Cancer CRCdb

TF information

TF name:	ETV6
TF family:	ETS
Ensembl gene ID:	ENSG00000139083
Ensembl protein ID:	ENSP00000379658, ENSP00000266427
Entrez gene ID:	2120

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ETV6 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.1264367816092
Sample_02_242	Cell line	Colon	V481	0.66419919246299
Sample_02_268	Cell line	Kidney	A-498	0.24976924496954
Sample_02_300	Cell line	Neuroblastoma	CLB-PE	0.08974358974359
Sample_02_356	Cell line	Colon	Sw480	0.25161290322581
Sample_02_430	Cell line	Kidney	12364284	0.35714285714286

ETV6 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_242	Colon	Cell line	V481

ETV6 distribution in all CRCs

Genomic distribution of SEs associated with ETV6

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Mutation of ETV6

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ETV6

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr12	11803022	11803022	A	-	UTR5	ETV6	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs201820837	chr12	12022466	12022466	G	A	exonic	ETV6	nonsynonymous	HNSC\|2\|512\|0.00391
rs140005721	chr12	12022779	12022779	C	T	exonic	ETV6	synonymous	PAAD\|1\|185\|0.00541
-	chr12	12022474	12022474	C	T	exonic	ETV6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	12037408	12037408	C	T	exonic	ETV6	stopgain	BLCA\|1\|396\|0.00253
-	chr12	12037492	12037492	G	C	exonic	ETV6	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	12006395	12006395	G	T	exonic	ETV6	synonymous	BLCA\|1\|396\|0.00253
-	chr12	12037425	12037425	C	T	exonic	ETV6	synonymous	LUSC\|1\|178\|0.00562
-	chr12	11905470	11905470	G	T	exonic	ETV6	synonymous	TGCT\|1\|155\|0.00645
-	chr12	12022774	12022774	G	A	exonic	ETV6	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	12022615	12022615	G	A	exonic	ETV6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	12037452	12037452	G	A	exonic	ETV6	synonymous	PRAD\|1\|499\|0.00200
rs786205226	chr12	12038959	12038959	A	G	exonic	ETV6	nonsynonymous	LAML\|1\|197\|0.00508
-	chr12	12038927	12038927	T	C	exonic	ETV6	nonsynonymous	UCS\|1\|57\|0.01754
-	chr12	11992146	11992146	T	C	exonic	ETV6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	11992227	11992227	C	G	exonic	ETV6	nonsynonymous	BLCA\|1\|396\|0.00253,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	11992235	11992235	T	G	exonic	ETV6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	11992221	11992233	ATCGATCTCCTCA	-	exonic	ETV6	frameshift	LAML\|1\|197\|0.00508
rs111871763	chr12	12022526	12022526	G	A	exonic	ETV6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	12043951	12043951	G	A	exonic	ETV6	nonsynonymous	HNSC\|1\|512\|0.00195
rs149660037	chr12	12022435	12022435	C	T	exonic	ETV6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	11803078	11803078	C	T	exonic	ETV6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	12037502	12037502	G	C	exonic	ETV6	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr12	12022503	12022503	C	G	exonic	ETV6	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	12022825	12022825	G	A	exonic	ETV6	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr12	12037406	12037406	A	G	exonic	ETV6	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	12037513	12037513	A	G	exonic	ETV6	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	12022436	12022436	G	T	exonic	ETV6	nonsynonymous	LUSC\|1\|178\|0.00562
rs724159947	chr12	12022535	12022535	C	T	exonic	ETV6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs772696896	chr12	11992232	11992232	C	T	exonic	ETV6	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	12006447	12006447	T	-	exonic	ETV6	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	12043947	12043947	G	A	exonic	ETV6	synonymous	BLCA\|1\|396\|0.00253
-	chr12	12022819	12022819	C	T	exonic	ETV6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	12022357	12022357	G	T	splicing	ETV6	splicing	BLCA\|1\|396\|0.00253
-	chr12	11992182	11992182	G	A	exonic	ETV6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	12022507	12022507	C	T	exonic	ETV6	synonymous	SKCM\|1\|368\|0.00272
-	chr12	11905406	11905406	C	A	exonic	ETV6	nonsynonymous	LUSC\|1\|178\|0.00562
rs753422664	chr12	12022525	12022525	C	T	exonic	ETV6	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
rs762232508	chr12	12022522	12022522	C	T	exonic	ETV6	nonsynonymous	SKCM\|1\|368\|0.00272
rs769260605	chr12	12006464	12006464	G	A	exonic	ETV6	synonymous	UCEC\|1\|248\|0.00403
-	chr12	12038893	12038893	A	G	exonic	ETV6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	12022865	12022865	C	A	exonic	ETV6	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	12038864	12038864	G	T	exonic	ETV6	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr12	11905405	11905405	C	T	exonic	ETV6	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	12006363	12006363	G	A	exonic	ETV6	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	12022897	12022897	A	G	exonic	ETV6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	12022707	12022707	C	T	exonic	ETV6	synonymous	BRCA\|1\|982\|0.00102
-	chr12	12022716	12022716	G	T	exonic	ETV6	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr12	11905486	11905486	G	C	exonic	ETV6	nonsynonymous	CESC\|1\|194\|0.00515
