Cancer CRCdb

TF information

TF name:	MECOM
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000085276
Ensembl protein ID:	ENSP00000420072, ENSP00000419770, ENSP00000417299, ENSP00000394302, ENSP00000417506, ENSP00000420466, ENSP00000486104, ENSP00000417922, ENSP00000420048, ENSP00000264674, ENSP00000419757, ENSP00000417899, ENSP00000419995
Entrez gene ID:	2122

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of MECOM in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_021	Cell line	Colon	V429	0.12827904295186
Sample_02_080	Cell line	Lung	Calu-3	0.40909090909091
Sample_02_114	Cell line	Mammary Gland	CAL51	0.19597989949749
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.074074074074074
Sample_02_236	Cell line	Colon	V206	0.53623188405797
Sample_02_237	Cell line	Colon	V389	0.11205595435303
Sample_02_242	Cell line	Colon	V481	0.18871370890213
Sample_02_285	Cell line	Liver	HuH7_untreat	0.069686411149826
Sample_02_361	Cell line	Colon	HT29_DMSO	0.14159292035398

MECOM distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_080	Lung	Cell line	Calu-3
Sample_02_236	Colon	Cell line	V206

MECOM distribution in all CRCs

Genomic distribution of SEs associated with MECOM

Download

Mutation of MECOM

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MECOM

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr3	168838939	168838939	C	T	exonic	MECOM	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs750896996	chr3	168802736	168802736	C	T	exonic	MECOM	synonymous	BRCA\|1\|982\|0.00102
-	chr3	168833867	168833867	C	T	exonic	MECOM	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	168834204	168834204	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168812977	168812977	C	T	exonic	MECOM	nonsynonymous	HNSC\|1\|512\|0.00195
rs201825977	chr3	168802737	168802737	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs757020094	chr3	169099271	169099271	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168834131	168834131	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168807896	168807896	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	169099087	169099087	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168813030	168813030	G	A	exonic	MECOM	synonymous	BRCA\|1\|982\|0.00102
-	chr3	168834210	168834210	C	T	exonic	MECOM	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168807822	168807822	C	T	exonic	MECOM	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	168840409	168840409	G	T	exonic	MECOM	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr3	168833913	168833913	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168807957	168807957	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168833682	168833682	C	G	exonic	MECOM	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168834323	168834323	G	T	exonic	MECOM	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	168813013	168813013	G	A	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	168810745	168810745	C	A	splicing	MECOM	splicing	LIHC\|1\|373\|0.00268
-	chr3	168833862	168833862	C	G	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	168861605	168861605	A	-	exonic	MECOM	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168838947	168838947	G	T	exonic	MECOM	synonymous	HNSC\|1\|512\|0.00195
rs188482846	chr3	168845829	168845829	G	A	exonic	MECOM	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs865872961	chr3	169099040	169099040	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168810858	168810858	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	169309473	169309473	-	GTCGA	intronic	MECOM	unknown	-
-	chr3	169099121	169099121	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	169099149	169099149	G	A	exonic	MECOM	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168807855	168807855	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168833219	168833219	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168833196	168833196	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168802722	168802722	G	A	exonic	MECOM	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	168834483	168834483	G	T	exonic	MECOM	nonsynonymous	UCEC\|2\|248\|0.00806
-	chr3	168838969	168838969	C	T	exonic	MECOM	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs750090830	chr3	168802733	168802733	C	T	exonic	MECOM	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168833569	168833569	G	A	exonic	MECOM	synonymous	SKCM\|2\|368\|0.00543
-	chr3	168833929	168833931	TGA	-	exonic	MECOM	nonframeshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	169099283	169099283	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168838978	168838978	T	C	exonic	MECOM	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168818726	168818726	C	T	exonic	MECOM	synonymous	UCEC\|1\|248\|0.00403
-	chr3	168838922	168838922	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	169099225	169099225	T	C	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	168845696	168845722	GATCATTCTCGCTTTCGAGTTTTTGCT	-	exonic	MECOM	nonframeshift	-
-	chr3	168834173	168834173	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168810787	168810787	G	C	exonic	MECOM	nonsynonymous	LUSC\|1\|178\|0.00562
rs773080349	chr3	168833257	168833257	T	-	exonic	MECOM	frameshift	BRCA\|2\|982\|0.00204,COAD\|14\|367\|0.03815,COADREAD\|14\|489\|0.02863,ESCA\|1\|185\|0.00541,PAAD\|2\|185\|0.01081,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs771927221	chr3	168849256	168849256	C	T	exonic	MECOM	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUSC\|1\|178\|0.00562
