TF information
| TF name: | FOXD3 |
| TF family: | Fork_head |
| Ensembl gene ID: | ENSG00000187140 |
| Ensembl protein ID: | ENSP00000360157 |
| Entrez gene ID: | 27022 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of FOXD3 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_180 | Cell line | Human melanoma | CJM | 0.5390625 |
| Sample_02_181 | Cell line | Human melanoma | COLO679 | 0.4432 |
| Sample_02_183 | Cell line | Skin | SKMEL2 | 1 |
| Sample_02_184 | Cell line | Skin | SKMEL30 | 0.4887459807074 |
FOXD3 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_180 | Human melanoma | Cell line | CJM |
| Sample_02_181 | Human melanoma | Cell line | COLO679 |
| Sample_02_183 | Skin | Cell line | SKMEL2 |
| Sample_02_184 | Skin | Cell line | SKMEL30 |
FOXD3 distribution in all CRCs
Genomic distribution of SEs associated with FOXD3
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of FOXD3
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr1 | 63789224 | 63789224 | C | T | exonic | FOXD3 | synonymous | LIHC|1|373|0.00268 |
| - | chr1 | 63789386 | 63789386 | G | A | exonic | FOXD3 | synonymous | HNSC|1|512|0.00195 |
| rs202214846 | chr1 | 63790037 | 63790037 | G | A | exonic | FOXD3 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 63789535 | 63789535 | G | T | exonic | FOXD3 | nonsynonymous | LUAD|1|543|0.00184 |
| rs145695569 | chr1 | 63789108 | 63789108 | G | A | exonic | FOXD3 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 63789206 | 63789206 | G | A | exonic | FOXD3 | synonymous | BRCA|1|982|0.00102 |
| - | chr1 | 63789443 | 63789443 | G | C | exonic | FOXD3 | nonsynonymous | SARC|1|247|0.00405 |
| - | chr1 | 63789824 | 63789824 | G | A | exonic | FOXD3 | synonymous | LIHC|1|373|0.00268 |
| - | chr1 | 63789273 | 63789273 | T | G | exonic | FOXD3 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr1 | 63789224 | 63789224 | C | G | exonic | FOXD3 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr1 | 63789106 | 63789106 | C | T | exonic | FOXD3 | nonsynonymous | UCEC|1|248|0.00403 |
| rs2274187 | chr1 | 63788951 | 63788951 | C | A | exonic | FOXD3 | synonymous | ACC|4|90|0.04444 |
| - | chr1 | 63789265 | 63789265 | G | A | exonic | FOXD3 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 63789229 | 63789229 | T | A | exonic | FOXD3 | nonsynonymous | LUAD|1|543|0.00184 |
| rs760636951 | chr1 | 63789347 | 63789347 | G | A | exonic | FOXD3 | synonymous | PAAD|1|185|0.00541 |
| - | chr1 | 63789463 | 63789463 | T | A | exonic | FOXD3 | nonsynonymous | LUAD|1|543|0.00184 |
| rs756791555 | chr1 | 63789125 | 63789125 | G | A | exonic | FOXD3 | synonymous | UCEC|1|248|0.00403 |
| - | chr1 | 63788897 | 63788897 | C | T | exonic | FOXD3 | synonymous | LIHC|1|373|0.00268 |
| - | chr1 | 63789206 | 63789207 | GA | - | exonic | FOXD3 | frameshift | ACC|1|90|0.01111 |
| - | chr1 | 63789483 | 63789483 | A | G | exonic | FOXD3 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 63789164 | 63789164 | G | A | exonic | FOXD3 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 63789968 | 63789968 | G | A | exonic | FOXD3 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 63790123 | 63790123 | C | - | exonic | FOXD3 | frameshift | UVM|1|80|0.01250 |
| - | chr1 | 63789346 | 63789346 | C | T | exonic | FOXD3 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr1 | 63788839 | 63788839 | A | G | exonic | FOXD3 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr1 | 63788985 | 63788995 | GCCGGAGCCGG | - | exonic | FOXD3 | frameshift | SARC|1|247|0.00405 |
| - | chr1 | 63789491 | 63789491 | G | C | exonic | FOXD3 | nonsynonymous | CESC|1|194|0.00515 |
| rs114453593 | chr1 | 63789368 | 63789368 | C | T | exonic | FOXD3 | synonymous | LUAD|1|543|0.00184 |
| - | chr1 | 63789225 | 63789225 | G | A | exonic | FOXD3 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr1 | 63789287 | 63789287 | G | A | exonic | FOXD3 | synonymous | BLCA|1|396|0.00253 |
| - | chr1 | 63789349 | 63789349 | G | A | exonic | FOXD3 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr1 | 63789348 | 63789348 | G | T | exonic | FOXD3 | nonsynonymous | LUAD|1|543|0.00184 |
| rs765929377 | chr1 | 63789525 | 63789525 | G | A | exonic | FOXD3 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr1 | 63789297 | 63789297 | C | T | exonic | FOXD3 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr1 | 63789409 | 63789409 | A | G | exonic | FOXD3 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr1 | 63788817 | 63788817 | G | A | exonic | FOXD3 | nonsynonymous | BRCA|1|982|0.00102 |
| rs776336618 | chr1 | 63789081 | 63789081 | G | A | exonic | FOXD3 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs746549793 | chr1 | 63789072 | 63789072 | G | A | exonic | FOXD3 | nonsynonymous | LIHC|1|373|0.00268 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| FOXD3 | Unipolar Depression | F03 | Mental or Behavioral Dysfunction | PSYGENET |
| FOXD3 | Major Depressive Disorder | F03 | Mental or Behavioral Dysfunction | PSYGENET |
| FOXD3 | AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 1 | Finding | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0001701 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 | 36 |
| pathway0002747 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 | 129 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE | BP | FOXD3 |
| GO_NUCLEAR_CHROMOSOME | CC | FOXD3 |