Cancer CRCdb

TF information

TF name:	SOX5
TF family:	HMG
Ensembl gene ID:	ENSG00000134532
Ensembl protein ID:	ENSP00000439832, ENSP00000398273, ENSP00000443520, ENSP00000441973, ENSP00000379328, ENSP00000370788, ENSP00000493866, ENSP00000437487
Entrez gene ID:	6660

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SOX5 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_180	Cell line	Human melanoma	CJM	0.9765625
Sample_02_181	Cell line	Human melanoma	COLO679	0.5616
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.074712643678161
Sample_02_184	Cell line	Skin	SKMEL30	0.35369774919614
Sample_02_285	Cell line	Liver	HuH7_untreat	0.25087108013937
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.057971014492754

SOX5 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_180	Human melanoma	Cell line	CJM
Sample_02_181	Human melanoma	Cell line	COLO679
Sample_02_285	Liver	Cell line	HuH7_untreat

SOX5 distribution in all CRCs

Genomic distribution of SEs associated with SOX5

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Mutation of SOX5

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SOX5

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs762757188	chr12	23716202	23716202	C	T	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr12	23893848	23893848	C	G	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	24048945	24048945	G	A	exonic	SOX5	stopgain	PAAD\|1\|185\|0.00541
-	chr12	24048840	24048840	G	A	exonic	SOX5	nonsynonymous	SKCM\|1\|368\|0.00272
rs760608804	chr12	23818466	23818466	G	A	exonic	SOX5	synonymous	SKCM\|1\|368\|0.00272
-	chr12	23908589	23908589	T	G	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23699250	23699250	C	T	exonic	SOX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	23716316	23716316	G	T	exonic	SOX5	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	23999036	23999036	C	A	exonic	SOX5	nonsynonymous	LUAD\|6\|543\|0.01105
-	chr12	23699249	23699249	C	T	splicing	SOX5	splicing	SKCM\|1\|368\|0.00272
-	chr12	23696167	23696167	G	A	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23757415	23757415	A	C	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	24048786	24048786	A	G	exonic	SOX5	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs772561388	chr12	23793749	23793749	C	A	exonic	SOX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	23728683	23728683	T	C	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs780771208	chr12	23728629	23728629	C	T	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23818415	23818415	G	A	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23687162	23687162	T	A	exonic	SOX5	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	23699316	23699316	T	A	exonic	SOX5	stopgain	LUSC\|1\|178\|0.00562,SKCM\|1\|368\|0.00272
rs557463084	chr12	23818447	23818447	G	A	exonic	SOX5	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222,THYM\|1\|123\|0.00813
-	chr12	23893822	23893822	C	A	exonic	SOX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	23689547	23689547	C	G	exonic	SOX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	24048941	24048941	G	C	exonic	SOX5	nonsynonymous	OV\|1\|469\|0.00213
rs776219045	chr12	24048776	24048776	G	A	exonic	SOX5	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr12	23689453	23689453	C	T	exonic	SOX5	nonsynonymous	PRAD\|1\|499\|0.00200,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr12	23818387	23818387	C	T	exonic	SOX5	nonsynonymous	ACC\|1\|90\|0.01111
-	chr12	23893916	23893916	A	T	exonic	SOX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	23757351	23757351	C	T	exonic	SOX5	synonymous	BLCA\|1\|396\|0.00253
-	chr12	23999045	23999045	C	T	exonic	SOX5	nonsynonymous	CESC\|1\|194\|0.00515
-	chr12	23893901	23893901	T	C	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23699306	23699306	T	A	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	23757333	23757333	T	G	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	24539945	24539945	-	AT	intronic	SOX5	unknown	LUAD\|1\|543\|0.00184
-	chr12	23998926	23998926	C	G	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23908624	23908624	G	T	exonic	SOX5	nonsynonymous	SARC\|1\|247\|0.00405
-	chr12	24102519	24102519	T	C	exonic	SOX5	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	23999034	23999034	C	T	exonic	SOX5	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr12	23687199	23687199	T	A	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
rs780207349	chr12	23893839	23893839	G	A	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23687440	23687440	G	A	exonic	SOX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	24596342	24596342	T	-	intronic	SOX5	unknown	LUAD\|1\|543\|0.00184
-	chr12	23757393	23757393	G	T	exonic	SOX5	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr12	23793772	23793772	G	A	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253,SKCM\|1\|368\|0.00272
-	chr12	23887636	23887636	C	A	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23689418	23689418	G	A	exonic	SOX5	nonsynonymous	CESC\|1\|194\|0.00515
-	chr12	23687272	23687272	C	T	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	23728609	23728609	C	G	exonic	SOX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	23696281	23696281	T	A	exonic	SOX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	24048842	24048842	A	C	exonic	SOX5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	23728652	23728652	G	-	exonic	SOX5	frameshift	LUAD\|1\|543\|0.00184
-	chr12	23999076	23999076	T	A	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23893833	23893833	G	T	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23728616	23728616	A	G	exonic	SOX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	23689501	23689501	T	A	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