-	chr3	168833388	168833388	G	A	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168807797	168807797	G	T	exonic	MECOM	nonsynonymous	PRAD\|1\|499\|0.00200
rs761913499	chr3	168864307	168864307	C	T	UTR5	MECOM	unknown	SKCM\|1\|368\|0.00272
-	chr3	168819908	168819908	G	A	exonic	MECOM	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr3	168812894	168812894	G	A	exonic	MECOM	synonymous	UCEC\|1\|248\|0.00403
rs779331325	chr3	168810844	168810844	C	T	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168845663	168845663	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168849266	168849266	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	169381144	169381144	C	T	exonic	MECOM	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	168830627	168830627	G	T	exonic	MECOM	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	168807816	168807816	C	A	exonic	MECOM	stopgain	HNSC\|1\|512\|0.00195
rs753395114	chr3	168833285	168833285	C	T	exonic	MECOM	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	168833715	168833715	C	G	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	168806964	168806964	C	T	exonic	MECOM	nonsynonymous	SARC\|1\|247\|0.00405
-	chr3	168833394	168833394	G	C	exonic	MECOM	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	168802758	168802758	C	T	exonic	MECOM	stopgain	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	168833226	168833226	C	G	exonic	MECOM	nonsynonymous	CESC\|1\|194\|0.00515
-	chr3	168830606	168830606	C	A	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
rs267599685	chr3	168834197	168834197	G	A	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168833655	168833655	C	A	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
rs570291681	chr3	169099230	169099230	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168806945	168806945	C	G	exonic	MECOM	nonsynonymous	LIHC\|1\|373\|0.00268
rs774213367	chr3	168834168	168834168	C	T	exonic	MECOM	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	169099286	169099286	G	A	exonic	MECOM	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168807858	168807858	C	A	exonic	MECOM	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168838981	168838981	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	169099182	169099182	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168819948	168819948	C	T	exonic	MECOM	nonsynonymous	CESC\|1\|194\|0.00515
-	chr3	168833467	168833467	C	T	exonic	MECOM	synonymous	SKCM\|2\|368\|0.00543
-	chr3	168834113	168834113	G	C	exonic	MECOM	stopgain	BLCA\|1\|396\|0.00253
rs375314275	chr3	168833702	168833702	G	A	exonic	MECOM	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	168810803	168810803	C	A	exonic	MECOM	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	168834376	168834376	C	T	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
rs147788700	chr3	168840423	168840423	C	T	exonic	MECOM	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168819910	168819910	C	A	exonic	MECOM	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	168838988	168838988	C	T	exonic	MECOM	nonsynonymous	SARC\|1\|247\|0.00405
-	chr3	168807841	168807841	A	G	exonic	MECOM	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	169099072	169099072	C	T	exonic	MECOM	nonsynonymous	SKCM\|3\|368\|0.00815
-	chr3	168819859	168819859	G	A	exonic	MECOM	synonymous	LIHC\|1\|373\|0.00268
-	chr3	168819903	168819903	G	A	exonic	MECOM	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	168834254	168834254	T	C	exonic	MECOM	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	168819924	168819924	T	C	exonic	MECOM	nonsynonymous	OV\|1\|469\|0.00213
-	chr3	168834507	168834507	A	G	exonic	MECOM	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	168819864	168819864	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168833494	168833494	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168834474	168834474	G	A	exonic	MECOM	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	168802767	168802767	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168834410	168834410	G	C	exonic	MECOM	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	168807967	168807967	G	A	exonic	MECOM	synonymous	BRCA\|1\|982\|0.00102
-	chr3	168812960	168812960	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
rs771184600	chr3	168833244	168833244	C	T	exonic	MECOM	nonsynonymous	SKCM\|3\|368\|0.00815
-	chr3	168840516	168840516	C	T	splicing	MECOM	splicing	SKCM\|1\|368\|0.00272
rs756402551	chr3	168833245	168833245	G	A	exonic	MECOM	synonymous	UCEC\|1\|248\|0.00403
-	chr3	168833757	168833762	TATTAT	-	exonic	MECOM	nonframeshift	PAAD\|1\|185\|0.00541
-	chr3	168838844	168838844	A	C	exonic	MECOM	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	168849314	168849314	G	-	exonic	MECOM	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	169381209	169381209	C	A	UTR5	MECOM	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168833806	168833806	C	A	exonic	MECOM	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs368981948	chr3	168833509	168833509	C	T	exonic	MECOM	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168861552	168861552	G	C	exonic	MECOM	synonymous	BLCA\|1\|396\|0.00253
