Cancer CRCdb

TF information

TF name:	MAZ
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000103495
Ensembl protein ID:	ENSP00000458201, ENSP00000443956, ENSP00000313362, ENSP00000455913, ENSP00000461630, ENSP00000219782, ENSP00000480440, ENSP00000460057, ENSP00000455794
Entrez gene ID:	4150

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of MAZ in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_022	Cell line	Prostate	C4-2B	0.095238095238095
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.14238410596026
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.48913043478261
Sample_02_179	Cell line	Urinary bladder	T24	0.25287356321839
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.52941176470588
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.21777777777778
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.22494261667942
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.29736211031175
Sample_02_303	Cell line	Neuroblastoma	LAN1	0.28571428571429
Sample_02_304	Cell line	Neuroblastoma	N206	0.34782608695652
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.32701421800948
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.40366972477064
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.23936170212766
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.23166023166023
Sample_02_318	Cell line	Neuroblastoma	NB69	0.2421875
Sample_02_395	Cell line	Mammary Gland	BT-549	0.35972027972028

MAZ distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_258	Lung	Other	NCI-H1299_EGFP-NEO_reporter_cells_DMSO
Sample_02_310	Neuroblastoma	Cell line	SJNB8

MAZ distribution in all CRCs

Genomic distribution of SEs associated with MAZ

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Mutation of MAZ

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MAZ

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr16	29818187	29818187	C	T	exonic	MAZ	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs71650270	chr16	29821984	29821984	T	-	UTR3	MAZ	unknown	ESCA\|1\|185\|0.00541
rs746270470	chr16	29821425	29821425	C	T	exonic	MAZ	nonsynonymous	BRCA\|4\|982\|0.00407
-	chr16	29821434	29821434	C	T	exonic	MAZ	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	29820861	29820861	G	C	exonic	MAZ	nonsynonymous	OV\|1\|469\|0.00213
rs767720617	chr16	29818054	29818054	C	-	exonic	MAZ	frameshift	COAD\|5\|367\|0.01362,COADREAD\|5\|489\|0.01022,STAD\|4\|395\|0.01013,STES\|4\|395\|0.01013
rs769505112	chr16	29821006	29821006	G	-	exonic	MAZ	frameshift	PRAD\|1\|499\|0.00200
rs748661675	chr16	29819948	29819948	G	A	exonic	MAZ	nonsynonymous	LUAD\|4\|543\|0.00737
rs372208027	chr16	29821444	29821444	A	G	exonic	MAZ	synonymous	BLCA\|1\|396\|0.00253
rs768501778	chr16	29820119	29820119	C	T	intronic	MAZ	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29819028	29819028	C	T	exonic	MAZ	stopgain	BLCA\|1\|396\|0.00253
-	chr16	29821437	29821438	CG	-	exonic	MAZ	frameshift	HNSC\|1\|512\|0.00195
-	chr16	29818739	29818739	C	A	exonic	MAZ	synonymous	BLCA\|1\|396\|0.00253
-	chr16	29820948	29820948	T	A	exonic	MAZ	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr16	29821425	29821444	CGGCAGCGGCAGCGGCGGCA	-	exonic	MAZ	frameshift	LIHC\|1\|373\|0.00268
-	chr16	29820065	29820065	A	G	intronic	MAZ	unknown	HNSC\|1\|512\|0.00195
-	chr16	29821428	29821450	CAGCGGCAGCGGCGGCAGCGGCA	-	exonic	MAZ	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs768483206	chr16	29819074	29819074	G	A	exonic	MAZ	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29821543	29821543	A	T	exonic	MAZ	nonsynonymous	UCS\|1\|57\|0.01754
rs781589376	chr16	29820871	29820871	G	T	exonic	MAZ	synonymous	LIHC\|1\|373\|0.00268
rs571424053	chr16	29821568	29821568	C	T	UTR3	MAZ	unknown	ESCA\|1\|185\|0.00541
-	chr16	29821553	29821553	G	C	UTR3	MAZ	unknown	BLCA\|1\|396\|0.00253
-	chr16	29818051	29818051	T	C	exonic	MAZ	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr16	29821431	29821438	CGGCAGCG	-	exonic	MAZ	frameshift	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29819933	29819933	C	T	exonic	MAZ	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	29818801	29818801	C	A	exonic	MAZ	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr16	29820038	29820038	C	T	exonic	MAZ	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr16	29819136	29819136	A	T	exonic	MAZ	stopgain	LUSC\|1\|178\|0.00562
rs775841544	chr16	29818053	29818053	-	C	exonic	MAZ	frameshift	BRCA\|1\|982\|0.00102,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr16	29818087	29818087	G	-	exonic	MAZ	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29820927	29820927	C	A	exonic	MAZ	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs370548510	chr16	29821441	29821441	G	A	exonic	MAZ	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29819170	29819170	G	A	intronic	MAZ	unknown	BRCA\|1\|982\|0.00102
-	chr16	29819111	29819111	G	-	exonic	MAZ	frameshift	LIHC\|1\|373\|0.00268
-	chr16	29820974	29820974	G	T	exonic	MAZ	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr16	29819057	29819064	GCGCAAGG	-	exonic	MAZ	frameshift	DLBC\|1\|48\|0.02083
-	chr16	29818724	29818724	G	A	exonic	MAZ	synonymous	SKCM\|1\|368\|0.00272
