Cancer CRCdb

TF information

TF name:	E2F3
TF family:	E2F
Ensembl gene ID:	ENSG00000112242
Ensembl protein ID:	ENSP00000443418, ENSP00000262904, ENSP00000483249
Entrez gene ID:	1871

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of E2F3 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.053268765133172
Sample_01_068	Cell line	Prostate: derived from metastatic site: vertebral metastasis	VCaP	0.32876712328767
Sample_02_241	Cell line	Colon	V456	0.073363431151242
Sample_02_359	Cell line	Colon	Colo741	0.25602409638554
Sample_02_395	Cell line	Mammary Gland	BT-549	0.13062937062937

E2F3 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_068	Prostate: derived from metastatic site: vertebral metastasis	Cell line	VCaP

E2F3 distribution in all CRCs

Genomic distribution of SEs associated with E2F3

Download

Mutation of E2F3

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of E2F3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr6	20490617	20490617	G	A	exonic	E2F3	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	20481455	20481455	A	-	exonic	E2F3	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr6	20402625	20402625	G	C	exonic	E2F3	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs765868574	chr6	20480168	20480168	G	A	exonic	E2F3	nonsynonymous	CESC\|1\|194\|0.00515,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr6	20490622	20490622	-	C	exonic	E2F3	frameshift	HNSC\|1\|512\|0.00195
rs773205736	chr6	20490526	20490526	G	A	exonic	E2F3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs4134982	chr6	20490428	20490428	G	A	exonic	E2F3	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr6	20481597	20481597	C	A	exonic	E2F3	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	20402610	20402610	C	T	exonic	E2F3	synonymous	LUAD\|1\|543\|0.00184,TGCT\|1\|155\|0.00645,THCA\|2\|504\|0.00397
-	chr6	20481472	20481472	A	G	exonic	E2F3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	20402596	20402597	GC	-	exonic	E2F3	frameshift	BLCA\|2\|396\|0.00505
rs746277803	chr6	20402595	20402595	C	T	exonic	E2F3	synonymous	BLCA\|1\|396\|0.00253
-	chr6	20490515	20490515	C	T	exonic	E2F3	synonymous	SKCM\|2\|368\|0.00543
-	chr6	20481576	20481576	G	C	exonic	E2F3	nonsynonymous	LUAD\|1\|543\|0.00184
rs139915140	chr6	20483131	20483131	C	T	exonic	E2F3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	20481488	20481488	T	G	exonic	E2F3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	20402537	20402537	T	C	exonic	E2F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	20487011	20487011	C	A	exonic	E2F3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	20402643	20402643	C	G	exonic	E2F3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr6	20487000	20487000	C	T	exonic	E2F3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	20490660	20490660	G	C	exonic	E2F3	stoploss	HNSC\|1\|512\|0.00195
-	chr6	20490506	20490506	C	T	exonic	E2F3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	20490417	20490417	C	G	exonic	E2F3	stopgain	BLCA\|1\|396\|0.00253
-	chr6	20483134	20483134	G	A	exonic	E2F3	synonymous	UCEC\|1\|248\|0.00403
-	chr6	20486987	20486987	G	T	exonic	E2F3	nonsynonymous	THCA\|1\|504\|0.00198
-	chr6	20490632	20490632	C	T	exonic	E2F3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	20490622	20490622	G	C	exonic	E2F3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	20490430	20490430	T	G	exonic	E2F3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	20402509	20402509	G	A	exonic	E2F3	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	20488383	20488383	G	C	exonic	E2F3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	20402521	20402521	G	A	exonic	E2F3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	20481611	20481611	G	T	exonic	E2F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	20490441	20490441	C	A	exonic	E2F3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	20490451	20490451	C	G	exonic	E2F3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	20483017	20483017	G	T	exonic	E2F3	synonymous	ACC\|1\|90\|0.01111
-	chr6	20481646	20481646	G	A	exonic	E2F3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	20402603	20402613	CCGCCGCCGCT	-	exonic	E2F3	frameshift	UCEC\|1\|248\|0.00403
-	chr6	20481454	20481454	-	A	splicing	E2F3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SARC\|1\|247\|0.00405
-	chr6	20486928	20486928	A	G	exonic	E2F3	nonsynonymous	PRAD\|2\|499\|0.00401
-	chr6	20481483	20481483	T	C	exonic	E2F3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	20480156	20480156	G	A	exonic	E2F3	nonsynonymous	CESC\|1\|194\|0.00515
rs147333935	chr6	20488470	20488470	G	A	exonic	E2F3	nonsynonymous	ACC\|1\|90\|0.01111,LUAD\|3\|543\|0.00552
-	chr6	20483065	20483065	C	T	exonic	E2F3	synonymous	SKCM\|1\|368\|0.00272
-	chr6	20488347	20488347	C	T	exonic	E2F3	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	20402547	20402547	C	A	exonic	E2F3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	20483009	20483009	G	C	exonic	E2F3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	20483090	20483090	G	A	exonic	E2F3	nonsynonymous	BRCA\|1\|982\|0.00102
rs763278356	chr6	20481645	20481645	C	T	exonic	E2F3	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr6	20481626	20481627	AG	-	exonic	E2F3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	20490545	20490545	C	T	exonic	E2F3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	20490452	20490452	C	G	exonic	E2F3	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr6	20402541	20402541	C	T	exonic	E2F3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	20402468	20402468	G	T	exonic	E2F3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	20490487	20490487	G	A	exonic	E2F3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs151305307	chr6	20490464	20490464	G	T	exonic	E2F3	nonsynonymous	OV\|1\|469\|0.00213,PAAD\|1\|185\|0.00541
rs779389567	chr6	20490607	20490607	C	T	exonic	E2F3	synonymous	UCEC\|1\|248\|0.00403
-	chr6	20490512	20490512	A	G	exonic	E2F3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	20490568	20490568	C	T	exonic	E2F3	synonymous	SKCM\|1\|368\|0.00272
-	chr6	20481589	20481589	G	A	exonic	E2F3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	20481452	20481452	C	T	exonic	E2F3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	20481593	20481593	T	C	exonic	E2F3	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr6	20483077	20483077	G	A	exonic	E2F3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253

Disease information of E2F3

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with E2F3

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000225	Association of licensing factors with the pre-replicative complex	reactome	15	58
pathway0000391	CDC6 association with the ORC:origin complex	reactome	11	41
pathway0000517	Cyclin D associated events in G1	reactome	38	366
pathway0000648	E2F transcription factor network	pid	77	897
pathway0000864	G2 Phase	reactome	5	11
pathway0001543	Oncogene Induced Senescence	reactome	30	146
pathway0001559	Oxidative Stress Induced Senescence	reactome	120	3580
pathway0001711	Pre-NOTCH Transcription and Translation	reactome	29	220
pathway0001857	Regulation of retinoblastoma protein	pid	67	718
pathway0002390	Validated targets of C-MYC transcriptional activation	pid	80	573
pathway0002659	Pancreatic cancer	kegg	70	835
pathway0002661	Glioma	kegg	65	998
pathway0002662	Prostate cancer	kegg	85	1261
pathway0002665	Melanoma	kegg	69	1192
pathway0002666	Bladder cancer	kegg	38	233
pathway0002667	Chronic myeloid leukemia	kegg	69	881
pathway0002669	Small cell lung cancer	kegg	83	807
pathway0002670	Non-small cell lung cancer	kegg	54	623

Go term information of E2F3

Download

GO_term_name	GO_term_type	TF_name
GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION	BP	E2F3

Survival analysis of E2F3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of E2F3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)