Cancer CRCdb

TF information

TF name:	ZEB1
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000148516
Ensembl protein ID:	ENSP00000452787, ENSP00000452787, ENSP00000415961, ENSP00000453559, ENSP00000319248, ENSP00000319248, ENSP00000453674, ENSP00000444891, ENSP00000444891, ENSP00000453970, ENSP00000354487, ENSP00000354487, ENSP00000391612
Entrez gene ID:	6935

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ZEB1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_181	Cell line	Human melanoma	COLO679	0.424
Sample_02_304	Cell line	Neuroblastoma	N206	0.48369565217391
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.55555555555556
Sample_02_323	Cell line	Colon	RKO	0.1
Sample_02_395	Cell line	Mammary Gland	BT-549	0.04027972027972
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.28985507246377

ZEB1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_181	Human melanoma	Cell line	COLO679
Sample_02_304	Neuroblastoma	Cell line	N206

ZEB1 distribution in all CRCs

Genomic distribution of SEs associated with ZEB1

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Mutation of ZEB1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ZEB1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr10	31809260	31809260	G	C	exonic	ZEB1	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr10	31816100	31816100	G	C	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31815882	31815882	C	T	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
rs866888806	chr10	31815822	31815822	G	T	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31815612	31815612	A	G	exonic	ZEB1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr10	31815987	31815987	A	G	exonic	ZEB1	nonsynonymous	BRCA\|1\|982\|0.00102
rs775271989	chr10	31810320	31810320	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31784758	31784758	G	T	exonic	ZEB1	stopgain	UCEC\|1\|248\|0.00403
-	chr10	31791302	31791302	G	T	exonic	ZEB1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr10	31816112	31816112	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31809607	31809607	C	T	exonic	ZEB1	synonymous	SKCM\|1\|368\|0.00272
-	chr10	31812941	31812941	G	T	exonic	ZEB1	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr10	31803585	31803585	A	T	exonic	ZEB1	stopgain	SKCM\|1\|368\|0.00272
rs577934227	chr10	31816027	31816027	A	G	exonic	ZEB1	synonymous	HNSC\|1\|512\|0.00195
-	chr10	31799619	31799619	C	G	exonic	ZEB1	stopgain	LUAD\|1\|543\|0.00184
-	chr10	31799803	31799805	AGT	-	exonic	ZEB1	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr10	31815707	31815707	A	T	exonic	ZEB1	stopgain	LUAD\|2\|543\|0.00368
-	chr10	31608200	31608200	G	T	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31799678	31799678	G	C	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31810426	31810426	C	A	exonic	ZEB1	stopgain	UCEC\|1\|248\|0.00403
-	chr10	31809560	31809560	C	T	exonic	ZEB1	stopgain	SKCM\|1\|368\|0.00272
-	chr10	31810783	31810783	G	T	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs755654045	chr10	31810825	31810825	A	G	exonic	ZEB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31816022	31816022	G	A	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31608219	31608219	A	G	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs759615272	chr10	31810806	31810806	C	T	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31809437	31809437	C	A	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31815672	31815672	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31809072	31809072	G	A	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31815698	31815698	C	T	exonic	ZEB1	stopgain	CESC\|1\|194\|0.00515
-	chr10	31809830	31809830	G	C	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31651797	31651797	C	T	intronic	ZEB1	unknown	SARC\|1\|247\|0.00405
rs202145455	chr10	31810851	31810851	C	G	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31815766	31815766	C	T	exonic	ZEB1	synonymous	PAAD\|1\|185\|0.00541
-	chr10	31799797	31799797	A	C	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31791374	31791374	C	T	exonic	ZEB1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr10	31809581	31809581	G	A	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr10	31809938	31809938	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31812883	31812883	C	A	exonic	ZEB1	stopgain	LUAD\|1\|543\|0.00184
rs754576407	chr10	31809248	31809248	C	T	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs567460090	chr10	31652896	31652896	C	T	intronic	ZEB1	unknown	ESCA\|1\|185\|0.00541
-	chr10	31815734	31815734	G	A	exonic	ZEB1	nonsynonymous	UCS\|1\|57\|0.01754
-	chr10	31812973	31812973	C	A	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31815845	31815845	C	A	exonic	ZEB1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr10	31810534	31810534	G	C	exonic	ZEB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr10	31809073	31809073	C	T	exonic	ZEB1	synonymous	LUSC\|1\|178\|0.00562
-	chr10	31815808	31815808	G	A	exonic	ZEB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31810575	31810575	C	T	exonic	ZEB1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr10	31809156	31809156	T	C	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31809761	31809761	A	G	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31810100	31810100	A	C	exonic	ZEB1	nonsynonymous	ESCA\|1\|185\|0.00541
rs749371907	chr10	31791321	31791321	A	G	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31810322	31810322	C	A	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs146821579	chr10	31810297	31810297	A	C	exonic	ZEB1	nonsynonymous	PAAD\|1\|185\|0.00541
rs749059172	chr10	31810669	31810669	C	T	exonic	ZEB1	synonymous	SKCM\|2\|368\|0.00543
