TF information

TF name: NR4A2
TF family: NGFIB-like
Ensembl gene ID: ENSG00000153234
Ensembl protein ID: ENSP00000386747, ENSP00000415632, ENSP00000385379, ENSP00000344479, ENSP00000394671, ENSP00000386993, ENSP00000389986, ENSP00000410952
Entrez gene ID: 4929
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of NR4A2 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_046Cell lineMammary GlandMCF-70.4
Sample_02_021Cell lineColonV4290.24819832804843
Sample_02_096Cell lineMammary GlandZR-75-1_10.51086956521739
Sample_02_181Cell lineHuman melanomaCOLO6790.37066666666667
Sample_02_184Cell lineSkinSKMEL300.37299035369775
Sample_02_191Cell lineStomachSNU7190.78571428571429
Sample_02_192Cell lineStomachMKN450.33333333333333
Sample_02_204Cell lineStomachIM950.77272727272727
Sample_02_236Cell lineColonV2060.43271221532091
Sample_02_237Cell lineColonV3890.22190318424443
Sample_02_241Cell lineColonV4560.33182844243792
Sample_02_242Cell lineColonV4810.25187463949241
Sample_02_258OtherLungNCI-H1299_EGFP-NEO_reporter_cells_DMSO0.3
Sample_02_268Cell lineKidneyA-4980.22687834594794
Sample_02_285Cell lineLiverHuH7_untreat0.21254355400697
Sample_02_355Cell lineColonHCT150.4702380952381
Sample_02_359Cell lineColonColo7410.7078313253012

NR4A2 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_01_046Mammary GlandCell lineMCF-7
Sample_02_096Mammary GlandCell lineZR-75-1_1
Sample_02_181Human melanomaCell lineCOLO679
Sample_02_191StomachCell lineSNU719
Sample_02_204StomachCell lineIM95
Sample_02_236ColonCell lineV206
Sample_02_355ColonCell lineHCT15
Sample_02_359ColonCell lineColo741

