Cancer CRCdb

TF information

TF name:	HOXB3
TF family:	Homeobox
Ensembl gene ID:	ENSG00000120093
Ensembl protein ID:	ENSP00000418035, ENSP00000417207, ENSP00000418729, ENSP00000308252, ENSP00000420595, ENSP00000418892, ENSP00000449977, ENSP00000419676
Entrez gene ID:	3213

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of HOXB3 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.27602905569007
Sample_02_114	Cell line	Mammary Gland	CAL51	0.38693467336683
Sample_02_250	Tissue	Brain	tumormodel3691	0.15625
Sample_02_355	Cell line	Colon	HCT15	0.1547619047619
Sample_02_356	Cell line	Colon	Sw480	0.56774193548387
Sample_02_358	Cell line	Colon	LS180	0.40481832543444
Sample_02_395	Cell line	Mammary Gland	BT-549	0.21594405594406
Sample_02_424	Cell line	Colon	SW620	0.15942028985507

HOXB3 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_358	Colon	Cell line	LS180

HOXB3 distribution in all CRCs

Genomic distribution of SEs associated with HOXB3

Download

Mutation of HOXB3

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HOXB3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr17	46629586	46629586	G	A	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46628473	46628473	G	A	exonic	HOXB3	synonymous	UCEC\|1\|248\|0.00403
-	chr17	46628488	46628488	G	A	exonic	HOXB3	synonymous	PRAD\|1\|499\|0.00200
-	chr17	46627999	46627999	C	T	exonic	HOXB3	synonymous	HNSC\|1\|512\|0.00195
-	chr17	46628270	46628270	A	C	exonic	HOXB3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	46628440	46628440	C	-	exonic	HOXB3	frameshift	HNSC\|1\|512\|0.00195
-	chr17	46628044	46628044	G	A	exonic	HOXB3	synonymous	ESCA\|1\|185\|0.00541,PAAD\|1\|185\|0.00541
-	chr17	46629754	46629754	C	A	exonic	HOXB3	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	46629585	46629585	C	A	exonic	HOXB3	synonymous	UCEC\|1\|248\|0.00403
rs764323967	chr17	46627830	46627830	C	T	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
rs374434430	chr17	46628458	46628458	C	T	exonic	HOXB3	synonymous	SKCM\|2\|368\|0.00543
rs761755598	chr17	46629478	46629478	C	T	exonic	HOXB3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	46629702	46629702	G	A	exonic	HOXB3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46627923	46627923	C	A	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46628422	46628422	C	T	exonic	HOXB3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46629511	46629511	G	T	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
rs762708970	chr17	46629749	46629749	C	G	exonic	HOXB3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	46628219	46628219	C	-	exonic	HOXB3	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	46629580	46629580	G	A	exonic	HOXB3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46629704	46629704	C	T	exonic	HOXB3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	46628304	46628304	G	A	exonic	HOXB3	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	46627789	46627789	G	A	exonic	HOXB3	synonymous	UCEC\|1\|248\|0.00403
rs781526391	chr17	46628230	46628230	C	T	exonic	HOXB3	synonymous	HNSC\|1\|512\|0.00195
-	chr17	46627925	46627925	C	-	exonic	HOXB3	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46628160	46628160	C	-	exonic	HOXB3	frameshift	BLCA\|1\|396\|0.00253
-	chr17	46629792	46629792	G	A	exonic	HOXB3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46628308	46628308	G	A	exonic	HOXB3	synonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46627744	46627744	A	G	exonic	HOXB3	synonymous	ESCA\|1\|185\|0.00541
-	chr17	46627701	46627701	G	T	splicing	HOXB3	splicing	LUAD\|1\|543\|0.00184
-	chr17	46627847	46627847	C	T	exonic	HOXB3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	46628422	46628422	C	A	exonic	HOXB3	synonymous	LUSC\|1\|178\|0.00562
-	chr17	46627775	46627775	G	A	exonic	HOXB3	nonsynonymous	SKCM\|1\|368\|0.00272
rs766032924	chr17	46628218	46628218	-	C	exonic	HOXB3	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	46629778	46629778	G	T	exonic	HOXB3	stopgain	LUSC\|1\|178\|0.00562
-	chr17	46628303	46628303	C	A	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46628027	46628027	G	T	exonic	HOXB3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	46628343	46628343	G	C	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46627865	46627865	A	G	exonic	HOXB3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	46628242	46628242	C	A	exonic	HOXB3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46628442	46628442	C	A	exonic	HOXB3	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	46628327	46628327	G	A	exonic	HOXB3	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr17	46627838	46627838	T	G	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46628504	46628504	C	T	exonic	HOXB3	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr17	46628225	46628225	G	T	exonic	HOXB3	stopgain	LUAD\|1\|543\|0.00184
-	chr17	46629725	46629725	G	C	exonic	HOXB3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	46628126	46628126	G	-	exonic	HOXB3	frameshift	LUAD\|1\|543\|0.00184
-	chr17	46629716	46629716	T	C	exonic	HOXB3	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr17	46628070	46628070	A	-	exonic	HOXB3	frameshift	SKCM\|1\|368\|0.00272
-	chr17	46628343	46628343	G	A	exonic	HOXB3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	46628524	46628524	G	A	exonic	HOXB3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46629658	46629658	G	T	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46629396	46629396	G	-	exonic	HOXB3	frameshift	BRCA\|1\|982\|0.00102,PAAD\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46629749	46629749	C	T	exonic	HOXB3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	46628146	46628146	C	G	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
