Cancer CRCdb

TF information

TF name:	CREB1
TF family:	TF_bZIP
Ensembl gene ID:	ENSG00000118260
Ensembl protein ID:	ENSP00000236995, ENSP00000405539, ENSP00000387699
Entrez gene ID:	1385

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of CREB1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_179	Cell line	Urinary bladder	T24	0.068965517241379
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.045977011494253
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.21777777777778
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.045141545524101
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.10958904109589
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.55844155844156
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.33510638297872
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.1003861003861
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.17283950617284
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.22972972972973
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.092485549132948
Sample_02_323	Cell line	Colon	RKO	0.4

CREB1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_311	Neuroblastoma	Cell line	SK-N-AS
Sample_02_313	Neuroblastoma	Cell line	SK-N-DZ

CREB1 distribution in all CRCs

Genomic distribution of SEs associated with CREB1

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Mutation of CREB1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of CREB1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	208461780	208461780	T	G	exonic	CREB1	stoploss	PAAD\|1\|185\|0.00541
-	chr2	208440098	208440098	C	T	exonic	CREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs768152463	chr2	208434996	208434996	C	T	exonic	CREB1	synonymous	BRCA\|1\|982\|0.00102
-	chr2	208440037	208440037	G	T	exonic	CREB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	208442363	208442363	C	T	exonic	CREB1	nonsynonymous	BRCA\|1\|982\|0.00102,PRAD\|1\|499\|0.00200
-	chr2	208440097	208440097	C	T	exonic	CREB1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	208442362	208442362	C	T	exonic	CREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	208461637	208461637	G	T	splicing	CREB1	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	208432219	208432219	G	T	exonic	CREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	208440158	208440158	G	A	exonic	CREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	208424959	208424959	C	T	exonic	CREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	208461841	208461841	G	A	UTR3	CREB1	unknown	CESC\|1\|194\|0.00515
-	chr2	208440050	208440050	T	A	exonic	CREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	208461732	208461732	A	G	exonic	CREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	208461697	208461697	G	A	exonic	CREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	208434968	208434971	AAGA	-	exonic	CREB1	frameshift	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr2	208462088	208462088	G	A	UTR3	CREB1	unknown	CESC\|1\|194\|0.00515
-	chr2	208440111	208440111	T	G	exonic	CREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	208440042	208440042	C	A	exonic	CREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	208420421	208420421	A	-	exonic	CREB1	frameshift	HNSC\|1\|512\|0.00195
-	chr2	208420438	208420438	G	A	exonic	CREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	208440095	208440107	AGCCGGGTACTAC	-	exonic	CREB1	frameshift	PAAD\|1\|185\|0.00541
-	chr2	208420450	208420450	C	T	exonic	CREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	208461657	208461657	C	T	exonic	CREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	208425875	208425875	C	A	exonic	CREB1	synonymous	HNSC\|1\|512\|0.00195
-	chr2	208432253	208432253	C	T	exonic	CREB1	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs376739437	chr2	208440042	208440042	C	T	exonic	CREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	208442472	208442472	C	A	intronic	CREB1	unknown	UCEC\|1\|248\|0.00403
-	chr2	208420472	208420472	A	G	exonic	CREB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	208442310	208442310	C	-	exonic	CREB1	frameshift	LIHC\|1\|373\|0.00268
-	chr2	208441407	208441407	G	A	intronic	CREB1	unknown	BRCA\|1\|982\|0.00102
-	chr2	208440061	208440061	C	T	exonic	CREB1	stopgain	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr2	208434952	208434952	G	C	exonic	CREB1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	208414500	208414508	ATCGAGACC	-	intronic	CREB1	unknown	-
-	chr2	208461648	208461648	C	T	exonic	CREB1	stopgain	UCEC\|1\|248\|0.00403

