TF Enrichment (GSEA)

Example of upload file

Function Introduction

KnockTF 2.0 embedded the popular gene set enrichment analysis (GSEA) algorithm to perform the enrichment analysis of T(co)F target genes. The top 100 differentially expressed genes of each T(co)F knockdown/knockout dataset were taken as a gene set S. The disease-related differential gene rank list entered by the users (eg. Differential genes of breast cancer from TCGA project) is referred to the rank list L of GSEA. If the members of a gene set S are significantly located at the top or bottom of L under the threshold of P<0.01, it indicates that the corresponding TF or TcoF regulates the entered disease-related differential genes. Thus, all the potential T(co)Fs are identified.