NR4A2 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with NR4A2
Download

Mutation of NR4A2
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NR4A2

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr2157185038157185038AGexonicNR4A2nonsynonymous BRCA|1|982|0.00102
-chr2157183331157183331CAexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157184464157184464GAexonicNR4A2stopgain UCEC|1|248|0.00403
-chr2157186333157186333GTexonicNR4A2stopgain LUSC|1|178|0.00562
-chr2157186454157186454GAexonicNR4A2nonsynonymous ACC|1|90|0.01111
-chr2157184401157184401CTexonicNR4A2nonsynonymous UCEC|1|248|0.00403
-chr2157184520157184520CTexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157186608157186608TAexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157186659157186659CTexonicNR4A2nonsynonymous LIHC|2|373|0.00536
rs772578858chr2157183359157183359GAexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157185939157185980GCGACGGCGGTGAGGGCACCTGCGTGTCGAGCAGCTGAGACG-exonicNR4A2nonframeshift -
-chr2157186008157186008CAexonicNR4A2nonsynonymous LUAD|2|543|0.00368
-chr2157183254157183254AGexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157186342157186342CTexonicNR4A2synonymous PAAD|1|185|0.00541
-chr2157185866157185866CTexonicNR4A2nonsynonymous OV|1|469|0.00213
-chr2157182511157182511CAexonicNR4A2nonsynonymous HNSC|1|512|0.00195
-chr2157182448157182448GCexonicNR4A2synonymous BLCA|1|396|0.00253
-chr2157186128157186128G-exonicNR4A2frameshift ESCA|1|185|0.00541
-chr2157186322157186322GAexonicNR4A2nonsynonymous SKCM|2|368|0.00543
-chr2157185943157185943CTexonicNR4A2synonymous ESCA|1|185|0.00541
rs557438711chr2157183425157183425GAexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157182338157182338CTexonicNR4A2nonsynonymous TGCT|1|155|0.00645
-chr2157184460157184460T-exonicNR4A2frameshift OV|1|469|0.00213
-chr2157182339157182339GTexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157183293157183293GTexonicNR4A2nonsynonymous TGCT|1|155|0.00645
-chr2157186256157186256GCexonicNR4A2nonsynonymous BLCA|1|396|0.00253
-chr2157186448157186448GAexonicNR4A2nonsynonymous BLCA|1|396|0.00253
-chr2157186105157186105C-exonicNR4A2frameshift LUAD|1|543|0.00184
-chr2157184493157184493CAexonicNR4A2nonsynonymous BRCA|1|982|0.00102
rs774046320chr2157182776157182776CTexonicNR4A2nonsynonymous PRAD|1|499|0.00200
-chr2157184435157184435CTexonicNR4A2synonymous BLCA|1|396|0.00253
-chr2157182748157182748GAexonicNR4A2nonsynonymous SKCM|1|368|0.00272
-chr2157185981157185981CTexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157182791157182791GAexonicNR4A2nonsynonymous HNSC|1|512|0.00195
-chr2157185033157185033TGexonicNR4A2nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr2157186376157186376GAexonicNR4A2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr2157186571157186571CTexonicNR4A2nonsynonymous HNSC|1|512|0.00195
-chr2157184440157184440-AexonicNR4A2frameshift COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr2157186496157186496CAexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157186101157186101CTexonicNR4A2nonsynonymous PRAD|1|499|0.00200
-chr2157185008157185008GTexonicNR4A2nonsynonymous ESCA|1|185|0.00541
-chr2157182456157182456TGexonicNR4A2nonsynonymous LUSC|1|178|0.00562
-chr2157182695157182695AGexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157186374157186374G-exonicNR4A2frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204,LIHC|1|373|0.00268,STAD|2|395|0.00506,STES|2|395|0.00506
rs201103933chr2157184995157184995GAexonicNR4A2synonymous DLBC|1|48|0.02083
-chr2157186238157186238TAexonicNR4A2nonsynonymous LIHC|1|373|0.00268
-chr2157183325157183325CTexonicNR4A2synonymous SKCM|1|368|0.00272
-chr2157184439157184439G-exonicNR4A2frameshift LIHC|1|373|0.00268
rs776226389chr2157186347157186347CAexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157185874157185874GAexonicNR4A2synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157186670157186670GAexonicNR4A2nonsynonymous SKCM|1|368|0.00272
-chr2157186111157186111C-exonicNR4A2frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr2157183285157183285CAexonicNR4A2nonsynonymous UCEC|1|248|0.00403
-chr2157182363157182363TAexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157182823157182823CTexonicNR4A2nonsynonymous THCA|2|504|0.00397
-chr2157182419157182419CTexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157186266157186266CTexonicNR4A2nonsynonymous UCEC|1|248|0.00403
-chr2157183361157183361CAexonicNR4A2synonymous OV|1|469|0.00213
-chr2157186171157186171GAexonicNR4A2synonymous SKCM|1|368|0.00272
-chr2157186485157186485CTexonicNR4A2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,PAAD|1|185|0.00541
-chr2157186542157186542CTexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157182339157182339GAexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs142345639chr2157182707157182707CTexonicNR4A2nonsynonymous UCEC|2|248|0.00806
-chr2157184975157184975CTexonicNR4A2nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189,THYM|1|123|0.00813,UCEC|1|248|0.00403
-chr2157186268157186268TCexonicNR4A2nonsynonymous COAD|1|367|0.00272,COADREAD|2|489|0.00409,READ|1|122|0.00820
-chr2157183340157183340GAexonicNR4A2synonymous SKCM|1|368|0.00272
rs755138263chr2157186312157186312CTexonicNR4A2synonymous PRAD|1|499|0.00200
rs550135305chr2157182439157182439GAexonicNR4A2synonymous BLCA|1|396|0.00253,COAD|1|367|0.00272,COADREAD|1|489|0.00204,STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157182288157182288CGexonicNR4A2nonsynonymous LUSC|1|178|0.00562
-chr2157186597157186597GCexonicNR4A2nonsynonymous BLCA|1|396|0.00253
-chr2157184499157184499CTexonicNR4A2nonsynonymous LUAD|1|543|0.00184
rs772647221chr2157184501157184501GAexonicNR4A2synonymous UCEC|1|248|0.00403
-chr2157184934157184934CAexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157184976157184976GAexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157184376157184376ACexonicNR4A2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr2157186683157186683CTexonicNR4A2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr2157182757157182757CTexonicNR4A2stopgain SKCM|1|368|0.00272
-chr2157182365157182365CTexonicNR4A2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr2157184955157184955GAexonicNR4A2stopgain UCEC|1|248|0.00403
-chr2157186159157186159TCexonicNR4A2synonymous LUAD|1|543|0.00184
-chr2157185028157185028-TexonicNR4A2frameshift STAD|1|395|0.00253,STES|1|395|0.00253
rs777699862chr2157183310157183310GAexonicNR4A2synonymous BLCA|1|396|0.00253
rs775615135chr2157182425157182425TCexonicNR4A2nonsynonymous PAAD|1|185|0.00541
rs141522485chr2157182274157182274CTexonicNR4A2synonymous HNSC|1|512|0.00195
-chr2157186237157186237CTexonicNR4A2synonymous SKCM|1|368|0.00272
-chr2157182714157182714-AexonicNR4A2frameshift HNSC|1|512|0.00195
-chr2157185855157185855CAexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157186116157186116CTexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157185044157185044CTexonicNR4A2nonsynonymous COAD|1|367|0.00272,COADREAD|2|489|0.00409,LUAD|2|543|0.00368,READ|1|122|0.00820
rs759305222chr2157186121157186121CTexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253,UCEC|1|248|0.00403
rs773502234chr2157185018157185018CTexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157184479157184479TGexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157186462157186462GTexonicNR4A2stopgain STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157186647157186647CTexonicNR4A2nonsynonymous UCEC|1|248|0.00403
-chr2157186301157186301GAexonicNR4A2nonsynonymous LIHC|1|373|0.00268
rs752342124chr2157186681157186681CTexonicNR4A2synonymous LUSC|1|178|0.00562
-chr2157184481157184481GAexonicNR4A2nonsynonymous BLCA|1|396|0.00253
-chr2157186269157186269C-exonicNR4A2frameshift BRCA|1|982|0.00102
-chr2157186669157186669GAexonicNR4A2synonymous SKCM|1|368|0.00272
-chr2157185931157185931GTexonicNR4A2synonymous ACC|1|90|0.01111
-chr2157186267157186267GAexonicNR4A2synonymous OV|1|469|0.00213
-chr2157186157157186157GAexonicNR4A2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr2157182673157182673GCexonicNR4A2nonsynonymous ACC|1|90|0.01111
-chr2157183351157183351TCexonicNR4A2nonsynonymous LUAD|1|543|0.00184
-chr2157184947157184947CAexonicNR4A2nonsynonymous PAAD|1|185|0.00541
-chr2157184490157184490CTexonicNR4A2nonsynonymous UCEC|1|248|0.00403
-chr2157182788157182788TAexonicNR4A2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157182418157182418C-exonicNR4A2frameshift ESCA|1|185|0.00541
-chr2157185029157185029T-exonicNR4A2frameshift BRCA|1|982|0.00102,COAD|2|367|0.00545,COADREAD|2|489|0.00409,STAD|1|395|0.00253,STES|1|395|0.00253
-chr2157182348157182348CAexonicNR4A2nonsynonymous LUSC|1|178|0.00562
-chr2157182345157182345-AexonicNR4A2frameshift LUAD|1|543|0.00184
rs774629025chr2157186373157186373-GexonicNR4A2frameshift BRCA|1|982|0.00102,COAD|1|367|0.00272,COADREAD|1|489|0.00204,KIPAN|2|799|0.00250,KIRC|2|451|0.00443,LUAD|3|543|0.00552,OV|1|469|0.00213