-	chr3	168833635	168833635	T	A	exonic	MECOM	synonymous	LUAD\|1\|543\|0.00184
-	chr3	168840403	168840403	T	A	exonic	MECOM	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	168830619	168830619	C	G	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	168833688	168833688	C	A	exonic	MECOM	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	168806963	168806963	T	C	exonic	MECOM	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs866698177	chr3	168810796	168810796	G	A	exonic	MECOM	synonymous	SKCM\|2\|368\|0.00543
-	chr3	168849246	168849246	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
rs745981639	chr3	168833870	168833870	G	A	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	169099085	169099085	C	A	exonic	MECOM	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	168833510	168833510	G	A	exonic	MECOM	nonsynonymous	SKCM\|3\|368\|0.00815
-	chr3	168807883	168807883	C	T	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
rs755819303	chr3	168833417	168833417	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
rs202240336	chr3	168838909	168838909	G	A	exonic	MECOM	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	169099312	169099312	T	G	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168833803	168833803	G	A	exonic	MECOM	synonymous	HNSC\|1\|512\|0.00195
-	chr3	168833604	168833604	-	T	exonic	MECOM	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs199555172	chr3	168825738	168825738	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168834306	168834306	C	A	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
rs761171278	chr3	169099133	169099133	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168806817	168806817	G	T	exonic	MECOM	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	168834234	168834234	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168833460	168833460	G	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	169381319	169381319	C	T	UTR5	MECOM	unknown	BRCA\|1\|982\|0.00102
-	chr3	168840444	168840444	T	A	exonic	MECOM	nonsynonymous	LIHC\|1\|373\|0.00268
rs748747672	chr3	168838897	168838897	G	A	exonic	MECOM	nonsynonymous	BRCA\|1\|982\|0.00102,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|2\|368\|0.00543
-	chr3	169099123	169099123	A	C	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	168834185	168834185	G	A	exonic	MECOM	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	168840402	168840402	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168833639	168833639	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	169099103	169099103	G	C	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	169099249	169099249	C	T	exonic	MECOM	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	169099220	169099220	G	A	exonic	MECOM	stopgain	BLCA\|1\|396\|0.00253
-	chr3	168807793	168807793	T	C	exonic	MECOM	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs116535717	chr3	168861536	168861536	C	T	exonic	MECOM	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs745329183	chr3	168840424	168840424	G	A	exonic	MECOM	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr3	168812899	168812899	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
rs150481592	chr3	168845679	168845679	C	T	exonic	MECOM	synonymous	PAAD\|1\|185\|0.00541,SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168840481	168840481	T	-	exonic	MECOM	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168845847	168845847	T	G	exonic	MECOM	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	169098995	169098995	C	A	exonic	MECOM	nonsynonymous	OV\|1\|469\|0.00213
-	chr3	168819935	168819935	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168861491	168861491	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168834174	168834174	G	A	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168807995	168807995	T	-	exonic	MECOM	frameshift	PRAD\|1\|499\|0.00200
rs770124328	chr3	168833701	168833701	C	T	exonic	MECOM	synonymous	BRCA\|1\|982\|0.00102
-	chr3	169099127	169099127	G	T	exonic	MECOM	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	168845701	168845701	T	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
rs756700169	chr3	168810803	168810803	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
rs774868800	chr3	168833869	168833869	C	T	exonic	MECOM	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	168838959	168838959	G	A	exonic	MECOM	synonymous	HNSC\|1\|512\|0.00195
-	chr3	168802779	168802779	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168834457	168834457	G	C	exonic	MECOM	nonsynonymous	CESC\|1\|194\|0.00515
-	chr3	168833289	168833289	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168834351	168834351	C	A	exonic	MECOM	stopgain	HNSC\|1\|512\|0.00195
-	chr3	169089960	169089979	GTTCGAAAGAAGAAAACTAA	-	intronic	MECOM	unknown	-
-	chr3	169381201	169381201	T	-	UTR5	MECOM	unknown	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr3	168833529	168833529	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168825717	168825717	A	G	exonic	MECOM	synonymous	LUSC\|1\|178\|0.00562
rs758678191	chr3	169099049	169099049	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168833780	168833780	T	G	exonic	MECOM	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	168807914	168807914	T	A	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	168813034	168813034	C	G	splicing	MECOM	splicing	SKCM\|1\|368\|0.00272