-	chr10	31810404	31810404	G	A	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31816109	31816109	G	A	exonic	ZEB1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr10	31810622	31810622	G	C	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31809580	31809580	A	G	exonic	ZEB1	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr10	31810481	31810481	C	T	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31815819	31815819	C	T	exonic	ZEB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	31810601	31810601	G	C	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
rs866987044	chr10	31809237	31809237	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31809717	31809717	T	A	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr10	31791305	31791305	G	A	exonic	ZEB1	nonsynonymous	CHOL\|1\|35\|0.02857
rs143340752	chr10	31810579	31810579	C	T	exonic	ZEB1	synonymous	OV\|1\|469\|0.00213
-	chr10	31809318	31809318	A	T	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31809063	31809063	C	A	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs78449005	chr10	31812973	31812973	C	G	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs142039874	chr10	31750087	31750087	C	T	exonic	ZEB1	synonymous	LUAD\|1\|543\|0.00184
rs754135071	chr10	31810580	31810580	G	A	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31810432	31810432	T	C	exonic	ZEB1	synonymous	ESCA\|1\|185\|0.00541
-	chr10	31810412	31810412	C	A	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
rs867898481	chr10	31816128	31816128	G	A	exonic	ZEB1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr10	31810091	31810091	G	A	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31809110	31809110	T	C	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr10	31810359	31810359	G	T	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31815998	31815998	G	T	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31815888	31815888	A	-	exonic	ZEB1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31816061	31816061	A	G	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31810034	31810034	A	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31791287	31791287	G	A	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
rs746581968	chr10	31809058	31809058	G	A	exonic	ZEB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31809823	31809823	A	C	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr10	31809187	31809187	A	G	exonic	ZEB1	synonymous	COADREAD\|2\|489\|0.00409,READ\|2\|122\|0.01639
-	chr10	31815705	31815705	A	G	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31750138	31750138	G	A	exonic	ZEB1	synonymous	SKCM\|2\|368\|0.00543
-	chr10	31799649	31799649	G	T	exonic	ZEB1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr10	31815797	31815797	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31810827	31810827	A	C	exonic	ZEB1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr10	31809278	31809278	G	C	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31809262	31809262	G	A	exonic	ZEB1	synonymous	HNSC\|1\|512\|0.00195
-	chr10	31810698	31810698	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31815999	31815999	G	A	exonic	ZEB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	31809607	31809607	C	A	exonic	ZEB1	synonymous	LUAD\|1\|543\|0.00184
-	chr10	31810433	31810433	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
rs753017859	chr10	31816159	31816159	G	A	exonic	ZEB1	synonymous	UCEC\|1\|248\|0.00403
-	chr10	31809970	31809970	T	C	exonic	ZEB1	synonymous	ESCA\|1\|185\|0.00541
-	chr10	31803616	31803616	A	G	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31803553	31803553	G	T	exonic	ZEB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr10	31812969	31812969	T	C	exonic	ZEB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr10	31809210	31809210	T	G	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31791356	31791356	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31791301	31791301	T	A	exonic	ZEB1	nonsynonymous	OV\|1\|469\|0.00213
-	chr10	31810369	31810369	A	G	exonic	ZEB1	synonymous	LUSC\|1\|178\|0.00562
-	chr10	31809806	31809806	A	C	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31810200	31810200	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31809256	31809256	G	A	exonic	ZEB1	synonymous	SKCM\|1\|368\|0.00272
-	chr10	31799625	31799625	T	C	exonic	ZEB1	nonsynonymous	PAAD\|1\|185\|0.00541
rs780092874	chr10	31810202	31810202	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31810814	31810814	C	T	exonic	ZEB1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr10	31812972	31812972	G	C	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr10	31750013	31750013	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31809650	31809650	C	A	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs373826858	chr10	31809205	31809205	G	A	exonic	ZEB1	synonymous	UCEC\|1\|248\|0.00403
rs369330183	chr10	31812931	31812931	C	T	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31809281	31809281	C	T	exonic	ZEB1	stopgain	UCEC\|1\|248\|0.00403
-	chr10	31809297	31809297	A	T	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31810616	31810616	G	A	exonic	ZEB1	nonsynonymous	HNSC\|1\|512\|0.00195,KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr10	31815986	31815986	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
rs753521729	chr10	31799694	31799694	G	A	exonic	ZEB1	nonsynonymous	CESC\|1\|194\|0.00515
rs755327991	chr10	31816045	31816045	G	A	exonic	ZEB1	synonymous	SKCM\|1\|368\|0.00272
