Cancer CRCdb

TF information

TF name:	POU3F3
TF family:	Pou
Ensembl gene ID:	ENSG00000198914
Ensembl protein ID:	ENSP00000355001
Entrez gene ID:	5455

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of POU3F3 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_114	Cell line	Mammary Gland	CAL51	0.33165829145729
Sample_02_250	Tissue	Brain	tumormodel3691	1
Sample_02_268	Cell line	Kidney	A-498	0.77607531844194
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	1
Sample_02_413	Tissue	Brain	GBM_2493	0.79120879120879
Sample_02_430	Cell line	Kidney	12364284	1

POU3F3 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_250	Brain	Tissue	tumormodel3691
Sample_02_268	Kidney	Cell line	A-498
Sample_02_314	Neuroblastoma	Cell line	SK-N-FI
Sample_02_413	Brain	Tissue	GBM_2493
Sample_02_430	Kidney	Cell line	12364284

POU3F3 distribution in all CRCs

Genomic distribution of SEs associated with POU3F3

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Mutation of POU3F3

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of POU3F3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	105473061	105473061	G	A	exonic	POU3F3	nonsynonymous	UCEC\|1\|248\|0.00403
rs764256978	chr2	105473394	105473394	G	A	exonic	POU3F3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	105473259	105473259	C	G	exonic	POU3F3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	105473036	105473036	G	A	exonic	POU3F3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213
-	chr2	105472921	105472921	C	T	exonic	POU3F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105472206	105472206	G	T	exonic	POU3F3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	105473071	105473071	T	G	exonic	POU3F3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	105472918	105472918	C	T	exonic	POU3F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105473180	105473180	C	A	exonic	POU3F3	synonymous	ACC\|1\|90\|0.01111
-	chr2	105473035	105473035	C	T	exonic	POU3F3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	105473217	105473217	G	A	exonic	POU3F3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	105472906	105472906	A	G	exonic	POU3F3	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	105472966	105472966	G	A	exonic	POU3F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs186512421	chr2	105472055	105472055	T	C	exonic	POU3F3	synonymous	ACC\|2\|90\|0.02222
rs867028851	chr2	105472298	105472298	T	C	exonic	POU3F3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UVM\|1\|80\|0.01250
-	chr2	105473304	105473304	G	T	exonic	POU3F3	stopgain	ESCA\|1\|185\|0.00541
-	chr2	105472187	105472187	C	G	exonic	POU3F3	synonymous	LUAD\|2\|543\|0.00368
-	chr2	105473009	105473009	G	-	exonic	POU3F3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	105473434	105473434	C	T	exonic	POU3F3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs377188135	chr2	105473243	105473243	C	T	exonic	POU3F3	synonymous	SKCM\|1\|368\|0.00272
-	chr2	105472909	105472909	A	T	exonic	POU3F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105473431	105473431	C	T	exonic	POU3F3	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	105473459	105473459	G	C	exonic	POU3F3	synonymous	BLCA\|2\|396\|0.00505
-	chr2	105473140	105473140	C	T	exonic	POU3F3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	105473369	105473369	C	A	exonic	POU3F3	synonymous	LUSC\|1\|178\|0.00562
-	chr2	105472278	105472279	GC	-	exonic	POU3F3	frameshift	LUAD\|1\|543\|0.00184
-	chr2	105473228	105473228	G	A	exonic	POU3F3	synonymous	DLBC\|1\|48\|0.02083
rs769870078	chr2	105472295	105472295	C	T	exonic	POU3F3	synonymous	UVM\|1\|80\|0.01250
-	chr2	105472851	105472852	GG	-	exonic	POU3F3	frameshift	ESCA\|1\|185\|0.00541,PRAD\|1\|499\|0.00200,THCA\|1\|504\|0.00198
