Cancer CRCdb

TF information

TF name:	NR2F1
TF family:	RXR-like
Ensembl gene ID:	ENSG00000175745
Ensembl protein ID:	ENSP00000481517, ENSP00000325819, ENSP00000495420, ENSP00000495740
Entrez gene ID:	7025

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NR2F1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_250	Tissue	Brain	tumormodel3691	0.375
Sample_02_285	Cell line	Liver	HuH7_untreat	0.12543554006969
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.055701179554391
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.46753246753247
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.028901734104046
Sample_02_413	Tissue	Brain	GBM_2493	0.21978021978022

NR2F1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

NR2F1 distribution in all CRCs

Genomic distribution of SEs associated with NR2F1

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Mutation of NR2F1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NR2F1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr5	92923673	92923673	G	A	exonic	NR2F1	nonsynonymous	UCEC\|1\|248\|0.00403
rs749201458	chr5	92924011	92924011	C	T	exonic	NR2F1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	92929432	92929432	G	A	exonic	NR2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	92929324	92929324	T	G	exonic	NR2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	92923863	92923863	G	A	exonic	NR2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	92923685	92923685	G	A	exonic	NR2F1	nonsynonymous	BRCA\|1\|982\|0.00102,SKCM\|1\|368\|0.00272
rs777533706	chr5	92923970	92923970	C	T	exonic	NR2F1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	92923744	92923744	C	T	exonic	NR2F1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92923831	92923831	G	A	exonic	NR2F1	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr5	92923969	92923969	G	A	exonic	NR2F1	synonymous	BLCA\|1\|396\|0.00253
-	chr5	92920997	92920997	G	A	exonic	NR2F1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	92923762	92923762	G	A	exonic	NR2F1	synonymous	PAAD\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs747863258	chr5	92923699	92923699	C	T	exonic	NR2F1	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr5	92929285	92929285	G	A	exonic	NR2F1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	92923881	92923881	C	T	exonic	NR2F1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr5	92923860	92923860	C	T	exonic	NR2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	92929327	92929327	G	T	exonic	NR2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	92923852	92923852	C	T	exonic	NR2F1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	92923983	92923983	C	T	exonic	NR2F1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr5	92920775	92920775	G	T	exonic	NR2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	92923708	92923708	C	T	exonic	NR2F1	synonymous	UCEC\|1\|248\|0.00403
-	chr5	92929319	92929319	C	T	exonic	NR2F1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	92924027	92924027	G	A	exonic	NR2F1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr5	92923702	92923702	C	T	exonic	NR2F1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	92929390	92929390	C	T	exonic	NR2F1	synonymous	OV\|1\|469\|0.00213
-	chr5	92929334	92929334	A	T	exonic	NR2F1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	92923833	92923833	G	A	exonic	NR2F1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr5	92929485	92929485	C	A	exonic	NR2F1	synonymous	HNSC\|1\|512\|0.00195
-	chr5	92923742	92923742	G	A	exonic	NR2F1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	92923984	92923984	G	A	exonic	NR2F1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92929399	92929399	C	A	exonic	NR2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	92923806	92923806	T	C	exonic	NR2F1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr5	92924048	92924048	G	A	exonic	NR2F1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr5	92923850	92923850	G	A	exonic	NR2F1	nonsynonymous	STAD\|3\|395\|0.00759,STES\|3\|395\|0.00759
rs138827038	chr5	92929473	92929473	C	T	exonic	NR2F1	synonymous	LUAD\|1\|543\|0.00184
rs530910180	chr5	92929326	92929326	C	T	exonic	NR2F1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92921192	92921192	G	A	exonic	NR2F1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	92923897	92923897	C	T	exonic	NR2F1	synonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92929486	92929486	C	T	exonic	NR2F1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	92921132	92921132	C	A	exonic	NR2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	92923832	92923832	C	T	exonic	NR2F1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184
-	chr5	92923652	92923652	C	A	exonic	NR2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	92929440	92929440	C	T	exonic	NR2F1	synonymous	CESC\|1\|194\|0.00515