Disease information of NR4A2
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
NR4A2 Alcoholic Intoxication, Chronic C25;F03 Mental or Behavioral Dysfunction PSYGENET
NR4A2 Arthritis, Psoriatic C05;C17 Disease or Syndrome CTD_human
NR4A2 Bipolar Disorder F03 Mental or Behavioral Dysfunction PSYGENET
NR4A2 Cocaine Abuse C25;F03 Mental or Behavioral Dysfunction PSYGENET
NR4A2 Colorectal Carcinoma C04;C06 Neoplastic Process CTD_human
NR4A2 Colorectal Neoplasms C04;C06 Neoplastic Process CTD_human
NR4A2 Parkinson Disease C10 Disease or Syndrome GENOMICS_ENGLAND
NR4A2 Schizophrenia F03 Mental or Behavioral Dysfunction PSYGENET
NR4A2 Dermatologic disorders C17 Disease or Syndrome CTD_human
NR4A2 Unipolar Depression F03 Mental or Behavioral Dysfunction PSYGENET
NR4A2 Juvenile-Onset Still Disease C05;C17;C20 Disease or Syndrome CTD_human
NR4A2 Arsenic Poisoning, Inorganic C10;C25 Injury or Poisoning CTD_human
NR4A2 Nervous System, Organic Arsenic Poisoning C10;C25 Injury or Poisoning CTD_human
NR4A2 Arsenic Poisoning C10;C25 Injury or Poisoning CTD_human
NR4A2 Arsenic Encephalopathy C10;C25 Disease or Syndrome CTD_human
NR4A2 Arsenic Induced Polyneuropathy C10;C25 Injury or Poisoning CTD_human
NR4A2 Major Depressive Disorder F03 Mental or Behavioral Dysfunction PSYGENET
NR4A2 Colorectal Cancer C04;C06 Neoplastic Process CTD_human
NR4A2 PARKINSON DISEASE, LATE-ONSET Disease or Syndrome CTD_human
NR4A2 Juvenile arthritis C05;C17;C20 Disease or Syndrome CTD_human
NR4A2 Juvenile psoriatic arthritis C05;C17;C20 Disease or Syndrome CTD_human

