TF information
| TF name: | BHLHE41 |
| TF family: | bHLH |
| Ensembl gene ID: | ENSG00000123095 |
| Ensembl protein ID: | ENSP00000242728 |
| Entrez gene ID: | 79365 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of BHLHE41 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_01_059 | Cell line | Lung | PC-9 | 0.26666666666667 |
| Sample_02_007 | Other | Cervical | cervical-cancer_vector | 0.016556291390728 |
| Sample_02_242 | Cell line | Colon | V481 | 0.11738127283215 |
| Sample_02_267 | Cell line | Kidney | 786-O | 0.3 |
| Sample_02_268 | Cell line | Kidney | A-498 | 0.04965848255492 |
| Sample_02_359 | Cell line | Colon | Colo741 | 0.08433734939759 |
| Sample_02_361 | Cell line | Colon | HT29_DMSO | 0.21061946902655 |
| Sample_02_413 | Tissue | Brain | GBM_2493 | 0.093406593406593 |
| Sample_02_430 | Cell line | Kidney | 12364284 | 0.10714285714286 |
BHLHE41 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
BHLHE41 distribution in all CRCs
Genomic distribution of SEs associated with BHLHE41
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of BHLHE41
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| rs61754129 | chr12 | 26275827 | 26275827 | C | G | exonic | BHLHE41 | synonymous | ACC|1|90|0.01111 |
| - | chr12 | 26277661 | 26277661 | C | A | exonic | BHLHE41 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr12 | 26277082 | 26277082 | C | A | exonic | BHLHE41 | stopgain | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 26275863 | 26275863 | G | A | exonic | BHLHE41 | synonymous | ACC|1|90|0.01111 |
| - | chr12 | 26278872 | 26278872 | - | C | upstream | BHLHE41 | unknown | LUAD|1|543|0.00184 |
| - | chr12 | 26275589 | 26275589 | - | CT | exonic | BHLHE41 | frameshift | LIHC|1|373|0.00268 |
| - | chr12 | 26275005 | 26275005 | A | T | exonic | BHLHE41 | synonymous | LIHC|1|373|0.00268 |
| - | chr12 | 26277466 | 26277466 | G | A | exonic | BHLHE41 | stopgain | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 26277038 | 26277038 | C | T | exonic | BHLHE41 | synonymous | BLCA|1|396|0.00253 |
| rs561601016 | chr12 | 26276042 | 26276042 | G | A | exonic | BHLHE41 | stopgain | LUAD|1|543|0.00184 |
| - | chr12 | 26276595 | 26276595 | - | G | exonic | BHLHE41 | frameshift | BLCA|1|396|0.00253 |
| - | chr12 | 26276658 | 26276658 | T | C | exonic | BHLHE41 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr12 | 26276576 | 26276576 | A | G | exonic | BHLHE41 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 26275865 | 26275865 | C | T | exonic | BHLHE41 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr12 | 26275580 | 26275580 | C | G | exonic | BHLHE41 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr12 | 26277452 | 26277452 | C | T | exonic | BHLHE41 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr12 | 26276649 | 26276649 | A | G | exonic | BHLHE41 | nonsynonymous | UCEC|1|248|0.00403 |
| rs121912617 | chr12 | 26275297 | 26275297 | G | T | exonic | BHLHE41 | nonsynonymous | DLBC|1|48|0.02083 |
| - | chr12 | 26277742 | 26277742 | G | C | UTR5 | BHLHE41 | unknown | BLCA|1|396|0.00253 |
| - | chr12 | 26276012 | 26276012 | G | A | exonic | BHLHE41 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr12 | 26275624 | 26275624 | G | - | exonic | BHLHE41 | frameshift | HNSC|1|512|0.00195 |
| - | chr12 | 26276620 | 26276620 | T | G | exonic | BHLHE41 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr12 | 26277470 | 26277470 | C | T | exonic | BHLHE41 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 26277069 | 26277069 | C | T | exonic | BHLHE41 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr12 | 26277481 | 26277481 | T | G | exonic | BHLHE41 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr12 | 26275895 | 26275895 | G | T | exonic | BHLHE41 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr12 | 26275715 | 26275715 | C | T | exonic | BHLHE41 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 26275892 | 26275892 | G | C | exonic | BHLHE41 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr12 | 26276075 | 26276075 | G | A | exonic | BHLHE41 | stopgain | BLCA|1|396|0.00253 |
