Cancer CRCdb

TF information

TF name:	PROX1
TF family:	HPD
Ensembl gene ID:	ENSG00000117707
Ensembl protein ID:	ENSP00000420283, ENSP00000261454, ENSP00000355925, ENSP00000400694
Entrez gene ID:	5629

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of PROX1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_220	Cell line	Brain	BE2C_1	0.051282051282051
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.054794520547945
Sample_02_300	Cell line	Neuroblastoma	CLB-PE	0.076923076923077
Sample_02_304	Cell line	Neuroblastoma	N206	0.032608695652174
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.098591549295775
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.09375
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.019659239842726
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.20779220779221
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.090425531914894
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.052023121387283
Sample_02_338	Cell line	Neuroblastoma	BE2	0.058823529411765

PROX1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

PROX1 distribution in all CRCs

Genomic distribution of SEs associated with PROX1

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Mutation of PROX1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of PROX1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr1	214171167	214171167	C	T	exonic	PROX1	nonsynonymous	LUSC\|1\|178\|0.00562
rs763076142	chr1	214170906	214170906	C	T	exonic	PROX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214185006	214185006	G	T	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214171352	214171352	C	T	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195,SKCM\|1\|368\|0.00272
-	chr1	214171370	214171370	G	T	exonic	PROX1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	214171089	214171089	C	A	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214170908	214170908	G	C	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214170581	214170581	G	A	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214171320	214171320	G	A	exonic	PROX1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	214171174	214171174	C	T	exonic	PROX1	synonymous	UCEC\|1\|248\|0.00403
-	chr1	214171497	214171497	C	T	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214185050	214185050	G	A	exonic	PROX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	214170395	214170395	A	T	exonic	PROX1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	214178556	214178556	T	-	exonic	PROX1	frameshift	COADREAD\|2\|489\|0.00409,READ\|2\|122\|0.01639,SARC\|1\|247\|0.00405,STAD\|3\|395\|0.00759,STES\|3\|395\|0.00759
-	chr1	214171148	214171148	T	G	exonic	PROX1	nonsynonymous	PAAD\|1\|185\|0.00541
rs148478012	chr1	214171467	214171467	C	G	exonic	PROX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	214170000	214170000	T	G	exonic	PROX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	214184960	214184960	A	C	exonic	PROX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	214171232	214171232	G	T	exonic	PROX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	214170203	214170203	C	G	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214170722	214170722	G	A	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214171387	214171387	C	T	exonic	PROX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	214170630	214170630	G	T	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214170185	214170185	A	T	exonic	PROX1	stopgain	SKCM\|1\|368\|0.00272
-	chr1	214169881	214169881	G	T	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214171394	214171394	G	-	exonic	PROX1	frameshift	LUAD\|1\|543\|0.00184
rs773788297	chr1	214184963	214184963	G	A	exonic	PROX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	214170276	214170276	C	G	exonic	PROX1	stopgain	CESC\|1\|194\|0.00515
-	chr1	214170863	214170863	G	A	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214170265	214170265	C	T	exonic	PROX1	synonymous	OV\|1\|469\|0.00213
-	chr1	214170382	214170382	G	C	exonic	PROX1	synonymous	LUAD\|3\|543\|0.00552
-	chr1	214170122	214170122	G	C	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214171121	214171121	G	A	exonic	PROX1	nonsynonymous	BLCA\|1\|396\|0.00253,BRCA\|2\|982\|0.00204,PRAD\|1\|499\|0.00200
-	chr1	214169975	214169975	T	-	exonic	PROX1	frameshift	ESCA\|1\|185\|0.00541
rs868611779	chr1	214171209	214171209	G	A	exonic	PROX1	nonsynonymous	PAAD\|4\|185\|0.02162