-	chr10	31809531	31809531	A	G	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31809553	31809553	G	T	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31815922	31815922	C	T	exonic	ZEB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31784731	31784731	G	C	exonic	ZEB1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr10	31809741	31809741	A	G	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31810200	31810200	C	A	exonic	ZEB1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr10	31810175	31810175	T	C	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31810301	31810301	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31809331	31809331	A	C	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31608218	31608218	A	G	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31809552	31809552	A	T	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr10	31815884	31815884	G	A	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs766305306	chr10	31809832	31809832	-	G	exonic	ZEB1	frameshift	HNSC\|1\|512\|0.00195,KIPAN\|11\|799\|0.01377,KIRC\|11\|451\|0.02439,LIHC\|1\|373\|0.00268,LUAD\|10\|543\|0.01842
-	chr10	31810442	31810442	C	T	exonic	ZEB1	stopgain	ESCA\|1\|185\|0.00541
-	chr10	31812998	31812998	C	T	exonic	ZEB1	synonymous	BLCA\|1\|396\|0.00253,SKCM\|1\|368\|0.00272
-	chr10	31812949	31812949	G	T	exonic	ZEB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr10	31809222	31809222	C	G	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31803581	31803581	T	C	exonic	ZEB1	synonymous	LUSC\|1\|178\|0.00562
-	chr10	31815847	31815847	C	A	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31791299	31791299	G	T	exonic	ZEB1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr10	31810466	31810466	C	T	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
rs758185926	chr10	31809757	31809757	C	T	exonic	ZEB1	synonymous	UCEC\|1\|248\|0.00403
-	chr10	31809760	31809760	T	C	exonic	ZEB1	synonymous	OV\|1\|469\|0.00213
-	chr10	31809236	31809236	C	T	exonic	ZEB1	stopgain	PRAD\|1\|499\|0.00200
-	chr10	31809098	31809098	C	T	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31809186	31809186	C	T	exonic	ZEB1	nonsynonymous	OV\|1\|469\|0.00213
rs267602470	chr10	31810846	31810846	C	T	exonic	ZEB1	synonymous	SKCM\|1\|368\|0.00272
-	chr10	31799672	31799672	C	A	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31810825	31810825	A	C	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31810791	31810791	A	G	exonic	ZEB1	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr10	31810511	31810511	T	C	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31661980	31661980	G	A	intronic	ZEB1	unknown	ESCA\|1\|185\|0.00541
-	chr10	31809977	31809977	T	C	exonic	ZEB1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr10	31809541	31809541	G	T	exonic	ZEB1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr10	31810711	31810711	C	T	exonic	ZEB1	synonymous	LUAD\|1\|543\|0.00184
-	chr10	31813004	31813004	G	A	exonic	ZEB1	synonymous	LUAD\|1\|543\|0.00184
-	chr10	31809603	31809603	C	T	exonic	ZEB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr10	31816025	31816025	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31652033	31652033	T	A	intronic	ZEB1	unknown	ESCA\|1\|185\|0.00541
-	chr10	31810580	31810580	G	T	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31810843	31810843	G	A	exonic	ZEB1	synonymous	SKCM\|2\|368\|0.00543
-	chr10	31815839	31815839	A	G	exonic	ZEB1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr10	31815698	31815698	C	G	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31810238	31810238	A	C	exonic	ZEB1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr10	31784735	31784735	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31809185	31809185	A	G	exonic	ZEB1	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr10	31810442	31810442	C	A	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31815671	31815671	C	T	exonic	ZEB1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PRAD\|1\|499\|0.00200,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31809369	31809369	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
rs765964382	chr10	31815708	31815708	A	G	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31816173	31816173	A	G	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31816166	31816166	T	C	exonic	ZEB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr10	31815754	31815754	G	A	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31809813	31809813	A	C	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31784752	31784752	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31810284	31810284	C	A	exonic	ZEB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	31810288	31810288	A	G	exonic	ZEB1	synonymous	ESCA\|1\|185\|0.00541
-	chr10	31799699	31799699	G	C	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31816121	31816121	G	T	exonic	ZEB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr10	31815883	31815883	G	C	exonic	ZEB1	synonymous	HNSC\|1\|512\|0.00195
rs771873166	chr10	31809597	31809597	A	G	exonic	ZEB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	31809758	31809758	G	T	exonic	ZEB1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr10	31810098	31810098	C	T	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31815926	31815926	G	T	exonic	ZEB1	stopgain	UCEC\|1\|248\|0.00403
-	chr10	31812911	31812911	G	C	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31809461	31809461	G	-	exonic	ZEB1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31799649	31799649	G	C	exonic	ZEB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	31815679	31815679	T	G	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31809256	31809256	G	C	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31652674	31652674	C	T	intronic	ZEB1	unknown	SARC\|1\|247\|0.00405
-	chr10	31810746	31810746	C	T	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PRAD\|1\|499\|0.00200
-	chr10	31810494	31810494	G	A	exonic	ZEB1	nonsynonymous	SKCM\|3\|368\|0.00815