Disease information of CREB1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
CREB1	Alcoholic Intoxication, Chronic	C25;F03	Mental or Behavioral Dysfunction	PSYGENET
CREB1	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
CREB1	Cocaine Abuse	C25;F03	Mental or Behavioral Dysfunction	CTD_human
CREB1	Mental Depression	F01	Mental or Behavioral Dysfunction	PSYGENET
CREB1	Depressive disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
CREB1	Morphine Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human
CREB1	Myocardial Infarction	C14	Disease or Syndrome	CTD_human
CREB1	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
CREB1	Substance Withdrawal Syndrome	C25;F03	Mental or Behavioral Dysfunction	CTD_human
CREB1	Unipolar Depression	F03	Mental or Behavioral Dysfunction	PSYGENET
CREB1	Drug Withdrawal Symptoms	C25;F03	Sign or Symptom	CTD_human
CREB1	Withdrawal Symptoms	C25;F03	Sign or Symptom	CTD_human
CREB1	Clear Cell Sarcoma of Soft Tissue	C04	Neoplastic Process	ORPHANET
CREB1	Cocaine-Related Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
CREB1	Mood Disorders	F03	Mental or Behavioral Dysfunction	PSYGENET
CREB1	Morphine Abuse	C25;F03	Mental or Behavioral Dysfunction	CTD_human
CREB1	Cocaine Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human;PSYGENET
CREB1	Histiocytoma, Angiomatoid Fibrous	C04	Neoplastic Process	CTD_human
CREB1	Major Depressive Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET

Pathway associated with CREB1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000118	AKT phosphorylates targets in the nucleus	reactome	9	27
pathway0000176	AndrogenReceptor	netpath	167	2267
pathway0000187	AP-1 transcription factor network	pid	71	659
pathway0000229	ATF-2 transcription factor network	pid	59	451
pathway0000270	BCR	netpath	161	2850
pathway0000316	BMAL1:CLOCK,NPAS2 activates circadian gene expression	reactome	42	282
pathway0000351	CaMK IV-mediated phosphorylation of CREB	reactome	5	7
pathway0000430	Circadian Clock	reactome	49	389
pathway0000479	Constitutive Signaling by AKT1 E17K in Cancer	reactome	25	137
pathway0000501	CREB phosphorylation	reactome	7	11
pathway0000502	CREB phosphorylation through the activation of Adenylate Cyclase	reactome	7	16
pathway0000503	CREB phosphorylation through the activation of CaMKII	reactome	17	121
pathway0000504	CREB phosphorylation through the activation of CaMKK	reactome	6	11
pathway0000505	CREB phosphorylation through the activation of Ras	reactome	13	43
pathway0000671	Enkephalin release	panther	17	70
pathway0000692	ErbB1 downstream signaling	pid	105	1597
pathway0000741	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin	smpdb	7	11
pathway0000742	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin	smpdb	7	11
pathway0000743	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin	smpdb	7	11
pathway0000825	FOXA2 and FOXA3 transcription factor networks	pid	45	202
pathway0000842	FSH	netpath	44	301
pathway0000888	Gastrin-CREB signalling pathway via PKC and MAPK	reactome	9	21
pathway0000916	Glucocorticoid receptor regulatory network	pid	85	876
pathway0001005	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	panther	126	1529
pathway0001008	Heterotrimeric GPCR signaling pathway (through Adenosine G alpha s) ( GPCR Adenosine A2A receptor signaling pathway )	inoh	9	19
pathway0001009	Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s) ( GPCR Dopamine D1like receptor signaling pathway )	inoh	45	355
pathway0001021	HIF-1-alpha transcription factor network	pid	67	420
pathway0001120	IL2	netpath	81	1364
pathway0001126	IL3	netpath	84	1284
pathway0001170	Integrin-linked kinase signaling	pid	46	234
pathway0001194	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine	smpdb	37	233
pathway0001195	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine	smpdb	38	237
pathway0001196	Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone	smpdb	10	24
pathway0001197	Intracellular Signalling Through Histamine H2 Receptor and Histamine	smpdb	8	13
pathway0001198	Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin	smpdb	10	23
pathway0001264	Leptin	netpath	98	1355
pathway0001287	LKB1 signaling events	pid	43	314
pathway0001296	LPA4-mediated signaling events	pid	16	49
pathway0001437	NCAM signaling for neurite out-growth	reactome	22	163
pathway0001507	Nongenotropic Androgen signaling	pid	31	254
pathway0001526	NOTCH2 intracellular domain regulates transcription	reactome	12	53
pathway0001574	p38 signaling mediated by MAPKAP kinases	pid	21	107
pathway0001799	RANKL	netpath	84	1002
pathway0001849	Regulation of nuclear SMAD2/3 signaling	pid	82	1072
pathway0002043	Signaling events regulated by Ret tyrosine kinase	pid	39	421
pathway0002044	Signaling mediated by p38-alpha and p38-beta	pid	35	174
pathway0002249	TNFalpha	netpath	274	5236
pathway0002299	Transcriptional activation of mitochondrial biogenesis	reactome	43	230
pathway0002339	Trk receptor signaling mediated by PI3K and PLC-gamma	pid	36	303
pathway0002340	Trk receptor signaling mediated by the MAPK pathway	pid	34	175
pathway0002354	TSH	netpath	82	750
pathway0002391	Validated targets of C-MYC transcriptional repression	pid	63	385
pathway0002413	VEGFR3 signaling in lymphatic endothelium	pid	26	155
pathway0002601	Antigen processing and presentation	kegg	75	466
pathway0002627	Melanogenesis	kegg	100	1225
pathway0002633	Vasopressin-regulated water reabsorption	kegg	35	126
pathway0002642	Huntingtons disease	kegg	182	1941
pathway0002662	Prostate cancer	kegg	85	1261

