Cancer CRCdb

TF information

TF name:	NFATC2
TF family:	RHD
Ensembl gene ID:	ENSG00000101096
Ensembl protein ID:	ENSP00000396471, ENSP00000379330, ENSP00000360619, ENSP00000477370, ENSP00000477342, ENSP00000477142
Entrez gene ID:	4773

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NFATC2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_069	Cell line	Brain	SF268	0.099236641221374
Sample_02_164	Cell line	Lung	H2087_Parental	0.083333333333333
Sample_02_180	Cell line	Human melanoma	CJM	0.0703125
Sample_02_181	Cell line	Human melanoma	COLO679	0.0688
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.81896551724138
Sample_02_322	Cell line	Colon	Caco-2	0.016150740242261
Sample_02_356	Cell line	Colon	Sw480	0.63870967741935
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.89855072463768

NFATC2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_182	Human melanoma	Cell line	LOX-IMVI
Sample_02_406	Mammary Gland	Cell line	ZR-75-30_parental

NFATC2 distribution in all CRCs

Genomic distribution of SEs associated with NFATC2

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Mutation of NFATC2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NFATC2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs561066890	chr20	50051779	50051779	C	T	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	50140170	50140170	G	A	exonic	NFATC2	stopgain	SKCM\|1\|368\|0.00272
-	chr20	50092014	50092014	T	G	exonic	NFATC2	nonsynonymous	CHOL\|1\|35\|0.02857,ESCA\|1\|185\|0.00541,SKCM\|1\|368\|0.00272
-	chr20	50139722	50139722	C	A	exonic	NFATC2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	50139989	50139989	G	A	exonic	NFATC2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs142272268	chr20	50048989	50048989	G	A	exonic	NFATC2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50158922	50158922	C	T	exonic	NFATC2	synonymous	HNSC\|1\|512\|0.00195
-	chr20	50140511	50140511	T	C	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50092010	50092010	T	-	exonic	NFATC2	frameshift	PAAD\|3\|185\|0.01622,SKCM\|1\|368\|0.00272
rs528842461	chr20	50048859	50048859	C	T	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs376937921	chr20	50139845	50139845	G	A	exonic	NFATC2	nonsynonymous	LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs781620004	chr20	50139819	50139819	-	G	exonic	NFATC2	frameshift	LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs773542213	chr20	50051821	50051821	G	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr20	50071220	50071220	G	A	exonic	NFATC2	stopgain	PAAD\|1\|185\|0.00541
rs867932067	chr20	50140605	50140605	C	T	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PAAD\|3\|185\|0.01622,UVM\|1\|80\|0.01250
-	chr20	50048808	50048808	C	T	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	50051770	50051770	C	A	exonic	NFATC2	nonsynonymous	LUAD\|2\|543\|0.00368
rs774669305	chr20	50139933	50139933	C	T	exonic	NFATC2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr20	50139941	50139941	G	A	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	50140113	50140113	G	A	exonic	NFATC2	stopgain	SKCM\|2\|368\|0.00543
-	chr20	50049117	50049117	A	G	exonic	NFATC2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	50140118	50140118	G	A	exonic	NFATC2	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr20	50090623	50090623	G	A	exonic	NFATC2	synonymous	UCEC\|1\|248\|0.00403
-	chr20	50139780	50139780	C	T	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs371747422	chr20	50139794	50139794	G	A	exonic	NFATC2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	50139946	50139946	C	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50158976	50158976	C	T	exonic	NFATC2	synonymous	LIHC\|1\|373\|0.00268
rs12479626	chr20	50092193	50092193	T	C	exonic	NFATC2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr20	50048882	50048882	G	A	exonic	NFATC2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	50139979	50139979	G	A	exonic	NFATC2	synonymous	UCEC\|1\|248\|0.00403
-	chr20	50159027	50159027	G	A	exonic	NFATC2	synonymous	SKCM\|2\|368\|0.00543
-	chr20	50140069	50140069	G	T	exonic	NFATC2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs768827421	chr20	50140530	50140530	-	G	exonic	NFATC2	frameshift	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr20	50071199	50071199	T	C	exonic	NFATC2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr20	50140551	50140551	T	C	exonic	NFATC2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs751261116	chr20	50139907	50139907	C	T	exonic	NFATC2	synonymous	UCS\|1\|57\|0.01754
-	chr20	50140311	50140311	C	T	exonic	NFATC2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	50048730	50048730	G	A	exonic	NFATC2	stopgain	UCEC\|1\|248\|0.00403
-	chr20	50007939	50007939	C	A	exonic	NFATC2	nonsynonymous	LUAD\|1\|543\|0.00184
rs374413124	chr20	50139752	50139752	C	T	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
