1. TF detail

TF information

TF name: FOXO3
TF family: Fork_head
Ensembl gene ID: ENSG00000118689
Ensembl protein ID: ENSP00000339527, ENSP00000385824
Entrez gene ID: 2309
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:
Frequency of FOXO3 in all biosamples
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Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_007OtherCervicalcervical-cancer_vector0.62582781456954
Sample_02_241Cell lineColonV4560.31151241534989
Sample_02_298Cell lineNeuroblastomaCLB-GA0.34246575342466
Sample_02_299Cell lineNeuroblastomaCLB-MA0.48201438848921
Sample_02_300Cell lineNeuroblastomaCLB-PE0.46153846153846
Sample_02_303Cell lineNeuroblastomaLAN10.94285714285714
Sample_02_313Cell lineNeuroblastomaSK-N-DZ0.996138996139
Sample_02_314Cell lineNeuroblastomaSK-N-FI0.50617283950617
Sample_02_317Cell lineNeuroblastomaGICAN0.67567567567568
Sample_02_413TissueBrainGBM_24930.1978021978022
FOXO3 distribution in samples’ most representative CRC
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Sample ID Tissue type Biosample type Biosample name
Sample_02_007CervicalOthercervical-cancer_vector
Sample_02_299NeuroblastomaCell lineCLB-MA
Sample_02_303NeuroblastomaCell lineLAN1
Sample_02_313NeuroblastomaCell lineSK-N-DZ
Sample_02_314NeuroblastomaCell lineSK-N-FI
Sample_02_317NeuroblastomaCell lineGICAN
FOXO3 distribution in all CRCs
Biosample type
Biosample name
Sample ID
Genomic distribution of SEs associated with FOXO3
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Mutation of FOXO3
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Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of FOXO3

