1. TF detail

TF information

TF name: CEBPB
TF family: TF_bZIP
Ensembl gene ID: ENSG00000172216
Ensembl protein ID: ENSP00000305422
Entrez gene ID: 1051
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:
Frequency of CEBPB in all biosamples
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Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_059Cell lineLungPC-90.2
Sample_02_096Cell lineMammary GlandZR-75-1_10.71739130434783
Sample_02_237Cell lineColonV3890.04343824774526
Sample_02_241Cell lineColonV4560.30925507900677
Sample_02_258OtherLungNCI-H1299_EGFP-NEO_reporter_cells_DMSO0.16666666666667
Sample_02_280Cell lineMammary GlandSUM159_DMSO_24h0.3
Sample_02_285Cell lineLiverHuH7_untreat0.34146341463415
Sample_02_300Cell lineNeuroblastomaCLB-PE0.038461538461538
Sample_02_322Cell lineColonCaco-20.36473755047106
Sample_02_361Cell lineColonHT29_DMSO0.10088495575221
Sample_02_395Cell lineMammary GlandBT-5490.12223776223776
CEBPB distribution in samples’ most representative CRC
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Sample ID Tissue type Biosample type Biosample name
Sample_02_096Mammary GlandCell lineZR-75-1_1
Sample_02_258LungOtherNCI-H1299_EGFP-NEO_reporter_cells_DMSO
CEBPB distribution in all CRCs
Biosample type
Biosample name
Sample ID
Genomic distribution of SEs associated with CEBPB
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Mutation of CEBPB
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Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of CEBPB