-	chr2	105472929	105472929	G	T	exonic	POU3F3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	105472929	105472929	G	A	exonic	POU3F3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	105473365	105473365	C	T	exonic	POU3F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105473289	105473289	G	A	exonic	POU3F3	nonsynonymous	HNSC\|1\|512\|0.00195,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105473057	105473057	C	T	exonic	POU3F3	synonymous	LUAD\|1\|543\|0.00184,UCEC\|3\|248\|0.01210
-	chr2	105473259	105473259	C	A	exonic	POU3F3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	105473172	105473172	G	T	exonic	POU3F3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	105473102	105473102	G	A	exonic	POU3F3	synonymous	UCEC\|1\|248\|0.00403
-	chr2	105473034	105473034	T	C	exonic	POU3F3	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr2	105473462	105473462	C	T	exonic	POU3F3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105473124	105473124	G	T	exonic	POU3F3	stopgain	LUAD\|1\|543\|0.00184
-	chr2	105473362	105473362	C	T	exonic	POU3F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105473021	105473021	C	A	exonic	POU3F3	stopgain	LUSC\|1\|178\|0.00562
-	chr2	105473139	105473139	A	T	exonic	POU3F3	nonsynonymous	SKCM\|1\|368\|0.00272
rs745546456	chr2	105473129	105473129	G	A	exonic	POU3F3	synonymous	UCEC\|1\|248\|0.00403
-	chr2	105473134	105473134	C	G	exonic	POU3F3	stopgain	ESCA\|1\|185\|0.00541
-	chr2	105473170	105473170	C	T	exonic	POU3F3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	105472255	105472255	A	C	exonic	POU3F3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	105473227	105473227	C	T	exonic	POU3F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105473121	105473121	G	C	exonic	POU3F3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	105472922	105472922	G	A	exonic	POU3F3	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	105472182	105472182	A	G	exonic	POU3F3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	105473303	105473303	C	G	exonic	POU3F3	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr2	105473199	105473199	A	G	exonic	POU3F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105472801	105472801	C	T	exonic	POU3F3	nonsynonymous	OV\|1\|469\|0.00213
-	chr2	105473386	105473386	C	T	exonic	POU3F3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	105472990	105472990	C	T	exonic	POU3F3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	105473018	105473018	C	A	exonic	POU3F3	synonymous	UCEC\|1\|248\|0.00403
-	chr2	105473174	105473180	GCAGGGC	-	exonic	POU3F3	frameshift	BLCA\|1\|396\|0.00253
rs199565525	chr2	105473141	105473141	C	T	exonic	POU3F3	synonymous	SKCM\|1\|368\|0.00272
-	chr2	105472985	105472985	G	A	exonic	POU3F3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	105473188	105473188	G	A	exonic	POU3F3	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr2	105473058	105473058	G	C	exonic	POU3F3	nonsynonymous	BLCA\|1\|396\|0.00253

Disease information of POU3F3

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
POU3F3	Degenerative polyarthritis	C05	Disease or Syndrome	CTD_human
POU3F3	Osteoarthrosis Deformans	C05	Disease or Syndrome	CTD_human

Pathway associated with POU3F3

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of POU3F3

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GO_term_name	GO_term_type	TF_name
GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT	BP	POU3F3
GO_LOOP_OF_HENLE_DEVELOPMENT	BP	POU3F3
GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT	BP	POU3F3
GO_CELL_PROLIFERATION_IN_FOREBRAIN	BP	POU3F3
GO_FOREBRAIN_CELL_MIGRATION	BP	POU3F3
GO_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	POU3F3
GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT	BP	POU3F3
GO_RENAL_TUBULE_DEVELOPMENT	BP	POU3F3
GO_DISTAL_TUBULE_DEVELOPMENT	BP	POU3F3
GO_CEREBRAL_CORTEX_CELL_MIGRATION	BP	POU3F3
GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION	BP	POU3F3
GO_HMG_BOX_DOMAIN_BINDING	MF	POU3F3

Survival analysis of POU3F3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of POU3F3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)