Cancer CRCdb

TF information

TF name:	XBP1
TF family:	TF_bZIP
Ensembl gene ID:	ENSG00000100219
Ensembl protein ID:	ENSP00000216037, ENSP00000481170, ENSP00000343155, ENSP00000385162, ENSP00000384295
Entrez gene ID:	7494

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of XBP1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.1452784503632
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.5
Sample_02_079	Cell line	Mammary Gland	T-47D_1	0.55555555555556
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.40217391304348
Sample_02_115	Cell line	Mammary Gland	MCF-7	0.6
Sample_02_168	Cell line	Prostate	LNCaP	0.20152091254753
Sample_02_285	Cell line	Liver	HuH7_untreat	0.11498257839721
Sample_02_394	Cell line	Mammary Gland	T-47D_2	0.38461538461538
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	1
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.050359712230216

XBP1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_046	Mammary Gland	Cell line	MCF-7
Sample_02_079	Mammary Gland	Cell line	T-47D_1
Sample_02_403	Mammary Gland	Cell line	T-47D_untreat

XBP1 distribution in all CRCs

Genomic distribution of SEs associated with XBP1

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Mutation of XBP1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of XBP1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr22	29191569	29191569	G	A	exonic	XBP1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr22	29191246	29191246	C	G	exonic	XBP1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	29191587	29191587	-	G	exonic	XBP1	frameshift	BRCA\|1\|982\|0.00102
rs139447098	chr22	29193194	29193194	C	T	splicing	XBP1	splicing	UCEC\|1\|248\|0.00403
rs570172086	chr22	29196469	29196469	G	A	exonic	XBP1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr22	29193152	29193152	T	C	exonic	XBP1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	29193133	29193133	C	G	exonic	XBP1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr22	29195130	29195130	T	C	exonic	XBP1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	29191690	29191690	A	C	exonic	XBP1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	29196386	29196386	G	A	exonic	XBP1	stopgain	LIHC\|1\|373\|0.00268
-	chr22	29195100	29195100	C	G	exonic	XBP1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr22	29195090	29195090	A	C	exonic	XBP1	synonymous	PRAD\|1\|499\|0.00200
-	chr22	29191682	29191682	T	A	exonic	XBP1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr22	29192120	29192120	G	T	exonic	XBP1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr22	29191286	29191286	-	T	exonic	XBP1	stopgain	UCEC\|1\|248\|0.00403
-	chr22	29191491	29191491	A	C	exonic	XBP1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	29191399	29191399	C	-	exonic	XBP1	frameshift	BRCA\|1\|982\|0.00102
-	chr22	29191670	29191670	G	A	exonic	XBP1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr22	29196498	29196498	-	CC	exonic	XBP1	frameshift	HNSC\|1\|512\|0.00195,LUAD\|1\|543\|0.00184,PRAD\|1\|499\|0.00200
-	chr22	29191393	29191393	C	T	exonic	XBP1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	29195126	29195126	T	-	exonic	XBP1	frameshift	BRCA\|1\|982\|0.00102
-	chr22	29191304	29191304	G	T	exonic	XBP1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	29195100	29195100	C	A	exonic	XBP1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr22	29192074	29192074	G	C	exonic	XBP1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr22	29193155	29193155	C	G	exonic	XBP1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr22	29191534	29191534	T	C	exonic	XBP1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	29193079	29193079	C	G	exonic	XBP1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr22	29193155	29193155	C	A	exonic	XBP1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	29195047	29195048	CT	-	exonic	XBP1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	29191483	29191483	C	G	exonic	XBP1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr22	29195079	29195079	T	C	exonic	XBP1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr22	29195030	29195030	C	T	intronic	XBP1	unknown	CHOL\|1\|35\|0.02857
-	chr22	29191414	29191414	G	A	exonic	XBP1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr22	29193181	29193181	A	C	exonic	XBP1	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr22	29191294	29191294	C	T	exonic	XBP1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	29191375	29191375	C	G	exonic	XBP1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr22	29191699	29191699	G	A	exonic	XBP1	synonymous	LUAD\|2\|543\|0.00368
-	chr22	29195982	29195982	T	A	intronic	XBP1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253

