TF information
| TF name: | GATA6 |
| TF family: | zf-GATA |
| Ensembl gene ID: | ENSG00000141448 |
| Ensembl protein ID: | ENSP00000269216, ENSP00000462313 |
| Entrez gene ID: | 2627 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of GATA6 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_021 | Cell line | Colon | V429 | 0.18679734793889 |
| Sample_02_203 | Cell line | Stomach | YCC21 | 0.33333333333333 |
| Sample_02_205 | Tissue | Stomach | Gastric_Primary_Sample_T | 0.19259259259259 |
| Sample_02_208 | Cell line | Stomach | YCC3 | 0.25 |
| Sample_02_236 | Cell line | Colon | V206 | 0.084886128364389 |
| Sample_02_237 | Cell line | Colon | V389 | 0.11779863795325 |
| Sample_02_242 | Cell line | Colon | V481 | 0.15224636287893 |
| Sample_02_280 | Cell line | Mammary Gland | SUM159_DMSO_24h | 0.10833333333333 |
| Sample_02_322 | Cell line | Colon | Caco-2 | 0.083445491251682 |
| Sample_02_355 | Cell line | Colon | HCT15 | 0.089285714285714 |
| Sample_02_358 | Cell line | Colon | LS180 | 0.17496050552923 |
| Sample_02_361 | Cell line | Colon | HT29_DMSO | 0.20530973451327 |
| Sample_02_404 | Cell line | Mammary Gland | ZR-75-1_2 | 0.14388489208633 |
GATA6 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
GATA6 distribution in all CRCs
Genomic distribution of SEs associated with GATA6
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of GATA6
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr18 | 19762737 | 19762737 | T | C | exonic | GATA6 | nonsynonymous | OV|1|469|0.00213 |
| - | chr18 | 19761506 | 19761506 | C | T | exonic | GATA6 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr18 | 19751182 | 19751182 | C | A | exonic | GATA6 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr18 | 19761419 | 19761419 | A | G | exonic | GATA6 | synonymous | BRCA|1|982|0.00102 |
| - | chr18 | 19762738 | 19762738 | G | A | exonic | GATA6 | nonsynonymous | BLCA|1|396|0.00253,COAD|1|367|0.00272,COADREAD|1|489|0.00204,SKCM|1|368|0.00272 |
| rs117646477 | chr18 | 19762989 | 19762989 | A | G | exonic | GATA6 | synonymous | DLBC|1|48|0.02083 |
| - | chr18 | 19780756 | 19780756 | G | T | exonic | GATA6 | synonymous | LUAD|1|543|0.00184 |
| - | chr18 | 19780633 | 19780633 | G | A | exonic | GATA6 | synonymous | HNSC|1|512|0.00195 |
| rs368297251 | chr18 | 19751457 | 19751457 | C | T | exonic | GATA6 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr18 | 19780785 | 19780785 | G | C | exonic | GATA6 | stoploss | LUSC|1|178|0.00562 |
| rs143026087 | chr18 | 19761485 | 19761485 | C | T | exonic | GATA6 | synonymous | HNSC|1|512|0.00195 |
| - | chr18 | 19780715 | 19780715 | A | T | exonic | GATA6 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr18 | 19751152 | 19751152 | C | A | exonic | GATA6 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr18 | 19762943 | 19762943 | C | G | exonic | GATA6 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr18 | 19751448 | 19751448 | T | C | exonic | GATA6 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr18 | 19756993 | 19756993 | G | - | exonic | GATA6 | frameshift | UCS|1|57|0.01754 |
| - | chr18 | 19780729 | 19780729 | G | A | exonic | GATA6 | synonymous | HNSC|1|512|0.00195 |
| - | chr18 | 19751534 | 19751534 | G | T | exonic | GATA6 | nonsynonymous | STAD|2|395|0.00506,STES|2|395|0.00506 |
| - | chr18 | 19780746 | 19780746 | C | A | exonic | GATA6 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr18 | 19762749 | 19762749 | G | T | exonic | GATA6 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr18 | 19756976 | 19756976 | C | T | exonic | GATA6 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr18 | 19762725 | 19762725 | G | T | exonic | GATA6 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr18 | 19780725 | 19780725 | C | T | exonic | GATA6 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr18 | 19762931 | 19762931 | C | T | exonic | GATA6 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr18 | 19762767 | 19762767 | G | A | exonic | GATA6 | nonsynonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122,UCEC|1|248|0.00403 |
| - | chr18 | 19762729 | 19762729 | A | G | exonic | GATA6 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr18 | 19762971 | 19762971 | T | A | exonic | GATA6 | nonsynonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