rs752700803	chr20	50051757	50051757	C	T	exonic	NFATC2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	50092197	50092197	G	-	exonic	NFATC2	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr20	50048654	50048654	C	A	exonic	NFATC2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	50048652	50048652	C	-	exonic	NFATC2	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs751513686	chr20	50049200	50049200	G	A	exonic	NFATC2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs763306998	chr20	50007976	50007976	A	G	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	50133367	50133367	G	A	exonic	NFATC2	stopgain	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr20	50140512	50140512	C	A	exonic	NFATC2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	50071200	50071200	G	A	exonic	NFATC2	synonymous	LUSC\|1\|178\|0.00562
-	chr20	50139826	50139826	G	A	exonic	NFATC2	synonymous	BLCA\|1\|396\|0.00253
-	chr20	50090601	50090601	C	T	exonic	NFATC2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	50139969	50139969	G	A	exonic	NFATC2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs773854579	chr20	50048860	50048860	G	A	exonic	NFATC2	synonymous	BRCA\|1\|982\|0.00102
-	chr20	50140414	50140414	G	A	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
rs755321935	chr20	50007990	50007990	T	A	splicing	NFATC2	splicing	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr20	50139753	50139753	G	A	exonic	NFATC2	nonsynonymous	LUAD\|2\|543\|0.00368
rs541251947	chr20	50140049	50140049	C	T	exonic	NFATC2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	50049030	50049030	G	A	exonic	NFATC2	stopgain	HNSC\|1\|512\|0.00195
-	chr20	50140209	50140209	C	T	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs772742074	chr20	50049132	50049132	G	A	exonic	NFATC2	nonsynonymous	SKCM\|1\|368\|0.00272
rs768194029	chr20	50139825	50139825	G	A	exonic	NFATC2	nonsynonymous	SKCM\|2\|368\|0.00543
rs375019669	chr20	50091995	50091995	G	A	exonic	NFATC2	nonsynonymous	OV\|1\|469\|0.00213
-	chr20	50090554	50090554	G	T	exonic	NFATC2	synonymous	UVM\|1\|80\|0.01250
-	chr20	50139938	50139938	G	A	exonic	NFATC2	nonsynonymous	SKCM\|1\|368\|0.00272
rs146686251	chr20	50071158	50071158	G	A	exonic	NFATC2	synonymous	THCA\|1\|504\|0.00198
-	chr20	50051820	50051820	C	G	exonic	NFATC2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs780399979	chr20	50140064	50140064	G	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50092134	50092134	G	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50140650	50140650	C	T	splicing	NFATC2	splicing	BLCA\|1\|396\|0.00253
-	chr20	50140072	50140072	C	T	exonic	NFATC2	synonymous	HNSC\|2\|512\|0.00391
rs748148486	chr20	50092097	50092097	C	T	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCS\|1\|57\|0.01754
-	chr20	50139894	50139894	G	T	exonic	NFATC2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	50140440	50140440	C	A	exonic	NFATC2	stopgain	LUAD\|1\|543\|0.00184
-	chr20	50140360	50140360	C	T	exonic	NFATC2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr20	50049078	50049078	C	T	exonic	NFATC2	nonsynonymous	TGCT\|1\|155\|0.00645
rs750107839	chr20	50140616	50140616	G	A	exonic	NFATC2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	50139906	50139906	C	A	exonic	NFATC2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr20	50158922	50158922	C	G	exonic	NFATC2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	50090662	50090662	A	C	exonic	NFATC2	synonymous	LUAD\|1\|543\|0.00184
-	chr20	50048651	50048651	A	C	exonic	NFATC2	nonsynonymous	BRCA\|1\|982\|0.00102
rs768990056	chr20	50048947	50048947	C	G	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	50140068	50140068	C	T	exonic	NFATC2	nonsynonymous	ESCA\|1\|185\|0.00541,PRAD\|1\|499\|0.00200
-	chr20	50139803	50139803	C	A	exonic	NFATC2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	50049033	50049033	A	G	exonic	NFATC2	nonsynonymous	SKCM\|1\|368\|0.00272
rs765804863	chr20	50140171	50140171	C	T	exonic	NFATC2	synonymous	ESCA\|1\|185\|0.00541
-	chr20	50133334	50133334	G	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50048656	50048656	C	A	exonic	NFATC2	synonymous	LUAD\|1\|543\|0.00184
-	chr20	50090571	50090571	C	G	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	50048649	50048649	T	C	exonic	NFATC2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr20	50071118	50071118	C	T	exonic	NFATC2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs748599482	chr20	50139915	50139915	C	T	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs760093998	chr20	50133456	50133456	G	A	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs771443055	chr20	50049133	50049133	G	T	exonic	NFATC2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr20	50051746	50051746	G	A	exonic	NFATC2	stopgain	BLCA\|1\|396\|0.00253
-	chr20	50159027	50159027	G	-	exonic	NFATC2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50139662	50139662	G	T	exonic	NFATC2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	50140003	50140003	G	A	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
-	chr20	50139740	50139740	G	A	exonic	NFATC2	nonsynonymous	LUAD\|3\|543\|0.00552
