Cancer CRCdb

TF information

TF name:	KLF7
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000118263
Ensembl protein ID:	ENSP00000387510, ENSP00000393268, ENSP00000309570, ENSP00000403284
Entrez gene ID:	8609

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of KLF7 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_006	Other	Cervical	cervical-cancer_parental	0.25
Sample_02_161	Cell line	Brain	U87	0.4
Sample_02_168	Cell line	Prostate	LNCaP	0.39543726235741
Sample_02_179	Cell line	Urinary bladder	T24	0.48275862068966
Sample_02_181	Cell line	Human melanoma	COLO679	0.25973333333333
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.44252873563218
Sample_02_220	Cell line	Brain	BE2C_1	0.52564102564103
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.65555555555556
Sample_02_268	Cell line	Kidney	A-498	0.32859516337456
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.075
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.51185921958684
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.76712328767123
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.33812949640288
Sample_02_300	Cell line	Neuroblastoma	CLB-PE	0.3974358974359
Sample_02_302	Cell line	Neuroblastoma	IMR32	0.35714285714286
Sample_02_303	Cell line	Neuroblastoma	LAN1	0.45714285714286
Sample_02_304	Cell line	Neuroblastoma	N206	0.48097826086957
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.98591549295775
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.984375
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.34123222748815
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.4259501965924
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.28571428571429
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.49468085106383
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.38610038610039
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.66666666666667
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.37837837837838
Sample_02_318	Cell line	Neuroblastoma	NB69	0.4921875
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.41040462427746
Sample_02_338	Cell line	Neuroblastoma	BE2	0.58823529411765
Sample_02_395	Cell line	Mammary Gland	BT-549	0.098461538461538

KLF7 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_182	Human melanoma	Cell line	LOX-IMVI
Sample_02_220	Brain	Cell line	BE2C_1
Sample_02_258	Lung	Other	NCI-H1299_EGFP-NEO_reporter_cells_DMSO
Sample_02_268	Kidney	Cell line	A-498
Sample_02_296	Neuroblastoma	Cell line	CLB-BER-Lud
Sample_02_298	Neuroblastoma	Cell line	CLB-GA
Sample_02_302	Neuroblastoma	Cell line	IMR32
Sample_02_304	Neuroblastoma	Cell line	N206
Sample_02_307	Neuroblastoma	Cell line	SJNB12
Sample_02_308	Neuroblastoma	Cell line	SJNB1
Sample_02_310	Neuroblastoma	Cell line	SJNB8
Sample_02_312	Neuroblastoma	Cell line	SK-N-BE_2-C
Sample_02_314	Neuroblastoma	Cell line	SK-N-FI
Sample_02_318	Neuroblastoma	Cell line	NB69
Sample_02_319	Neuroblastoma	Cell line	NB-EBc1
Sample_02_338	Neuroblastoma	Cell line	BE2

