Cancer CRCdb

TF information

TF name:	TCF12
TF family:	bHLH
Ensembl gene ID:	ENSG00000140262
Ensembl protein ID:	ENSP00000444696, ENSP00000453264, ENSP00000388940, ENSP00000440017, ENSP00000331057, ENSP00000267811, ENSP00000453876, ENSP00000454102, ENSP00000453737, ENSP00000342459
Entrez gene ID:	6938

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of TCF12 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_267	Cell line	Kidney	786-O	0.6
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.19462647444299
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.14893617021277
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.14814814814815

TCF12 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_267	Kidney	Cell line	786-O

TCF12 distribution in all CRCs

Genomic distribution of SEs associated with TCF12

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Mutation of TCF12

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TCF12

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr15	57523426	57523426	-	T	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57543591	57543591	C	A	exonic	TCF12	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57355950	57355950	A	T	exonic	TCF12	nonsynonymous	KIPAN\|3\|799\|0.00375,KIRC\|3\|451\|0.00665
rs138618347	chr15	57524951	57524951	G	A	exonic	TCF12	synonymous	SKCM\|1\|368\|0.00272
-	chr15	57565312	57565312	A	G	exonic	TCF12	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	57578621	57578623	AAT	-	UTR3	TCF12	unknown	ESCA\|1\|185\|0.00541
-	chr15	57545612	57545612	C	A	exonic	TCF12	synonymous	OV\|1\|469\|0.00213
-	chr15	57554331	57554331	A	C	exonic	TCF12	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	57565390	57565390	A	C	exonic	TCF12	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	57484401	57484401	C	A	exonic	TCF12	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs772390979	chr15	57524979	57524979	C	T	exonic	TCF12	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr15	57484479	57484479	T	-	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57545524	57545524	C	A	exonic	TCF12	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr15	57484473	57484473	C	T	exonic	TCF12	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	57523417	57523417	-	GGT	exonic	TCF12	nonframeshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57545575	57545575	T	C	exonic	TCF12	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr15	57565230	57565244	GTACTAATGAAGATG	-	exonic	TCF12	nonframeshift	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr15	57565238	57565238	G	A	exonic	TCF12	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr15	57523364	57523364	C	T	exonic	TCF12	synonymous	SKCM\|2\|368\|0.00543
-	chr15	57356002	57356002	C	T	exonic	TCF12	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	57524504	57524504	C	A	exonic	TCF12	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	57526287	57526296	TGGAAAGGCT	-	exonic	TCF12	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57384051	57384051	G	A	exonic	TCF12	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	57384044	57384044	C	A	exonic	TCF12	nonsynonymous	SARC\|1\|247\|0.00405
-	chr15	57384059	57384059	C	T	exonic	TCF12	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	57545488	57545488	G	C	exonic	TCF12	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	57511694	57511694	C	A	UTR5	TCF12	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	57511760	57511760	C	A	exonic	TCF12	nonsynonymous	UCEC\|1\|248\|0.00403,UCS\|1\|57\|0.01754
-	chr15	57578647	57578647	C	A	UTR3	TCF12	unknown	BRCA\|1\|982\|0.00102
rs765920481	chr15	57544626	57544626	G	A	exonic	TCF12	nonsynonymous	CESC\|1\|194\|0.00515
-	chr15	57578959	57578959	T	C	UTR3	TCF12	unknown	SARC\|1\|247\|0.00405
-	chr15	57356019	57356019	A	G	exonic	TCF12	nonsynonymous	OV\|1\|469\|0.00213
-	chr15	57484374	57484374	G	C	exonic	TCF12	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	57523450	57523450	-	CAA	exonic	TCF12	nonframeshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57258577	57258577	C	T	intronic	TCF12	unknown	SARC\|1\|247\|0.00405
rs757369824	chr15	57565325	57565325	C	T	exonic	TCF12	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	57574736	57574736	G	A	exonic	TCF12	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	57384057	57384057	C	-	exonic	TCF12	frameshift	BRCA\|1\|982\|0.00102
rs753261578	chr15	57545466	57545466	C	T	exonic	TCF12	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57565326	57565326	G	T	exonic	TCF12	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57565437	57565437	-	TGAC	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57525047	57525047	C	T	exonic	TCF12	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57554313	57554313	T	-	exonic	TCF12	frameshift	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr15	57458600	57458600	G	T	exonic	TCF12	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs77034126	chr15	57565432	57565432	C	T	exonic	TCF12	synonymous	DLBC\|1\|48\|0.02083
-	chr15	57544484	57544484	T	C	intronic	TCF12	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	57524985	57524985	A	C	exonic	TCF12	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	57458653	57458653	C	T	exonic	TCF12	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	57511744	57511744	G	A	exonic	TCF12	nonsynonymous	LUAD\|1\|543\|0.00184
rs730880016	chr15	57565320	57565320	G	A	exonic	TCF12	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr15	57356001	57356001	C	T	exonic	TCF12	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	57535737	57535737	C	T	exonic	TCF12	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	57565345	57565345	C	A	exonic	TCF12	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57544626	57544626	G	T	exonic	TCF12	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	57555420	57555420	G	C	exonic	TCF12	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	57565319	57565319	C	T	exonic	TCF12	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	57484418	57484418	A	G	exonic	TCF12	synonymous	LIHC\|1\|373\|0.00268
-	chr15	57526295	57526295	-	T	exonic	TCF12	frameshift	BLCA\|1\|396\|0.00253