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr204880798648807986AGexonicCEBPBnonsynonymous BLCA|1|396|0.00253
-chr204880833248808332GTexonicCEBPBsynonymous TGCT|1|155|0.00645
-chr204880846748808467GAexonicCEBPBsynonymous LUAD|1|543|0.00184
-chr204880761848807618GAexonicCEBPBsynonymous PRAD|1|499|0.00200
-chr204880840248808402CTexonicCEBPBnonsynonymous TGCT|1|155|0.00645
-chr204880761448807614CTexonicCEBPBnonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr204880857648808576GTexonicCEBPBstopgain BLCA|1|396|0.00253
-chr204880764048807640AGexonicCEBPBnonsynonymous BLCA|1|396|0.00253
-chr204880860448808604GAexonicCEBPBnonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr204880847648808476GAexonicCEBPBsynonymous LUSC|1|178|0.00562
-chr204880787548807885CCGCGCCCGCC-exonicCEBPBframeshift PRAD|1|499|0.00200
-chr204880781148807898CCGCTGGGCGCGCCGCAGGCCCCGGCGCCCGCCACGGCCACGGACACCTTCGAGGCGGCTCCGCCCGCGCCCGCCCCCGCGCCCGCCT-exonicCEBPBframeshift -
-chr204880844948808449GTexonicCEBPBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr204880790248807902C-exonicCEBPBframeshift ACC|1|90|0.01111
Disease information of CEBPB
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TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
CEBPB Brain Ischemia C10;C14 Disease or Syndrome CTD_human
CEBPB Fatty Liver C06 Disease or Syndrome CTD_human
CEBPB Female infertility C13 Pathologic Function CTD_human
CEBPB Pulmonary Fibrosis C08 Disease or Syndrome CTD_human
CEBPB Sterility, Postpartum C13 Pathologic Function CTD_human
CEBPB Injuries, Acute Brain C10;C26 Injury or Poisoning CTD_human
CEBPB Hamman-Rich syndrome C08 Disease or Syndrome CTD_human
CEBPB Brain Injuries C10;C26 Injury or Poisoning CTD_human
CEBPB Brain Lacerations C10;C26 Injury or Poisoning CTD_human
CEBPB Subfertility, Female C13 Disease or Syndrome CTD_human
CEBPB Brain Injuries, Focal C10;C26 Injury or Poisoning CTD_human
CEBPB Female sterility C13 Finding CTD_human
CEBPB Cerebral Ischemia C10;C14 Disease or Syndrome CTD_human
CEBPB Liver carcinoma C04;C06 Neoplastic Process CTD_human
CEBPB Steatohepatitis C06 Disease or Syndrome CTD_human
Pathway associated with CEBPB
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pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000335 C-MYB transcription factor network pid 87 525
pathway0000824 FOXA1 transcription factor network pid 45 204
pathway0000825 FOXA2 and FOXA3 transcription factor networks pid 45 202
pathway0001079 IFN-gamma pathway pid 43 345
pathway0001125 IL3-mediated signaling events pid 27 155
pathway0001127 IL4-mediated signaling events pid 66 512
pathway0001128 IL4 netpath 75 1239
pathway0001131 IL6-mediated signaling events pid 48 426
pathway0001132 IL6 netpath 85 1335
pathway0001799 RANKL netpath 84 1002
pathway0001849 Regulation of nuclear SMAD2/3 signaling pid 82 1072
pathway0001857 Regulation of retinoblastoma protein pid 67 718
pathway0001980 Senescence-Associated Secretory Phenotype (SASP) reactome 108 2712
pathway0002044 Signaling mediated by p38-alpha and p38-beta pid 35 174
pathway0002302 Transcriptional regulation of white adipocyte differentiation reactome 79 1522
pathway0002388 Validated nuclear estrogen receptor alpha network pid 65 386
pathway0002722 Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 wikipathways 62 254
pathway0002760 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44 408
pathway0002777 Hs_Transcriptional_activation_by_NRF2_WP3_79527 wikipathways 6 7
pathway0002797 Hs_Lung_fibrosis_WP3624_91475 wikipathways 23 45
pathway0002809 Hs_IL17_signaling_pathway_WP2112_89838 wikipathways 20 67
Go term information of CEBPB
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GO_term_name GO_term_type TF_name
GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION BP CEBPB
GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION BP CEBPB
GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION BP CEBPB
GO_ORGAN_REGENERATION BP CEBPB
GO_GLAND_MORPHOGENESIS BP CEBPB
GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT BP CEBPB
GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION BP CEBPB
GO_RESPONSE_TO_EXTERNAL_STIMULUS BP CEBPB
GO_OVARIAN_FOLLICLE_DEVELOPMENT BP CEBPB
GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION BP CEBPB
GO_ACUTE_INFLAMMATORY_RESPONSE BP CEBPB
GO_ORGAN_MORPHOGENESIS BP CEBPB
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS BP CEBPB
GO_REGULATION_OF_CELL_DIFFERENTIATION BP CEBPB
GO_RESPONSE_TO_INTERLEUKIN_1 BP CEBPB
GO_LIVER_REGENERATION BP CEBPB
GO_BROWN_FAT_CELL_DIFFERENTIATION BP CEBPB
GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION BP CEBPB
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION BP CEBPB
GO_ALPHA_BETA_T_CELL_ACTIVATION BP CEBPB
GO_REGULATION_OF_CELL_CELL_ADHESION BP CEBPB
GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION BP CEBPB
GO_CELL_FATE_COMMITMENT BP CEBPB
GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION BP CEBPB
GO_CHRONIC_INFLAMMATORY_RESPONSE BP CEBPB
GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION BP CEBPB
GO_EPITHELIAL_CELL_PROLIFERATION BP CEBPB
GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS BP CEBPB
GO_PLACENTA_DEVELOPMENT BP CEBPB
GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT BP CEBPB
GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION BP CEBPB
GO_NEGATIVE_REGULATION_OF_NEURON_DEATH BP CEBPB
GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS BP CEBPB
GO_DEFENSE_RESPONSE_TO_BACTERIUM BP CEBPB
GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION BP CEBPB
GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN BP CEBPB
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS BP CEBPB
GO_ACUTE_PHASE_RESPONSE BP CEBPB
GO_CHROMOSOME CC CEBPB
GO_TRANSCRIPTION_FACTOR_COMPLEX CC CEBPB
GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION CC CEBPB
GO_NUCLEAR_MATRIX CC CEBPB
GO_NUCLEAR_PERIPHERY CC CEBPB
GO_KINASE_BINDING MF CEBPB
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING MF CEBPB
GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY MF CEBPB
GO_GLUCOCORTICOID_RECEPTOR_BINDING MF CEBPB
GO_STEROID_HORMONE_RECEPTOR_BINDING MF CEBPB
GO_HISTONE_ACETYLTRANSFERASE_BINDING MF CEBPB

Survival analysis of CEBPB


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of CEBPB

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)