Cancer CRCdb

TF information

TF name:	KLF4
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000136826
Ensembl protein ID:	ENSP00000363804, ENSP00000483629
Entrez gene ID:	9314

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of KLF4 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_059	Cell line	Lung	PC-9	0.26666666666667
Sample_01_068	Cell line	Prostate: derived from metastatic site: vertebral metastasis	VCaP	0.13698630136986
Sample_02_021	Cell line	Colon	V429	0.54309599308158
Sample_02_161	Cell line	Brain	U87	0.4
Sample_02_164	Cell line	Lung	H2087_Parental	0.18333333333333
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.444
Sample_02_180	Cell line	Human melanoma	CJM	0.3125
Sample_02_196	Cell line	Stomach	NCC59	0.85714285714286
Sample_02_236	Cell line	Colon	V206	0.3064182194617
Sample_02_237	Cell line	Colon	V389	0.32770108595619
Sample_02_241	Cell line	Colon	V456	0.051918735891648
Sample_02_268	Cell line	Kidney	A-498	0.47055565811335
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.6

KLF4 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_021	Colon	Cell line	V429
Sample_02_166	Mammary Gland	Cell line	HCC1954_Parental
Sample_02_196	Stomach	Cell line	NCC59
Sample_02_236	Colon	Cell line	V206
Sample_02_268	Kidney	Cell line	A-498

