
-	chr5	50685716	50685716	C	T	exonic	ISL1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50687164	50687164	C	A	exonic	ISL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	50685717	50685717	G	A	exonic	ISL1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr5	50689371	50689371	G	T	exonic	ISL1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr5	50685712	50685712	G	C	exonic	ISL1	nonsynonymous	BLCA\|1\|396\|0.00253
rs777359230	chr5	50685493	50685493	C	T	exonic	ISL1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	50685508	50685508	C	T	exonic	ISL1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50685698	50685698	C	T	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	50685513	50685513	G	-	exonic	ISL1	frameshift	LUAD\|1\|543\|0.00184
-	chr5	50679518	50679518	G	A	exonic	ISL1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr5	50679529	50679529	A	-	exonic	ISL1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	50683411	50683411	C	T	exonic	ISL1	synonymous	CESC\|1\|194\|0.00515
-	chr5	50685758	50685758	G	C	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50683336	50683336	C	A	exonic	ISL1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr5	50685733	50685733	G	A	exonic	ISL1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr5	50683348	50683348	G	A	exonic	ISL1	synonymous	DLBC\|1\|48\|0.02083
-	chr5	50685631	50685631	G	T	exonic	ISL1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	50689344	50689344	G	A	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50685507	50685507	C	T	exonic	ISL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	50683521	50683521	C	A	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50685751	50685751	G	T	exonic	ISL1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	50680543	50680543	A	G	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50680437	50680437	A	T	exonic	ISL1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	50687198	50687198	A	C	exonic	ISL1	nonsynonymous	SKCM\|1\|368\|0.00272
rs762338816	chr5	50683457	50683457	G	A	exonic	ISL1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	50685485	50685485	C	-	exonic	ISL1	frameshift	ACC\|1\|90\|0.01111
-	chr5	50683340	50683340	T	A	exonic	ISL1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	50687247	50687247	A	T	exonic	ISL1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	50689391	50689391	T	C	exonic	ISL1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr5	50683527	50683527	T	G	exonic	ISL1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	50680390	50680390	C	A	exonic	ISL1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	50683572	50683572	T	A	exonic	ISL1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	50683438	50683438	C	A	exonic	ISL1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr5	50687262	50687262	C	T	exonic	ISL1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr5	50687144	50687144	G	T	exonic	ISL1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	50683468	50683468	G	A	exonic	ISL1	synonymous	CESC\|1\|194\|0.00515
-	chr5	50680408	50680408	G	A	exonic	ISL1	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr5	50680528	50680528	G	T	exonic	ISL1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr5	50683335	50683335	T	A	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50687119	50687119	G	A	exonic	ISL1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	50685635	50685635	G	C	exonic	ISL1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr5	50683538	50683538	G	A	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50683565	50683565	C	A	exonic	ISL1	synonymous	LUAD\|2\|543\|0.00368
-	chr5	50685630	50685630	T	A	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50685624	50685624	C	T	exonic	ISL1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr5	50687127	50687127	G	A	exonic	ISL1	nonsynonymous	SKCM\|1\|368\|0.00272
rs777485181	chr5	50680535	50680535	G	A	exonic	ISL1	synonymous	LUSC\|1\|178\|0.00562
-	chr5	50683460	50683460	G	A	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr5	50685525	50685525	A	T	exonic	ISL1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	50685569	50685569	G	C	exonic	ISL1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr5	50685598	50685598	C	T	exonic	ISL1	synonymous	UCEC\|1\|248\|0.00403
-	chr5	50683359	50683359	G	A	exonic	ISL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50689350	50689350	C	T	exonic	ISL1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	50687238	50687238	T	C	exonic	ISL1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	50685659	50685659	C	T	exonic	ISL1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr5	50683495	50683495	A	T	exonic	ISL1	synonymous	LUSC\|1\|178\|0.00562
-	chr5	50680410	50680410	A	G	exonic	ISL1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr5	50683549	50683549	T	C	exonic	ISL1	synonymous	LIHC\|1\|373\|0.00268
-	chr5	50680542	50680542	T	A	exonic	ISL1	nonsynonymous	LUAD\|1\|543\|0.00184
rs121913540	chr5	50685514	50685514	G	A	exonic	ISL1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	50680462	50680462	A	C	exonic	ISL1	nonsynonymous	ACC\|1\|90\|0.01111
rs764011682	chr5	50685521	50685521	G	A	exonic	ISL1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	50687133	50687133	C	T	exonic	ISL1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	50685569	50685569	G	A	exonic	ISL1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	50685666	50685666	C	A	exonic	ISL1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr5	50685762	50685762	A	C	exonic	ISL1	nonsynonymous	SKCM\|1\|368\|0.00272
rs779219677	chr5	50680505	50680505	C	T	exonic	ISL1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	50685554	50685554	C	T	exonic	ISL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	50683365	50683365	G	C	exonic	ISL1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr5	50685565	50685565	G	C	exonic	ISL1	synonymous	BLCA\|1\|396\|0.00253
-	chr5	50685764	50685764	A	G	exonic	ISL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	50683584	50683584	G	T	splicing	ISL1	splicing	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355

Disease information of ISL1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ISL1	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
ISL1	Malignant neoplasm of urinary bladder	C04;C12;C13	Neoplastic Process	CTD_human
ISL1	Bladder Exstrophy	C12;C13;C16	Disease or Syndrome	ORPHANET
ISL1	Bladder Neoplasm	C04;C12;C13	Neoplastic Process	CTD_human
ISL1	Neoplasm Recurrence, Local	C04;C23	Neoplastic Process	CTD_human

Pathway associated with ISL1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002182	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	reactome	13	22
pathway0002747	Hs_Neural_Crest_Differentiation_WP2064_79263	wikipathways	40	129
pathway0002768	Hs_Heart_Development_WP1591_90186	wikipathways	28	78