-	chr10	31810643	31810643	C	G	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31815683	31815683	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31810429	31810429	A	G	exonic	ZEB1	synonymous	HNSC\|2\|512\|0.00391
-	chr10	31791344	31791344	C	T	exonic	ZEB1	synonymous	SKCM\|1\|368\|0.00272
-	chr10	31810831	31810831	A	C	exonic	ZEB1	synonymous	BRCA\|1\|982\|0.00102
-	chr10	31809231	31809231	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31810011	31810011	C	-	exonic	ZEB1	frameshift	LUAD\|1\|543\|0.00184
-	chr10	31809791	31809791	G	A	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31809766	31809766	C	T	exonic	ZEB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31799699	31799699	G	A	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31809818	31809818	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31809776	31809776	A	G	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31810592	31810592	C	G	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31809819	31809819	A	G	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs747486342	chr10	31815838	31815838	G	A	exonic	ZEB1	synonymous	SKCM\|1\|368\|0.00272
-	chr10	31810812	31810812	G	A	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31816005	31816005	A	G	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31791358	31791358	C	T	exonic	ZEB1	synonymous	PCPG\|1\|184\|0.00543
-	chr10	31791294	31791294	A	T	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr10	31809275	31809275	C	T	exonic	ZEB1	stopgain	SKCM\|1\|368\|0.00272
-	chr10	31810367	31810367	A	G	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31809368	31809368	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
rs141110915	chr10	31810254	31810254	C	A	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31815971	31815971	G	A	exonic	ZEB1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr10	31799728	31799728	C	T	exonic	ZEB1	synonymous	LUAD\|1\|543\|0.00184
-	chr10	31810641	31810641	T	A	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31815884	31815884	G	C	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31803542	31803542	G	T	exonic	ZEB1	synonymous	TGCT\|1\|155\|0.00645
-	chr10	31749965	31749965	G	A	splicing	ZEB1	splicing	SKCM\|1\|368\|0.00272
rs779622931	chr10	31791292	31791292	C	T	exonic	ZEB1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,ESCA\|1\|185\|0.00541,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr10	31810768	31810768	G	A	exonic	ZEB1	synonymous	BRCA\|1\|982\|0.00102,SKCM\|1\|368\|0.00272
-	chr10	31810747	31810747	G	C	exonic	ZEB1	synonymous	LUAD\|1\|543\|0.00184
-	chr10	31816120	31816120	A	T	exonic	ZEB1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr10	31799743	31799743	C	T	exonic	ZEB1	synonymous	SKCM\|1\|368\|0.00272
-	chr10	31809946	31809946	C	T	exonic	ZEB1	synonymous	SKCM\|1\|368\|0.00272
-	chr10	31791274	31791274	A	G	splicing	ZEB1	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31809698	31809698	C	A	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31815878	31815878	G	T	exonic	ZEB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr10	31815804	31815804	C	T	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31750000	31750000	A	G	exonic	ZEB1	synonymous	LUAD\|1\|543\|0.00184
-	chr10	31809345	31809345	C	A	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31810040	31810040	T	A	exonic	ZEB1	nonsynonymous	PRAD\|2\|499\|0.00401
-	chr10	31809579	31809579	A	G	exonic	ZEB1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr10	31809133	31809133	G	C	exonic	ZEB1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr10	31809312	31809312	C	T	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31810643	31810643	C	T	exonic	ZEB1	nonsynonymous	LUAD\|6\|543\|0.01105
-	chr10	31810044	31810044	C	A	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31749974	31749974	T	A	exonic	ZEB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr10	31815887	31815887	G	A	exonic	ZEB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs143438972	chr10	31816148	31816148	G	A	exonic	ZEB1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr10	31610457	31610457	G	A	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31809857	31809857	C	A	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31809358	31809358	C	A	exonic	ZEB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	31750115	31750115	G	T	exonic	ZEB1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr10	31816064	31816064	G	A	exonic	ZEB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	31809433	31809433	G	T	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31809685	31809685	C	A	exonic	ZEB1	synonymous	UCEC\|1\|248\|0.00403
-	chr10	31810524	31810524	G	T	exonic	ZEB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31815877	31815877	C	T	exonic	ZEB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	31810519	31810519	C	T	exonic	ZEB1	synonymous	SKCM\|1\|368\|0.00272
rs35653460	chr10	31812949	31812949	G	A	exonic	ZEB1	nonsynonymous	COADREAD\|2\|489\|0.00409,READ\|2\|122\|0.01639
-	chr10	31809203	31809203	C	T	exonic	ZEB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	31812948	31812948	C	A	exonic	ZEB1	synonymous	HNSC\|1\|512\|0.00195
-	chr10	31815599	31815599	G	T	splicing	ZEB1	splicing	HNSC\|1\|512\|0.00195
rs765424726	chr10	31816024	31816024	G	A	exonic	ZEB1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	31810867	31810867	A	-	intronic	ZEB1	unknown	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr10	31812861	31812861	G	A	exonic	ZEB1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr10	31810697	31810697	C	A	exonic	ZEB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	31809478	31809478	A	G	exonic	ZEB1	nonsynonymous	PRAD\|1\|499\|0.00200
rs767228225	chr10	31815861	31815861	C	T	exonic	ZEB1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820

