TF information
| TF name: | ATF3 |
| TF family: | TF_bZIP |
| Ensembl gene ID: | ENSG00000162772 |
| Ensembl protein ID: | ENSP00000355954, ENSP00000355948, ENSP00000480606, ENSP00000336908, ENSP00000432208, ENSP00000344352, ENSP00000355952, ENSP00000483576, ENSP00000355950 |
| Entrez gene ID: | 467 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of ATF3 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_168 | Cell line | Prostate | LNCaP | 0.14448669201521 |
| Sample_02_236 | Cell line | Colon | V206 | 0.2712215320911 |
| Sample_02_237 | Cell line | Colon | V389 | 0.27609055770293 |
| Sample_02_241 | Cell line | Colon | V456 | 0.36343115124153 |
| Sample_02_242 | Cell line | Colon | V481 | 0.32484137665833 |
| Sample_02_314 | Cell line | Neuroblastoma | SK-N-FI | 0.25308641975309 |
| Sample_02_319 | Cell line | Neuroblastoma | NB-EBc1 | 0.057803468208092 |
| Sample_02_430 | Cell line | Kidney | 12364284 | 0.19642857142857 |
ATF3 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_242 | Colon | Cell line | V481 |
ATF3 distribution in all CRCs
Genomic distribution of SEs associated with ATF3
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of ATF3
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr1 | 212788581 | 212788581 | G | A | exonic | ATF3 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr1 | 212792825 | 212792825 | G | C | exonic | ATF3 | nonsynonymous | STAD|2|395|0.00506,STES|2|395|0.00506 |
| - | chr1 | 212792856 | 212792856 | C | A | exonic | ATF3 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr1 | 212788511 | 212788511 | C | A | exonic | ATF3 | nonsynonymous | LUSC|1|178|0.00562 |
| rs774446012 | chr1 | 212788546 | 212788546 | G | A | exonic | ATF3 | synonymous | LUSC|1|178|0.00562 |
| - | chr1 | 212788549 | 212788549 | G | T | exonic | ATF3 | synonymous | HNSC|1|512|0.00195 |
| - | chr1 | 212788425 | 212788425 | C | G | exonic | ATF3 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr1 | 212792760 | 212792760 | A | C | exonic | ATF3 | nonsynonymous | UCS|1|57|0.01754 |
| - | chr1 | 212792763 | 212792763 | G | A | exonic | ATF3 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr1 | 212792799 | 212792799 | C | T | exonic | ATF3 | nonsynonymous | UCEC|1|248|0.00403 |
| rs555908176 | chr1 | 212792490 | 212792490 | G | A | UTR3 | ATF3 | unknown | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 212793751 | 212793751 | T | G | UTR3 | ATF3 | unknown | CESC|1|194|0.00515 |
| - | chr1 | 212788505 | 212788505 | G | A | exonic | ATF3 | nonsynonymous | PRAD|1|499|0.00200 |
| rs2229346 | chr1 | 212788567 | 212788567 | C | T | exonic | ATF3 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 212788387 | 212788387 | G | T | exonic | ATF3 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs142921239 | chr1 | 212793520 | 212793520 | G | A | UTR3 | ATF3 | unknown | BRCA|1|982|0.00102 |
| - | chr1 | 212788594 | 212788594 | A | - | exonic | ATF3 | frameshift | LIHC|2|373|0.00536 |
| - | chr1 | 212792728 | 212792728 | C | T | exonic | ATF3 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr1 | 212792438 | 212792438 | A | G | exonic | ATF3 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs760151080 | chr1 | 212791561 | 212791561 | G | A | exonic | ATF3 | synonymous | BRCA|2|982|0.00204 |
| - | chr1 | 212792935 | 212792935 | G | A | UTR3 | ATF3 | unknown | SARC|1|247|0.00405 |
| rs756952643 | chr1 | 212791502 | 212791502 | C | T | exonic | ATF3 | stopgain | PAAD|1|185|0.00541 |
| - | chr1 | 212788564 | 212788564 | C | T | exonic | ATF3 | synonymous | BRCA|1|982|0.00102 |
| - | chr1 | 212792849 | 212792849 | G | C | exonic | ATF3 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr1 | 212792748 | 212792748 | G | A | exonic | ATF3 | nonsynonymous | LIHC|1|373|0.00268 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| ATF3 | Alloxan Diabetes | C18;C19 | Experimental Model of Disease | CTD_human |
| ATF3 | Non-Small Cell Lung Carcinoma | C04;C08 | Neoplastic Process | CTD_human |
| ATF3 | Mental Depression | F01 | Mental or Behavioral Dysfunction | PSYGENET |
| ATF3 | Depressive disorder | F03 | Mental or Behavioral Dysfunction | PSYGENET |
| ATF3 | Diabetes Mellitus, Experimental | C18;C19 | Experimental Model of Disease | CTD_human |
| ATF3 | Diabetes Mellitus, Non-Insulin-Dependent | C18;C19 | Disease or Syndrome | CTD_human |
| ATF3 | Influenza | C02;C08 | Disease or Syndrome | CTD_human |