Go term information of ISL1

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GO_term_name	GO_term_type	TF_name
GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS	BP	ISL1
GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS	BP	ISL1
GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION	BP	ISL1
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION	BP	ISL1
GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION	BP	ISL1
GO_ENDOCARDIAL_CUSHION_DEVELOPMENT	BP	ISL1
GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY	BP	ISL1
GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE	BP	ISL1
GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY	BP	ISL1
GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY	BP	ISL1
GO_PITUITARY_GLAND_DEVELOPMENT	BP	ISL1
GO_RESPONSE_TO_AXON_INJURY	BP	ISL1
GO_POSITIVE_REGULATION_OF_STAT_CASCADE	BP	ISL1
GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION	BP	ISL1
GO_CRANIAL_NERVE_DEVELOPMENT	BP	ISL1
GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS	BP	ISL1
GO_SPECIFICATION_OF_ORGAN_IDENTITY	BP	ISL1
GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD	BP	ISL1
GO_AXON_REGENERATION	BP	ISL1
GO_POSITIVE_REGULATION_OF_DNA_BINDING	BP	ISL1
GO_REGULATION_OF_ORGAN_FORMATION	BP	ISL1
GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION	BP	ISL1
GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION	BP	ISL1
GO_CELL_MOTILITY	BP	ISL1
GO_VENTRAL_SPINAL_CORD_DEVELOPMENT	BP	ISL1
GO_EMBRYO_DEVELOPMENT	BP	ISL1
GO_ORGAN_FORMATION	BP	ISL1
GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION	BP	ISL1
GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS	BP	ISL1
GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING	BP	ISL1
GO_RESPONSE_TO_EXTERNAL_STIMULUS	BP	ISL1
GO_CARDIAC_ATRIUM_DEVELOPMENT	BP	ISL1
GO_ATRIAL_SEPTUM_DEVELOPMENT	BP	ISL1
GO_NEURAL_CREST_CELL_MIGRATION	BP	ISL1
GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION	BP	ISL1
GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY	BP	ISL1
GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION	BP	ISL1
GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION	BP	ISL1
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION	BP	ISL1
GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	ISL1
GO_ATRIAL_SEPTUM_MORPHOGENESIS	BP	ISL1
GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY	BP	ISL1
GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS	BP	ISL1
GO_REGULATION_OF_HEART_MORPHOGENESIS	BP	ISL1
GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION	BP	ISL1
GO_REGULATION_OF_PEPTIDE_TRANSPORT	BP	ISL1
GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION	BP	ISL1
GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION	BP	ISL1
GO_MYOBLAST_DIFFERENTIATION	BP	ISL1
GO_REGULATION_OF_HORMONE_SECRETION	BP	ISL1
GO_CARDIAC_VENTRICLE_MORPHOGENESIS	BP	ISL1
GO_NEURON_FATE_SPECIFICATION	BP	ISL1
GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS	BP	ISL1
GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION	BP	ISL1
GO_CARDIAC_CELL_FATE_COMMITMENT	BP	ISL1
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION	BP	ISL1
GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS	BP	ISL1
GO_CARDIOBLAST_DIFFERENTIATION	BP	ISL1
GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE	BP	ISL1
GO_HEART_FORMATION	BP	ISL1
GO_CARDIAC_VENTRICLE_DEVELOPMENT	BP	ISL1
GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION	BP	ISL1
GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION	BP	ISL1
GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION	BP	ISL1
GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	ISL1
GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN	BP	ISL1
GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION	BP	ISL1
GO_CELL_FATE_DETERMINATION	BP	ISL1
GO_NEURON_PROJECTION_REGENERATION	BP	ISL1
GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION	BP	ISL1
GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION	BP	ISL1
GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS	BP	ISL1
GO_PHARYNGEAL_SYSTEM_DEVELOPMENT	BP	ISL1
GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION	BP	ISL1
GO_REGULATION_OF_CHROMOSOME_ORGANIZATION	BP	ISL1
GO_CELL_PROJECTION_ORGANIZATION	BP	ISL1
GO_STEM_CELL_DIFFERENTIATION	BP	ISL1
GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN	BP	ISL1
GO_OUTFLOW_TRACT_MORPHOGENESIS	BP	ISL1
GO_POSITIVE_REGULATION_OF_TRANSPORT	BP	ISL1
GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT	BP	ISL1
GO_CARDIAC_SEPTUM_MORPHOGENESIS	BP	ISL1
GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION	BP	ISL1
GO_MESENCHYME_MORPHOGENESIS	BP	ISL1
GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION	BP	ISL1
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION	BP	ISL1
GO_CIRCULATORY_SYSTEM_DEVELOPMENT	BP	ISL1
GO_INNERVATION	BP	ISL1
GO_TISSUE_DEVELOPMENT	BP	ISL1
GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION	BP	ISL1
GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION	BP	ISL1
GO_REGULATION_OF_VASCULATURE_DEVELOPMENT	BP	ISL1
GO_BHLH_TRANSCRIPTION_FACTOR_BINDING	MF	ISL1
GO_ENHANCER_BINDING	MF	ISL1
GO_ESTROGEN_RECEPTOR_BINDING	MF	ISL1
GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING	MF	ISL1
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	ISL1
GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING	MF	ISL1
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	ISL1
GO_STEROID_HORMONE_RECEPTOR_BINDING	MF	ISL1
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	ISL1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	ISL1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY	MF	ISL1
GO_RECEPTOR_BINDING	MF	ISL1

Survival analysis of ISL1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ISL1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)