Cancer CRCdb

TF information

TF name:	HOXA11
TF family:	Homeobox
Ensembl gene ID:	ENSG00000005073
Ensembl protein ID:	ENSP00000448962, ENSP00000006015
Entrez gene ID:	3207

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of HOXA11 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.23244552058111
Sample_02_021	Cell line	Colon	V429	0.40818679734794
Sample_02_114	Cell line	Mammary Gland	CAL51	0.68844221105528
Sample_02_242	Cell line	Colon	V481	0.42703326283407
Sample_02_268	Cell line	Kidney	A-498	0.17482001107624
Sample_02_358	Cell line	Colon	LS180	0.85979462875197
Sample_02_361	Cell line	Colon	HT29_DMSO	0.27079646017699
Sample_02_424	Cell line	Colon	SW620	1

HOXA11 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_242	Colon	Cell line	V481
Sample_02_358	Colon	Cell line	LS180
Sample_02_424	Colon	Cell line	SW620

HOXA11 distribution in all CRCs

Genomic distribution of SEs associated with HOXA11

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Mutation of HOXA11

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HOXA11

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr7	27224643	27224643	G	A	exonic	HOXA11	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr7	27222461	27222461	-	T	exonic	HOXA11	frameshift	PAAD\|9\|185\|0.04865,PCPG\|1\|184\|0.00543
-	chr7	27222479	27222479	C	T	exonic	HOXA11	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr7	27224066	27224066	G	A	exonic	HOXA11	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr7	27222458	27222458	T	A	exonic	HOXA11	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr7	27224468	27224468	G	A	exonic	HOXA11	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	27224559	27224559	G	C	exonic	HOXA11	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr7	27222632	27222632	C	T	exonic	HOXA11	nonsynonymous	PAAD\|1\|185\|0.00541
rs200352994	chr7	27224464	27224464	G	A	exonic	HOXA11	synonymous	LUAD\|1\|543\|0.00184
-	chr7	27224642	27224642	C	T	exonic	HOXA11	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr7	27224618	27224619	GA	-	exonic	HOXA11	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	27222546	27222546	G	A	exonic	HOXA11	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	27224590	27224590	G	A	exonic	HOXA11	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr7	27224653	27224653	G	T	exonic	HOXA11	synonymous	LUSC\|1\|178\|0.00562
-	chr7	27222562	27222562	G	A	exonic	HOXA11	synonymous	PAAD\|1\|185\|0.00541
-	chr7	27224386	27224386	G	C	exonic	HOXA11	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr7	27224337	27224337	A	T	exonic	HOXA11	nonsynonymous	CESC\|1\|194\|0.00515
-	chr7	27222523	27222523	G	C	exonic	HOXA11	synonymous	BRCA\|2\|982\|0.00204
rs777829525	chr7	27222462	27222462	T	-	exonic	HOXA11	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184,PAAD\|5\|185\|0.02703,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	27224168	27224169	CC	-	exonic	HOXA11	frameshift	SKCM\|1\|368\|0.00272,THYM\|1\|123\|0.00813
-	chr7	27224326	27224326	T	A	exonic	HOXA11	synonymous	LUSC\|1\|178\|0.00562
-	chr7	27224432	27224432	G	A	exonic	HOXA11	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr7	27224736	27224736	A	G	exonic	HOXA11	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr7	27224434	27224434	G	T	exonic	HOXA11	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr7	27224742	27224742	G	T	exonic	HOXA11	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	27224568	27224568	-	A	exonic	HOXA11	frameshift	BRCA\|1\|982\|0.00102
-	chr7	27224125	27224125	C	T	exonic	HOXA11	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	27224672	27224672	G	A	exonic	HOXA11	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	27224354	27224354	G	T	exonic	HOXA11	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	27222489	27222489	G	A	exonic	HOXA11	stopgain	SKCM\|1\|368\|0.00272
-	chr7	27222504	27222504	C	A	exonic	HOXA11	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr7	27222475	27222475	C	T	exonic	HOXA11	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr7	27224386	27224386	G	T	exonic	HOXA11	nonsynonymous	UCEC\|1\|248\|0.00403
rs748711854	chr7	27224700	27224700	C	T	exonic	HOXA11	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr7	27224538	27224538	G	-	exonic	HOXA11	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	27224340	27224340	G	T	exonic	HOXA11	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	27222437	27222437	T	C	exonic	HOXA11	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr7	27222531	27222531	G	A	exonic	HOXA11	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr7	27222559	27222559	A	C	exonic	HOXA11	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr7	27222459	27222459	T	G	exonic	HOXA11	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr7	27224509	27224509	C	A	exonic	HOXA11	synonymous	LIHC\|1\|373\|0.00268
-	chr7	27222434	27222434	G	A	exonic	HOXA11	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr7	27224352	27224352	G	A	exonic	HOXA11	stopgain	UCEC\|1\|248\|0.00403
-	chr7	27224674	27224674	G	A	exonic	HOXA11	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	27222608	27222608	T	C	exonic	HOXA11	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr7	27224287	27224287	G	A	exonic	HOXA11	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr7	27224475	27224475	G	C	exonic	HOXA11	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr7	27224479	27224479	C	A	exonic	HOXA11	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr7	27224662	27224662	C	A	exonic	HOXA11	synonymous	LUAD\|1\|543\|0.00184
-	chr7	27224431	27224431	C	T	exonic	HOXA11	synonymous	LUSC\|1\|178\|0.00562
-	chr7	27222618	27222618	G	A	exonic	HOXA11	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204