rs758437433	chr12	23757434	23757434	C	T	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	24048940	24048940	T	C	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23689448	23689448	C	T	exonic	SOX5	nonsynonymous	LUAD\|3\|543\|0.00552
-	chr12	23887621	23887621	G	A	exonic	SOX5	synonymous	BRCA\|1\|982\|0.00102
-	chr12	23728640	23728640	C	A	exonic	SOX5	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	23887649	23887649	T	C	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23893823	23893823	A	G	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	23689427	23689427	G	A	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	24048792	24048792	G	A	exonic	SOX5	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr12	23893870	23893870	C	T	exonic	SOX5	synonymous	LUSC\|1\|178\|0.00562
-	chr12	24048864	24048864	C	A	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23998950	23998950	T	A	exonic	SOX5	stopgain	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr12	23793809	23793809	C	T	exonic	SOX5	synonymous	BLCA\|1\|396\|0.00253
-	chr12	23687217	23687217	T	A	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23893932	23893932	C	A	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	24715337	24715337	C	A	UTR5	SOX5	unknown	CESC\|1\|194\|0.00515
-	chr12	23999032	23999032	C	T	exonic	SOX5	synonymous	BLCA\|1\|396\|0.00253
-	chr12	23696242	23696242	A	G	exonic	SOX5	synonymous	HNSC\|1\|512\|0.00195
-	chr12	23893901	23893901	T	A	exonic	SOX5	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	23893942	23893942	C	T	exonic	SOX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23999053	23999053	T	A	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23757375	23757375	A	G	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	24048783	24048783	G	C	exonic	SOX5	nonsynonymous	CESC\|1\|194\|0.00515
rs11369294	chr12	24673437	24673437	-	A	intronic	SOX5	unknown	LUAD\|1\|543\|0.00184
-	chr12	23757377	23757377	A	G	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr12	23687239	23687239	A	G	exonic	SOX5	nonsynonymous	LUAD\|2\|543\|0.00368
rs149450279	chr12	23998927	23998927	G	A	exonic	SOX5	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,SARC\|1\|247\|0.00405
-	chr12	23728684	23728684	G	T	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23689492	23689492	C	A	exonic	SOX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	23893858	23893858	G	T	exonic	SOX5	synonymous	PAAD\|1\|185\|0.00541
-	chr12	23687209	23687209	G	A	exonic	SOX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	23818459	23818459	G	A	exonic	SOX5	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr12	23689477	23689477	C	T	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23908593	23908593	C	A	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23689485	23689485	C	A	exonic	SOX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	23999037	23999037	C	T	exonic	SOX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	23818384	23818384	C	T	exonic	SOX5	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr12	23818392	23818392	T	C	exonic	SOX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	23818453	23818453	C	T	exonic	SOX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	23689454	23689454	G	A	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23716202	23716202	C	A	exonic	SOX5	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr12	24691534	24691538	CACAC	-	intronic	SOX5	unknown	LUAD\|1\|543\|0.00184
-	chr12	23999053	23999053	T	-	exonic	SOX5	frameshift	BLCA\|1\|396\|0.00253
-	chr12	23998941	23998941	C	G	exonic	SOX5	nonsynonymous	HNSC\|1\|512\|0.00195
rs369942747	chr12	23818465	23818465	C	T	exonic	SOX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	23728634	23728634	C	A	exonic	SOX5	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr12	24607816	24607816	T	-	intronic	SOX5	unknown	LUAD\|1\|543\|0.00184
rs144757257	chr12	23687228	23687228	G	A	exonic	SOX5	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	23818383	23818383	C	A	exonic	SOX5	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr12	23999001	23999001	C	T	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
rs761424973	chr12	23696276	23696276	C	T	exonic	SOX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	23998970	23998970	A	G	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,ESCA\|1\|185\|0.00541
-	chr12	23757416	23757416	G	C	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	23716277	23716277	T	C	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23757371	23757371	T	A	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	23689550	23689550	G	C	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23728769	23728769	C	T	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23893906	23893906	G	A	exonic	SOX5	synonymous	UCEC\|1\|248\|0.00403
-	chr12	23757422	23757422	C	G	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	23728679	23728679	G	A	exonic	SOX5	synonymous	BRCA\|1\|982\|0.00102
-	chr12	23908618	23908618	T	C	exonic	SOX5	synonymous	ESCA\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23716278	23716278	C	A	exonic	SOX5	stopgain	LUAD\|1\|543\|0.00184
-	chr12	23908599	23908599	C	T	exonic	SOX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	23893815	23893815	G	T	exonic	SOX5	nonsynonymous	ACC\|1\|90\|0.01111
