Cancer CRCdb

TF information

TF name:	POU2F1
TF family:	Pou
Ensembl gene ID:	ENSG00000143190
Ensembl protein ID:	ENSP00000414660, ENSP00000356840, ENSP00000356836, ENSP00000415993, ENSP00000401217, ENSP00000441285
Entrez gene ID:	5451

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of POU2F1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_180	Cell line	Human melanoma	CJM	0.3984375
Sample_02_181	Cell line	Human melanoma	COLO679	0.0128
Sample_02_197	Cell line	Stomach	SNU1750	0.11111111111111

POU2F1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_180	Human melanoma	Cell line	CJM

POU2F1 distribution in all CRCs

Genomic distribution of SEs associated with POU2F1

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Mutation of POU2F1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of POU2F1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr1	167301706	167301706	G	C	splicing	POU2F1	splicing	CESC\|1\|194\|0.00515
-	chr1	167343484	167343484	C	A	exonic	POU2F1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	167339439	167339439	T	G	exonic	POU2F1	synonymous	BLCA\|1\|396\|0.00253
rs149991945	chr1	167353161	167353161	G	A	exonic	POU2F1	synonymous	HNSC\|1\|512\|0.00195
-	chr1	167367341	167367341	C	T	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
rs561712054	chr1	167384904	167384904	G	A	exonic	POU2F1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	167368544	167368544	G	T	exonic	POU2F1	nonsynonymous	LUAD\|1\|543\|0.00184
rs34658638	chr1	167384807	167384807	G	A	exonic	POU2F1	synonymous	HNSC\|1\|512\|0.00195
-	chr1	167341272	167341272	G	T	exonic	POU2F1	nonsynonymous	LUAD\|1\|543\|0.00184
rs144698259	chr1	167341161	167341161	C	T	exonic	POU2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	167381285	167381285	C	T	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	167381535	167381535	C	T	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	167370733	167370733	C	A	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	167385076	167385076	T	-	UTR3	POU2F1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	167370700	167370700	C	A	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	167381426	167381426	G	-	exonic	POU2F1	frameshift	OV\|1\|469\|0.00213
-	chr1	167385027	167385027	A	G	exonic	POU2F1	nonsynonymous	BLCA\|1\|396\|0.00253,PAAD\|2\|185\|0.01081,SKCM\|1\|368\|0.00272
-	chr1	167382310	167382310	G	A	exonic	POU2F1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	167382323	167382323	G	C	exonic	POU2F1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	167381214	167381214	C	T	exonic	POU2F1	nonsynonymous	SARC\|1\|247\|0.00405
rs758722261	chr1	167343356	167343356	G	A	exonic	POU2F1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	167384897	167384897	T	C	exonic	POU2F1	synonymous	LIHC\|1\|373\|0.00268
-	chr1	167365627	167365627	G	T	exonic	POU2F1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	167334748	167334748	G	T	exonic	POU2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	167381363	167381363	C	T	exonic	POU2F1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr1	167365587	167365587	G	A	exonic	POU2F1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	167367302	167367302	C	T	exonic	POU2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	167343475	167343475	C	G	exonic	POU2F1	nonsynonymous	LUSC\|1\|178\|0.00562
rs767389373	chr1	167381303	167381303	G	A	exonic	POU2F1	nonsynonymous	PAAD\|1\|185\|0.00541
rs774001310	chr1	167343435	167343435	G	C	exonic	POU2F1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	167381312	167381312	T	C	exonic	POU2F1	nonsynonymous	BRCA\|1\|982\|0.00102
rs34899926	chr1	167339406	167339406	C	T	exonic	POU2F1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	167301713	167301713	G	C	exonic	POU2F1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	167368547	167368547	G	A	exonic	POU2F1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	167301757	167301757	G	A	exonic	POU2F1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	167365537	167365537	C	T	exonic	POU2F1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	167341239	167341239	C	-	exonic	POU2F1	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr1	167343365	167343365	G	T	exonic	POU2F1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	167365661	167365661	G	A	exonic	POU2F1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	167385180	167385180	A	-	UTR3	POU2F1	unknown	ESCA\|1\|185\|0.00541
-	chr1	167381351	167381351	A	C	exonic	POU2F1	nonsynonymous	UCS\|1\|57\|0.01754
-	chr1	167365569	167365569	G	A	exonic	POU2F1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	167381395	167381395	G	A	exonic	POU2F1	synonymous	BLCA\|1\|396\|0.00253
-	chr1	167381364	167381364	C	T	exonic	POU2F1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	167343528	167343528	G	C	exonic	POU2F1	nonsynonymous	ESCA\|1\|185\|0.00541
rs562014026	chr1	167343527	167343527	C	T	exonic	POU2F1	synonymous	ESCA\|1\|185\|0.00541
-	chr1	167384943	167384943	C	G	exonic	POU2F1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs754961256	chr1	167382320	167382320	A	G	exonic	POU2F1	synonymous	LUSC\|1\|178\|0.00562
-	chr1	167384860	167384860	T	-	exonic	POU2F1	frameshift	BLCA\|1\|396\|0.00253
-	chr1	167345366	167345366	T	A	exonic	POU2F1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	167370723	167370723	A	G	exonic	POU2F1	synonymous	LUSC\|1\|178\|0.00562
-	chr1	167365649	167365649	T	C	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