-	chr5	92924063	92924063	T	G	exonic	NR2F1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr5	92923847	92923847	G	A	exonic	NR2F1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr5	92921039	92921039	G	A	exonic	NR2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	92923755	92923755	C	T	exonic	NR2F1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	92929424	92929424	C	A	exonic	NR2F1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr5	92921011	92921011	C	T	exonic	NR2F1	synonymous	PAAD\|1\|185\|0.00541
-	chr5	92921109	92921109	A	G	exonic	NR2F1	nonsynonymous	OV\|1\|469\|0.00213
-	chr5	92924056	92924056	C	A	exonic	NR2F1	synonymous	LUAD\|1\|543\|0.00184
rs761244180	chr5	92929488	92929488	C	T	exonic	NR2F1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,HNSC\|1\|512\|0.00195
-	chr5	92929388	92929388	T	G	exonic	NR2F1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	92929289	92929289	C	T	exonic	NR2F1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,PAAD\|1\|185\|0.00541
-	chr5	92929415	92929415	T	G	exonic	NR2F1	nonsynonymous	OV\|1\|469\|0.00213
-	chr5	92923651	92923651	C	A	exonic	NR2F1	synonymous	LUAD\|1\|543\|0.00184
-	chr5	92929487	92929487	G	A	exonic	NR2F1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr5	92923700	92923700	G	T	exonic	NR2F1	nonsynonymous	BLCA\|1\|396\|0.00253
rs370092446	chr5	92929431	92929431	C	T	exonic	NR2F1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92923849	92923849	C	A	exonic	NR2F1	synonymous	LUAD\|1\|543\|0.00184
-	chr5	92923753	92923753	C	T	exonic	NR2F1	synonymous	LUAD\|1\|543\|0.00184
-	chr5	92923770	92923770	G	A	exonic	NR2F1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr5	92924128	92924128	A	C	exonic	NR2F1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92923999	92923999	C	T	exonic	NR2F1	synonymous	HNSC\|2\|512\|0.00391
-	chr5	92923980	92923980	C	T	exonic	NR2F1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92923623	92923623	C	T	exonic	NR2F1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	92924099	92924099	G	A	exonic	NR2F1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92929393	92929393	C	T	exonic	NR2F1	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92924033	92924033	G	A	exonic	NR2F1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr5	92923819	92923819	C	T	exonic	NR2F1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	92923860	92923860	C	G	exonic	NR2F1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92921161	92921161	G	T	exonic	NR2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	92923892	92923892	A	G	exonic	NR2F1	nonsynonymous	BLCA\|1\|396\|0.00253
rs142689077	chr5	92929320	92929320	G	A	exonic	NR2F1	synonymous	UCS\|1\|57\|0.01754
-	chr5	92929548	92929548	G	C	exonic	NR2F1	stoploss	HNSC\|1\|512\|0.00195
-	chr5	92924138	92924138	C	T	exonic	NR2F1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92923837	92923837	G	C	exonic	NR2F1	synonymous	HNSC\|1\|512\|0.00195
-	chr5	92929450	92929450	C	T	exonic	NR2F1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	92921100	92921100	C	T	exonic	NR2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	92924092	92924092	G	A	exonic	NR2F1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs371426115	chr5	92929368	92929368	C	T	exonic	NR2F1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	92923924	92923924	C	A	exonic	NR2F1	synonymous	PAAD\|1\|185\|0.00541
-	chr5	92923842	92923842	T	C	exonic	NR2F1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr5	92923686	92923686	G	A	exonic	NR2F1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	92921019	92921019	A	G	exonic	NR2F1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92923690	92923690	C	-	exonic	NR2F1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92923678	92923678	C	T	exonic	NR2F1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	92929449	92929449	C	T	exonic	NR2F1	synonymous	SKCM\|1\|368\|0.00272

Disease information of NR2F1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
NR2F1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
NR2F1	Corpus Luteum Cyst	C04;C13;C19	Disease or Syndrome	CTD_human
NR2F1	Ovarian Cysts	C04;C13;C19	Disease or Syndrome	CTD_human
NR2F1	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
NR2F1	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
NR2F1	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
NR2F1	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
NR2F1	BOSCH-BOONSTRA-SCHAAF OPTIC ATROPHY SYNDROME		Disease or Syndrome	CTD_human;ORPHANET;UNIPROT

Pathway associated with NR2F1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001534	Nuclear Receptor transcription pathway	reactome	51	284

Go term information of NR2F1

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GO_term_name	GO_term_type	TF_name
GO_RESPONSE_TO_STEROID_HORMONE	BP	NR2F1
GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS	BP	NR2F1
GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY	BP	NR2F1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING	MF	NR2F1
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY	MF	NR2F1

Survival analysis of NR2F1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NR2F1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)