-	chr12	23793762	23793762	C	T	exonic	SOX5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	23716293	23716293	C	G	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	24048849	24048849	A	C	exonic	SOX5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	24048957	24048957	T	C	exonic	SOX5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	23728680	23728680	A	C	exonic	SOX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23893954	23893954	A	G	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23728661	23728661	C	A	exonic	SOX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	23687389	23687389	T	A	exonic	SOX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	23757383	23757383	C	A	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23687309	23687309	A	C	exonic	SOX5	synonymous	ESCA\|2\|185\|0.01081
-	chr12	23696294	23696294	C	G	exonic	SOX5	nonsynonymous	LUSC\|1\|178\|0.00562
rs777406674	chr12	23689490	23689490	G	A	exonic	SOX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	23728637	23728637	G	C	exonic	SOX5	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	23689459	23689459	T	-	exonic	SOX5	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23887679	23887679	C	G	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23893968	23893968	G	A	exonic	SOX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	23716277	23716277	T	G	exonic	SOX5	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	23728667	23728667	T	A	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	23687346	23687346	C	T	exonic	SOX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	23818434	23818434	G	T	exonic	SOX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	23728718	23728718	T	C	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23699304	23699304	C	T	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23793806	23793806	G	T	exonic	SOX5	synonymous	BLCA\|1\|396\|0.00253
-	chr12	24048839	24048839	G	A	exonic	SOX5	nonsynonymous	SKCM\|1\|368\|0.00272
rs751975537	chr12	23757376	23757376	G	A	exonic	SOX5	nonsynonymous	CHOL\|1\|35\|0.02857,OV\|1\|469\|0.00213
-	chr12	23818467	23818467	G	A	exonic	SOX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	23818489	23818489	G	A	exonic	SOX5	stopgain	LUAD\|1\|543\|0.00184
-	chr12	23998928	23998928	T	-	exonic	SOX5	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	24102509	24102509	C	G	exonic	SOX5	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr12	23998945	23998945	C	T	exonic	SOX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	23696258	23696258	T	C	exonic	SOX5	nonsynonymous	THCA\|1\|504\|0.00198
rs138618584	chr12	23687261	23687261	G	A	exonic	SOX5	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,UCEC\|1\|248\|0.00403
-	chr12	23893927	23893927	C	G	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
rs749574255	chr12	23887621	23887621	G	T	exonic	SOX5	synonymous	BLCA\|1\|396\|0.00253
rs765602417	chr12	23893816	23893816	C	T	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	24048900	24048900	C	T	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23687162	23687162	T	C	exonic	SOX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	23716308	23716308	T	C	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs767392175	chr12	23999114	23999114	T	C	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23696305	23696305	G	A	exonic	SOX5	synonymous	SKCM\|1\|368\|0.00272
-	chr12	23728724	23728724	C	T	exonic	SOX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	24048881	24048881	A	C	exonic	SOX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	23699264	23699264	C	G	exonic	SOX5	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr12	23998945	23998945	C	A	exonic	SOX5	nonsynonymous	SARC\|1\|247\|0.00405
rs528695217	chr12	23687401	23687401	C	T	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23687439	23687439	G	A	exonic	SOX5	nonsynonymous	PRAD\|1\|499\|0.00200
rs370713247	chr12	23999035	23999035	G	A	exonic	SOX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23999004	23999004	G	A	exonic	SOX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	23687163	23687163	T	C	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	24048769	24048769	C	T	exonic	SOX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	23689406	23689406	G	A	exonic	SOX5	nonsynonymous	LAML\|1\|197\|0.00508
-	chr12	23893843	23893843	T	G	exonic	SOX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	24102511	24102511	G	A	exonic	SOX5	stopgain	CESC\|1\|194\|0.00515
-	chr12	24048856	24048856	G	A	exonic	SOX5	synonymous	SKCM\|1\|368\|0.00272
-	chr12	23908572	23908572	C	A	exonic	SOX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	23728774	23728774	T	A	splicing	SOX5	splicing	LUAD\|1\|543\|0.00184
-	chr12	23728734	23728734	G	A	exonic	SOX5	synonymous	LUSC\|1\|178\|0.00562
-	chr12	24048886	24048886	C	A	exonic	SOX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	24048873	24048873	C	T	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23893859	23893859	G	T	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23687344	23687344	T	G	exonic	SOX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	23687456	23687456	-	A	exonic	SOX5	frameshift	BRCA\|1\|982\|0.00102
-	chr12	23716299	23716299	G	C	exonic	SOX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	23887624	23887624	C	T	exonic	SOX5	synonymous	BLCA\|1\|396\|0.00253
-	chr12	23699267	23699267	-	T	exonic	SOX5	frameshift	UCS\|1\|57\|0.01754
-	chr12	24048791	24048791	G	T	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	23716248	23716248	C	G	exonic	SOX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	23696176	23696176	G	A	exonic	SOX5	synonymous	HNSC\|1\|512\|0.00195
-	chr12	23687282	23687282	A	G	exonic	SOX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	23999030	23999030	G	A	exonic	SOX5	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr12	23818455	23818455	G	A	exonic	SOX5	nonsynonymous	LUAD\|1\|543\|0.00184
rs376617830	chr12	23687402	23687402	G	A	exonic	SOX5	synonymous	UCEC\|1\|248\|0.00403