| rs770825513 | chr18 | 19751212 | 19751212 | C | T | exonic | GATA6 | nonsynonymous | SKCM|2|368|0.00543 |
| - | chr18 | 19780748 | 19780748 | G | T | exonic | GATA6 | nonsynonymous | LUAD|1|543|0.00184 |
| rs142079702 | chr18 | 19780747 | 19780747 | C | T | exonic | GATA6 | synonymous | SKCM|1|368|0.00272 |
| rs772285401 | chr18 | 19780588 | 19780588 | G | A | intronic | GATA6 | unknown | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr18 | 19762733 | 19762733 | G | T | exonic | GATA6 | nonsynonymous | ESCA|1|185|0.00541 |
| rs387906819 | chr18 | 19761478 | 19761478 | G | A | exonic | GATA6 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr18 | 19762952 | 19762952 | C | G | exonic | GATA6 | stopgain | HNSC|1|512|0.00195 |
| - | chr18 | 19780774 | 19780774 | G | C | exonic | GATA6 | synonymous | ACC|1|90|0.01111 |
| - | chr18 | 19762801 | 19762801 | C | A | exonic | GATA6 | stopgain | UCEC|1|248|0.00403 |
| - | chr18 | 19761413 | 19761413 | G | A | splicing | GATA6 | splicing | HNSC|2|512|0.00391 |
| - | chr18 | 19762740 | 19762740 | A | - | exonic | GATA6 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs777072337 | chr18 | 19780673 | 19780673 | G | C | exonic | GATA6 | nonsynonymous | THCA|1|504|0.00198 |
| - | chr18 | 19751533 | 19751533 | A | G | exonic | GATA6 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr18 | 19780733 | 19780733 | G | A | exonic | GATA6 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr18 | 19751547 | 19751547 | T | A | exonic | GATA6 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr18 | 19751577 | 19751577 | G | A | exonic | GATA6 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr18 | 19751408 | 19751408 | C | - | exonic | GATA6 | frameshift | PRAD|1|499|0.00200 |
| - | chr18 | 19763002 | 19763002 | G | A | exonic | GATA6 | nonsynonymous | SKCM|1|368|0.00272 |
| rs144512170 | chr18 | 19761423 | 19761423 | C | T | exonic | GATA6 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs151176879 | chr18 | 19761486 | 19761486 | G | A | exonic | GATA6 | nonsynonymous | LUAD|2|543|0.00368 |
| - | chr18 | 19751291 | 19751291 | G | T | exonic | GATA6 | synonymous | LUAD|1|543|0.00184 |
| rs762765948 | chr18 | 19751274 | 19751274 | G | A | exonic | GATA6 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr18 | 19751506 | 19751506 | C | G | exonic | GATA6 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr18 | 19751405 | 19751405 | G | A | exonic | GATA6 | synonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr18 | 19762796 | 19762796 | A | T | exonic | GATA6 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr18 | 19751314 | 19751314 | C | A | exonic | GATA6 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr18 | 19762791 | 19762791 | - | A | exonic | GATA6 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr18 | 19762969 | 19762969 | A | C | exonic | GATA6 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr18 | 19752074 | 19752075 | CC | - | exonic | GATA6 | frameshift | BLCA|2|396|0.00505,PRAD|3|499|0.00601,SKCM|1|368|0.00272,THCA|1|504|0.00198 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| GATA6 | Double Outlet Right Ventricle | C14;C16 | Congenital Abnormality | CTD_human;UNIPROT |
| GATA6 | Diaphragmatic Hernia | C23 | Anatomical Abnormality | CTD_human |
| GATA6 | Lung Neoplasms | C04;C08 | Neoplastic Process | CTD_human |
| GATA6 | Tetralogy of Fallot | C14;C16 | Congenital Abnormality | CTD_human;ORPHANET;UNIPROT |
| GATA6 | Truncus Arteriosus, Persistent | C14;C16 | Congenital Abnormality | CTD_human;UNIPROT |
| GATA6 | Interrupted aortic arch | Congenital Abnormality | CTD_human;UNIPROT | |
| GATA6 | Congenital diaphragmatic hernia | C16;C23 | Disease or Syndrome | ORPHANET |
| GATA6 | Malignant neoplasm of lung | C04;C08 | Neoplastic Process | CTD_human |
| GATA6 | Ostium secundum atrial septal defect | C14;C16 | Congenital Abnormality | ORPHANET |
| GATA6 | Partial atrioventricular canal | C14;C16 | Congenital Abnormality | ORPHANET |
| GATA6 | CONOTRUNCAL ANOMALY FACE SYNDROME | C05;C14;C15;C16;C19 | Disease or Syndrome | CTD_human;UNIPROT |
| GATA6 | ATRIOVENTRICULAR CANAL DEFECT | C14;C16 | Anatomical Abnormality | CTD_human |
| GATA6 | Atrioventricular Septal Defect | C14;C16 | Congenital Abnormality | CTD_human |
| GATA6 | Pancreatic Hypoplasia, Congenital, with Diabetes Mellitus and Congenital Heart Disease | C14;C16;C18;C19 | Disease or Syndrome | CTD_human;UNIPROT |