Disease information of ZEB1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ZEB1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
ZEB1	Neoplastic Cell Transformation	C04;C23	Neoplastic Process	CTD_human
ZEB1	Endometrial Neoplasms	C04;C13	Neoplastic Process	CTD_human
ZEB1	Fuchs Endothelial Dystrophy	C11;C16	Disease or Syndrome	ORPHANET
ZEB1	Neoplasm Invasiveness	C04;C23	Pathologic Function	CTD_human
ZEB1	Oral Submucous Fibrosis	C07	Disease or Syndrome	CTD_human
ZEB1	Sezary Syndrome	C04;C15;C20	Neoplastic Process	CTD_human
ZEB1	Lymphoma, T-Cell, Cutaneous	C04;C15;C20	Neoplastic Process	CTD_human
ZEB1	Myocardial Ischemia	C14	Disease or Syndrome	CTD_human
ZEB1	Disease Exacerbation	C23	Finding	CTD_human
ZEB1	Papillary thyroid carcinoma	C04;C19	Neoplastic Process	CTD_human
ZEB1	Polymorphous corneal dystrophy	C11;C16	Disease or Syndrome	ORPHANET
ZEB1	Granulomatous Slack Skin	C04;C15;C20	Neoplastic Process	CTD_human
ZEB1	Endometrial Carcinoma	C04;C13	Neoplastic Process	CTD_human
ZEB1	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
ZEB1	ovarian neoplasm	C04;C13;C19	Neoplastic Process	CTD_human
ZEB1	Malignant neoplasm of ovary	C04;C13;C19	Neoplastic Process	CTD_human
ZEB1	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
ZEB1	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
ZEB1	CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder)	C11;C16	Disease or Syndrome	CTD_human
ZEB1	Abnormality of the cornea		Finding	GENOMICS_ENGLAND
ZEB1	CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6	C11;C16	Disease or Syndrome	CTD_human;UNIPROT
ZEB1	Non-medullary thyroid carcinoma	C04;C19	Neoplastic Process	CTD_human
ZEB1	Familial Nonmedullary Thyroid Cancer	C04;C19	Neoplastic Process	CTD_human