KLF4 distribution in all CRCs

Genomic distribution of SEs associated with KLF4

Download

Mutation of KLF4

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of KLF4

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr9	110249507	110249507	C	T	intronic	KLF4	unknown	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs45596731	chr9	110249415	110249415	T	C	exonic	KLF4	synonymous	DLBC\|1\|48\|0.02083
-	chr9	110249990	110249990	A	G	exonic	KLF4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	110249364	110249364	G	A	exonic	KLF4	synonymous	PAAD\|1\|185\|0.00541
rs774893122	chr9	110248119	110248119	C	T	exonic	KLF4	synonymous	SKCM\|2\|368\|0.00543
-	chr9	110249902	110249902	C	T	exonic	KLF4	nonsynonymous	PAAD\|1\|185\|0.00541
rs747114701	chr9	110249393	110249393	C	T	exonic	KLF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	110249982	110249982	C	T	exonic	KLF4	synonymous	BLCA\|1\|396\|0.00253
-	chr9	110248040	110248040	G	T	exonic	KLF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr9	110251299	110251299	C	T	exonic	KLF4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	110250158	110250158	A	G	exonic	KLF4	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr9	110249387	110249387	G	T	exonic	KLF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	110250387	110250387	G	A	exonic	KLF4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	110249642	110249642	C	T	exonic	KLF4	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr9	110249615	110249615	C	T	exonic	KLF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr9	110249405	110249405	G	A	exonic	KLF4	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr9	110249601	110249601	C	T	exonic	KLF4	synonymous	SARC\|1\|247\|0.00405
rs749653127	chr9	110250325	110250325	G	A	exonic	KLF4	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr9	110249711	110249711	C	G	exonic	KLF4	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr9	110250242	110250242	G	T	exonic	KLF4	nonsynonymous	PRAD\|2\|499\|0.00401
-	chr9	110249759	110249759	G	A	exonic	KLF4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr9	110249362	110249362	C	T	exonic	KLF4	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr9	110249341	110249341	G	T	exonic	KLF4	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr9	110251328	110251328	C	T	exonic	KLF4	synonymous	UCEC\|1\|248\|0.00403
-	chr9	110249589	110249589	C	T	exonic	KLF4	synonymous	UCEC\|2\|248\|0.00806
rs768093198	chr9	110249616	110249616	G	C	exonic	KLF4	synonymous	LUAD\|1\|543\|0.00184
-	chr9	110250469	110250469	G	C	exonic	KLF4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr9	110249864	110249864	G	A	exonic	KLF4	nonsynonymous	SKCM\|1\|368\|0.00272
rs781269132	chr9	110250473	110250473	C	T	exonic	KLF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	110249348	110249348	T	G	exonic	KLF4	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr9	110249327	110249327	G	A	exonic	KLF4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	110251228	110251228	C	A	exonic	KLF4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr9	110249774	110249774	C	A	exonic	KLF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr9	110250404	110250404	G	T	exonic	KLF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	110249444	110249444	C	A	exonic	KLF4	stopgain	UCEC\|1\|248\|0.00403
-	chr9	110250290	110250290	A	G	exonic	KLF4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	110249369	110249369	C	A	exonic	KLF4	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr9	110250280	110250280	G	C	exonic	KLF4	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr9	110249965	110249965	G	A	exonic	KLF4	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr9	110249863	110249863	G	A	exonic	KLF4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr9	110250484	110250484	T	A	exonic	KLF4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	110248160	110248160	C	A	exonic	KLF4	nonsynonymous	LUAD\|3\|543\|0.00552
-	chr9	110248154	110248154	A	C	exonic	KLF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr9	110249755	110249755	-	G	exonic	KLF4	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	110249320	110249320	C	T	exonic	KLF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	110249793	110249793	G	A	exonic	KLF4	synonymous	HNSC\|1\|512\|0.00195
-	chr9	110250264	110250264	C	T	exonic	KLF4	synonymous	SKCM\|1\|368\|0.00272
-	chr9	110250239	110250239	A	C	exonic	KLF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs767308895	chr9	110251228	110251228	C	T	exonic	KLF4	nonsynonymous	UCEC\|1\|248\|0.00403
rs747308187	chr9	110250031	110250031	G	A	exonic	KLF4	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr9	110249778	110249778	C	T	exonic	KLF4	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr9	110249330	110249330	C	T	exonic	KLF4	nonsynonymous	UCEC\|1\|248\|0.00403
rs867964623	chr9	110248069	110248069	G	A	exonic	KLF4	nonsynonymous	LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	110248112	110248112	G	A	exonic	KLF4	nonsynonymous	BLCA\|1\|396\|0.00253,UCEC\|1\|248\|0.00403
-	chr9	110249674	110249674	A	G	exonic	KLF4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr9	110248208	110248208	C	A	splicing	KLF4	splicing	PAAD\|1\|185\|0.00541
-	chr9	110249320	110249320	C	A	exonic	KLF4	nonsynonymous	THCA\|1\|504\|0.00198
-	chr9	110249590	110249590	G	T	exonic	KLF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr9	110250112	110250112	G	A	exonic	KLF4	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr9	110251264	110251293	ACGCGAACGTGGAGAAAGATGGGAGCAGCG	-	exonic	KLF4	nonframeshift	ACC\|1\|90\|0.01111
-	chr9	110249346	110249346	C	G	exonic	KLF4	nonsynonymous	BLCA\|2\|396\|0.00505,PRAD\|1\|499\|0.00200
-	chr9	110249810	110249810	C	A	exonic	KLF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr9	110249648	110249648	G	T	exonic	KLF4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr9	110249798	110249798	G	A	exonic	KLF4	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr9	110249719	110249719	-	G	exonic	KLF4	frameshift	PAAD\|1\|185\|0.00541
-	chr9	110250458	110250458	C	T	exonic	KLF4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr9	110250404	110250404	G	A	exonic	KLF4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs761126579	chr9	110249974	110249974	G	A	exonic	KLF4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr9	110248186	110248186	T	A	exonic	KLF4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204

Disease information of KLF4

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
KLF4	Congenital Abnormality	C16	Congenital Abnormality	CTD_human
KLF4	Congenital Heart Defects	C14;C16	Congenital Abnormality	CTD_human
KLF4	Meningioma	C04;C10	Neoplastic Process	CGI
KLF4	Thrombosis	C14	Pathologic Function	CTD_human
KLF4	Juvenile-Onset Still Disease	C05;C17;C20	Disease or Syndrome	CTD_human
KLF4	Thrombus	C14	Pathologic Function	CTD_human
KLF4	Myocardial Ischemia	C14	Disease or Syndrome	CTD_human
KLF4	Juvenile arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
KLF4	Juvenile psoriatic arthritis	C05;C17;C20	Disease or Syndrome	CTD_human

Pathway associated with KLF4

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001848	Regulation of nuclear beta catenin signaling and target gene transcription	pid	80	611
pathway0002180	Synthesis, secretion, and deacylation of Ghrelin	reactome	17	39
pathway0002301	Transcriptional regulation of pluripotent stem cells	reactome	28	184
pathway0002302	Transcriptional regulation of white adipocyte differentiation	reactome	79	1522
pathway0002726	Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525	wikipathways	9	11
pathway0002755	Hs_White_fat_cell_differentiation_WP3946_90940	wikipathways	30	59
pathway0002826	Hs_Mesodermal_Commitment_Pathway_WP2857_87780	wikipathways	47	175