rs199706857	chr1	167385178	167385178	G	A	UTR3	POU2F1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	167368580	167368580	T	-	exonic	POU2F1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs766826910	chr1	167343473	167343473	C	T	exonic	POU2F1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	167368480	167368480	A	C	exonic	POU2F1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr1	167343522	167343522	C	T	exonic	POU2F1	stopgain	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr1	167343431	167343431	C	G	exonic	POU2F1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr1	167382293	167382293	C	A	exonic	POU2F1	synonymous	BRCA\|2\|982\|0.00204
-	chr1	167334802	167334802	C	G	exonic	POU2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	167190159	167190159	C	G	exonic	POU2F1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	167384851	167384851	C	T	exonic	POU2F1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	167367230	167367230	G	A	splicing	POU2F1	splicing	BLCA\|1\|396\|0.00253
-	chr1	167368478	167368478	A	-	exonic	POU2F1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	167370746	167370746	C	T	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	167367324	167367324	G	A	exonic	POU2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	167382306	167382306	C	G	exonic	POU2F1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	167365638	167365638	T	A	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	167343506	167343506	C	T	exonic	POU2F1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	167358976	167358976	G	A	exonic	POU2F1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	167365645	167365645	G	A	exonic	POU2F1	synonymous	SKCM\|1\|368\|0.00272
rs532966862	chr1	167343488	167343488	G	A	exonic	POU2F1	synonymous	LIHC\|1\|373\|0.00268
-	chr1	167190159	167190159	C	T	exonic	POU2F1	stopgain	CESC\|1\|194\|0.00515
-	chr1	167385017	167385018	CA	-	exonic	POU2F1	frameshift	PAAD\|22\|185\|0.11892
-	chr1	167358969	167358969	C	G	exonic	POU2F1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr1	167365615	167365615	G	C	exonic	POU2F1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	167365643	167365643	G	C	exonic	POU2F1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	167370776	167370776	C	A	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	167385180	167385181	AA	-	UTR3	POU2F1	unknown	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	167368588	167368588	A	G	exonic	POU2F1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	167382294	167382294	C	A	exonic	POU2F1	nonsynonymous	UCEC\|1\|248\|0.00403
rs771620813	chr1	167367336	167367336	A	G	exonic	POU2F1	nonsynonymous	THCA\|1\|504\|0.00198
rs763145018	chr1	167339407	167339407	G	A	exonic	POU2F1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	167381209	167381209	C	T	exonic	POU2F1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs142378150	chr1	167358837	167358837	A	G	exonic	POU2F1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr1	167341274	167341274	G	C	splicing	POU2F1	splicing	UCEC\|1\|248\|0.00403
-	chr1	167358827	167358827	A	T	exonic	POU2F1	synonymous	LUAD\|1\|543\|0.00184
-	chr1	167334776	167334776	C	A	exonic	POU2F1	nonsynonymous	THCA\|1\|504\|0.00198
rs770699801	chr1	167343434	167343434	C	T	exonic	POU2F1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs141034916	chr1	167341173	167341173	C	T	exonic	POU2F1	nonsynonymous	SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
rs765718905	chr1	167367365	167367365	T	G	exonic	POU2F1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	167381348	167381348	C	-	exonic	POU2F1	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr1	167367290	167367290	G	C	exonic	POU2F1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr1	167334762	167334762	C	G	exonic	POU2F1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs373597853	chr1	167385014	167385014	G	A	exonic	POU2F1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs773837915	chr1	167367303	167367303	G	A	exonic	POU2F1	nonsynonymous	PRAD\|2\|499\|0.00401
-	chr1	167365546	167365546	G	A	exonic	POU2F1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs376220117	chr1	167353107	167353107	G	A	exonic	POU2F1	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr1	167370762	167370762	C	T	exonic	POU2F1	synonymous	LUAD\|1\|543\|0.00184
rs774001310	chr1	167343435	167343435	G	A	exonic	POU2F1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr1	167358897	167358897	C	T	exonic	POU2F1	stopgain	UCEC\|1\|248\|0.00403
-	chr1	167353143	167353143	A	G	exonic	POU2F1	synonymous	UCEC\|1\|248\|0.00403
-	chr1	167385180	167385182	AAA	-	UTR3	POU2F1	unknown	ESCA\|1\|185\|0.00541

Disease information of POU2F1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
POU2F1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	UNIPROT

Pathway associated with POU2F1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000343	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	pid	50	304
pathway0000347	Calcium signaling in the CD4+ TCR pathway	pid	29	153
pathway0000824	FOXA1 transcription factor network	pid	45	204
pathway0001825	Regulation of Androgen receptor activity	pid	54	338
pathway0001926	RNA Polymerase III Abortive And Retractive Initiation	reactome	41	663
pathway0001930	RNA Polymerase III Transcription Initiation From Type 3 Promoter	reactome	28	378
pathway0002751	Hs_Integrated_Cancer_Pathway_WP1971_82939	wikipathways	33	206

Go term information of POU2F1

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GO_term_name	GO_term_type	TF_name
GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT	BP	POU2F1
GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS	BP	POU2F1
GO_LIVER_REGENERATION	BP	POU2F1

Survival analysis of POU2F1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of POU2F1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)