-	chr3	168813034	168813034	C	A	splicing	MECOM	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168833312	168833312	G	T	exonic	MECOM	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	169099259	169099259	C	G	exonic	MECOM	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	168838941	168838941	G	T	exonic	MECOM	synonymous	HNSC\|1\|512\|0.00195
-	chr3	169099121	169099121	G	C	exonic	MECOM	nonsynonymous	ESCA\|1\|185\|0.00541
rs540158912	chr3	168810878	168810878	G	A	exonic	MECOM	nonsynonymous	PRAD\|2\|499\|0.00401,SKCM\|1\|368\|0.00272
-	chr3	168833622	168833622	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168819859	168819859	G	T	exonic	MECOM	synonymous	ESCA\|1\|185\|0.00541
-	chr3	168833573	168833573	G	A	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
rs779967808	chr3	168806927	168806927	T	C	exonic	MECOM	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	168833844	168833844	C	T	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	168807903	168807903	T	C	exonic	MECOM	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	168845829	168845829	G	T	exonic	MECOM	stopgain	BLCA\|1\|396\|0.00253
-	chr3	168802789	168802789	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168833344	168833348	GGGCT	-	exonic	MECOM	frameshift	BLCA\|1\|396\|0.00253
rs759927166	chr3	168834490	168834490	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168833838	168833838	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
rs140021434	chr3	168833248	168833248	G	A	exonic	MECOM	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	168834378	168834378	C	T	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253,SKCM\|1\|368\|0.00272
-	chr3	168833184	168833184	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168812877	168812877	A	T	exonic	MECOM	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr3	168834289	168834289	A	T	exonic	MECOM	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs142755875	chr3	169099050	169099050	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
rs750702658	chr3	168833396	168833396	G	A	exonic	MECOM	nonsynonymous	ESCA\|1\|185\|0.00541
rs149892422	chr3	168845834	168845834	G	A	exonic	MECOM	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	168830641	168830641	A	G	exonic	MECOM	synonymous	LUSC\|1\|178\|0.00562
-	chr3	168834004	168834004	C	T	exonic	MECOM	synonymous	SKCM\|2\|368\|0.00543
-	chr3	168807915	168807915	C	T	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	168818731	168818731	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
rs772780683	chr3	168838947	168838947	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168807854	168807854	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168807953	168807953	T	C	exonic	MECOM	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	168810761	168810761	C	T	exonic	MECOM	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	168812908	168812908	T	C	exonic	MECOM	nonsynonymous	OV\|1\|469\|0.00213
-	chr3	168812978	168812978	G	A	exonic	MECOM	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr3	168845735	168845735	C	T	exonic	MECOM	nonsynonymous	LUSC\|1\|178\|0.00562
rs547084047	chr3	169099125	169099125	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168834350	168834350	C	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
rs770726960	chr3	168838908	168838908	C	T	exonic	MECOM	synonymous	UCEC\|1\|248\|0.00403
-	chr3	168833581	168833581	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168845762	168845762	T	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168807868	168807868	A	T	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	168838894	168838894	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168834261	168834261	C	A	exonic	MECOM	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	168861618	168861618	G	A	exonic	MECOM	synonymous	SKCM\|2\|368\|0.00543
-	chr3	168834410	168834410	G	A	exonic	MECOM	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	168825727	168825727	T	A	exonic	MECOM	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr3	168833626	168833626	C	T	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168806893	168806893	C	T	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168833655	168833655	-	A	exonic	MECOM	frameshift	LUSC\|1\|178\|0.00562
-	chr3	168812874	168812874	C	T	exonic	MECOM	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	168834404	168834404	G	A	exonic	MECOM	nonsynonymous	SKCM\|3\|368\|0.00815
-	chr3	168838875	168838875	-	TGTG	exonic	MECOM	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168833340	168833340	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168833251	168833251	G	-	exonic	MECOM	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs770124328	chr3	168833701	168833701	C	A	exonic	MECOM	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs766090691	chr3	168833263	168833263	T	C	exonic	MECOM	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168834494	168834494	G	A	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168834386	168834387	CT	-	exonic	MECOM	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168845848	168845848	T	C	exonic	MECOM	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs780293564	chr3	168834009	168834009	C	T	exonic	MECOM	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	168819875	168819875	C	T	exonic	MECOM	nonsynonymous	PRAD\|3\|499\|0.00601