-	chr16	29819072	29819072	G	A	exonic	MAZ	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	29819116	29819116	A	G	exonic	MAZ	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29818754	29818754	G	A	exonic	MAZ	synonymous	SKCM\|1\|368\|0.00272
rs372438870	chr16	29821450	29821450	A	G	exonic	MAZ	synonymous	CHOL\|1\|35\|0.02857
rs780618980	chr16	29821464	29821464	T	C	exonic	MAZ	nonsynonymous	LIHC\|1\|373\|0.00268,LUAD\|2\|543\|0.00368
-	chr16	29818879	29818879	C	T	exonic	MAZ	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	29819914	29819914	G	A	exonic	MAZ	synonymous	BRCA\|1\|982\|0.00102
-	chr16	29821507	29821507	G	-	exonic	MAZ	frameshift	ESCA\|1\|185\|0.00541
-	chr16	29818706	29818706	G	C	exonic	MAZ	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	29822000	29822000	-	G	UTR3	MAZ	unknown	ESCA\|1\|185\|0.00541
-	chr16	29818992	29818992	C	T	exonic	MAZ	stopgain	LUSC\|1\|178\|0.00562
rs11559001	chr16	29821498	29821498	G	A	exonic	MAZ	synonymous	THYM\|1\|123\|0.00813
-	chr16	29818771	29818771	C	G	exonic	MAZ	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	29820025	29820025	C	G	exonic	MAZ	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr16	29821422	29821435	CGGCGGCAGCGGCA	-	exonic	MAZ	frameshift	LUAD\|1\|543\|0.00184
rs549096750	chr16	29821465	29821465	A	G	exonic	MAZ	synonymous	LUAD\|2\|543\|0.00368
rs749236448	chr16	29818097	29818097	C	T	exonic	MAZ	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29821422	29821422	C	T	exonic	MAZ	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	29820003	29820003	C	G	exonic	MAZ	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr16	29818814	29818814	G	C	exonic	MAZ	synonymous	BLCA\|1\|396\|0.00253
-	chr16	29818593	29818593	G	C	exonic	MAZ	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr16	29820898	29820898	G	A	exonic	MAZ	synonymous	SKCM\|1\|368\|0.00272
-	chr16	29819563	29819563	C	G	exonic	MAZ	synonymous	BLCA\|1\|396\|0.00253,BRCA\|2\|982\|0.00204
-	chr16	29819148	29819148	C	T	exonic	MAZ	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr16	29821265	29821265	G	A	intronic	MAZ	unknown	CESC\|1\|194\|0.00515
-	chr16	29821441	29821441	G	T	exonic	MAZ	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs199924629	chr16	29821438	29821438	G	A	exonic	MAZ	synonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,DLBC\|1\|48\|0.02083,READ\|1\|122\|0.00820,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29821440	29821444	CGGCA	-	exonic	MAZ	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29819575	29819575	C	T	exonic	MAZ	synonymous	BLCA\|1\|396\|0.00253
rs1043766	chr16	29819984	29819984	C	T	exonic	MAZ	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs765655408	chr16	29820923	29820923	C	T	exonic	MAZ	nonsynonymous	UCEC\|1\|248\|0.00403
rs201662748	chr16	29821429	29821429	A	G	exonic	MAZ	synonymous	HNSC\|1\|512\|0.00195,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29820995	29820995	C	T	exonic	MAZ	stopgain	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr16	29821038	29821038	C	-	exonic	MAZ	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29820889	29820889	C	G	exonic	MAZ	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	29821459	29821459	A	G	exonic	MAZ	synonymous	HNSC\|1\|512\|0.00195
-	chr16	29821856	29821856	C	T	UTR3	MAZ	unknown	ESCA\|1\|185\|0.00541
-	chr16	29818686	29818686	C	G	exonic	MAZ	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr16	29818672	29818672	C	T	exonic	MAZ	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29821526	29821526	C	T	exonic	MAZ	stopgain	BRCA\|1\|982\|0.00102
rs772574677	chr16	29821005	29821005	-	G	exonic	MAZ	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs532656391	chr16	29821426	29821426	G	A	exonic	MAZ	synonymous	HNSC\|1\|512\|0.00195
rs773428203	chr16	29821503	29821503	C	T	exonic	MAZ	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29821985	29821986	TT	-	UTR3	MAZ	unknown	ESCA\|1\|185\|0.00541
-	chr16	29818144	29818144	C	G	exonic	MAZ	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	29818711	29818711	G	A	exonic	MAZ	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	29819011	29819011	C	T	exonic	MAZ	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr16	29818106	29818106	G	T	exonic	MAZ	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	29821983	29821983	-	T	UTR3	MAZ	unknown	ESCA\|1\|185\|0.00541
-	chr16	29819018	29819018	G	A	exonic	MAZ	synonymous	BLCA\|1\|396\|0.00253
rs34942081	chr16	29821017	29821017	C	-	exonic	MAZ	frameshift	STAD\|3\|395\|0.00759,STES\|3\|395\|0.00759
-	chr16	29819890	29819890	G	A	splicing	MAZ	splicing	CESC\|1\|194\|0.00515

Disease information of MAZ

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
MAZ	HIV Infections	C02;C20	Disease or Syndrome	CTD_human
MAZ	HIV Coinfection	C02;C20	Disease or Syndrome	CTD_human

Pathway associated with MAZ

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of MAZ

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GO_term_name	GO_term_type	TF_name
GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	MAZ

Survival analysis of MAZ

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of MAZ

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)