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
rs752765431chr6108984964108984964CTexonicFOXO3nonsynonymous SKCM|1|368|0.00272
rs767271331chr6108985623108985623CTexonicFOXO3synonymous BLCA|1|396|0.00253
-chr6108984758108984758GCexonicFOXO3nonsynonymous ESCA|1|185|0.00541
-chr6108984970108984970CTexonicFOXO3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6108984826108984826CAexonicFOXO3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs202151097chr6108985226108985226CGexonicFOXO3nonsynonymous BLCA|1|396|0.00253
-chr6108985392108985392AGexonicFOXO3synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr6108984839108984839CTexonicFOXO3nonsynonymous UCEC|1|248|0.00403
rs767933077chr6108985341108985341CTexonicFOXO3synonymous BLCA|1|396|0.00253,KIPAN|1|799|0.00125,KIRC|1|451|0.00222,LUAD|1|543|0.00184
rs747294855chr6108985662108985662CTexonicFOXO3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs760685861chr6108985068108985068GAexonicFOXO3synonymous HNSC|1|512|0.00195
-chr6108882671108882671CTexonicFOXO3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs749629630chr6108984785108984785GAexonicFOXO3nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
rs779409413chr6108984910108984910CTexonicFOXO3nonsynonymous HNSC|1|512|0.00195,KIPAN|1|799|0.00125,KIRC|1|451|0.00222,THCA|1|504|0.00198
-chr6108882613108882613GTexonicFOXO3nonsynonymous OV|1|469|0.00213
rs150320900chr6108882915108882915CTexonicFOXO3synonymous DLBC|1|48|0.02083
-chr6108984700108984700CTexonicFOXO3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs761305424chr6108985342108985342GAexonicFOXO3nonsynonymous BLCA|1|396|0.00253
-chr6108985062108985062T-exonicFOXO3frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr6108985460108985460CTexonicFOXO3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6108985383108985383GTexonicFOXO3nonsynonymous SKCM|1|368|0.00272
rs745628720chr6108985227108985227GAexonicFOXO3synonymous PAAD|1|185|0.00541
-chr6108985779108985779AGexonicFOXO3synonymous UCEC|1|248|0.00403
-chr6108985310108985310CTexonicFOXO3nonsynonymous SKCM|1|368|0.00272
-chr6108985209108985209GAexonicFOXO3synonymous LUAD|1|543|0.00184
-chr6108984779108984779GAexonicFOXO3nonsynonymous BLCA|1|396|0.00253
-chr6108984932108984932GTexonicFOXO3nonsynonymous LUAD|1|543|0.00184
-chr6108882525108882525GAexonicFOXO3synonymous BLCA|1|396|0.00253
-chr6108984784108984784CTexonicFOXO3nonsynonymous PRAD|1|499|0.00200,STAD|1|395|0.00253,STES|1|395|0.00253
-chr6108985678108985678CTexonicFOXO3nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
rs34079373chr6108985269108985269CTexonicFOXO3synonymous CHOL|1|35|0.02857
-chr6108985148108985148ATexonicFOXO3nonsynonymous LUAD|1|543|0.00184
rs768572858chr6108985322108985322CAexonicFOXO3nonsynonymous UCEC|1|248|0.00403
-chr6108985055108985055AGexonicFOXO3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6108985039108985039GAexonicFOXO3nonsynonymous LUAD|1|543|0.00184
-chr6108984897108984897GAexonicFOXO3synonymous BLCA|1|396|0.00253
-chr6108882901108882901GAexonicFOXO3nonsynonymous LUAD|1|543|0.00184
-chr6108984928108984928CTexonicFOXO3nonsynonymous PAAD|1|185|0.00541
-chr6108985241108985241CTexonicFOXO3nonsynonymous SKCM|1|368|0.00272
-chr6108985287108985287CAexonicFOXO3synonymous LUSC|1|178|0.00562
-chr6108985201108985201GAexonicFOXO3nonsynonymous BRCA|1|982|0.00102
rs202151097chr6108985226108985226CTexonicFOXO3nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr6108882982108882982GAexonicFOXO3nonsynonymous STAD|2|395|0.00506,STES|2|395|0.00506
-chr6108985303108985303CAexonicFOXO3nonsynonymous PAAD|1|185|0.00541
-chr6108882649108882650GG-exonicFOXO3frameshift LUAD|1|543|0.00184,SARC|1|247|0.00405
-chr6108985121108985121GTexonicFOXO3nonsynonymous LUSC|1|178|0.00562
-chr6108984767108984767GCexonicFOXO3nonsynonymous HNSC|2|512|0.00391
-chr6108985224108985224CTexonicFOXO3synonymous BLCA|1|396|0.00253
-chr6108985340108985340TCexonicFOXO3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs750580274chr6108985160108985160CGexonicFOXO3nonsynonymous PAAD|1|185|0.00541
rs145756480chr6108985003108985003CTexonicFOXO3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs34133353chr6108985176108985176-GexonicFOXO3frameshift PAAD|1|185|0.00541
rs200866771chr6108985092108985092CGexonicFOXO3synonymous ACC|1|90|0.01111,ESCA|1|185|0.00541,UCEC|1|248|0.00403
-chr6108985225108985225CTexonicFOXO3nonsynonymous BLCA|1|396|0.00253
-chr6108984984108984984CTexonicFOXO3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr6108985143108985143GTexonicFOXO3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr6108985271108985271CGexonicFOXO3nonsynonymous BLCA|1|396|0.00253
-chr6108985251108985251GAexonicFOXO3synonymous BRCA|1|982|0.00102
-chr6108984662108984662CTexonicFOXO3nonsynonymous PAAD|1|185|0.00541
rs535867091chr6108985561108985561GAexonicFOXO3nonsynonymous UVM|1|80|0.01250
-chr6108984918108984918CTexonicFOXO3synonymous SKCM|1|368|0.00272
-chr6108985242108985242GAexonicFOXO3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6108984958108984958GTexonicFOXO3nonsynonymous LUAD|1|543|0.00184
