TF information

TF name: HOXB8
TF family: Homeobox
Ensembl gene ID: ENSG00000120068
Ensembl protein ID: ENSP00000460659, ENSP00000460254, ENSP00000239144
Entrez gene ID: 3218
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of HOXB8 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_001Cell lineProstate22Rv10.13317191283293
Sample_02_007OtherCervicalcervical-cancer_vector0.16556291390728
Sample_02_021Cell lineColonV4290.3046987604497
Sample_02_069Cell lineBrainSF2680.038167938931298
Sample_02_242Cell lineColonV4810.20351855412421
Sample_02_355Cell lineColonHCT150.49404761904762
Sample_02_356Cell lineColonSw4800.43225806451613
Sample_02_358Cell lineColonLS1800.76461295418641
Sample_02_395Cell lineMammary GlandBT-5490.38993006993007
Sample_02_424Cell lineColonSW6200.66666666666667

HOXB8 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_355ColonCell lineHCT15
Sample_02_358ColonCell lineLS180
Sample_02_395Mammary GlandCell lineBT-549
Sample_02_424ColonCell lineSW620

HOXB8 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with HOXB8
Download

Mutation of HOXB8
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HOXB8

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr174669197646691976CTexonicHOXB8nonsynonymous BLCA|1|396|0.00253
-chr174669168246691682GAexonicHOXB8nonsynonymous SKCM|1|368|0.00272
-chr174669178146691781GTexonicHOXB8nonsynonymous PAAD|1|185|0.00541
rs757836046chr174669059646690596CTexonicHOXB8nonsynonymous BLCA|1|396|0.00253
-chr174669074646690746CTexonicHOXB8nonsynonymous SKCM|1|368|0.00272
-chr174669070746690707GTexonicHOXB8synonymous ESCA|1|185|0.00541
-chr174669202046692020CGexonicHOXB8nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr174669190446691904GCexonicHOXB8nonsynonymous UVM|1|80|0.01250
-chr174669168646691686CGexonicHOXB8nonsynonymous BLCA|1|396|0.00253
-chr174669186446691864GAexonicHOXB8nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr174669073346690733CTexonicHOXB8nonsynonymous HNSC|1|512|0.00195
-chr174669205146692051CTexonicHOXB8nonsynonymous PRAD|1|499|0.00200
-chr174669174646691746GAexonicHOXB8synonymous UCEC|1|248|0.00403
rs45441492chr174669077746690777AGexonicHOXB8synonymous DLBC|1|48|0.02083
rs777216868chr174669169246691692GAexonicHOXB8synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr174669063946690639CAexonicHOXB8nonsynonymous LUAD|1|543|0.00184
rs112046402chr174669062346690623GCexonicHOXB8nonsynonymous DLBC|1|48|0.02083
-chr174669164646691646GAexonicHOXB8stopgain LUSC|1|178|0.00562
-chr174669182946691829CTexonicHOXB8nonsynonymous SKCM|1|368|0.00272
-chr174669197846691978TGexonicHOXB8nonsynonymous LUAD|1|543|0.00184
rs771982800chr174669065046690650CTexonicHOXB8nonsynonymous BLCA|1|396|0.00253
-chr174669205246692052GAexonicHOXB8synonymous SKCM|1|368|0.00272
-chr174669063346690633CAexonicHOXB8nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr174669176546691765TCexonicHOXB8nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr174669184546691845GAexonicHOXB8synonymous LUAD|1|543|0.00184
-chr174669075746690757GCexonicHOXB8nonsynonymous HNSC|1|512|0.00195
-chr174669179646691796GTexonicHOXB8nonsynonymous LUSC|1|178|0.00562
-chr174669174746691747TCexonicHOXB8nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr174669058546690585CAexonicHOXB8synonymous LUAD|6|543|0.01105
-chr174669058646690586GTexonicHOXB8nonsynonymous LUSC|1|178|0.00562
-chr174669072046690720GAexonicHOXB8synonymous BLCA|1|396|0.00253
-chr174669181146691811ATexonicHOXB8nonsynonymous LIHC|1|373|0.00268
-chr174669072646690726GAexonicHOXB8synonymous BLCA|1|396|0.00253
-chr174669171146691711CTexonicHOXB8nonsynonymous SKCM|1|368|0.00272
-chr174669057046690570CTexonicHOXB8synonymous BLCA|2|396|0.00505
-chr174669083846690838TCexonicHOXB8nonsynonymous LUSC|1|178|0.00562
-chr174669083946690839-GexonicHOXB8frameshift SKCM|1|368|0.00272
-chr174669195646691956GAexonicHOXB8synonymous SKCM|1|368|0.00272
-chr174669056946690569TGexonicHOXB8nonsynonymous SKCM|1|368|0.00272
rs774086334chr174669167746691677CTexonicHOXB8synonymous PAAD|1|185|0.00541
-chr174669193446691934CAexonicHOXB8nonsynonymous LUAD|1|543|0.00184
-chr174669184146691841CTexonicHOXB8nonsynonymous BLCA|1|396|0.00253
-chr174669061046690610-AexonicHOXB8frameshift LUAD|1|543|0.00184
-chr174669061846690618CAexonicHOXB8nonsynonymous BRCA|1|982|0.00102
rs766516844chr174669198346691983GAexonicHOXB8synonymous BLCA|1|396|0.00253
-chr174669166146691661GAexonicHOXB8nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr174669073746690737-TexonicHOXB8frameshift LUAD|1|543|0.00184
-chr174669072646690726GCexonicHOXB8synonymous HNSC|1|512|0.00195
-chr174669179746691797CTexonicHOXB8synonymous PAAD|1|185|0.00541

Disease information of HOXB8
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
HOXB8 Obsessive-Compulsive Disorder F03 Mental or Behavioral Dysfunction CTD_human
HOXB8 Trichotillomania F03 Mental or Behavioral Dysfunction CTD_human

Pathway associated with HOXB8
pathway_ID pathway_name pathway_source gene_number edge_number

Go term information of HOXB8
GO_term_name GO_term_type TF_name
GO_SPINAL_CORD_DEVELOPMENT BP HOXB8
GO_SINGLE_ORGANISM_BEHAVIOR BP HOXB8
GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION BP HOXB8
GO_REGULATION_OF_HEMOPOIESIS BP HOXB8
GO_GROOMING_BEHAVIOR BP HOXB8
GO_DORSAL_SPINAL_CORD_DEVELOPMENT BP HOXB8

Survival analysis of HOXB8



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of HOXB8