Disease information of HOXA11

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
HOXA11	Cytopenia		Pathologic Function	GENOMICS_ENGLAND
HOXA11	Endometrial Neoplasms	C04;C13	Neoplastic Process	CTD_human
HOXA11	Kidney Diseases	C12;C13	Disease or Syndrome	CTD_human
HOXA11	Congenital anemia		Disease or Syndrome	GENOMICS_ENGLAND
HOXA11	Limb Deformities, Congenital	C05;C16	Congenital Abnormality	CTD_human
HOXA11	Endometrial Carcinoma	C04;C13	Neoplastic Process	CTD_human
HOXA11	Female Urogenital Diseases	C13	Disease or Syndrome	CTD_human
HOXA11	Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia	C05;C15;C16	Disease or Syndrome	CTD_human;ORPHANET

Pathway associated with HOXA11

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of HOXA11

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GO_term_name	GO_term_type	TF_name
GO_SINGLE_FERTILIZATION	BP	HOXA11
GO_METANEPHROS_DEVELOPMENT	BP	HOXA11
GO_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	HOXA11
GO_EMBRYONIC_DIGIT_MORPHOGENESIS	BP	HOXA11
GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT	BP	HOXA11
GO_MORPHOGENESIS_OF_AN_EPITHELIUM	BP	HOXA11
GO_DEVELOPMENTAL_INDUCTION	BP	HOXA11
GO_FORELIMB_MORPHOGENESIS	BP	HOXA11
GO_KIDNEY_EPITHELIUM_DEVELOPMENT	BP	HOXA11
GO_REGULATION_OF_ORGAN_FORMATION	BP	HOXA11
GO_PROXIMAL_DISTAL_PATTERN_FORMATION	BP	HOXA11
GO_EMBRYONIC_FORELIMB_MORPHOGENESIS	BP	HOXA11
GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER	BP	HOXA11
GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT	BP	HOXA11
GO_NEPHRON_EPITHELIUM_DEVELOPMENT	BP	HOXA11
GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS	BP	HOXA11
GO_APPENDAGE_DEVELOPMENT	BP	HOXA11
GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	HOXA11
GO_MESONEPHRIC_TUBULE_MORPHOGENESIS	BP	HOXA11
GO_ORGAN_INDUCTION	BP	HOXA11
GO_MESODERM_MORPHOGENESIS	BP	HOXA11
GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	HOXA11
GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT	BP	HOXA11
GO_MESODERMAL_CELL_DIFFERENTIATION	BP	HOXA11
GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS	BP	HOXA11
GO_SEX_DIFFERENTIATION	BP	HOXA11
GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	HOXA11
GO_BONE_MORPHOGENESIS	BP	HOXA11
GO_CELL_FATE_SPECIFICATION	BP	HOXA11
GO_ENDOCHONDRAL_BONE_MORPHOGENESIS	BP	HOXA11
GO_KIDNEY_MORPHOGENESIS	BP	HOXA11
GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	HOXA11
GO_MESONEPHROS_DEVELOPMENT	BP	HOXA11
GO_MESODERMAL_CELL_FATE_COMMITMENT	BP	HOXA11
GO_UTERUS_DEVELOPMENT	BP	HOXA11
GO_PROTEIN_DNA_COMPLEX	CC	HOXA11

Survival analysis of HOXA11

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of HOXA11

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)