-	chr20	50139887	50139887	G	C	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	50140461	50140461	A	G	exonic	NFATC2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr20	50133480	50133480	G	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50090599	50090599	C	G	exonic	NFATC2	synonymous	BRCA\|1\|982\|0.00102
-	chr20	50049146	50049146	G	T	exonic	NFATC2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr20	50048876	50048876	T	C	exonic	NFATC2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	50140112	50140112	C	T	exonic	NFATC2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	50049066	50049066	G	A	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs568487915	chr20	50140459	50140459	C	T	exonic	NFATC2	synonymous	OV\|1\|469\|0.00213
-	chr20	50048638	50048638	C	T	exonic	NFATC2	synonymous	HNSC\|1\|512\|0.00195
-	chr20	50140566	50140566	A	G	exonic	NFATC2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	50049221	50049221	A	G	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	50049142	50049142	G	C	exonic	NFATC2	nonsynonymous	SARC\|1\|247\|0.00405
rs774864876	chr20	50139763	50139763	G	A	exonic	NFATC2	synonymous	CESC\|1\|194\|0.00515
-	chr20	50048694	50048694	C	T	exonic	NFATC2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr20	50139646	50139646	C	T	exonic	NFATC2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs758439316	chr20	50049108	50049108	C	T	exonic	NFATC2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs201848514	chr20	50140011	50140011	C	T	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195
rs200028027	chr20	50091994	50091994	C	T	splicing	NFATC2	splicing	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	50051813	50051813	C	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs768655246	chr20	50139715	50139715	G	A	exonic	NFATC2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	50140575	50140575	G	A	exonic	NFATC2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs199948885	chr20	50048815	50048815	G	A	exonic	NFATC2	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr20	50048630	50048630	T	C	exonic	NFATC2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	50140482	50140482	C	T	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	50139925	50139925	G	A	exonic	NFATC2	synonymous	LUAD\|1\|543\|0.00184
-	chr20	50049244	50049244	G	A	exonic	NFATC2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs779382116	chr20	50048903	50048903	G	A	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253,DLBC\|1\|48\|0.02083,ESCA\|1\|185\|0.00541,HNSC\|1\|512\|0.00195,LUAD\|1\|543\|0.00184,LUSC\|1\|178\|0.00562
-	chr20	50051837	50051837	A	G	exonic	NFATC2	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr20	50133389	50133389	G	A	exonic	NFATC2	synonymous	HNSC\|1\|512\|0.00195
-	chr20	50092156	50092156	G	A	exonic	NFATC2	synonymous	BLCA\|1\|396\|0.00253
-	chr20	50158912	50158912	C	T	exonic	NFATC2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr20	50051765	50051765	C	G	exonic	NFATC2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr20	50133356	50133356	G	A	exonic	NFATC2	synonymous	BLCA\|1\|396\|0.00253
-	chr20	50140079	50140079	C	T	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50071192	50071192	T	C	exonic	NFATC2	nonsynonymous	PAAD\|1\|185\|0.00541
rs762633017	chr20	50139950	50139950	G	A	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195
rs201617985	chr20	50007937	50007937	G	A	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	50158908	50158908	C	T	splicing	NFATC2	splicing	SKCM\|1\|368\|0.00272
-	chr20	50007935	50007935	A	G	exonic	NFATC2	stoploss	UCEC\|1\|248\|0.00403
-	chr20	50092153	50092153	G	T	exonic	NFATC2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr20	50049292	50049292	G	A	exonic	NFATC2	synonymous	LUSC\|1\|178\|0.00562
rs148642400	chr20	50007936	50007936	C	T	exonic	NFATC2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr20	50048864	50048864	C	A	exonic	NFATC2	nonsynonymous	LUAD\|1\|543\|0.00184
rs753968378	chr20	50049180	50049180	C	T	exonic	NFATC2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr20	50139652	50139652	G	-	exonic	NFATC2	frameshift	HNSC\|1\|512\|0.00195
-	chr20	50140465	50140465	-	A	exonic	NFATC2	frameshift	ESCA\|1\|185\|0.00541
rs61735418	chr20	50139876	50139876	C	A	exonic	NFATC2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr20	50139710	50139710	T	G	exonic	NFATC2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr20	50140431	50140431	G	C	exonic	NFATC2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr20	50140149	50140149	G	C	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	50139727	50139727	G	A	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
rs558006319	chr20	50049127	50049127	C	T	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
-	chr20	50051848	50051848	T	C	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253
rs772973119	chr20	50139988	50139988	C	T	exonic	NFATC2	synonymous	UCEC\|1\|248\|0.00403