Disease information of XBP1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
XBP1	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
XBP1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	UNIPROT
XBP1	Fatty Liver	C06	Disease or Syndrome	CTD_human
XBP1	Glioma	C04	Neoplastic Process	CTD_human
XBP1	Insulin Resistance	C18	Pathologic Function	CTD_human
XBP1	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
XBP1	mixed gliomas	C04	Neoplastic Process	CTD_human
XBP1	Impaired glucose tolerance	C18	Disease or Syndrome	CTD_human
XBP1	Non-alcoholic Fatty Liver Disease	C06	Disease or Syndrome	CTD_human
XBP1	Malignant Glioma	C04	Neoplastic Process	CTD_human
XBP1	Bipolar I disorder		Mental or Behavioral Dysfunction	PSYGENET
XBP1	Insulin Sensitivity	C18	Pathologic Function	CTD_human
XBP1	MAJOR AFFECTIVE DISORDER 7	F03	Mental or Behavioral Dysfunction	CTD_human
XBP1	Steatohepatitis	C06	Disease or Syndrome	CTD_human
XBP1	Nonalcoholic Steatohepatitis	C06	Disease or Syndrome	CTD_human

Pathway associated with XBP1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000054	Acetylcholine Neurotransmitter Release Cycle	reactome	17	107
pathway0000231	ATF6-alpha activates chaperone genes	reactome	10	27
pathway0000627	Dopamine Neurotransmitter Release Cycle	reactome	23	249
pathway0000650	Effects of Botulinum toxin	pid	9	29
pathway0000873	GABA synthesis, release, reuptake and degradation	reactome	13	78
pathway0000928	Glutamate Neurotransmitter Release Cycle	reactome	24	195
pathway0001513	Norepinephrine Neurotransmitter Release Cycle	reactome	18	136
pathway0001844	Regulation of insulin secretion	reactome	33	278
pathway0001988	Serotonin Neurotransmitter Release Cycle	reactome	18	150
pathway0002142	Synaptic_vesicle_trafficking	panther	21	171
pathway0002756	Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330	wikipathways	6	6

