TF information
| TF name: | ETS1 |
| TF family: | ETS |
| Ensembl gene ID: | ENSG00000134954 |
| Ensembl protein ID: | ENSP00000441430, ENSP00000433500, ENSP00000376436, ENSP00000324578 |
| Entrez gene ID: | 2113 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of ETS1 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_180 | Cell line | Human melanoma | CJM | 1 |
| Sample_02_181 | Cell line | Human melanoma | COLO679 | 0.5104 |
| Sample_02_182 | Cell line | Human melanoma | LOX-IMVI | 0.80172413793103 |
| Sample_02_205 | Tissue | Stomach | Gastric_Primary_Sample_T | 0.40740740740741 |
| Sample_02_219 | Cell line | Mammary Gland | MDA-MB-231 | 0.11764705882353 |
| Sample_02_258 | Other | Lung | NCI-H1299_EGFP-NEO_reporter_cells_DMSO | 0.50222222222222 |
| Sample_02_268 | Cell line | Kidney | A-498 | 0.59737862285398 |
| Sample_02_280 | Cell line | Mammary Gland | SUM159_DMSO_24h | 0.40833333333333 |
| Sample_02_395 | Cell line | Mammary Gland | BT-549 | 0.39636363636364 |
| Sample_02_430 | Cell line | Kidney | 12364284 | 0.71428571428571 |
ETS1 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_180 | Human melanoma | Cell line | CJM |
| Sample_02_182 | Human melanoma | Cell line | LOX-IMVI |
| Sample_02_258 | Lung | Other | NCI-H1299_EGFP-NEO_reporter_cells_DMSO |
| Sample_02_268 | Kidney | Cell line | A-498 |
| Sample_02_395 | Mammary Gland | Cell line | BT-549 |
| Sample_02_430 | Kidney | Cell line | 12364284 |
ETS1 distribution in all CRCs
Genomic distribution of SEs associated with ETS1
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of ETS1
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr11 | 128442997 | 128442997 | C | T | exonic | ETS1 | nonsynonymous | DLBC|1|48|0.02083 |
| - | chr11 | 128354726 | 128354726 | G | A | exonic | ETS1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr11 | 128443000 | 128443000 | C | T | exonic | ETS1 | nonsynonymous | BRCA|2|982|0.00204 |
| rs763167051 | chr11 | 128350146 | 128350146 | G | A | exonic | ETS1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr11 | 128333448 | 128333448 | A | C | exonic | ETS1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr11 | 128355972 | 128355972 | T | C | exonic | ETS1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr11 | 128360469 | 128360469 | T | C | exonic | ETS1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr11 | 128354817 | 128354817 | G | T | exonic | ETS1 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs137970618 | chr11 | 128354757 | 128354757 | C | T | exonic | ETS1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr11 | 128360395 | 128360395 | G | A | exonic | ETS1 | synonymous | LUSC|1|178|0.00562 |
| - | chr11 | 128426289 | 128426289 | G | C | exonic | ETS1 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr11 | 128354828 | 128354828 | G | A | exonic | ETS1 | nonsynonymous | CHOL|1|35|0.02857,GBM|1|290|0.00345,GBMLGG|1|820|0.00122,LUAD|1|543|0.00184 |
| rs766647712 | chr11 | 128354930 | 128354930 | G | A | exonic | ETS1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr11 | 128332363 | 128332363 | C | T | exonic | ETS1 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr11 | 128332386 | 128332386 | T | A | exonic | ETS1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr11 | 128356014 | 128356014 | C | G | exonic | ETS1 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr11 | 128360362 | 128360362 | C | T | exonic | ETS1 | synonymous | LUSC|1|178|0.00562 |
| - | chr11 | 128354878 | 128354878 | G | A | exonic | ETS1 | synonymous | SKCM|1|368|0.00272 |
| - | chr11 | 128359375 | 128359375 | C | A | exonic | ETS1 | nonsynonymous | OV|1|469|0.00213 |
| - | chr11 | 128350208 | 128350208 | T | C | exonic | ETS1 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| rs775466195 | chr11 | 128354888 | 128354888 | G | A | exonic | ETS1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs772398305 | chr11 | 128359246 | 128359246 | G | A | exonic | ETS1 | synonymous | LUAD|1|543|0.00184 |