-	chr3	168833560	168833560	A	-	exonic	MECOM	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr3	168834399	168834399	T	A	exonic	MECOM	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	168838893	168838893	C	T	exonic	MECOM	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168840502	168840502	T	G	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	168849232	168849232	C	T	exonic	MECOM	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	168818709	168818709	C	T	exonic	MECOM	nonsynonymous	UCEC\|2\|248\|0.00806
rs753180534	chr3	168849290	168849290	C	T	exonic	MECOM	synonymous	BRCA\|3\|982\|0.00305
-	chr3	168819922	168819922	C	T	exonic	MECOM	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168830608	168830608	C	A	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	168833916	168833916	G	T	exonic	MECOM	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	168845836	168845836	T	C	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	168810804	168810804	G	A	exonic	MECOM	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168840452	168840452	C	A	exonic	MECOM	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs748021716	chr3	168838887	168838887	G	A	exonic	MECOM	synonymous	BLCA\|1\|396\|0.00253
rs780473763	chr3	168830631	168830631	C	G	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	168864352	168864352	G	C	UTR5	MECOM	unknown	BLCA\|1\|396\|0.00253
-	chr3	168813010	168813010	A	T	exonic	MECOM	nonsynonymous	SARC\|1\|247\|0.00405
-	chr3	168819869	168819869	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
rs376930807	chr3	169099029	169099029	C	T	exonic	MECOM	synonymous	LUAD\|1\|543\|0.00184
rs267599684	chr3	168833264	168833264	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168834252	168834252	A	C	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	168807887	168807887	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168840508	168840508	T	C	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	168807843	168807843	C	T	exonic	MECOM	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	169099128	169099128	G	A	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168834501	168834501	G	A	exonic	MECOM	stopgain	BLCA\|1\|396\|0.00253
-	chr3	168845771	168845771	G	A	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
rs762099223	chr3	168833597	168833597	G	T	exonic	MECOM	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	168810878	168810878	G	-	exonic	MECOM	frameshift	ESCA\|1\|185\|0.00541
rs139044661	chr3	168833255	168833255	C	T	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168849229	168849229	G	A	exonic	MECOM	nonsynonymous	SARC\|1\|247\|0.00405
rs775007213	chr3	168849257	168849257	G	A	exonic	MECOM	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|2\|820\|0.00244,LGG\|1\|530\|0.00189
-	chr3	168818719	168818719	T	C	exonic	MECOM	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	168834358	168834358	C	G	exonic	MECOM	synonymous	PRAD\|2\|499\|0.00401
-	chr3	169099103	169099103	G	A	exonic	MECOM	stopgain	UCEC\|1\|248\|0.00403
-	chr3	168808021	168808021	C	T	exonic	MECOM	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs376191747	chr3	168806813	168806813	G	A	exonic	MECOM	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	168818745	168818745	C	G	exonic	MECOM	nonsynonymous	LUAD\|1\|543\|0.00184
rs778191764	chr3	168845770	168845770	G	A	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	168830608	168830608	C	G	exonic	MECOM	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	169099256	169099256	C	A	exonic	MECOM	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	168802820	168802820	C	T	exonic	MECOM	nonsynonymous	PRAD\|1\|499\|0.00200
rs267599686	chr3	168834324	168834324	G	A	exonic	MECOM	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	169099056	169099056	C	T	exonic	MECOM	synonymous	SKCM\|1\|368\|0.00272
-	chr3	168806814	168806814	G	T	exonic	MECOM	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	168840366	168840366	A	G	splicing	MECOM	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	168834418	168834418	G	C	exonic	MECOM	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	168834483	168834483	G	C	exonic	MECOM	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	168834343	168834343	A	-	exonic	MECOM	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168834235	168834235	A	C	exonic	MECOM	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr3	169099207	169099207	G	T	exonic	MECOM	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	168833983	168833983	G	A	exonic	MECOM	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	168845645	168845645	G	A	exonic	MECOM	nonsynonymous	SKCM\|3\|368\|0.00815
-	chr3	169099148	169099148	-	G	exonic	MECOM	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs150819501	chr3	168838970	168838970	G	A	exonic	MECOM	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	169099264	169099264	A	G	exonic	MECOM	nonsynonymous	THYM\|1\|123\|0.00813
-	chr3	168834464	168834464	G	A	exonic	MECOM	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs185054275	chr3	168838896	168838896	C	A	exonic	MECOM	synonymous	HNSC\|2\|512\|0.00391,LIHC\|1\|373\|0.00268
-	chr3	168834302	168834302	T	C	exonic	MECOM	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs149928659	chr3	168833976	168833976	C	T	exonic	MECOM	nonsynonymous	DLBC\|1\|48\|0.02083,HNSC\|1\|512\|0.00195