Disease information of SOX5

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SOX5	Atrial Fibrillation	C14;C23	Disease or Syndrome	CTD_human
SOX5	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
SOX5	Paroxysmal atrial fibrillation	C14;C23	Disease or Syndrome	CTD_human
SOX5	Autism Spectrum Disorders	F03	Mental or Behavioral Dysfunction	CTD_human
SOX5	Persistent atrial fibrillation	C14;C23	Pathologic Function	CTD_human
SOX5	familial atrial fibrillation	C14;C23	Pathologic Function	CTD_human
SOX5	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
SOX5	LAMB-SHAFFER SYNDROME		Disease or Syndrome	CTD_human

Pathway associated with SOX5

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002725	Hs_Endochondral_Ossification_WP474_87977	wikipathways	43	117
pathway0002747	Hs_Neural_Crest_Differentiation_WP2064_79263	wikipathways	40	129

Go term information of SOX5

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GO_term_name	GO_term_type	TF_name
GO_NEURONAL_STEM_CELL_DIVISION	BP	SOX5
GO_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	SOX5
GO_STEM_CELL_PROLIFERATION	BP	SOX5
GO_ASYMMETRIC_CELL_DIVISION	BP	SOX5
GO_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	SOX5
GO_STEM_CELL_DIVISION	BP	SOX5
GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	SOX5
GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	SOX5
GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	SOX5
GO_RESPONSE_TO_GROWTH_FACTOR	BP	SOX5
GO_SOMATIC_STEM_CELL_DIVISION	BP	SOX5
GO_NEUROBLAST_PROLIFERATION	BP	SOX5
GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	SOX5

Survival analysis of SOX5

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SOX5

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)