| GATA6 | ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) | C14;C23 | Disease or Syndrome | ORPHANET |
| GATA6 | CONOTRUNCAL HEART MALFORMATIONS (disorder) | C14;C16 | Disease or Syndrome | CTD_human;UNIPROT |
| GATA6 | Yorifuji Okuno syndrome | C10;C12;C13;C14;C18;C19;C23;F01;F03 | Disease or Syndrome | ORPHANET |
| GATA6 | ATRIOVENTRICULAR SEPTAL DEFECT 5 | Congenital Abnormality; Disease or Syndrome | UNIPROT | |
| GATA6 | ATRIAL SEPTAL DEFECT 9 | Congenital Abnormality; Disease or Syndrome | CTD_human;UNIPROT | |
| GATA6 | Intellectual Disability | C10;C23;F01;F03 | Mental or Behavioral Dysfunction | GENOMICS_ENGLAND |
| GATA6 | PANCREATIC AGENESIS AND CONGENITAL HEART DEFECTS | Disease or Syndrome | CTD_human;UNIPROT | |
| GATA6 | HEART DEFECTS, CONGENITAL, AND OTHER CONGENITAL ANOMALIES | Disease or Syndrome | CTD_human;UNIPROT |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000747 | Factors involved in megakaryocyte development and platelet production | reactome | 111 | 689 |
| pathway0001516 | Notch-mediated HES/HEY network | pid | 48 | 337 |
| pathway0001702 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 | 27 |
| pathway0002140 | Surfactant metabolism | reactome | 30 | 71 |
| pathway0002740 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 | 260 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_CARDIAC_MUSCLE_ADAPTATION | BP | GATA6 |
| GO_LUNG_EPITHELIUM_DEVELOPMENT | BP | GATA6 |
| GO_CARDIAC_SEPTUM_DEVELOPMENT | BP | GATA6 |
| GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS | BP | GATA6 |
| GO_CORONARY_VASCULATURE_DEVELOPMENT | BP | GATA6 |
| GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT | BP | GATA6 |
| GO_CARDIAC_CHAMBER_MORPHOGENESIS | BP | GATA6 |
| GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_LUNG_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT | BP | GATA6 |
| GO_POSITIVE_REGULATION_OF_HEART_GROWTH | BP | GATA6 |
| GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION | BP | GATA6 |
| GO_PANCREAS_DEVELOPMENT | BP | GATA6 |
| GO_DIGESTIVE_SYSTEM_DEVELOPMENT | BP | GATA6 |
| GO_ORGAN_FORMATION | BP | GATA6 |
| GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY | BP | GATA6 |
| GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER | BP | GATA6 |
| GO_ENDOCRINE_PANCREAS_DEVELOPMENT | BP | GATA6 |
| GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION | BP | GATA6 |
| GO_ENDODERMAL_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_MUSCLE_ADAPTATION | BP | GATA6 |
| GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_RESPONSE_TO_ESTROGEN | BP | GATA6 |
| GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT | BP | GATA6 |
| GO_GASTRULATION | BP | GATA6 |
| GO_ENDODERM_DEVELOPMENT | BP | GATA6 |
| GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH | BP | GATA6 |
| GO_SYSTEM_PROCESS | BP | GATA6 |
| GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_CELL_FATE_DETERMINATION | BP | GATA6 |
| GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION | BP | GATA6 |
| GO_CARDIOCYTE_DIFFERENTIATION | BP | GATA6 |
| GO_MUSCLE_HYPERTROPHY | BP | GATA6 |
| GO_REGULATION_OF_BMP_SIGNALING_PATHWAY | BP | GATA6 |
| GO_ENDODERM_FORMATION | BP | GATA6 |
| GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT | BP | GATA6 |
| GO_RESPIRATORY_SYSTEM_DEVELOPMENT | BP | GATA6 |
| GO_REGULATION_OF_HEART_GROWTH | BP | GATA6 |
| GO_OUTFLOW_TRACT_MORPHOGENESIS | BP | GATA6 |
| GO_RESPONSE_TO_GONADOTROPIN | BP | GATA6 |
| GO_STRIATED_MUSCLE_ADAPTATION | BP | GATA6 |
| GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH | BP | GATA6 |
| GO_ENDODERMAL_CELL_FATE_COMMITMENT | BP | GATA6 |
| GO_MALE_SEX_DIFFERENTIATION | BP | GATA6 |
| GO_LUNG_ALVEOLUS_DEVELOPMENT | BP | GATA6 |
| GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS | BP | GATA6 |
| GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION | BP | GATA6 |
| GO_TRANSCRIPTION_FACTOR_COMPLEX | CC | GATA6 |
| GO_CORE_PROMOTER_BINDING | MF | GATA6 |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING | MF | GATA6 |
| GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING | MF | GATA6 |
| GO_DOUBLE_STRANDED_DNA_BINDING | MF | GATA6 |
| GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING | MF | GATA6 |
| GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING | MF | GATA6 |