Go term information of KLF4

Download

GO_term_name	GO_term_type	TF_name
GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE	BP	KLF4
GO_EPIDERMIS_MORPHOGENESIS	BP	KLF4
GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS	BP	KLF4
GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY	BP	KLF4
GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION	BP	KLF4
GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING	BP	KLF4
GO_RESPONSE_TO_FLUID_SHEAR_STRESS	BP	KLF4
GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION	BP	KLF4
GO_POSITIVE_REGULATION_OF_BINDING	BP	KLF4
GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION	BP	KLF4
GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS	BP	KLF4
GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS	BP	KLF4
GO_NEGATIVE_REGULATION_OF_LOCOMOTION	BP	KLF4
GO_REGULATION_OF_DEFENSE_RESPONSE	BP	KLF4
GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS	BP	KLF4
GO_WNT_SIGNALING_PATHWAY	BP	KLF4
GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE	BP	KLF4
GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS	BP	KLF4
GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY	BP	KLF4
GO_POSITIVE_REGULATION_OF_DNA_BINDING	BP	KLF4
GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY	BP	KLF4
GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER	BP	KLF4
GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS	BP	KLF4
GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY	BP	KLF4
GO_CANONICAL_WNT_SIGNALING_PATHWAY	BP	KLF4
GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS	BP	KLF4
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION	BP	KLF4
GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING	BP	KLF4
GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE	BP	KLF4
GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION	BP	KLF4
GO_REGULATION_OF_DNA_BINDING	BP	KLF4
GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS	BP	KLF4
GO_REGULATION_OF_LIPID_KINASE_ACTIVITY	BP	KLF4
GO_REGULATION_OF_CHEMOKINE_PRODUCTION	BP	KLF4
GO_GASTRULATION	BP	KLF4
GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS	BP	KLF4
GO_MESODERM_MORPHOGENESIS	BP	KLF4
GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE	BP	KLF4
GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY	BP	KLF4
GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS	BP	KLF4
GO_REGULATION_OF_GASTRULATION	BP	KLF4
GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION	BP	KLF4
GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION	BP	KLF4
GO_MESODERMAL_CELL_DIFFERENTIATION	BP	KLF4
GO_REGULATION_OF_CELL_CELL_ADHESION	BP	KLF4
GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION	BP	KLF4
GO_CELL_FATE_DETERMINATION	BP	KLF4
GO_CELL_FATE_COMMITMENT	BP	KLF4
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING	BP	KLF4
GO_CELLULAR_RESPONSE_TO_KETONE	BP	KLF4
GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS	BP	KLF4
GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION	BP	KLF4
GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY	BP	KLF4
GO_CELLULAR_RESPONSE_TO_ALCOHOL	BP	KLF4
GO_SENSORY_ORGAN_DEVELOPMENT	BP	KLF4
GO_REGULATION_OF_INFLAMMATORY_RESPONSE	BP	KLF4
GO_CELLULAR_RESPONSE_TO_PEPTIDE	BP	KLF4
GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS	BP	KLF4
GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION	BP	KLF4
GO_REGULATION_OF_SPROUTING_ANGIOGENESIS	BP	KLF4
GO_REGULATION_OF_MUSCLE_ADAPTATION	BP	KLF4
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING	BP	KLF4
GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING	BP	KLF4
GO_MESODERMAL_CELL_FATE_COMMITMENT	BP	KLF4
GO_REGULATION_OF_TELOMERASE_ACTIVITY	BP	KLF4
GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES	BP	KLF4
GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS	BP	KLF4
GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT	BP	KLF4
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS	BP	KLF4
GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES	BP	KLF4
GO_TRANSCRIPTION_FACTOR_COMPLEX	CC	KLF4
GO_NUCLEAR_EUCHROMATIN	CC	KLF4
GO_EUCHROMATIN	CC	KLF4
GO_CORE_PROMOTER_BINDING	MF	KLF4
GO_TRANSCRIPTION_COFACTOR_BINDING	MF	KLF4
GO_DOUBLE_STRANDED_DNA_BINDING	MF	KLF4

Survival analysis of KLF4

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of KLF4

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)