Cancer CRCdb

TF information

TF name:	SNAI2
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000019549
Ensembl protein ID:	ENSP00000494171, ENSP00000020945
Entrez gene ID:	6591

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SNAI2 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.24137931034483
Sample_02_184	Cell line	Skin	SKMEL30	0.21221864951768
Sample_02_227	Cell line	Oesophagus	TE7	0.24
Sample_02_359	Cell line	Colon	Colo741	0.051204819277108
Sample_02_395	Cell line	Mammary Gland	BT-549	0.095384615384615

SNAI2 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_182	Human melanoma	Cell line	LOX-IMVI

SNAI2 distribution in all CRCs

Genomic distribution of SEs associated with SNAI2

Download

Mutation of SNAI2

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SNAI2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr8	49833768	49833768	G	A	exonic	SNAI2	synonymous	SKCM\|1\|368\|0.00272
-	chr8	49833799	49833799	T	C	exonic	SNAI2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49832545	49832545	G	A	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49831547	49831547	C	G	exonic	SNAI2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	49831428	49831428	T	G	exonic	SNAI2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49833789	49833789	G	A	exonic	SNAI2	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr8	49831458	49831458	T	C	exonic	SNAI2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	49832741	49832741	T	C	exonic	SNAI2	synonymous	LIHC\|1\|373\|0.00268
-	chr8	49833819	49833819	C	T	exonic	SNAI2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49833813	49833813	G	A	exonic	SNAI2	synonymous	SKCM\|1\|368\|0.00272
-	chr8	49832752	49832752	C	T	exonic	SNAI2	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr8	49831376	49831376	A	G	exonic	SNAI2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr8	49831426	49831426	G	A	exonic	SNAI2	synonymous	SKCM\|1\|368\|0.00272
-	chr8	49832655	49832655	C	A	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49831491	49831491	G	T	exonic	SNAI2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	49832656	49832656	C	A	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49831439	49831439	T	-	exonic	SNAI2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49832690	49832690	G	A	exonic	SNAI2	synonymous	UCEC\|1\|248\|0.00403
-	chr8	49831549	49831549	T	A	splicing	SNAI2	splicing	LUAD\|1\|543\|0.00184
-	chr8	49832849	49832849	G	A	exonic	SNAI2	synonymous	BLCA\|1\|396\|0.00253,LUAD\|1\|543\|0.00184
-	chr8	49832925	49832925	G	T	exonic	SNAI2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49833817	49833817	C	G	exonic	SNAI2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr8	49831474	49831474	C	A	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49832751	49832751	T	A	exonic	SNAI2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr8	49832658	49832658	G	A	exonic	SNAI2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr8	49832680	49832680	T	C	exonic	SNAI2	nonsynonymous	OV\|1\|469\|0.00213
-	chr8	49831491	49831491	G	A	exonic	SNAI2	synonymous	UCEC\|1\|248\|0.00403
-	chr8	49832991	49832991	G	A	exonic	SNAI2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|1\|368\|0.00272
-	chr8	49832453	49832453	A	T	splicing	SNAI2	splicing	BLCA\|1\|396\|0.00253
-	chr8	49833801	49833801	C	A	exonic	SNAI2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	49833768	49833768	G	C	exonic	SNAI2	stopgain	ESCA\|1\|185\|0.00541
-	chr8	49832731	49832731	G	T	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49832964	49832964	A	G	exonic	SNAI2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49831433	49831433	G	A	exonic	SNAI2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr8	49832582	49832582	C	A	exonic	SNAI2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr8	49831516	49831516	G	T	exonic	SNAI2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr8	49832848	49832848	C	T	exonic	SNAI2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr8	49833765	49833765	G	A	exonic	SNAI2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs748128814	chr8	49832983	49832983	G	C	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49832867	49832867	A	T	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49832490	49832490	G	A	exonic	SNAI2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	49832557	49832557	T	C	exonic	SNAI2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	49831547	49831547	C	A	exonic	SNAI2	nonsynonymous	COAD\|4\|367\|0.01090,COADREAD\|4\|489\|0.00818
-	chr8	49832560	49832560	G	A	exonic	SNAI2	synonymous	HNSC\|1\|512\|0.00195
-	chr8	49831372	49831372	T	C	exonic	SNAI2	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr8	49832466	49832466	C	T	exonic	SNAI2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	49832654	49832654	C	T	exonic	SNAI2	synonymous	LUSC\|1\|178\|0.00562
-	chr8	49832485	49832485	A	C	exonic	SNAI2	nonsynonymous	ESCA\|1\|185\|0.00541
rs200799419	chr8	49832679	49832679	T	C	exonic	SNAI2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr8	49832466	49832466	C	A	exonic	SNAI2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49832626	49832626	C	T	exonic	SNAI2	nonsynonymous	ESCA\|2\|185\|0.01081
-	chr8	49832877	49832877	T	C	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49832627	49832627	G	C	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49832788	49832788	C	A	exonic	SNAI2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	49832867	49832867	A	G	exonic	SNAI2	synonymous	LUSC\|1\|178\|0.00562
-	chr8	49832563	49832563	C	T	exonic	SNAI2	nonsynonymous	THCA\|1\|504\|0.00198
-	chr8	49831546	49831546	C	T	exonic	SNAI2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	49832952	49832952	G	T	exonic	SNAI2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	49832997	49832997	A	C	exonic	SNAI2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	49832627	49832627	G	A	exonic	SNAI2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184
-	chr8	49832564	49832564	G	A	exonic	SNAI2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49832958	49832958	A	G	exonic	SNAI2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	49831507	49831507	A	-	exonic	SNAI2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49832790	49832790	T	A	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49832598	49832598	C	T	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49831524	49831524	G	T	exonic	SNAI2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr8	49831524	49831524	G	A	exonic	SNAI2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	49832962	49832962	G	A	exonic	SNAI2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49831390	49831390	T	A	exonic	SNAI2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	49832489	49832489	G	A	exonic	SNAI2	synonymous	SKCM\|1\|368\|0.00272
-	chr8	49832848	49832848	C	A	exonic	SNAI2	stopgain	LUAD\|1\|543\|0.00184
-	chr8	49832880	49832880	G	T	exonic	SNAI2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	49832516	49832516	C	G	exonic	SNAI2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr8	49831546	49831546	C	A	exonic	SNAI2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213
-	chr8	49831548	49831548	C	A	splicing	SNAI2	splicing	COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613
-	chr8	49832540	49832540	G	A	exonic	SNAI2	synonymous	UCEC\|1\|248\|0.00403
-	chr8	49832989	49832989	G	A	exonic	SNAI2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	49833817	49833817	C	T	exonic	SNAI2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs560825840	chr8	49833764	49833764	C	T	exonic	SNAI2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr8	49831459	49831459	T	C	exonic	SNAI2	synonymous	UCEC\|1\|248\|0.00403