Go term information of XBP1

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GO_term_name	GO_term_type	TF_name
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS	BP	XBP1
GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION	BP	XBP1
GO_ACYLGLYCEROL_HOMEOSTASIS	BP	XBP1
GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS	BP	XBP1
GO_GLUTAMATE_SECRETION	BP	XBP1
GO_REGULATION_OF_VESICLE_FUSION	BP	XBP1
GO_EPITHELIUM_DEVELOPMENT	BP	XBP1
GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS	BP	XBP1
GO_REGULATION_OF_HISTONE_METHYLATION	BP	XBP1
GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE	BP	XBP1
GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS	BP	XBP1
GO_MUSCLE_ORGAN_DEVELOPMENT	BP	XBP1
GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION	BP	XBP1
GO_RESPONSE_TO_INTERLEUKIN_4	BP	XBP1
GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS	BP	XBP1
GO_STEROL_HOMEOSTASIS	BP	XBP1
GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION	BP	XBP1
GO_EPITHELIAL_CELL_DEVELOPMENT	BP	XBP1
GO_SALIVARY_GLAND_DEVELOPMENT	BP	XBP1
GO_RESPONSE_TO_FLUID_SHEAR_STRESS	BP	XBP1
GO_VESICLE_ORGANIZATION	BP	XBP1
GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS	BP	XBP1
GO_PLATELET_ACTIVATION	BP	XBP1
GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	XBP1
GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS	BP	XBP1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS	BP	XBP1
GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS	BP	XBP1
GO_POSITIVE_REGULATION_OF_TOR_SIGNALING	BP	XBP1
GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION	BP	XBP1
GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION	BP	XBP1
GO_NEUROTRANSMITTER_TRANSPORT	BP	XBP1
GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION	BP	XBP1
GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION	BP	XBP1
GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION	BP	XBP1
GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION	BP	XBP1
GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY	BP	XBP1
GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN	BP	XBP1
GO_MEMBRANE_DOCKING	BP	XBP1
GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4	BP	XBP1
GO_DIGESTIVE_SYSTEM_DEVELOPMENT	BP	XBP1
GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION	BP	XBP1
GO_FATTY_ACID_HOMEOSTASIS	BP	XBP1
GO_PROTEIN_DESTABILIZATION	BP	XBP1
GO_REGULATION_OF_SYNAPTIC_PLASTICITY	BP	XBP1
GO_LONG_TERM_SYNAPTIC_DEPRESSION	BP	XBP1
GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS	BP	XBP1
GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY	BP	XBP1
GO_ER_NUCLEUS_SIGNALING_PATHWAY	BP	XBP1
GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS	BP	XBP1
GO_RESPONSE_TO_BACTERIUM	BP	XBP1
GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION	BP	XBP1
GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION	BP	XBP1
GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS	BP	XBP1
GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	XBP1
GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS	BP	XBP1
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION	BP	XBP1
GO_POSITIVE_REGULATION_OF_EXOCYTOSIS	BP	XBP1
GO_REGULATION_OF_B_CELL_DIFFERENTIATION	BP	XBP1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS	BP	XBP1
GO_ANION_HOMEOSTASIS	BP	XBP1
GO_REGULATION_OF_RESPONSE_TO_STRESS	BP	XBP1
GO_EXOCRINE_SYSTEM_DEVELOPMENT	BP	XBP1
GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT	BP	XBP1
GO_FATTY_ACID_BIOSYNTHETIC_PROCESS	BP	XBP1
GO_REGULATION_OF_REPRODUCTIVE_PROCESS	BP	XBP1
GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS	BP	XBP1
GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION	BP	XBP1
GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION	BP	XBP1
GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION	BP	XBP1
GO_REGULATION_OF_T_CELL_DIFFERENTIATION	BP	XBP1
GO_DICARBOXYLIC_ACID_TRANSPORT	BP	XBP1
GO_REGULATION_OF_PROTEIN_ACETYLATION	BP	XBP1
GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE	BP	XBP1
GO_RESPONSE_TO_CARBOHYDRATE	BP	XBP1
GO_FATTY_ACID_METABOLIC_PROCESS	BP	XBP1
GO_CELLULAR_RESPONSE_TO_NUTRIENT	BP	XBP1
GO_RESPONSE_TO_AMINO_ACID	BP	XBP1
GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION	BP	XBP1
GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION	BP	XBP1
GO_REGULATION_OF_B_CELL_ACTIVATION	BP	XBP1
GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION	BP	XBP1
GO_REGULATION_OF_TOR_SIGNALING	BP	XBP1
GO_CELLULAR_GLUCOSE_HOMEOSTASIS	BP	XBP1
GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE	BP	XBP1
GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION	BP	XBP1
GO_ENDOTHELIAL_CELL_PROLIFERATION	BP	XBP1
GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION	BP	XBP1
GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS	BP	XBP1
GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS	BP	XBP1
GO_HOMOTYPIC_CELL_CELL_ADHESION	BP	XBP1
GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT	BP	XBP1
GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS	BP	XBP1
GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION	BP	XBP1
GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION	BP	XBP1
GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	XBP1
GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC	BP	XBP1
GO_REGULATION_OF_CELL_ADHESION	BP	XBP1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	XBP1
GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION	BP	XBP1
GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE	BP	XBP1
GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS	BP	XBP1
GO_VESICLE_DOCKING	BP	XBP1
GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION	BP	XBP1
GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION	BP	XBP1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS	BP	XBP1
GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE	BP	XBP1
GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS	BP	XBP1
GO_EPITHELIAL_CELL_MATURATION	BP	XBP1
GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	XBP1
GO_NEGATIVE_REGULATION_OF_NEURON_DEATH	BP	XBP1
GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS	BP	XBP1
GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS	BP	XBP1
GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS	BP	XBP1
GO_REGULATION_OF_ERAD_PATHWAY	BP	XBP1
GO_DEVELOPMENTAL_MATURATION	BP	XBP1
GO_ADIPOSE_TISSUE_DEVELOPMENT	BP	XBP1
GO_PLATELET_AGGREGATION	BP	XBP1
GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS	BP	XBP1
GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING	BP	XBP1
GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY	BP	XBP1
GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT	BP	XBP1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS	BP	XBP1
GO_INOSITOL_LIPID_MEDIATED_SIGNALING	BP	XBP1
GO_SECRETORY_GRANULE	CC	XBP1
GO_PLATELET_ALPHA_GRANULE	CC	XBP1
GO_NEURON_PROJECTION_TERMINUS	CC	XBP1
GO_MYELIN_SHEATH	CC	XBP1
GO_SYNTAXIN_1_BINDING	MF	XBP1
GO_ESTROGEN_RECEPTOR_BINDING	MF	XBP1
GO_KINASE_BINDING	MF	XBP1
GO_HISTONE_DEACETYLASE_BINDING	MF	XBP1
GO_PROTEIN_HOMODIMERIZATION_ACTIVITY	MF	XBP1
GO_STEROID_HORMONE_RECEPTOR_BINDING	MF	XBP1
GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING	MF	XBP1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	XBP1
GO_STRUCTURE_SPECIFIC_DNA_BINDING	MF	XBP1

Survival analysis of XBP1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of XBP1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)