| ATF3 | Liver Cirrhosis, Experimental | C06 | Experimental Model of Disease | CTD_human |
| ATF3 | Liver neoplasms | C04;C06 | Neoplastic Process | CTD_human |
| ATF3 | nervous system disorder | C10 | Disease or Syndrome | CTD_human |
| ATF3 | Peripheral Neuropathy | C10 | Disease or Syndrome | CTD_human |
| ATF3 | Cardiomyopathies, Primary | C14 | Disease or Syndrome | CTD_human |
| ATF3 | Prostatic Neoplasms | C04;C12 | Neoplastic Process | CTD_human |
| ATF3 | Myocardial Diseases, Secondary | C14 | Disease or Syndrome | CTD_human |
| ATF3 | Streptozotocin Diabetes | C18;C19 | Experimental Model of Disease | CTD_human |
| ATF3 | Middle Cerebral Artery Syndrome | C10;C14 | Disease or Syndrome | CTD_human |
| ATF3 | Malignant neoplasm of liver | C04;C06 | Neoplastic Process | CTD_human |
| ATF3 | Malignant neoplasm of prostate | C04;C12 | Neoplastic Process | CTD_human |
| ATF3 | Middle Cerebral Artery Thrombosis | C10;C14 | Disease or Syndrome | CTD_human |
| ATF3 | Middle Cerebral Artery Occlusion | C10;C14 | Acquired Abnormality | CTD_human |
| ATF3 | Infarction, Middle Cerebral Artery | C10;C14 | Disease or Syndrome | CTD_human |
| ATF3 | Middle Cerebral Artery Embolus | C10;C14 | Disease or Syndrome | CTD_human |
| ATF3 | Left Middle Cerebral Artery Infarction | C10;C14 | Disease or Syndrome | CTD_human |
| ATF3 | Embolic Infarction, Middle Cerebral Artery | C10;C14 | Disease or Syndrome | CTD_human |
| ATF3 | Thrombotic Infarction, Middle Cerebral Artery | C10;C14 | Disease or Syndrome | CTD_human |
| ATF3 | Right Middle Cerebral Artery Infarction | C10;C14 | Disease or Syndrome | CTD_human |
| ATF3 | Hypospadias | C12;C13;C16 | Congenital Abnormality | CTD_human |
| ATF3 | Cardiomyopathies | C14 | Disease or Syndrome | CTD_human |
| ATF3 | ovarian neoplasm | C04;C13;C19 | Neoplastic Process | CTD_human |
| ATF3 | Malignant neoplasm of ovary | C04;C13;C19 | Neoplastic Process | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000187 | AP-1 transcription factor network | pid | 71 | 659 |
| pathway0000196 | Apoptosis signaling pathway | panther | 104 | 1308 |
| pathway0000229 | ATF-2 transcription factor network | pid | 59 | 451 |
| pathway0000230 | ATF4 activates genes | reactome | 25 | 112 |
| pathway0000343 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 | 304 |
| pathway0000347 | Calcium signaling in the CD4+ TCR pathway | pid | 29 | 153 |
| pathway0000608 | Direct p53 effectors | pid | 141 | 972 |
| pathway0001078 | ID | netpath | 38 | 213 |
| pathway0001849 | Regulation of nuclear SMAD2/3 signaling | pid | 82 | 1072 |
| pathway0002222 | TGF_beta_Receptor | netpath | 220 | 4100 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE | BP | ATF3 |
| GO_DENDRITIC_CELL_DIFFERENTIATION | BP | ATF3 |
| GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS | BP | ATF3 |
| GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER | BP | ATF3 |
| GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS | BP | ATF3 |
| GO_ER_NUCLEUS_SIGNALING_PATHWAY | BP | ATF3 |
| GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS | BP | ATF3 |
| GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE | BP | ATF3 |
| GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS | BP | ATF3 |
| GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS | BP | ATF3 |
| GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION | BP | ATF3 |
| GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE | BP | ATF3 |
| GO_GLUCOSE_METABOLIC_PROCESS | BP | ATF3 |
| GO_CELLULAR_RESPONSE_TO_STARVATION | BP | ATF3 |
| GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE | BP | ATF3 |
| GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION | BP | ATF3 |
| GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | BP | ATF3 |
| GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS | BP | ATF3 |
| GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER | BP | ATF3 |
| GO_MYELOID_DENDRITIC_CELL_ACTIVATION | BP | ATF3 |
| GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION | BP | ATF3 |
| GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN | BP | ATF3 |
| GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS | BP | ATF3 |
| GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING | MF | ATF3 |
| GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING | MF | ATF3 |
| GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY | MF | ATF3 |