Pathway associated with ZEB1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of ZEB1

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GO_term_name	GO_term_type	TF_name
GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING	BP	ZEB1
GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION	BP	ZEB1
GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS	BP	ZEB1
GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT	BP	ZEB1
GO_REGULATION_OF_THYMOCYTE_AGGREGATION	BP	ZEB1
GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION	BP	ZEB1
GO_EAR_DEVELOPMENT	BP	ZEB1
GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	ZEB1
GO_EMBRYONIC_ORGAN_MORPHOGENESIS	BP	ZEB1
GO_REGULATION_OF_T_CELL_DIFFERENTIATION	BP	ZEB1
GO_RESPONSE_TO_AMINO_ACID	BP	ZEB1
GO_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	ZEB1
GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS	BP	ZEB1
GO_COCHLEA_DEVELOPMENT	BP	ZEB1
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION	BP	ZEB1
GO_COCHLEA_MORPHOGENESIS	BP	ZEB1
GO_EMBRYONIC_EYE_MORPHOGENESIS	BP	ZEB1
GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS	BP	ZEB1
GO_PATTERN_SPECIFICATION_PROCESS	BP	ZEB1
GO_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	ZEB1
GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT	BP	ZEB1
GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION	BP	ZEB1
GO_EYE_MORPHOGENESIS	BP	ZEB1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING	MF	ZEB1
GO_E_BOX_BINDING	MF	ZEB1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING	MF	ZEB1
GO_ZINC_ION_BINDING	MF	ZEB1
GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY	MF	ZEB1

Survival analysis of ZEB1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ZEB1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)