Cancer CRCdb

TF information

TF name:	PRRX1
TF family:	Homeobox
Ensembl gene ID:	ENSG00000116132
Ensembl protein ID:	ENSP00000450762, ENSP00000239461, ENSP00000356734
Entrez gene ID:	5396

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of PRRX1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_180	Cell line	Human melanoma	CJM	0.2421875
Sample_02_181	Cell line	Human melanoma	COLO679	0.0976
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.051948051948052
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.027472527472527
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.30434782608696

PRRX1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_180	Human melanoma	Cell line	CJM

PRRX1 distribution in all CRCs

Genomic distribution of SEs associated with PRRX1

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Mutation of PRRX1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of PRRX1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr1	170633455	170633455	G	A	exonic	PRRX1	synonymous	UCS\|1\|57\|0.01754
-	chr1	170695412	170695412	C	A	exonic	PRRX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	170695377	170695377	G	A	exonic	PRRX1	nonsynonymous	BRCA\|1\|982\|0.00102,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	170688895	170688895	G	T	exonic	PRRX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	170689004	170689004	C	A	exonic	PRRX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	170699435	170699435	G	A	exonic	PRRX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	170695367	170695367	T	C	exonic	PRRX1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	170688908	170688908	C	T	exonic	PRRX1	stopgain	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	170699423	170699423	C	T	exonic	PRRX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	170705408	170705408	C	T	UTR3	PRRX1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	170688965	170688965	G	C	exonic	PRRX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	170695482	170695482	T	C	exonic	PRRX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs374262561	chr1	170695456	170695456	C	T	exonic	PRRX1	synonymous	LUAD\|1\|543\|0.00184
rs780981143	chr1	170689011	170689011	G	A	exonic	PRRX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	170695536	170695536	C	G	exonic	PRRX1	nonsynonymous	HNSC\|2\|512\|0.00391,LUAD\|1\|543\|0.00184
-	chr1	170695370	170695370	C	T	exonic	PRRX1	stopgain	CESC\|1\|194\|0.00515
rs753046896	chr1	170695392	170695392	G	A	exonic	PRRX1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr1	170688905	170688905	C	T	exonic	PRRX1	stopgain	UCEC\|1\|248\|0.00403
rs148536447	chr1	170699464	170699464	G	A	exonic	PRRX1	nonsynonymous	PAAD\|1\|185\|0.00541,PRAD\|1\|499\|0.00200
-	chr1	170695400	170695400	G	C	exonic	PRRX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	170699423	170699423	C	A	exonic	PRRX1	stopgain	LUAD\|1\|543\|0.00184
-	chr1	170705412	170705412	G	T	UTR3	PRRX1	unknown	SARC\|1\|247\|0.00405
rs747075971	chr1	170689014	170689014	G	A	exonic	PRRX1	nonsynonymous	UCEC\|1\|248\|0.00403
rs748836293	chr1	170633528	170633528	G	A	exonic	PRRX1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	170688997	170688997	A	-	exonic	PRRX1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs778731656	chr1	170705330	170705330	A	-	UTR3	PRRX1	unknown	BRCA\|1\|982\|0.00102
rs760448348	chr1	170705270	170705270	G	C	exonic	PRRX1	synonymous	CESC\|1\|194\|0.00515
-	chr1	170688909	170688909	G	T	exonic	PRRX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	170633519	170633519	G	C	exonic	PRRX1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr1	170695469	170695469	G	C	exonic	PRRX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	170688965	170688965	G	A	exonic	PRRX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	170688913	170688913	G	A	exonic	PRRX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	170705269	170705269	T	A	exonic	PRRX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	170695528	170695528	A	G	exonic	PRRX1	synonymous	LUAD\|1\|543\|0.00184
-	chr1	170695514	170695514	C	T	exonic	PRRX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	170633413	170633413	C	A	exonic	PRRX1	synonymous	HNSC\|1\|512\|0.00195
-	chr1	170695452	170695452	G	C	exonic	PRRX1	nonsynonymous	BLCA\|1\|396\|0.00253
rs759679693	chr1	170633563	170633563	G	C	exonic	PRRX1	synonymous	LUAD\|1\|543\|0.00184
-	chr1	170695477	170695477	C	A	exonic	PRRX1	synonymous	LUAD\|1\|543\|0.00184
-	chr1	170695530	170695530	C	T	exonic	PRRX1	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr1	170695527	170695527	C	A	exonic	PRRX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	170695522	170695522	G	A	exonic	PRRX1	stopgain	BRCA\|1\|982\|0.00102
-	chr1	170695481	170695481	G	A	exonic	PRRX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,OV\|1\|469\|0.00213
-	chr1	170705230	170705230	C	G	exonic	PRRX1	nonsynonymous	LUAD\|1\|543\|0.00184
rs761253714	chr1	170695427	170695427	G	A	exonic	PRRX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	170705388	170705388	C	T	UTR3	PRRX1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	170695487	170695487	C	T	exonic	PRRX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	170699383	170699383	T	A	intronic	PRRX1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs540157709	chr1	170688866	170688866	G	C	splicing	PRRX1	splicing	HNSC\|2\|512\|0.00391
-	chr1	170699465	170699465	G	A	exonic	PRRX1	nonsynonymous	BLCA\|1\|396\|0.00253,SKCM\|1\|368\|0.00272
-	chr1	170695391	170695391	C	T	exonic	PRRX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	170699420	170699420	C	T	exonic	PRRX1	nonsynonymous	SKCM\|1\|368\|0.00272
rs778365686	chr1	170705309	170705309	G	A	exonic	PRRX1	synonymous	LUAD\|1\|543\|0.00184
-	chr1	170695388	170695388	T	C	exonic	PRRX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	170689004	170689004	C	G	exonic	PRRX1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	170695471	170695471	G	T	exonic	PRRX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	170695431	170695431	C	T	exonic	PRRX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	170695375	170695375	C	A	exonic	PRRX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	170695468	170695468	G	T	exonic	PRRX1	synonymous	LUAD\|2\|543\|0.00368
-	chr1	170705312	170705312	G	A	exonic	PRRX1	synonymous	HNSC\|1\|512\|0.00195
-	chr1	170695457	170695457	G	T	exonic	PRRX1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	170633455	170633455	G	T	exonic	PRRX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	170695443	170695443	C	T	exonic	PRRX1	nonsynonymous	SKCM\|1\|368\|0.00272
rs766027745	chr1	170695524	170695524	G	A	exonic	PRRX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	170705416	170705416	A	G	UTR3	PRRX1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	170633465	170633465	G	T	exonic	PRRX1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	170705262	170705262	G	C	exonic	PRRX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	170695386	170695386	A	G	exonic	PRRX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	170633534	170633534	G	A	exonic	PRRX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	170705372	170705372	T	C	UTR3	PRRX1	unknown	BRCA\|1\|982\|0.00102
-	chr1	170688895	170688895	G	A	exonic	PRRX1	synonymous	SKCM\|2\|368\|0.00543
-	chr1	170699449	170699449	G	A	exonic	PRRX1	nonsynonymous	CESC\|1\|194\|0.00515,SKCM\|1\|368\|0.00272
-	chr1	170633439	170633439	C	T	exonic	PRRX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	170633362	170633362	G	A	exonic	PRRX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	170705354	170705354	A	G	UTR3	PRRX1	unknown	ESCA\|1\|185\|0.00541
rs770288919	chr1	170695497	170695497	C	T	exonic	PRRX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr1	170688882	170688882	C	T	exonic	PRRX1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	170695426	170695426	C	T	exonic	PRRX1	synonymous	HNSC\|1\|512\|0.00195,UCEC\|1\|248\|0.00403
-	chr1	170688909	170688909	G	A	exonic	PRRX1	nonsynonymous	BRCA\|1\|982\|0.00102,SKCM\|2\|368\|0.00543,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	170688987	170688987	C	A	exonic	PRRX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	170705230	170705230	C	A	exonic	PRRX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	170699432	170699432	C	T	exonic	PRRX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	170695491	170695491	C	A	exonic	PRRX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	170705233	170705233	C	T	exonic	PRRX1	nonsynonymous	LIHC\|1\|373\|0.00268
rs767923329	chr1	170688957	170688957	G	A	exonic	PRRX1	nonsynonymous	PRAD\|2\|499\|0.00401