Disease information of SNAI2

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SNAI2	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
SNAI2	Esophageal Neoplasms	C04;C06	Neoplastic Process	CTD_human
SNAI2	Neoplasm Invasiveness	C04;C23	Pathologic Function	CTD_human
SNAI2	Neoplasm Metastasis	C04;C23	Neoplastic Process	CTD_human
SNAI2	Piebaldism	C16;C17;C18	Congenital Abnormality	CTD_human;ORPHANET
SNAI2	Papillary thyroid carcinoma	C04;C19	Neoplastic Process	CTD_human
SNAI2	Malignant neoplasm of esophagus	C04;C06	Neoplastic Process	CTD_human
SNAI2	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
SNAI2	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
SNAI2	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
SNAI2	WAARDENBURG SYNDROME, TYPE IID	C16	Disease or Syndrome	CTD_human
SNAI2	Waardenburg Syndrome Type 2	C16	Disease or Syndrome	ORPHANET
SNAI2	Non-medullary thyroid carcinoma	C04;C19	Neoplastic Process	CTD_human
SNAI2	Familial Nonmedullary Thyroid Cancer	C04;C19	Neoplastic Process	CTD_human

Pathway associated with SNAI2

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002039	Signaling events mediated by Stem cell factor receptor (c-Kit)	pid	53	547
pathway0002597	Adherens junction	kegg	70	644
pathway0002764	Hs_miR-509-3p_alteration_of_YAP1-ECM_axis_WP3967_91491	wikipathways	14	29

Go term information of SNAI2

Download

GO_term_name	GO_term_type	TF_name
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION	BP	SNAI2
GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT	BP	SNAI2
GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION	BP	SNAI2
GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS	BP	SNAI2
GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	SNAI2
GO_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	SNAI2
GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY	BP	SNAI2
GO_ENDOCARDIAL_CUSHION_DEVELOPMENT	BP	SNAI2
GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS	BP	SNAI2
GO_WHITE_FAT_CELL_DIFFERENTIATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS	BP	SNAI2
GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY	BP	SNAI2
GO_CARTILAGE_MORPHOGENESIS	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE	BP	SNAI2
GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS	BP	SNAI2
GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR	BP	SNAI2
GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	SNAI2
GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS	BP	SNAI2
GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR	BP	SNAI2
GO_ENDOCARDIAL_CUSHION_FORMATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT	BP	SNAI2
GO_PALATE_DEVELOPMENT	BP	SNAI2
GO_CELL_JUNCTION_ORGANIZATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	SNAI2
GO_MESENCHYMAL_CELL_DIFFERENTIATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS	BP	SNAI2
GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION	BP	SNAI2
GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND	BP	SNAI2
GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN	BP	SNAI2
GO_REGULATION_OF_CHEMOKINE_PRODUCTION	BP	SNAI2
GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_ANOIKIS	BP	SNAI2
GO_REGULATION_OF_PROTEIN_ACETYLATION	BP	SNAI2
GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION	BP	SNAI2
GO_REGULATION_OF_PROTEIN_LOCALIZATION	BP	SNAI2
GO_OSSIFICATION	BP	SNAI2
GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION	BP	SNAI2
GO_REGULATION_OF_ANOIKIS	BP	SNAI2
GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE	BP	SNAI2
GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS	BP	SNAI2
GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION	BP	SNAI2
GO_CELLULAR_RESPONSE_TO_RADIATION	BP	SNAI2
GO_CELLULAR_COMPONENT_MORPHOGENESIS	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS	BP	SNAI2
GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS	BP	SNAI2
GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR	BP	SNAI2
GO_REGULATION_OF_STEROID_METABOLIC_PROCESS	BP	SNAI2
GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	SNAI2
GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION	BP	SNAI2
GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS	BP	SNAI2
GO_MESENCHYME_MORPHOGENESIS	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY	BP	SNAI2
GO_REGULATION_OF_CELL_PROLIFERATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	SNAI2
GO_NEURAL_CREST_CELL_DIFFERENTIATION	BP	SNAI2
GO_REGULATION_OF_PROTEIN_TARGETING	BP	SNAI2
GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION	BP	SNAI2
GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR	BP	SNAI2
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	SNAI2
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	SNAI2
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	SNAI2

Survival analysis of SNAI2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SNAI2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)