Pathway associated with NR4A2
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0001534 Nuclear Receptor transcription pathway reactome 51 284
pathway0002746 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19 37
pathway0002858 Hs_IL-6_signaling_pathway_WP364_89832 wikipathways 26 174

Go term information of NR4A2
GO_term_name GO_term_type TF_name
GO_NEURON_DEVELOPMENT BP NR4A2
GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS BP NR4A2
GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS BP NR4A2
GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS BP NR4A2
GO_RESPONSE_TO_AMINE BP NR4A2
GO_NEURON_MATURATION BP NR4A2
GO_CATECHOLAMINE_METABOLIC_PROCESS BP NR4A2
GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS BP NR4A2
GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS BP NR4A2
GO_RESPONSE_TO_ENDOGENOUS_STIMULUS BP NR4A2
GO_HORMONE_MEDIATED_SIGNALING_PATHWAY BP NR4A2
GO_DOPAMINE_METABOLIC_PROCESS BP NR4A2
GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS BP NR4A2
GO_RESPONSE_TO_AMPHETAMINE BP NR4A2
GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS BP NR4A2
GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS BP NR4A2
GO_NEURON_MIGRATION BP NR4A2
GO_DOPAMINERGIC_NEURON_DIFFERENTIATION BP NR4A2
GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS BP NR4A2
GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE BP NR4A2
GO_POST_EMBRYONIC_DEVELOPMENT BP NR4A2
GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS BP NR4A2
GO_BETA_CATENIN_BINDING MF NR4A2
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING MF NR4A2
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY MF NR4A2
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING MF NR4A2
GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING MF NR4A2
GO_GLUCOCORTICOID_RECEPTOR_BINDING MF NR4A2
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING MF NR4A2
GO_STEROID_HORMONE_RECEPTOR_BINDING MF NR4A2
GO_RETINOIC_ACID_RECEPTOR_BINDING MF NR4A2
GO_RETINOID_X_RECEPTOR_BINDING MF NR4A2

Survival analysis of NR4A2



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of NR4A2