rs758351007	chr20	50049181	50049181	G	A	exonic	NFATC2	synonymous	ESCA\|1\|185\|0.00541
-	chr20	50071174	50071174	C	T	exonic	NFATC2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr20	50092025	50092025	G	T	exonic	NFATC2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr20	50140613	50140613	G	A	exonic	NFATC2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr20	50140306	50140306	G	A	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
-	chr20	50159030	50159030	G	A	exonic	NFATC2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50090640	50090640	G	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50048686	50048686	C	A	exonic	NFATC2	synonymous	LUAD\|1\|543\|0.00184
-	chr20	50049190	50049190	C	G	exonic	NFATC2	synonymous	BLCA\|1\|396\|0.00253
-	chr20	50140350	50140350	C	T	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	50140386	50140386	C	T	exonic	NFATC2	nonsynonymous	LUSC\|1\|178\|0.00562
rs781647966	chr20	50139839	50139839	G	A	exonic	NFATC2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	50090672	50090672	A	G	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213
rs745343071	chr20	50140540	50140540	G	A	exonic	NFATC2	synonymous	HNSC\|2\|512\|0.00391
-	chr20	50140128	50140128	G	C	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	50140026	50140026	G	A	exonic	NFATC2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	50090652	50090652	C	T	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs775920655	chr20	50090678	50090678	G	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50139701	50139701	C	A	exonic	NFATC2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	50140492	50140492	C	G	exonic	NFATC2	nonsynonymous	HNSC\|2\|512\|0.00391
rs553983994	chr20	50048703	50048703	C	T	exonic	NFATC2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr20	50092056	50092056	T	G	exonic	NFATC2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr20	50139830	50139830	C	T	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	50140318	50140318	G	C	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
-	chr20	50159018	50159018	C	T	exonic	NFATC2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs777716877	chr20	50140534	50140534	G	A	exonic	NFATC2	synonymous	LUAD\|1\|543\|0.00184
-	chr20	50092036	50092036	G	A	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
-	chr20	50140414	50140414	G	C	exonic	NFATC2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	50139769	50139769	G	A	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
-	chr20	50048821	50048821	C	T	exonic	NFATC2	synonymous	HNSC\|1\|512\|0.00195
-	chr20	50179163	50179163	C	T	exonic	NFATC2	synonymous	CESC\|1\|194\|0.00515
-	chr20	50048801	50048801	G	A	exonic	NFATC2	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr20	50139887	50139887	G	A	exonic	NFATC2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,ESCA\|1\|185\|0.00541
-	chr20	50092041	50092041	T	C	exonic	NFATC2	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr20	50133368	50133368	G	A	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
rs759897941	chr20	50140351	50140351	G	A	exonic	NFATC2	synonymous	BRCA\|1\|982\|0.00102
-	chr20	50133422	50133422	C	T	exonic	NFATC2	synonymous	UCEC\|1\|248\|0.00403
-	chr20	50048763	50048763	G	A	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272
rs759670807	chr20	50139893	50139893	G	T	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	50158928	50158928	C	G	exonic	NFATC2	nonsynonymous	OV\|1\|469\|0.00213
-	chr20	50140246	50140246	G	T	exonic	NFATC2	nonsynonymous	BLCA\|1\|396\|0.00253
rs556060763	chr20	50140514	50140514	G	A	exonic	NFATC2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
rs373570203	chr20	50048864	50048864	C	T	exonic	NFATC2	nonsynonymous	PAAD\|1\|185\|0.00541
rs142900177	chr20	50051780	50051780	G	A	exonic	NFATC2	synonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50133469	50133469	G	C	exonic	NFATC2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr20	50049280	50049280	C	T	exonic	NFATC2	synonymous	BLCA\|1\|396\|0.00253
-	chr20	50139944	50139944	G	T	exonic	NFATC2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr20	50048661	50048675	GTAATACTTCCTTTT	-	exonic	NFATC2	nonframeshift	LIHC\|1\|373\|0.00268
-	chr20	50051813	50051813	C	-	exonic	NFATC2	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr20	50139798	50139798	C	T	exonic	NFATC2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr20	50071134	50071134	C	-	exonic	NFATC2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	50133394	50133394	G	A	exonic	NFATC2	nonsynonymous	HNSC\|1\|512\|0.00195
rs774757283	chr20	50158937	50158937	G	A	exonic	NFATC2	synonymous	BLCA\|1\|396\|0.00253
-	chr20	50048713	50048713	G	A	exonic	NFATC2	synonymous	BLCA\|1\|396\|0.00253
-	chr20	50051831	50051831	G	A	exonic	NFATC2	synonymous	BLCA\|1\|396\|0.00253
rs774111681	chr20	50092117	50092117	G	A	exonic	NFATC2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	50049163	50049163	G	A	exonic	NFATC2	synonymous	SKCM\|1\|368\|0.00272