-	chr15	57543590	57543590	C	T	exonic	TCF12	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	57565458	57565458	G	T	exonic	TCF12	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr15	57574709	57574709	C	G	exonic	TCF12	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	57565423	57565423	C	A	exonic	TCF12	synonymous	UCEC\|1\|248\|0.00403
-	chr15	57525012	57525012	G	A	exonic	TCF12	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr15	57543518	57543518	A	T	intronic	TCF12	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	57545486	57545486	-	TCT	exonic	TCF12	nonframeshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57511745	57511745	G	T	exonic	TCF12	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	57565366	57565366	T	A	exonic	TCF12	stopgain	HNSC\|2\|512\|0.00391
-	chr15	57574774	57574774	G	T	exonic	TCF12	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	57543601	57543601	G	A	exonic	TCF12	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	57489984	57489984	A	-	exonic	TCF12	frameshift	PAAD\|4\|185\|0.02162,STAD\|4\|395\|0.01013,STES\|4\|395\|0.01013
-	chr15	57574703	57574703	C	T	exonic	TCF12	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs754118933	chr15	57565313	57565313	C	T	exonic	TCF12	nonsynonymous	ESCA\|1\|185\|0.00541,UCEC\|1\|248\|0.00403
-	chr15	57543589	57543589	T	C	exonic	TCF12	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	57543615	57543615	C	G	exonic	TCF12	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs796508804	chr15	57545469	57545469	A	G	exonic	TCF12	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs34560099	chr15	57384061	57384061	A	G	exonic	TCF12	synonymous	DLBC\|1\|48\|0.02083
-	chr15	57574699	57574699	T	C	exonic	TCF12	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	57523394	57523394	T	-	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57524959	57524962	CACC	-	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57523418	57523418	A	C	exonic	TCF12	synonymous	BRCA\|1\|982\|0.00102
-	chr15	57554304	57554304	C	T	exonic	TCF12	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57543547	57543547	G	A	splicing	TCF12	splicing	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57524624	57524624	-	C	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57555367	57555369	AAG	-	exonic	TCF12	nonframeshift	GBMLGG\|2\|820\|0.00244,LGG\|2\|530\|0.00377
-	chr15	57524546	57524546	G	A	exonic	TCF12	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57523456	57523456	-	T	splicing	TCF12	unknown	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57555309	57555309	G	C	splicing	TCF12	splicing	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr15	57484403	57484403	A	G	exonic	TCF12	synonymous	PRAD\|1\|499\|0.00200
-	chr15	57212181	57212181	A	G	exonic	TCF12	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr15	57384057	57384057	C	T	exonic	TCF12	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	57524926	57524926	C	G	exonic	TCF12	stopgain	BRCA\|1\|982\|0.00102
rs771571672	chr15	57545514	57545514	C	T	exonic	TCF12	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr15	57524624	57524624	G	-	exonic	TCF12	frameshift	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr15	57565279	57565280	GA	-	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57356019	57356019	A	C	exonic	TCF12	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57574749	57574749	G	C	exonic	TCF12	synonymous	OV\|1\|469\|0.00213
-	chr15	57526275	57526275	-	T	exonic	TCF12	frameshift	ESCA\|1\|185\|0.00541
-	chr15	57554348	57554348	T	C	exonic	TCF12	synonymous	OV\|1\|469\|0.00213
-	chr15	57544631	57544631	G	C	exonic	TCF12	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	57565418	57565418	C	G	exonic	TCF12	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	57489983	57489983	-	A	exonic	TCF12	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	57574769	57574769	C	T	exonic	TCF12	nonsynonymous	SARC\|1\|247\|0.00405
rs777290901	chr15	57212142	57212142	A	T	exonic	TCF12	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr15	57544625	57544625	C	T	exonic	TCF12	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr15	57578977	57578977	C	A	UTR3	TCF12	unknown	CESC\|1\|194\|0.00515
-	chr15	57355946	57355946	A	T	splicing	TCF12	splicing	KIPAN\|4\|799\|0.00501,KIRC\|4\|451\|0.00887
-	chr15	57574756	57574756	G	A	exonic	TCF12	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr15	57555431	57555431	C	A	exonic	TCF12	synonymous	UCS\|1\|57\|0.01754
-	chr15	57574716	57574716	G	T	exonic	TCF12	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr15	57545626	57545626	G	C	exonic	TCF12	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	57565415	57565416	CA	-	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57524621	57524621	A	G	exonic	TCF12	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	57511733	57511733	A	G	exonic	TCF12	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57526269	57526269	A	-	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57535668	57535668	A	T	splicing	TCF12	splicing	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr15	57213290	57213290	G	-	exonic	TCF12	frameshift	BRCA\|2\|982\|0.00204
-	chr15	57383997	57383997	A	G	exonic	TCF12	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	57526290	57526290	A	G	exonic	TCF12	synonymous	UCEC\|1\|248\|0.00403
-	chr15	57535688	57535688	A	G	exonic	TCF12	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	57524917	57524917	C	T	exonic	TCF12	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	57545536	57545536	C	-	exonic	TCF12	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	57543557	57543557	A	G	exonic	TCF12	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	57545542	57545542	-	T	exonic	TCF12	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	57458613	57458613	G	T	exonic	TCF12	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	57544619	57544619	A	G	exonic	TCF12	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	57554314	57554314	-	T	exonic	TCF12	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	57484420	57484420	C	G	exonic	TCF12	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	57524560	57524560	C	A	exonic	TCF12	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	57458628	57458628	C	A	exonic	TCF12	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222,LUSC\|1\|178\|0.00562