-	chr1	214170566	214170566	G	A	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214170875	214170875	G	C	exonic	PROX1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	214171103	214171103	C	T	exonic	PROX1	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr1	214171443	214171443	C	T	exonic	PROX1	nonsynonymous	BRCA\|1\|982\|0.00102,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214170286	214170286	C	-	exonic	PROX1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214170440	214170440	G	A	exonic	PROX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	214171453	214171453	G	A	exonic	PROX1	synonymous	SKCM\|1\|368\|0.00272
rs369204553	chr1	214178606	214178606	C	T	exonic	PROX1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355,UCEC\|1\|248\|0.00403
-	chr1	214170736	214170736	C	T	exonic	PROX1	synonymous	HNSC\|1\|512\|0.00195
-	chr1	214170355	214170355	T	A	exonic	PROX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214170561	214170561	G	A	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|1\|368\|0.00272
-	chr1	214171593	214171593	C	T	exonic	PROX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr1	214170487	214170487	T	C	exonic	PROX1	synonymous	SKCM\|1\|368\|0.00272
rs112763420	chr1	214170717	214170717	G	A	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214170466	214170466	G	T	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214170345	214170345	G	A	exonic	PROX1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	214178552	214178552	C	T	exonic	PROX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	214170133	214170133	G	A	exonic	PROX1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	214170552	214170552	T	A	exonic	PROX1	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr1	214171516	214171516	C	T	exonic	PROX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214170911	214170911	G	A	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214178532	214178532	C	A	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214170738	214170738	G	C	exonic	PROX1	nonsynonymous	BRCA\|1\|982\|0.00102
rs755137171	chr1	214171555	214171555	C	T	exonic	PROX1	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr1	214209037	214209037	T	-	exonic	PROX1	frameshift	LIHC\|1\|373\|0.00268
-	chr1	214170285	214170285	-	C	exonic	PROX1	frameshift	KIPAN\|6\|799\|0.00751,KIRC\|6\|451\|0.01330,LUAD\|2\|543\|0.00368
-	chr1	214170452	214170452	G	A	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
rs768687981	chr1	214170907	214170907	G	A	exonic	PROX1	synonymous	UCEC\|1\|248\|0.00403
-	chr1	214170503	214170503	C	T	exonic	PROX1	nonsynonymous	BLCA\|1\|396\|0.00253,PRAD\|1\|499\|0.00200
-	chr1	214178591	214178591	G	A	exonic	PROX1	synonymous	LUSC\|1\|178\|0.00562
rs758404044	chr1	214171287	214171287	C	G	exonic	PROX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	214209138	214209138	C	T	exonic	PROX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	214209112	214209112	C	T	exonic	PROX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	214170437	214170437	-	T	exonic	PROX1	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr1	214170027	214170027	C	A	exonic	PROX1	nonsynonymous	UCEC\|1\|248\|0.00403
rs373493766	chr1	214184962	214184962	C	T	exonic	PROX1	synonymous	UCEC\|1\|248\|0.00403
-	chr1	214170642	214170642	A	G	exonic	PROX1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr1	214178524	214178524	C	T	exonic	PROX1	nonsynonymous	SKCM\|2\|368\|0.00543
rs752227508	chr1	214171118	214171118	G	A	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195,SKCM\|2\|368\|0.00543
-	chr1	214171409	214171409	T	C	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214171377	214171377	C	T	exonic	PROX1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	214169914	214169914	G	A	exonic	PROX1	synonymous	UVM\|1\|80\|0.01250
-	chr1	214169999	214169999	T	-	exonic	PROX1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214171443	214171443	C	G	exonic	PROX1	nonsynonymous	OV\|1\|469\|0.00213
-	chr1	214170119	214170119	G	A	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
rs776561749	chr1	214171101	214171101	G	A	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214209048	214209048	C	T	exonic	PROX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	214209144	214209144	C	G	exonic	PROX1	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr1	214209055	214209055	G	T	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214170480	214170480	G	A	exonic	PROX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	214170224	214170224	C	G	exonic	PROX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	214170398	214170398	C	T	exonic	PROX1	nonsynonymous	SKCM\|3\|368\|0.00815,UCEC\|2\|248\|0.00806