Disease information of PRRX1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
PRRX1	Atrial Fibrillation	C14;C23	Disease or Syndrome	CTD_human
PRRX1	Craniosynostosis	C05;C16	Disease or Syndrome	GENOMICS_ENGLAND
PRRX1	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
PRRX1	Congenital retrognathism	C05;C07;C16	Congenital Abnormality	CTD_human
PRRX1	Paroxysmal atrial fibrillation	C14;C23	Disease or Syndrome	CTD_human
PRRX1	Otocephaly	C05;C16	Congenital Abnormality	ORPHANET;UNIPROT
PRRX1	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
PRRX1	Dysgnathia complex	C05;C07;C10;C16	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
PRRX1	Persistent atrial fibrillation	C14;C23	Pathologic Function	CTD_human
PRRX1	familial atrial fibrillation	C14;C23	Pathologic Function	CTD_human
PRRX1	Retrognathia	C05;C07;C16	Anatomical Abnormality	CTD_human
PRRX1	Maxillary Retroposition	C05;C07;C16	Anatomical Abnormality	CTD_human
PRRX1	Maxillary Retrusion	C05;C07;C16	Anatomical Abnormality	CTD_human
PRRX1	Mandibular Retroposition	C05;C07;C16	Anatomical Abnormality	CTD_human
PRRX1	Mandibular Retrusion	C05;C07;C16	Anatomical Abnormality	CTD_human

Pathway associated with PRRX1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of PRRX1

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GO_term_name	GO_term_type	TF_name
GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT	BP	PRRX1
GO_ARTERY_DEVELOPMENT	BP	PRRX1
GO_PALATE_DEVELOPMENT	BP	PRRX1
GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION	BP	PRRX1
GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION	BP	PRRX1
GO_MIDDLE_EAR_MORPHOGENESIS	BP	PRRX1
GO_APPENDAGE_DEVELOPMENT	BP	PRRX1
GO_MAINTENANCE_OF_CELL_NUMBER	BP	PRRX1
GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY	BP	PRRX1
GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION	BP	PRRX1
GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE	BP	PRRX1
GO_CELL_FATE_DETERMINATION	BP	PRRX1
GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION	BP	PRRX1
GO_NEURON_FATE_COMMITMENT	BP	PRRX1
GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY	BP	PRRX1
GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	PRRX1
GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	PRRX1
GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS	BP	PRRX1
GO_INNER_EAR_MORPHOGENESIS	BP	PRRX1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	PRRX1
GO_HMG_BOX_DOMAIN_BINDING	MF	PRRX1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	PRRX1
GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	PRRX1

Survival analysis of PRRX1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of PRRX1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)