-	chr12	12022745	12022745	C	T	exonic	ETV6	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr12	11905494	11905494	C	T	exonic	ETV6	synonymous	SKCM\|2\|368\|0.00543
-	chr12	12037418	12037418	C	T	exonic	ETV6	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	12022544	12022544	G	C	exonic	ETV6	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	11992157	11992157	G	A	exonic	ETV6	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	12037475	12037475	G	T	exonic	ETV6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	12022503	12022503	C	T	exonic	ETV6	synonymous	HNSC\|1\|512\|0.00195
-	chr12	12022535	12022535	C	A	exonic	ETV6	nonsynonymous	HNSC\|1\|512\|0.00195
rs11611479	chr12	11992168	11992168	G	A	exonic	ETV6	synonymous	ACC\|1\|90\|0.01111
-	chr12	12038866	12038866	A	G	exonic	ETV6	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr12	12022873	12022873	G	C	exonic	ETV6	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr12	11803094	11803094	G	C	exonic	ETV6	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr12	12022421	12022421	T	C	exonic	ETV6	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr12	12022455	12022455	G	C	exonic	ETV6	synonymous	LUAD\|1\|543\|0.00184
-	chr12	12038881	12038881	G	A	exonic	ETV6	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr12	12038938	12038938	C	T	exonic	ETV6	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	11905408	11905408	C	T	exonic	ETV6	nonsynonymous	BRCA\|1\|982\|0.00102
rs374744954	chr12	12022875	12022875	G	A	exonic	ETV6	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	11905486	11905486	G	-	exonic	ETV6	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs746757399	chr12	12022563	12022563	G	A	exonic	ETV6	synonymous	BLCA\|1\|396\|0.00253
-	chr12	12037492	12037492	G	A	exonic	ETV6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	12037474	12037474	C	T	exonic	ETV6	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr12	12037506	12037506	G	-	exonic	ETV6	frameshift	LUAD\|1\|543\|0.00184
rs724159946	chr12	12037475	12037475	G	A	exonic	ETV6	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	12037444	12037444	C	T	exonic	ETV6	stopgain	SKCM\|1\|368\|0.00272
-	chr12	12022502	12022502	C	-	exonic	ETV6	frameshift	PAAD\|2\|185\|0.01081,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr12	12022820	12022820	G	T	exonic	ETV6	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	12043913	12043913	-	A	exonic	ETV6	frameshift	BLCA\|1\|396\|0.00253
-	chr12	11992105	11992105	C	A	exonic	ETV6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	12006418	12006418	T	C	exonic	ETV6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs146150601	chr12	12006453	12006453	C	T	exonic	ETV6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	12006418	12006418	T	-	exonic	ETV6	frameshift	LIHC\|1\|373\|0.00268
rs145477191	chr12	12022496	12022496	T	C	exonic	ETV6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	11992151	11992153	CCA	-	exonic	ETV6	nonframeshift	HNSC\|1\|512\|0.00195
rs747770209	chr12	12022490	12022490	G	A	exonic	ETV6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	12022774	12022774	G	T	exonic	ETV6	stopgain	LUAD\|2\|543\|0.00368
rs781494988	chr12	11905391	11905391	G	A	exonic	ETV6	nonsynonymous	SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
rs745867456	chr12	12022684	12022684	C	T	exonic	ETV6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	11905414	11905414	A	T	exonic	ETV6	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs761268438	chr12	12022746	12022746	C	T	exonic	ETV6	synonymous	BRCA\|1\|982\|0.00102,SKCM\|1\|368\|0.00272
-	chr12	12043919	12043919	G	A	exonic	ETV6	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs141868934	chr12	12022669	12022669	C	G	exonic	ETV6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs201801905	chr12	11905443	11905443	G	A	exonic	ETV6	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	11803095	11803095	G	A	splicing	ETV6	splicing	DLBC\|1\|48\|0.02083
-	chr12	12022498	12022498	C	T	exonic	ETV6	nonsynonymous	SKCM\|1\|368\|0.00272
rs765265003	chr12	12006381	12006381	C	T	exonic	ETV6	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr12	11992222	11992233	TCGATCTCCTCA	-	exonic	ETV6	nonframeshift	LAML\|1\|197\|0.00508
-	chr12	12043881	12043881	G	T	exonic	ETV6	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	12022505	12022505	C	T	exonic	ETV6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	12022795	12022795	G	T	exonic	ETV6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	12038878	12038878	T	-	exonic	ETV6	frameshift	BRCA\|1\|982\|0.00102
-	chr12	12038880	12038880	T	A	exonic	ETV6	stopgain	BRCA\|1\|982\|0.00102
-	chr12	12022497	12022497	C	T	exonic	ETV6	synonymous	ESCA\|1\|185\|0.00541
-	chr12	12037501	12037501	C	T	exonic	ETV6	stopgain	UCEC\|1\|248\|0.00403
-	chr12	12037408	12037408	C	G	exonic	ETV6	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr12	12037483	12037483	G	C	exonic	ETV6	nonsynonymous	CESC\|1\|194\|0.00515
rs750795092	chr12	11905513	11905513	C	T	exonic	ETV6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr12	12037420	12037420	G	A	exonic	ETV6	nonsynonymous	BLCA\|1\|396\|0.00253