-	chr1	214171008	214171008	G	A	exonic	PROX1	nonsynonymous	ESCA\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214184904	214184904	G	T	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214170608	214170608	G	C	exonic	PROX1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	214170732	214170732	A	G	exonic	PROX1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	214171568	214171568	G	T	exonic	PROX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	214171004	214171004	T	G	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214170420	214170420	G	T	exonic	PROX1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr1	214169903	214169903	C	A	exonic	PROX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214171517	214171517	G	A	exonic	PROX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214169925	214169925	G	A	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214178567	214178567	C	T	exonic	PROX1	synonymous	SKCM\|1\|368\|0.00272
rs761424919	chr1	214171345	214171345	G	A	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214170240	214170240	C	T	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214171138	214171138	C	T	exonic	PROX1	synonymous	SKCM\|1\|368\|0.00272
rs763701960	chr1	214171237	214171237	C	T	exonic	PROX1	synonymous	PRAD\|1\|499\|0.00200
-	chr1	214170813	214170813	G	C	exonic	PROX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	214170934	214170934	G	C	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214178587	214178587	T	A	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214171556	214171556	G	A	exonic	PROX1	nonsynonymous	UCEC\|1\|248\|0.00403
rs764766771	chr1	214171117	214171117	C	T	exonic	PROX1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214170724	214170724	G	T	exonic	PROX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	214178607	214178607	G	A	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214169998	214169998	G	A	exonic	PROX1	synonymous	BLCA\|1\|396\|0.00253
-	chr1	214169991	214169991	G	C	exonic	PROX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	214170645	214170645	A	C	exonic	PROX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	214169895	214169895	G	A	exonic	PROX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs368029419	chr1	214171007	214171007	C	T	exonic	PROX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	214171528	214171528	C	A	exonic	PROX1	synonymous	UCS\|1\|57\|0.01754
rs201989339	chr1	214171226	214171226	C	A	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214170459	214170459	C	T	exonic	PROX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214171246	214171246	C	A	exonic	PROX1	synonymous	HNSC\|1\|512\|0.00195
-	chr1	214170989	214170989	T	G	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
rs745534059	chr1	214178610	214178610	G	A	exonic	PROX1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr1	214170140	214170140	C	T	exonic	PROX1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	214170675	214170675	C	T	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214171342	214171342	G	C	exonic	PROX1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	214170044	214170044	T	C	exonic	PROX1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	214209054	214209054	C	T	exonic	PROX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214171544	214171544	A	C	exonic	PROX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	214171380	214171380	C	T	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214171262	214171262	C	A	exonic	PROX1	nonsynonymous	ESCA\|1\|185\|0.00541
rs866889728	chr1	214170676	214170676	G	T	exonic	PROX1	synonymous	LIHC\|1\|373\|0.00268
-	chr1	214170701	214170701	T	A	exonic	PROX1	nonsynonymous	OV\|1\|469\|0.00213
rs777612764	chr1	214171022	214171022	G	A	exonic	PROX1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	214171399	214171399	A	C	exonic	PROX1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr1	214170542	214170542	C	T	exonic	PROX1	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,TGCT\|1\|155\|0.00645
-	chr1	214170305	214170305	C	T	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184,SKCM\|1\|368\|0.00272
-	chr1	214170114	214170114	C	T	exonic	PROX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	214171198	214171198	C	A	exonic	PROX1	synonymous	LUAD\|1\|543\|0.00184