| - | chr11 | 128359204 | 128359204 | A | T | exonic | ETS1 | nonsynonymous | LUAD|1|543|0.00184 |
| rs747494573 | chr11 | 128354758 | 128354758 | G | A | exonic | ETS1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr11 | 128354849 | 128354849 | T | G | exonic | ETS1 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr11 | 128354797 | 128354799 | GTC | - | exonic | ETS1 | nonframeshift | PAAD|1|185|0.00541 |
| - | chr11 | 128391833 | 128391833 | G | T | exonic | ETS1 | synonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr11 | 128350330 | 128350330 | C | A | exonic | ETS1 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr11 | 128332410 | 128332410 | C | T | exonic | ETS1 | nonsynonymous | THCA|1|504|0.00198 |
| - | chr11 | 128354731 | 128354731 | C | A | exonic | ETS1 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs768471010 | chr11 | 128332264 | 128332264 | C | T | exonic | ETS1 | nonsynonymous | LUAD|1|543|0.00184,STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs193272250 | chr11 | 128426297 | 128426297 | G | C | exonic | ETS1 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr11 | 128354817 | 128354817 | G | A | exonic | ETS1 | stopgain | COADREAD|1|489|0.00204,READ|1|122|0.00820,SKCM|1|368|0.00272,UCEC|1|248|0.00403 |
| - | chr11 | 128359187 | 128359187 | T | G | exonic | ETS1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr11 | 128356001 | 128356001 | G | C | exonic | ETS1 | synonymous | LUAD|1|543|0.00184 |
| - | chr11 | 128354830 | 128354830 | G | C | exonic | ETS1 | synonymous | BRCA|1|982|0.00102 |
| - | chr11 | 128360420 | 128360420 | A | G | exonic | ETS1 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| rs200548427 | chr11 | 128332364 | 128332364 | C | T | exonic | ETS1 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr11 | 128426323 | 128426323 | C | T | exonic | ETS1 | nonsynonymous | HNSC|1|512|0.00195 |
| rs765144107 | chr11 | 128360449 | 128360449 | T | A | exonic | ETS1 | synonymous | HNSC|1|512|0.00195 |
| - | chr11 | 128332286 | 128332286 | C | G | exonic | ETS1 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr11 | 128350255 | 128350255 | G | T | exonic | ETS1 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr11 | 128391808 | 128391808 | C | T | exonic | ETS1 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr11 | 128350145 | 128350145 | C | T | exonic | ETS1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr11 | 128359223 | 128359223 | C | T | exonic | ETS1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr11 | 128350260 | 128350260 | A | T | exonic | ETS1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr11 | 128360461 | 128360461 | A | T | exonic | ETS1 | stopgain | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| rs199815569 | chr11 | 128354720 | 128354720 | C | T | exonic | ETS1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr11 | 128426243 | 128426243 | A | G | exonic | ETS1 | nonsynonymous | GBM|1|290|0.00345,GBMLGG|2|820|0.00244,LGG|1|530|0.00189,LUAD|1|543|0.00184,PAAD|1|185|0.00541,PRAD|1|499|0.00200,UVM|1|80|0.01250 |
| - | chr11 | 128354827 | 128354827 | C | G | exonic | ETS1 | synonymous | HNSC|1|512|0.00195 |
| - | chr11 | 128426213 | 128426213 | G | A | exonic | ETS1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr11 | 128426192 | 128426192 | C | A | exonic | ETS1 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr11 | 128359355 | 128359355 | C | A | exonic | ETS1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr11 | 128359203 | 128359203 | G | A | exonic | ETS1 | synonymous | CESC|1|194|0.00515,LUAD|1|543|0.00184 |