Disease information of TCF12

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
TCF12	Craniosynostosis	C05;C16	Disease or Syndrome	CTD_human;GENOMICS_ENGLAND
TCF12	Hydrocephalus	C10	Disease or Syndrome	GENOMICS_ENGLAND
TCF12	Acrocephaly	C05;C16	Congenital Abnormality	CTD_human
TCF12	Brachycephaly	C05;C16	Congenital Abnormality	CTD_human;ORPHANET
TCF12	Plagiocephaly	C05;C16	Congenital Abnormality	ORPHANET
TCF12	Scaphycephaly	C05;C16	Congenital Abnormality	CTD_human
TCF12	Trigonocephaly	C05;C16	Congenital Abnormality	CTD_human
TCF12	Extraskeletal Myxoid Chondrosarcoma	C04	Neoplastic Process	ORPHANET
TCF12	Synostotic Posterior Plagiocephaly	C05;C16	Disease or Syndrome	CTD_human
TCF12	Metopic synostosis	C05;C16	Congenital Abnormality	CTD_human
TCF12	Synostotic Anterior Plagiocephaly	C05;C16	Congenital Abnormality; Disease or Syndrome	CTD_human
TCF12	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
TCF12	CRANIOSYNOSTOSIS 3		Disease or Syndrome	UNIPROT

Pathway associated with TCF12

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000393	CDO in myogenesis	reactome	29	200
pathway0001078	ID	netpath	38	213

Go term information of TCF12

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_NEURON_DIFFERENTIATION	BP	TCF12
GO_TRANSCRIPTION_FACTOR_COMPLEX	CC	TCF12
GO_SMAD_BINDING	MF	TCF12
GO_BHLH_TRANSCRIPTION_FACTOR_BINDING	MF	TCF12
GO_E_BOX_BINDING	MF	TCF12
GO_DOUBLE_STRANDED_DNA_BINDING	MF	TCF12
GO_HMG_BOX_DOMAIN_BINDING	MF	TCF12
GO_CAMP_RESPONSE_ELEMENT_BINDING	MF	TCF12

Survival analysis of TCF12

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of TCF12

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)