KLF7 distribution in all CRCs

Genomic distribution of SEs associated with KLF7

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Mutation of KLF7

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of KLF7

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs761636754	chr2	207988820	207988820	C	T	exonic	KLF7	synonymous	PRAD\|1\|499\|0.00200
-	chr2	207953304	207953304	A	G	exonic	KLF7	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	207945972	207945972	C	G	exonic	KLF7	nonsynonymous	BRCA\|1\|982\|0.00102
rs770650535	chr2	207989096	207989096	C	G	exonic	KLF7	synonymous	HNSC\|1\|512\|0.00195
-	chr2	207953206	207953206	G	A	exonic	KLF7	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	207953263	207953263	C	T	exonic	KLF7	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs2284934	chr2	207998800	207998800	C	T	exonic	KLF7	synonymous	BRCA\|1\|982\|0.00102
-	chr2	207945783	207945783	A	-	UTR3	KLF7	unknown	ESCA\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,THYM\|1\|123\|0.00813
-	chr2	207988671	207988671	G	A	exonic	KLF7	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	207989028	207989028	G	-	exonic	KLF7	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	207953246	207953246	C	A	exonic	KLF7	stopgain	UCEC\|1\|248\|0.00403
-	chr2	207989085	207989085	C	A	exonic	KLF7	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	207988910	207988910	C	A	exonic	KLF7	nonsynonymous	UCEC\|1\|248\|0.00403
rs758251787	chr2	207988664	207988664	C	T	exonic	KLF7	synonymous	ESCA\|1\|185\|0.00541
-	chr2	207953279	207953279	C	T	exonic	KLF7	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	207945962	207945962	G	C	exonic	KLF7	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	207988643	207988643	A	G	exonic	KLF7	synonymous	ESCA\|1\|185\|0.00541
-	chr2	207988945	207988945	C	A	exonic	KLF7	nonsynonymous	ACC\|1\|90\|0.01111
-	chr2	207988804	207988804	C	A	exonic	KLF7	stopgain	LUAD\|1\|543\|0.00184
rs536720710	chr2	207988858	207988858	C	T	exonic	KLF7	nonsynonymous	THCA\|1\|504\|0.00198
-	chr2	208030252	208030252	T	C	exonic	KLF7	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	207988717	207988717	C	A	exonic	KLF7	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	207988766	207988766	G	A	exonic	KLF7	synonymous	SKCM\|1\|368\|0.00272
-	chr2	207989096	207989096	C	T	exonic	KLF7	synonymous	UCEC\|1\|248\|0.00403
-	chr2	207988724	207988724	C	T	exonic	KLF7	synonymous	BLCA\|1\|396\|0.00253
-	chr2	208030260	208030260	C	T	exonic	KLF7	synonymous	SKCM\|1\|368\|0.00272
-	chr2	207953303	207953303	C	T	exonic	KLF7	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	207988567	207988567	G	C	exonic	KLF7	nonsynonymous	HNSC\|1\|512\|0.00195
rs780771483	chr2	207988633	207988633	C	T	exonic	KLF7	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	207988824	207988824	A	T	exonic	KLF7	stopgain	BRCA\|1\|982\|0.00102
-	chr2	207988572	207988572	C	T	exonic	KLF7	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	207988583	207988583	C	A	exonic	KLF7	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	207989075	207989075	C	T	exonic	KLF7	synonymous	UCEC\|1\|248\|0.00403
-	chr2	207988530	207988530	G	T	exonic	KLF7	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs371003779	chr2	207988552	207988552	G	A	exonic	KLF7	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs181473470	chr2	207953238	207953238	C	T	exonic	KLF7	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	207953210	207953210	T	C	exonic	KLF7	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	207988812	207988812	G	A	exonic	KLF7	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,HNSC\|1\|512\|0.00195
-	chr2	207988869	207988869	C	T	exonic	KLF7	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs761995114	chr2	207988594	207988594	C	T	exonic	KLF7	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	207945960	207945960	G	A	exonic	KLF7	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	208030259	208030259	C	T	exonic	KLF7	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,SKCM\|1\|368\|0.00272
-	chr2	207953272	207953272	C	A	exonic	KLF7	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	207988762	207988762	-	G	exonic	KLF7	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	207945785	207945785	-	GTG	UTR3	KLF7	unknown	ESCA\|1\|185\|0.00541
-	chr2	207988586	207988586	C	A	exonic	KLF7	nonsynonymous	UCEC\|1\|248\|0.00403
rs201005804	chr2	207988559	207988559	G	A	exonic	KLF7	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,UCEC\|1\|248\|0.00403

Disease information of KLF7

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with KLF7

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002689	Hs_Cytokines_and_Inflammatory_Response_WP530_79331	wikipathways	21	53

Go term information of KLF7

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GO_term_name	GO_term_type	TF_name
GO_DENDRITE_DEVELOPMENT	BP	KLF7
GO_DENDRITE_MORPHOGENESIS	BP	KLF7
GO_LOCOMOTION	BP	KLF7
GO_NEURON_PROJECTION_GUIDANCE	BP	KLF7

Survival analysis of KLF7

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of KLF7

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)