| - | chr11 | 128354801 | 128354801 | G | A | exonic | ETS1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr11 | 128350168 | 128350168 | G | A | exonic | ETS1 | synonymous | BRCA|1|982|0.00102 |
| rs752371038 | chr11 | 128359312 | 128359312 | A | C | exonic | ETS1 | synonymous | BRCA|1|982|0.00102 |
| rs774575276 | chr11 | 128332291 | 128332291 | C | T | exonic | ETS1 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr11 | 128360384 | 128360384 | G | C | exonic | ETS1 | nonsynonymous | THCA|1|504|0.00198 |
| - | chr11 | 128360370 | 128360370 | G | A | exonic | ETS1 | stopgain | LUAD|1|543|0.00184,UVM|1|80|0.01250 |
| - | chr11 | 128333475 | 128333475 | C | T | exonic | ETS1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr11 | 128350194 | 128350194 | G | T | exonic | ETS1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr11 | 128332376 | 128332376 | G | A | exonic | ETS1 | synonymous | SKCM|1|368|0.00272 |
| rs756820963 | chr11 | 128426255 | 128426255 | G | A | exonic | ETS1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr11 | 128391832 | 128391832 | C | T | exonic | ETS1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr11 | 128354815 | 128354815 | T | C | exonic | ETS1 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr11 | 128333509 | 128333509 | G | T | exonic | ETS1 | synonymous | LUAD|1|543|0.00184 |
| rs568094885 | chr11 | 128426321 | 128426321 | G | A | exonic | ETS1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr11 | 128391816 | 128391816 | G | A | exonic | ETS1 | nonsynonymous | LUAD|1|543|0.00184 |
| rs549425510 | chr11 | 128359270 | 128359270 | G | A | exonic | ETS1 | synonymous | ESCA|1|185|0.00541,LUSC|1|178|0.00562 |
| - | chr11 | 128360415 | 128360415 | G | C | exonic | ETS1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr11 | 128332407 | 128332407 | C | T | exonic | ETS1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr11 | 128360421 | 128360421 | T | C | exonic | ETS1 | nonsynonymous | COAD|2|367|0.00545,COADREAD|2|489|0.00409 |
| - | chr11 | 128333507 | 128333507 | T | C | exonic | ETS1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs757838796 | chr11 | 128359285 | 128359285 | A | G | exonic | ETS1 | synonymous | UCEC|1|248|0.00403 |
| - | chr11 | 128332356 | 128332356 | C | T | exonic | ETS1 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr11 | 128359261 | 128359261 | A | C | exonic | ETS1 | synonymous | BRCA|1|982|0.00102 |
| - | chr11 | 128354816 | 128354816 | C | A | exonic | ETS1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr11 | 128354833 | 128354833 | G | A | exonic | ETS1 | synonymous | UCEC|1|248|0.00403 |
| - | chr11 | 128354930 | 128354930 | G | C | exonic | ETS1 | nonsynonymous | HNSC|1|512|0.00195 |
| rs766964257 | chr11 | 128350152 | 128350152 | G | A | exonic | ETS1 | nonsynonymous | CHOL|1|35|0.02857,GBMLGG|1|820|0.00122,LGG|1|530|0.00189,STAD|1|395|0.00253,STES|1|395|0.00253,UCEC|1|248|0.00403 |
| - | chr11 | 128354788 | 128354788 | C | A | exonic | ETS1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr11 | 128359245 | 128359245 | C | G | exonic | ETS1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr11 | 128354818 | 128354818 | G | A | exonic | ETS1 | synonymous | SKCM|1|368|0.00272 |
| rs79963544 | chr11 | 128359269 | 128359269 | C | T | exonic | ETS1 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr11 | 128360374 | 128360374 | C | T | exonic | ETS1 | synonymous | UCEC|1|248|0.00403 |
| - | chr11 | 128359290 | 128359290 | T | C | exonic | ETS1 | nonsynonymous | HNSC|2|512|0.00391 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| ETS1 | Celiac Disease | C06;C18 | Disease or Syndrome | CTD_human |
| ETS1 | Lupus Erythematosus, Systemic | C17;C20 | Disease or Syndrome | CTD_human |
| ETS1 | Reperfusion Injury | C14;C23 | Injury or Poisoning | CTD_human |
| ETS1 | Libman-Sacks Disease | C17;C20 | Disease or Syndrome | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000177 | Angiogenesis | panther | 141 | 2497 |