-	chr1	214170689	214170689	G	T	exonic	PROX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	214171247	214171247	G	A	exonic	PROX1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	214170439	214170439	T	A	exonic	PROX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	214171381	214171381	C	T	exonic	PROX1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	214171384	214171384	C	T	exonic	PROX1	synonymous	LUSC\|1\|178\|0.00562
-	chr1	214178537	214178537	G	A	exonic	PROX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214170585	214170585	G	T	exonic	PROX1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	214171068	214171068	G	T	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214171386	214171386	C	T	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214170392	214170392	A	T	exonic	PROX1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	214170873	214170875	AAG	-	exonic	PROX1	nonframeshift	OV\|1\|469\|0.00213
-	chr1	214170084	214170084	T	A	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214171523	214171523	G	T	exonic	PROX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	214184944	214184944	C	G	exonic	PROX1	stopgain	HNSC\|1\|512\|0.00195
rs765586199	chr1	214169993	214169993	G	A	exonic	PROX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	214171142	214171142	G	A	exonic	PROX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	214170743	214170743	C	G	exonic	PROX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214170329	214170329	C	A	exonic	PROX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	214170683	214170683	G	C	exonic	PROX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	214171027	214171027	C	T	exonic	PROX1	synonymous	UCEC\|1\|248\|0.00403
-	chr1	214170404	214170404	A	G	exonic	PROX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214171349	214171349	T	C	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214170587	214170587	C	T	exonic	PROX1	stopgain	LUSC\|1\|178\|0.00562
-	chr1	214209143	214209143	C	T	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214170481	214170481	A	G	exonic	PROX1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214170479	214170479	C	T	exonic	PROX1	stopgain	PAAD\|1\|185\|0.00541
-	chr1	214170988	214170988	C	A	exonic	PROX1	synonymous	UCEC\|1\|248\|0.00403
-	chr1	214170981	214170981	T	-	exonic	PROX1	frameshift	HNSC\|1\|512\|0.00195
-	chr1	214170994	214170994	G	T	exonic	PROX1	synonymous	LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214185013	214185013	G	T	exonic	PROX1	synonymous	BLCA\|1\|396\|0.00253
-	chr1	214209100	214209100	G	T	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214178607	214178607	G	C	exonic	PROX1	nonsynonymous	BLCA\|1\|396\|0.00253
rs530123487	chr1	214171246	214171246	C	T	exonic	PROX1	synonymous	PAAD\|1\|185\|0.00541
-	chr1	214170344	214170344	C	T	exonic	PROX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	214171100	214171100	C	T	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214171436	214171436	G	A	exonic	PROX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	214171243	214171243	T	A	exonic	PROX1	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr1	214171498	214171498	A	G	exonic	PROX1	synonymous	LUAD\|2\|543\|0.00368
-	chr1	214184888	214184888	C	G	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214184965	214184965	-	G	exonic	PROX1	frameshift	LUAD\|1\|543\|0.00184
-	chr1	214170682	214170682	T	A	exonic	PROX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	214171001	214171001	C	T	exonic	PROX1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	214209089	214209089	C	T	exonic	PROX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	214170598	214170598	A	T	exonic	PROX1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	214171309	214171309	G	A	exonic	PROX1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	214169983	214169983	T	C	exonic	PROX1	synonymous	LUAD\|1\|543\|0.00184
rs754119506	chr1	214171271	214171271	C	A	exonic	PROX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	214178516	214178516	A	C	exonic	PROX1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr1	214170585	214170585	G	A	exonic	PROX1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	214170364	214170364	G	A	exonic	PROX1	synonymous	BLCA\|2\|396\|0.00505
rs866129714	chr1	214209146	214209146	C	T	exonic	PROX1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	214170575	214170575	C	T	exonic	PROX1	stopgain	UCEC\|1\|248\|0.00403
-	chr1	214171294	214171294	C	A	exonic	PROX1	synonymous	HNSC\|1\|512\|0.00195

