Cancer CRCdb

TF information

TF name:	ETV4
TF family:	ETS
Ensembl gene ID:	ENSG00000175832
Ensembl protein ID:	ENSP00000465718, ENSP00000377273, ENSP00000441749, ENSP00000321835, ENSP00000468636, ENSP00000440023, ENSP00000443846
Entrez gene ID:	2118

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ETV4 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_180	Cell line	Human melanoma	CJM	0.296875
Sample_02_181	Cell line	Human melanoma	COLO679	0.15786666666667
Sample_02_183	Cell line	Skin	SKMEL2	0.56410256410256
Sample_02_184	Cell line	Skin	SKMEL30	0.48231511254019
Sample_02_242	Cell line	Colon	V481	0.54515157341537
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.04521625163827
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.1978021978022
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.080924855491329
Sample_02_356	Cell line	Colon	Sw480	0.4258064516129
Sample_02_358	Cell line	Colon	LS180	0.37914691943128
Sample_02_359	Cell line	Colon	Colo741	0.39759036144578
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.30434782608696
Sample_02_424	Cell line	Colon	SW620	0.2536231884058

ETV4 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_184	Skin	Cell line	SKMEL30
Sample_02_242	Colon	Cell line	V481
Sample_02_356	Colon	Cell line	Sw480