| pathway0000178 | Angiopoietin receptor Tie2-mediated signaling | pid | 50 | 441 |
| pathway0000187 | AP-1 transcription factor network | pid | 71 | 659 |
| pathway0000271 | BCR signaling pathway | pid | 70 | 890 |
| pathway0000335 | C-MYB transcription factor network | pid | 87 | 525 |
| pathway0000702 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 | 71 |
| pathway0000703 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 | 71 |
| pathway0000781 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 | 66 |
| pathway0000782 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 | 53 |
| pathway0001021 | HIF-1-alpha transcription factor network | pid | 67 | 420 |
| pathway0001022 | HIF-2-alpha transcription factor network | pid | 34 | 119 |
| pathway0001120 | IL2 | netpath | 81 | 1364 |
| pathway0001127 | IL4-mediated signaling events | pid | 66 | 512 |
| pathway0001128 | IL4 | netpath | 75 | 1239 |
| pathway0001543 | Oncogene Induced Senescence | reactome | 30 | 146 |
| pathway0001604 | PDGF signaling pathway | panther | 113 | 1684 |
| pathway0001805 | Ras Pathway | panther | 69 | 921 |
| pathway0002032 | Signaling events mediated by focal adhesion kinase | pid | 63 | 616 |
| pathway0002036 | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | pid | 80 | 1068 |
| pathway0002408 | VEGF signaling pathway | panther | 54 | 637 |
| pathway0002565 | MAPK signaling pathway - fly | kegg | 16 | 62 |
| pathway0002588 | Dorso-ventral axis formation | kegg | 25 | 58 |
| pathway0002696 | Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 | wikipathways | 51 | 206 |
| pathway0002747 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 | 129 |
| pathway0002853 | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 | 576 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION | BP | ETS1 |
| GO_POSITIVE_REGULATION_OF_HEMOPOIESIS | BP | ETS1 |
| GO_RESPONSE_TO_FLUID_SHEAR_STRESS | BP | ETS1 |
| GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT | BP | ETS1 |
| GO_REGULATION_OF_DEFENSE_RESPONSE | BP | ETS1 |
| GO_PITUITARY_GLAND_DEVELOPMENT | BP | ETS1 |
| GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION | BP | ETS1 |
| GO_HYPOTHALAMUS_DEVELOPMENT | BP | ETS1 |
| GO_RESPONSE_TO_HORMONE | BP | ETS1 |
| GO_RESPONSE_TO_INTERLEUKIN_1 | BP | ETS1 |
| GO_RESPONSE_TO_ESTROGEN | BP | ETS1 |
| GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS | BP | ETS1 |
| GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE | BP | ETS1 |
| GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION | BP | ETS1 |
| GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION | BP | ETS1 |
| GO_REGULATION_OF_CELL_CELL_ADHESION | BP | ETS1 |
| GO_DIENCEPHALON_DEVELOPMENT | BP | ETS1 |
| GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION | BP | ETS1 |
| GO_REGULATION_OF_INFLAMMATORY_RESPONSE | BP | ETS1 |
| GO_NUCLEUS_ORGANIZATION | BP | ETS1 |
| GO_RESPONSE_TO_TOXIC_SUBSTANCE | BP | ETS1 |
| GO_RESPONSE_TO_ANTIBIOTIC | BP | ETS1 |
| GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING | BP | ETS1 |
| GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY | BP | ETS1 |
| GO_RESPONSE_TO_CYTOKINE | BP | ETS1 |
| GO_ANGIOGENESIS | BP | ETS1 |
| GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING | BP | ETS1 |
| GO_LIMBIC_SYSTEM_DEVELOPMENT | BP | ETS1 |
| GO_RESPONSE_TO_MECHANICAL_STIMULUS | BP | ETS1 |
| GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES | BP | ETS1 |
| GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS | BP | ETS1 |
| GO_RESPONSE_TO_HYDROGEN_PEROXIDE | BP | ETS1 |
| GO_ESTROUS_CYCLE | BP | ETS1 |
| GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS | BP | ETS1 |
| GO_TRANSCRIPTION_FACTOR_COMPLEX | CC | ETS1 |
| GO_HISTONE_ACETYLTRANSFERASE_BINDING | MF | ETS1 |