Disease information of PROX1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
PROX1	Diabetes Mellitus, Non-Insulin-Dependent	C18;C19	Disease or Syndrome	CTD_human
PROX1	Neoplasm Metastasis	C04;C23	Neoplastic Process	CTD_human

Pathway associated with PROX1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of PROX1

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GO_term_name	GO_term_type	TF_name
GO_CARDIAC_CHAMBER_DEVELOPMENT	BP	PROX1
GO_CIRCADIAN_RHYTHM	BP	PROX1
GO_SPINAL_CORD_DEVELOPMENT	BP	PROX1
GO_DENTATE_GYRUS_DEVELOPMENT	BP	PROX1
GO_HINDBRAIN_DEVELOPMENT	BP	PROX1
GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT	BP	PROX1
GO_LENS_FIBER_CELL_DIFFERENTIATION	BP	PROX1
GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT	BP	PROX1
GO_METENCEPHALON_DEVELOPMENT	BP	PROX1
GO_VENTRICULAR_SEPTUM_MORPHOGENESIS	BP	PROX1
GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS	BP	PROX1
GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION	BP	PROX1
GO_OTIC_VESICLE_DEVELOPMENT	BP	PROX1
GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS	BP	PROX1
GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS	BP	PROX1
GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION	BP	PROX1
GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION	BP	PROX1
GO_POSITIVE_REGULATION_OF_HEART_GROWTH	BP	PROX1
GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS	BP	PROX1
GO_CEREBELLAR_CORTEX_MORPHOGENESIS	BP	PROX1
GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION	BP	PROX1
GO_ARTERY_DEVELOPMENT	BP	PROX1
GO_CARDIAC_MYOFIBRIL_ASSEMBLY	BP	PROX1
GO_NEURAL_TUBE_DEVELOPMENT	BP	PROX1
GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS	BP	PROX1
GO_ENDOCARDIUM_DEVELOPMENT	BP	PROX1
GO_ENDOTHELIAL_CELL_DIFFERENTIATION	BP	PROX1
GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION	BP	PROX1
GO_AORTA_DEVELOPMENT	BP	PROX1
GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM	BP	PROX1
GO_CARDIAC_ATRIUM_DEVELOPMENT	BP	PROX1
GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT	BP	PROX1
GO_ARTERY_MORPHOGENESIS	BP	PROX1
GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT	BP	PROX1
GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	PROX1
GO_NOSE_DEVELOPMENT	BP	PROX1
GO_CEREBELLAR_CORTEX_DEVELOPMENT	BP	PROX1
GO_HIPPOCAMPUS_DEVELOPMENT	BP	PROX1
GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	PROX1
GO_LYMPHANGIOGENESIS	BP	PROX1
GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION	BP	PROX1
GO_REGULATION_OF_ORGAN_GROWTH	BP	PROX1
GO_HEART_MORPHOGENESIS	BP	PROX1
GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS	BP	PROX1
GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION	BP	PROX1
GO_CELL_DIFFERENTIATION_IN_HINDBRAIN	BP	PROX1
GO_MYOFIBRIL_ASSEMBLY	BP	PROX1
GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	PROX1
GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS	BP	PROX1
GO_ENDOTHELIUM_DEVELOPMENT	BP	PROX1
GO_CARDIAC_VENTRICLE_DEVELOPMENT	BP	PROX1
GO_ECTODERMAL_PLACODE_DEVELOPMENT	BP	PROX1
GO_NEUROGENESIS	BP	PROX1
GO_EAR_MORPHOGENESIS	BP	PROX1
GO_VASCULATURE_DEVELOPMENT	BP	PROX1
GO_VENTRICULAR_SEPTUM_DEVELOPMENT	BP	PROX1
GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE	BP	PROX1
GO_CELL_FATE_DETERMINATION	BP	PROX1
GO_LYMPH_VESSEL_MORPHOGENESIS	BP	PROX1
GO_HINDBRAIN_MORPHOGENESIS	BP	PROX1
GO_UROGENITAL_SYSTEM_DEVELOPMENT	BP	PROX1
GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY	BP	PROX1
GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS	BP	PROX1
GO_EMBRYONIC_EYE_MORPHOGENESIS	BP	PROX1
GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY	BP	PROX1
GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS	BP	PROX1
GO_REGULATION_OF_HEART_GROWTH	BP	PROX1
GO_CEREBELLAR_CORTEX_FORMATION	BP	PROX1
GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT	BP	PROX1
GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT	BP	PROX1
GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE	BP	PROX1
GO_CARDIAC_SEPTUM_MORPHOGENESIS	BP	PROX1
GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT	BP	PROX1
GO_LYMPH_VESSEL_DEVELOPMENT	BP	PROX1
GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE	BP	PROX1
GO_REGULATION_OF_VIRAL_GENOME_REPLICATION	BP	PROX1
GO_DORSAL_SPINAL_CORD_DEVELOPMENT	BP	PROX1
GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION	BP	PROX1
GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT	BP	PROX1
GO_CELL_DEVELOPMENT	BP	PROX1
GO_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	PROX1
GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT	BP	PROX1
GO_AORTA_MORPHOGENESIS	BP	PROX1
GO_EMBRYONIC_ORGAN_DEVELOPMENT	BP	PROX1
GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH	BP	PROX1
GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION	BP	PROX1
GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY	BP	PROX1
GO_EPITHELIAL_CELL_FATE_COMMITMENT	BP	PROX1
GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION	BP	PROX1
GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION	BP	PROX1
GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT	BP	PROX1
GO_LENS_FIBER_CELL_DEVELOPMENT	BP	PROX1
GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE	BP	PROX1
GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY	BP	PROX1
GO_CARDIAC_CELL_DEVELOPMENT	BP	PROX1
GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION	BP	PROX1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	PROX1
GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING	MF	PROX1
GO_PROTEIN_DOMAIN_SPECIFIC_BINDING	MF	PROX1

Survival analysis of PROX1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of PROX1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)