Disease information of ETV6

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ETV6	Burkitt Lymphoma	C02;C04;C15;C20	Neoplastic Process	ORPHANET
ETV6	Drug abuse	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ETV6	Drug habituation	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ETV6	Drug Use Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ETV6	Fibrosarcoma	C04	Neoplastic Process	ORPHANET
ETV6	Childhood Acute Lymphoblastic Leukemia	C04;C15;C20	Neoplastic Process	CTD_human
ETV6	Leukemia, Lymphocytic, Acute, L2	C04;C15;C20	Neoplastic Process	CTD_human
ETV6	Leukemia, Myelocytic, Acute	C04	Neoplastic Process	CGI
ETV6	Leukemia, Myelomonocytic, Chronic	C04;C15	Neoplastic Process	ORPHANET
ETV6	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
ETV6	Organic Mental Disorders, Substance-Induced	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ETV6	Substance Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ETV6	Substance Use Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ETV6	Thrombocytopenia	C15	Disease or Syndrome	CTD_human
ETV6	Juvenile-Onset Still Disease	C05;C17;C20	Disease or Syndrome	CTD_human
ETV6	Substance-Related Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ETV6	Papillary thyroid carcinoma	C04;C19	Neoplastic Process	ORPHANET
ETV6	Hematopoietic Neoplasms	C04;C15	Neoplastic Process	CTD_human
ETV6	Hematologic Neoplasms	C04;C15	Neoplastic Process	CTD_human;GENOMICS_ENGLAND
ETV6	Substance abuse problem	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ETV6	Precursor B-cell lymphoblastic leukemia		Neoplastic Process	ORPHANET
ETV6	Congenital Mesoblastic Nephroma	C04;C12;C13	Neoplastic Process	ORPHANET
ETV6	Drug Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ETV6	Platelet Disorder, Familial, with Associated Myeloid Malignancy	C04;C15;C16	Disease or Syndrome	ORPHANET
ETV6	Macrocytosis, Familial	C15	Disease or Syndrome	CTD_human
ETV6	Precursor Cell Lymphoblastic Leukemia Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
ETV6	Juvenile arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
ETV6	Juvenile psoriatic arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
ETV6	THROMBOCYTOPENIA 5		Disease or Syndrome	CTD_human;UNIPROT
ETV6	Prescription Drug Abuse	C25;F03	Finding	CTD_human

Pathway associated with ETV6

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000702	ERK cascade ( FGF8 signaling (Mouse) )	inoh	17	71
pathway0000703	ERK cascade ( FGF8 signaling (Xenopus) )	inoh	17	71
pathway0000781	FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) )	inoh	20	66
pathway0000782	FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) )	inoh	18	53
pathway0002565	MAPK signaling pathway - fly	kegg	16	62
pathway0002588	Dorso-ventral axis formation	kegg	25	58

Go term information of ETV6

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GO_term_name	GO_term_type	TF_name
GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION	BP	ETV6
GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	ETV6
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	ETV6

Survival analysis of ETV6

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ETV6

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)