Disease information of MECOM

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
MECOM	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
MECOM	Malignant tumor of colon	C04;C06	Neoplastic Process	CTD_human
MECOM	Colonic Neoplasms	C04;C06	Neoplastic Process	CTD_human
MECOM	Lymphoid leukemia	C04;C15;C20	Neoplastic Process	CTD_human
MECOM	Leukemia, Monocytic, Chronic	C04	Neoplastic Process	CTD_human
MECOM	Myeloid Leukemia	C04	Neoplastic Process	CTD_human
MECOM	Myelodysplasia		Congenital Abnormality	ORPHANET
MECOM	Nasopharyngeal Neoplasms	C04;C07;C09	Neoplastic Process	CTD_human
MECOM	Pancytopenia	C15	Disease or Syndrome	CTD_human
MECOM	Splenomegaly	C23	Finding	CTD_human
MECOM	Cancer of Nasopharynx	C04;C07;C09	Neoplastic Process	CTD_human
MECOM	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
MECOM	ovarian neoplasm	C04;C13;C19	Neoplastic Process	CTD_human
MECOM	Malignant neoplasm of ovary	C04;C13;C19	Neoplastic Process	CTD_human
MECOM	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
MECOM	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
MECOM	Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia	C05;C15;C16	Disease or Syndrome	ORPHANET
MECOM	MYELODYSPLASTIC SYNDROME	C15	Neoplastic Process	ORPHANET
MECOM	RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 2		Disease or Syndrome	UNIPROT

Pathway associated with MECOM

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002667	Chronic myeloid leukemia	kegg	69	881
pathway0002755	Hs_White_fat_cell_differentiation_WP3946_90940	wikipathways	30	59

Go term information of MECOM

Download

GO_term_name	GO_term_type	TF_name
GO_HISTONE_METHYLATION	BP	MECOM
GO_STEM_CELL_PROLIFERATION	BP	MECOM
GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION	BP	MECOM
GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS	BP	MECOM
GO_NEGATIVE_REGULATION_OF_JNK_CASCADE	BP	MECOM
GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE	BP	MECOM
GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS	BP	MECOM
GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY	BP	MECOM
GO_METHYLATION	BP	MECOM
GO_AGGRESOME	CC	MECOM
GO_HISTONE_DEACETYLASE_COMPLEX	CC	MECOM
GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY	MF	MECOM
GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY	MF	MECOM
GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY	MF	MECOM
GO_HISTONE_METHYLTRANSFERASE_ACTIVITY	MF	MECOM

Survival analysis of MECOM

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of MECOM

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)