rs745805494	chr17	46629806	46629806	C	T	exonic	HOXB3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	46627726	46627726	G	A	exonic	HOXB3	synonymous	SKCM\|2\|368\|0.00543
-	chr17	46628211	46628211	G	A	exonic	HOXB3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	46628479	46628479	A	G	exonic	HOXB3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46629646	46629646	G	T	exonic	HOXB3	nonsynonymous	UCEC\|1\|248\|0.00403
rs771928715	chr17	46629736	46629736	-	G	exonic	HOXB3	frameshift	BRCA\|2\|982\|0.00204,COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46628468	46628468	C	T	exonic	HOXB3	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	46628038	46628038	C	T	exonic	HOXB3	synonymous	BRCA\|1\|982\|0.00102
-	chr17	46628315	46628315	T	C	exonic	HOXB3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	46629656	46629656	C	T	exonic	HOXB3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	46627737	46627737	G	A	exonic	HOXB3	stopgain	CESC\|1\|194\|0.00515,SKCM\|1\|368\|0.00272
-	chr17	46629516	46629516	G	A	exonic	HOXB3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46628332	46628332	C	T	exonic	HOXB3	synonymous	BLCA\|1\|396\|0.00253
-	chr17	46629614	46629614	T	G	exonic	HOXB3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs756705326	chr17	46629701	46629701	C	T	exonic	HOXB3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	46628008	46628008	C	T	exonic	HOXB3	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs775438305	chr17	46629737	46629737	G	-	exonic	HOXB3	frameshift	COAD\|4\|367\|0.01090,COADREAD\|4\|489\|0.00818,ESCA\|1\|185\|0.00541,STAD\|4\|395\|0.01013,STES\|4\|395\|0.01013
-	chr17	46627823	46627823	G	T	exonic	HOXB3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs559346033	chr17	46628518	46628518	A	G	exonic	HOXB3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs557227249	chr17	46628509	46628509	G	A	exonic	HOXB3	synonymous	LUAD\|1\|543\|0.00184
-	chr17	46629484	46629484	C	A	exonic	HOXB3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46629594	46629594	C	A	exonic	HOXB3	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr17	46627892	46627892	C	A	exonic	HOXB3	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr17	46628102	46628102	G	A	exonic	HOXB3	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr17	46627846	46627846	C	T	exonic	HOXB3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46627886	46627886	G	C	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46628188	46628188	G	A	exonic	HOXB3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46628451	46628451	T	A	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46629486	46629486	G	A	exonic	HOXB3	synonymous	PCPG\|1\|184\|0.00543,THCA\|1\|504\|0.00198
-	chr17	46628425	46628425	C	A	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46628019	46628019	G	T	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46628218	46628218	G	C	exonic	HOXB3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46629478	46629478	C	A	exonic	HOXB3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs189100448	chr17	46629746	46629746	C	A	exonic	HOXB3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	46628160	46628160	C	T	exonic	HOXB3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46628527	46628527	G	A	exonic	HOXB3	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	46629400	46629400	G	A	exonic	HOXB3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	46628302	46628302	C	T	exonic	HOXB3	synonymous	PAAD\|1\|185\|0.00541
-	chr17	46627995	46627995	C	T	exonic	HOXB3	nonsynonymous	PAAD\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46628222	46628222	C	T	exonic	HOXB3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	46629818	46629818	A	G	exonic	HOXB3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs200719688	chr17	46628177	46628177	G	A	exonic	HOXB3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46629421	46629421	G	A	exonic	HOXB3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	46627825	46627825	C	T	exonic	HOXB3	synonymous	PRAD\|1\|499\|0.00200
-	chr17	46628435	46628435	G	T	exonic	HOXB3	nonsynonymous	PRAD\|2\|499\|0.00401

Disease information of HOXB3

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
HOXB3	Diaphragmatic Hernia	C23	Anatomical Abnormality	CTD_human

Pathway associated with HOXB3

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of HOXB3

Download

GO_term_name	GO_term_type	TF_name
GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS	BP	HOXB3
GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION	BP	HOXB3
GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING	BP	HOXB3
GO_CRANIAL_NERVE_MORPHOGENESIS	BP	HOXB3
GO_CRANIAL_NERVE_DEVELOPMENT	BP	HOXB3
GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION	BP	HOXB3
GO_EMBRYONIC_ORGAN_MORPHOGENESIS	BP	HOXB3
GO_FACE_DEVELOPMENT	BP	HOXB3
GO_NERVE_DEVELOPMENT	BP	HOXB3
GO_CONNECTIVE_TISSUE_DEVELOPMENT	BP	HOXB3
GO_DEFINITIVE_HEMOPOIESIS	BP	HOXB3
GO_SKELETAL_SYSTEM_MORPHOGENESIS	BP	HOXB3
GO_THYROID_GLAND_DEVELOPMENT	BP	HOXB3
GO_CORE_PROMOTER_BINDING	MF	HOXB3
GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	HOXB3

Survival analysis of HOXB3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of HOXB3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)