-chr6108985139108985139GAexonicFOXO3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6108985249108985249G-exonicFOXO3frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr6108882886108882886ACexonicFOXO3nonsynonymous ESCA|1|185|0.00541
-chr6108985299108985299GAexonicFOXO3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
Disease information of FOXO3
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TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
FOXO3 Alloxan Diabetes C18;C19 Experimental Model of Disease CTD_human
FOXO3 Bipolar Disorder F03 Mental or Behavioral Dysfunction PSYGENET
FOXO3 Non-Small Cell Lung Carcinoma C04;C08 Neoplastic Process CTD_human
FOXO3 Adenoid Cystic Carcinoma C04 Neoplastic Process CTD_human
FOXO3 Diabetes Mellitus, Experimental C18;C19 Experimental Model of Disease CTD_human
FOXO3 Experimental Autoimmune Encephalomyelitis C10;C20 Experimental Model of Disease CTD_human
FOXO3 Gastrointestinal Neoplasms C04;C06 Neoplastic Process GENOMICS_ENGLAND
FOXO3 Chronic Obstructive Airway Disease C08 Disease or Syndrome CTD_human
FOXO3 Obesity C18;C23 Disease or Syndrome CTD_human
FOXO3 Streptozotocin Diabetes C18;C19 Experimental Model of Disease CTD_human
FOXO3 Adenocarcinoma of lung (disorder) C04;C08 Neoplastic Process CTD_human
FOXO3 Chronic Airflow Obstruction C08 Disease or Syndrome CTD_human
Pathway associated with FOXO3
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pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000118 AKT phosphorylates targets in the nucleus reactome 9 27
pathway0000442 Class I PI3K signaling events pid 46 551
pathway0000443 Class I PI3K signaling events mediated by Akt pid 35 293
pathway0000479 Constitutive Signaling by AKT1 E17K in Cancer reactome 25 137
pathway0000827 FoxO family signaling pid 50 426
pathway0000842 FSH netpath 44 301
pathway0001112 IL-7 netpath 28 203
pathway0001120 IL2 netpath 81 1364
pathway0001121 IL2 signaling events mediated by PI3K pid 38 397
pathway0001126 IL3 netpath 84 1284
pathway0001130 IL5 netpath 59 739
pathway0001132 IL6 netpath 85 1335
pathway0001159 Insulin Pathway pid 47 338
pathway0001167 Insulin/IGF pathway-protein kinase B signaling cascade panther 22 94
pathway0001191 Interleukin signaling pathway panther 86 1548
pathway0001246 KitReceptor netpath 104 1591
pathway0001322 MAPK6/MAPK4 signaling reactome 90 1485
pathway0001460 Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) ) inoh 7 22
pathway0001461 Negative regulation of gene expression ( Insulin receptor signaling (Mammal) ) inoh 7 22
pathway0001582 p73 transcription factor network pid 80 478
pathway0001655 PI3 kinase pathway panther 38 374
pathway0001727 Prolactin netpath 105 1733
pathway0001849 Regulation of nuclear SMAD2/3 signaling pid 82 1072
pathway0002024 Signaling by NODAL reactome 19 89
pathway0002035 Signaling events mediated by HDAC Class III pid 41 421
pathway0002039 Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53 547
pathway0002339 Trk receptor signaling mediated by PI3K and PLC-gamma pid 36 303
pathway0002391 Validated targets of C-MYC transcriptional repression pid 63 385
pathway0002660 Endometrial cancer kegg 52 567
pathway0002670 Non-small cell lung cancer kegg 54 623
pathway0002691 Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 wikipathways 36 219
pathway0002693 Hs_Imatinib_and_Chronic_Myeloid_Leukemia_WP3640_89384 wikipathways 11 19
pathway0002725 Hs_Endochondral_Ossification_WP474_87977 wikipathways 43 117
pathway0002743 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153 1949
pathway0002757 Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 wikipathways 27 108
pathway0002773 Hs_Energy_Metabolism_WP1541_91584 wikipathways 13 34
pathway0002811 Hs_Estrogen_signaling_pathway_WP712_78491 wikipathways 13 57
pathway0002844 Hs_IL-2_Signaling_Pathway_WP49_91243 wikipathways 33 332
pathway0002855 Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178 wikipathways 8 17
pathway0002865 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80 623
Go term information of FOXO3
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GO_term_name GO_term_type TF_name
GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION BP FOXO3
GO_POSITIVE_REGULATION_OF_NEURON_DEATH BP FOXO3
GO_OOGENESIS BP FOXO3
GO_OVULATION_CYCLE BP FOXO3
GO_OVARIAN_FOLLICLE_DEVELOPMENT BP FOXO3
GO_CELL_MATURATION BP FOXO3
GO_OVULATION BP FOXO3
GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND BP FOXO3
GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS BP FOXO3
GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION BP FOXO3
GO_OOCYTE_MATURATION BP FOXO3
GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION BP FOXO3
GO_OOCYTE_DIFFERENTIATION BP FOXO3
GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE BP FOXO3
GO_RHYTHMIC_PROCESS BP FOXO3
GO_REGULATION_OF_NEURON_DEATH BP FOXO3
GO_GERM_CELL_DEVELOPMENT BP FOXO3
GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR BP FOXO3
GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS BP FOXO3
GO_BETA_CATENIN_BINDING MF FOXO3
GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING MF FOXO3
GO_TRANSCRIPTION_COFACTOR_BINDING MF FOXO3

Survival analysis of FOXO3


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of FOXO3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)