| - | chr12 | 26275803 | 26275803 | G | - | exonic | BHLHE41 | frameshift | LUSC|1|178|0.00562 |
| - | chr12 | 26276611 | 26276611 | T | C | exonic | BHLHE41 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr12 | 26277067 | 26277067 | C | T | exonic | BHLHE41 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr12 | 26277471 | 26277471 | A | G | exonic | BHLHE41 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr12 | 26277071 | 26277074 | TCTT | - | exonic | BHLHE41 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 26276608 | 26276608 | C | T | exonic | BHLHE41 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr12 | 26275573 | 26275583 | CCGCCGCCGCT | - | exonic | BHLHE41 | frameshift | LUSC|1|178|0.00562 |
| - | chr12 | 26276085 | 26276085 | T | C | exonic | BHLHE41 | synonymous | HNSC|1|512|0.00195 |
| - | chr12 | 26275918 | 26275918 | G | - | exonic | BHLHE41 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 26277707 | 26277707 | G | A | exonic | BHLHE41 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 26277809 | 26277809 | G | A | UTR5 | BHLHE41 | unknown | PRAD|1|499|0.00200 |
| - | chr12 | 26277093 | 26277093 | T | C | exonic | BHLHE41 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr12 | 26277501 | 26277501 | G | A | exonic | BHLHE41 | nonsynonymous | BLCA|1|396|0.00253 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| BHLHE41 | Bipolar Disorder | F03 | Mental or Behavioral Dysfunction | PSYGENET |
| BHLHE41 | Lung Neoplasms | C04;C08 | Neoplastic Process | CTD_human |
| BHLHE41 | Malignant neoplasm of lung | C04;C08 | Neoplastic Process | CTD_human |
| BHLHE41 | Long Sleeper Syndrome | C10;C23;F03 | Disease or Syndrome | CTD_human |
| BHLHE41 | Short Sleeper Syndrome | C10;C23;F03 | Disease or Syndrome | CTD_human |
| BHLHE41 | Sleep-Related Neurogenic Tachypnea | C10;C23;F03 | Disease or Syndrome | CTD_human |
| BHLHE41 | Subwakefullness Syndrome | C10;C23;F03 | Disease or Syndrome | CTD_human |
| BHLHE41 | Sleep Disorders | C10;C23;F03 | Disease or Syndrome | CTD_human |
| BHLHE41 | Sleep Wake Disorders | C10;C23;F03 | Mental or Behavioral Dysfunction | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000316 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 | 282 |
| pathway0001021 | HIF-1-alpha transcription factor network | pid | 67 | 420 |
| pathway0002614 | Circadian rhythm - mammal | kegg | 19 | 111 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_CIRCADIAN_RHYTHM | BP | BHLHE41 |
| GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION | BP | BHLHE41 |
| GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION | BP | BHLHE41 |
| GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION | BP | BHLHE41 |
| GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION | BP | BHLHE41 |
| GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION | BP | BHLHE41 |
| GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION | BP | BHLHE41 |
| GO_BHLH_TRANSCRIPTION_FACTOR_BINDING | MF | BHLHE41 |
| GO_HISTONE_DEACETYLASE_BINDING | MF | BHLHE41 |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING | MF | BHLHE41 |
| GO_E_BOX_BINDING | MF | BHLHE41 |
| GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING | MF | BHLHE41 |
| GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING | MF | BHLHE41 |
| GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING | MF | BHLHE41 |
| GO_SEQUENCE_SPECIFIC_DNA_BINDING | MF | BHLHE41 |
| GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING | MF | BHLHE41 |