Go term information of CREB1

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	CREB1
GO_LUNG_EPITHELIUM_DEVELOPMENT	BP	CREB1
GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION	BP	CREB1
GO_POSITIVE_REGULATION_OF_HEMOPOIESIS	BP	CREB1
GO_VESICLE_ORGANIZATION	BP	CREB1
GO_LUNG_CELL_DIFFERENTIATION	BP	CREB1
GO_ASSOCIATIVE_LEARNING	BP	CREB1
GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	CREB1
GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	CREB1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	CREB1
GO_PITUITARY_GLAND_DEVELOPMENT	BP	CREB1
GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT	BP	CREB1
GO_RESPONSE_TO_NERVE_GROWTH_FACTOR	BP	CREB1
GO_REGULATION_OF_CIRCADIAN_RHYTHM	BP	CREB1
GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS	BP	CREB1
GO_RESPONSE_TO_GLUCAGON	BP	CREB1
GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY	BP	CREB1
GO_RESPONSE_TO_EXTERNAL_STIMULUS	BP	CREB1
GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION	BP	CREB1
GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH	BP	CREB1
GO_REGULATION_OF_SYNAPTIC_PLASTICITY	BP	CREB1
GO_SECRETORY_GRANULE_ORGANIZATION	BP	CREB1
GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION	BP	CREB1
GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION	BP	CREB1
GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION	BP	CREB1
GO_REGULATION_OF_FIBROBLAST_PROLIFERATION	BP	CREB1
GO_PROTEIN_STABILIZATION	BP	CREB1
GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR	BP	CREB1
GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	CREB1
GO_REGULATION_OF_CELL_DIFFERENTIATION	BP	CREB1
GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION	BP	CREB1
GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR	BP	CREB1
GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	CREB1
GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH	BP	CREB1
GO_REGULATION_OF_PROTEIN_STABILITY	BP	CREB1
GO_RESPONSE_TO_NICOTINE	BP	CREB1
GO_CELLULAR_RESPONSE_TO_ZINC_ION	BP	CREB1
GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION	BP	CREB1
GO_RESPONSE_TO_FATTY_ACID	BP	CREB1
GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY	BP	CREB1
GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION	BP	CREB1
GO_CELLULAR_RESPONSE_TO_FATTY_ACID	BP	CREB1
GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY	BP	CREB1
GO_DIENCEPHALON_DEVELOPMENT	BP	CREB1
GO_BODY_FLUID_SECRETION	BP	CREB1
GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION	BP	CREB1
GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS	BP	CREB1
GO_RESPIRATORY_SYSTEM_DEVELOPMENT	BP	CREB1
GO_VISUAL_BEHAVIOR	BP	CREB1
GO_CELLULAR_RESPONSE_TO_PEPTIDE	BP	CREB1
GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS	BP	CREB1
GO_REGULATION_OF_GLIOGENESIS	BP	CREB1
GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH	BP	CREB1
GO_NEGATIVE_REGULATION_OF_NEURON_DEATH	BP	CREB1
GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	CREB1
GO_LUNG_ALVEOLUS_DEVELOPMENT	BP	CREB1
GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	CREB1
GO_RESPONSE_TO_ACTIVITY	BP	CREB1
GO_LACTATION	BP	CREB1
GO_CHROMOSOME	CC	CREB1
GO_TRANSCRIPTION_FACTOR_COMPLEX	CC	CREB1
GO_NUCLEAR_EUCHROMATIN	CC	CREB1
GO_EUCHROMATIN	CC	CREB1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	CREB1
GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY	MF	CREB1
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	CREB1
GO_CAMP_RESPONSE_ELEMENT_BINDING	MF	CREB1
GO_HSP70_PROTEIN_BINDING	MF	CREB1
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	CREB1
GO_HISTONE_ACETYLTRANSFERASE_BINDING	MF	CREB1
GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	CREB1

Survival analysis of CREB1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of CREB1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)