Disease information of NFATC2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
NFATC2	Pulmonary Hypertension	C08	Pathologic Function	CTD_human
NFATC2	nervous system disorder	C10	Disease or Syndrome	CTD_human

Pathway associated with NFATC2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000259	Axon guidance mediated by netrin	panther	30	253
pathway0000343	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	pid	50	304
pathway0000347	Calcium signaling in the CD4+ TCR pathway	pid	29	153
pathway0000450	CLEC7A (Dectin-1) induces NFAT activation	reactome	13	73
pathway0000767	Fc-epsilon receptor I signaling in mast cells	pid	64	826
pathway0000770	FCERI mediated Ca+2 mobilization	reactome	41	606
pathway0001117	IL12 signaling mediated by STAT4	pid	33	229
pathway0001121	IL2 signaling events mediated by PI3K	pid	38	397
pathway0001506	Noncanonical Wnt signaling pathway	pid	33	181
pathway0001935	Role of Calcineurin-dependent NFAT signaling in lymphocytes	pid	54	450
pathway0002031	Signaling by Wnt	reactome	10	33
pathway0002392	Validated transcriptional targets of AP1 family members Fra1 and Fra2	pid	37	165
pathway0002733	Hs_T-Cell_antigen_Receptor_(TCR)_pathway_during_Staphylococcus_aureus_infection_WP3863_90702	wikipathways	35	218
pathway0002783	Hs_Cardiac_Hypertrophic_Response_WP2795_85087	wikipathways	23	82

Go term information of NFATC2

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GO_term_name	GO_term_type	TF_name
GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION	BP	NFATC2
GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION	BP	NFATC2
GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION	BP	NFATC2
GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION	BP	NFATC2
GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION	BP	NFATC2
GO_CALCIUM_MEDIATED_SIGNALING	BP	NFATC2
GO_CYTOKINE_PRODUCTION	BP	NFATC2
GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION	BP	NFATC2
GO_FC_RECEPTOR_SIGNALING_PATHWAY	BP	NFATC2
GO_PROTEIN_SUMOYLATION	BP	NFATC2
GO_REGULATION_OF_B_CELL_ACTIVATION	BP	NFATC2
GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION	BP	NFATC2
GO_REGULATION_OF_MYOBLAST_FUSION	BP	NFATC2
GO_REGULATION_OF_B_CELL_PROLIFERATION	BP	NFATC2
GO_MYOTUBE_DIFFERENTIATION	BP	NFATC2
GO_MYOTUBE_CELL_DEVELOPMENT	BP	NFATC2
GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING	BP	NFATC2
GO_MUSCLE_CELL_DEVELOPMENT	BP	NFATC2
GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY	BP	NFATC2

Survival analysis of NFATC2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NFATC2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)