ETV4 distribution in all CRCs

Genomic distribution of SEs associated with ETV4

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Mutation of ETV4

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ETV4

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr17	41605896	41605896	G	A	exonic	ETV4	synonymous	HNSC\|1\|512\|0.00195
-	chr17	41606046	41606046	G	A	exonic	ETV4	synonymous	CESC\|1\|194\|0.00515
-	chr17	41610076	41610076	G	A	exonic	ETV4	synonymous	BLCA\|1\|396\|0.00253
rs765893929	chr17	41606543	41606543	C	T	exonic	ETV4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	41607485	41607485	G	A	exonic	ETV4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	41622350	41622350	G	A	exonic	ETV4	synonymous	BLCA\|1\|396\|0.00253
-	chr17	41610090	41610090	C	-	exonic	ETV4	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs746787291	chr17	41606988	41606988	G	A	exonic	ETV4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs753960184	chr17	41611270	41611270	G	A	exonic	ETV4	nonsynonymous	PRAD\|1\|499\|0.00200
rs774978942	chr17	41610061	41610061	C	T	exonic	ETV4	synonymous	SKCM\|1\|368\|0.00272
rs148198572	chr17	41606987	41606987	C	T	exonic	ETV4	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr17	41607026	41607026	C	T	exonic	ETV4	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	41610695	41610695	T	C	exonic	ETV4	synonymous	UCEC\|1\|248\|0.00403
-	chr17	41610116	41610116	C	T	exonic	ETV4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	41606973	41606973	G	A	exonic	ETV4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	41611239	41611239	C	T	exonic	ETV4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	41605953	41605953	G	-	exonic	ETV4	frameshift	LIHC\|1\|373\|0.00268
-	chr17	41610246	41610246	C	T	exonic	ETV4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	41611247	41611247	G	A	exonic	ETV4	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	41606503	41606503	C	T	exonic	ETV4	synonymous	BLCA\|1\|396\|0.00253
-	chr17	41610668	41610668	A	G	exonic	ETV4	synonymous	CESC\|1\|194\|0.00515
-	chr17	41606896	41606896	C	T	exonic	ETV4	synonymous	BLCA\|1\|396\|0.00253
-	chr17	41610182	41610182	C	A	exonic	ETV4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs751109306	chr17	41610212	41610212	G	A	exonic	ETV4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	41610241	41610241	G	T	exonic	ETV4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	41613828	41613828	A	G	exonic	ETV4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	41610101	41610101	C	T	exonic	ETV4	nonsynonymous	SKCM\|1\|368\|0.00272
rs768121396	chr17	41605991	41605991	C	T	exonic	ETV4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	41610701	41610701	G	A	exonic	ETV4	synonymous	SKCM\|1\|368\|0.00272
-	chr17	41622356	41622356	C	T	exonic	ETV4	synonymous	ESCA\|1\|185\|0.00541
rs776306922	chr17	41622708	41622708	C	T	exonic	ETV4	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr17	41607045	41607045	C	T	splicing	ETV4	splicing	ESCA\|1\|185\|0.00541
-	chr17	41622709	41622709	G	T	exonic	ETV4	synonymous	BLCA\|1\|396\|0.00253
-	chr17	41607297	41607297	G	A	exonic	ETV4	stopgain	UCEC\|1\|248\|0.00403
-	chr17	41606991	41606991	G	A	exonic	ETV4	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	41607307	41607307	C	A	exonic	ETV4	nonsynonymous	UCEC\|1\|248\|0.00403
rs144213199	chr17	41610249	41610249	G	A	exonic	ETV4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	41606539	41606539	C	G	exonic	ETV4	synonymous	OV\|1\|469\|0.00213
-	chr17	41610701	41610701	G	-	exonic	ETV4	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	41622708	41622708	C	A	exonic	ETV4	stopgain	BLCA\|1\|396\|0.00253,HNSC\|1\|512\|0.00195
rs147888887	chr17	41607273	41607273	C	G	exonic	ETV4	nonsynonymous	SKCM\|1\|368\|0.00272
rs374306817	chr17	41606906	41606906	C	T	exonic	ETV4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	41610182	41610182	C	T	exonic	ETV4	nonsynonymous	PRAD\|1\|499\|0.00200
rs749666909	chr17	41610054	41610054	C	T	exonic	ETV4	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,UCEC\|1\|248\|0.00403
rs769333020	chr17	41611318	41611318	C	T	exonic	ETV4	nonsynonymous	SKCM\|1\|368\|0.00272
rs367792700	chr17	41610575	41610575	A	G	exonic	ETV4	synonymous	LUSC\|1\|178\|0.00562
-	chr17	41606053	41606053	A	G	exonic	ETV4	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	41622670	41622670	C	T	exonic	ETV4	synonymous	LUAD\|1\|543\|0.00184
rs34260468	chr17	41606033	41606033	G	A	exonic	ETV4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs745944421	chr17	41610700	41610700	-	G	exonic	ETV4	frameshift	BRCA\|2\|982\|0.00204,COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,KIPAN\|5\|799\|0.00626,KIRC\|5\|451\|0.01109,LUAD\|2\|543\|0.00368
-	chr17	41613836	41613836	C	T	exonic	ETV4	nonsynonymous	BLCA\|1\|396\|0.00253,LUAD\|1\|543\|0.00184
-	chr17	41622935	41622935	G	T	exonic	ETV4	synonymous	ESCA\|1\|185\|0.00541
-	chr17	41610118	41610118	A	C	exonic	ETV4	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr17	41610308	41610308	C	T	splicing	ETV4	splicing	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs368196782	chr17	41611302	41611302	C	T	exonic	ETV4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	41611325	41611325	G	A	exonic	ETV4	synonymous	PRAD\|1\|499\|0.00200
-	chr17	41610582	41610582	G	T	exonic	ETV4	nonsynonymous	OV\|1\|469\|0.00213
-	chr17	41607295	41607295	T	C	exonic	ETV4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	41611278	41611278	C	T	exonic	ETV4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204

Disease information of ETV4

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ETV4	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
ETV4	Neoplasm Metastasis	C04;C23	Neoplastic Process	CTD_human
ETV4	Neoplastic Processes	C04;C23	Neoplastic Process	CTD_human
ETV4	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
ETV4	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
ETV4	Ewings sarcoma	C04	Neoplastic Process	ORPHANET
ETV4	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
ETV4	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
ETV4	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human

Pathway associated with ETV4

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001287	LKB1 signaling events	pid	43	314
pathway0001322	MAPK6/MAPK4 signaling	reactome	90	1485

Go term information of ETV4

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GO_term_name	GO_term_type	TF_name
GO_MAMMARY_GLAND_MORPHOGENESIS	BP	ETV4
GO_GLAND_MORPHOGENESIS	BP	ETV4
GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION	BP	ETV4
GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	ETV4
GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT	BP	ETV4
GO_MOTOR_NEURON_AXON_GUIDANCE	BP	ETV4
GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	ETV4
GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS	BP	ETV4
GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS	BP	ETV4

Survival analysis of ETV4

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ETV4

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)