Cancer CRCdb

TF information

TF name:	MAFB
TF family:	TF_bZIP
Ensembl gene ID:	ENSG00000204103
Ensembl protein ID:	ENSP00000362410
Entrez gene ID:	9935

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of MAFB in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_168	Cell line	Prostate	LNCaP	0.091254752851711
Sample_02_184	Cell line	Skin	SKMEL30	0.35048231511254
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.2158273381295
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.15057915057915

MAFB distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_184	Skin	Cell line	SKMEL30

MAFB distribution in all CRCs

Genomic distribution of SEs associated with MAFB

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Mutation of MAFB

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MAFB

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr20	39316685	39316685	T	C	exonic	MAFB	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	39316659	39316659	C	T	exonic	MAFB	nonsynonymous	LIHC\|1\|373\|0.00268
rs767338343	chr20	39317266	39317266	C	T	exonic	MAFB	synonymous	BLCA\|1\|396\|0.00253
-	chr20	39316829	39316829	A	T	exonic	MAFB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	39316595	39316595	T	C	exonic	MAFB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39316997	39316997	T	C	exonic	MAFB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	39317182	39317182	C	T	exonic	MAFB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39316981	39316981	C	T	exonic	MAFB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs377639854	chr20	39317238	39317238	G	T	exonic	MAFB	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	39317284	39317284	C	T	exonic	MAFB	synonymous	SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr20	39316830	39316830	C	T	exonic	MAFB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	39317281	39317281	C	T	exonic	MAFB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39317075	39317075	G	T	exonic	MAFB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39316747	39316747	G	C	exonic	MAFB	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	39317195	39317195	G	A	exonic	MAFB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39316580	39316580	G	A	exonic	MAFB	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	39317441	39317441	G	T	exonic	MAFB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39317311	39317311	G	A	exonic	MAFB	synonymous	LUAD\|1\|543\|0.00184
-	chr20	39317352	39317352	T	C	exonic	MAFB	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	39316588	39316588	G	A	exonic	MAFB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39317053	39317053	C	A	exonic	MAFB	synonymous	HNSC\|1\|512\|0.00195
-	chr20	39316633	39316633	C	A	exonic	MAFB	synonymous	LUAD\|1\|543\|0.00184
-	chr20	39317166	39317166	C	T	exonic	MAFB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	39317034	39317034	C	G	exonic	MAFB	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	39317196	39317196	C	T	exonic	MAFB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39316536	39316536	G	C	exonic	MAFB	nonsynonymous	ACC\|1\|90\|0.01111
-	chr20	39316774	39316774	C	T	exonic	MAFB	synonymous	BLCA\|1\|396\|0.00253
-	chr20	39317104	39317104	G	A	exonic	MAFB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39316690	39316690	C	G	exonic	MAFB	nonsynonymous	CESC\|1\|194\|0.00515
-	chr20	39317373	39317373	C	T	exonic	MAFB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39316679	39316679	G	A	exonic	MAFB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	39317231	39317231	C	T	exonic	MAFB	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	39317054	39317054	G	A	exonic	MAFB	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr20	39316780	39316780	G	A	exonic	MAFB	synonymous	BLCA\|1\|396\|0.00253
-	chr20	39317483	39317483	G	T	exonic	MAFB	nonsynonymous	ACC\|1\|90\|0.01111
-	chr20	39316865	39316865	T	C	exonic	MAFB	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr20	39316788	39316788	C	T	exonic	MAFB	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	39316726	39316726	G	C	exonic	MAFB	nonsynonymous	HNSC\|1\|512\|0.00195

Disease information of MAFB

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
MAFB	Cleft upper lip	C07;C16	Congenital Abnormality	CTD_human
MAFB	Duane Retraction Syndrome	C10;C11;C16	Disease or Syndrome	CTD_human;ORPHANET
MAFB	Osteogenesis Imperfecta	C05;C16;C17	Congenital Abnormality; Disease or Syndrome	GENOMICS_ENGLAND
MAFB	Duane Retraction Syndrome, Type 2	C10;C11;C16	Disease or Syndrome	CTD_human
MAFB	Duane Retraction Syndrome, Type 3	C10;C11;C16	Disease or Syndrome	CTD_human
MAFB	Type 1 Duane Retraction Syndrome	C10;C11;C16	Disease or Syndrome	CTD_human
MAFB	Okihiro Syndrome	C10;C11;C16	Disease or Syndrome	CTD_human
MAFB	Osteolysis, Hereditary, Of Carpal Bones With Or Without Nephropathy	C05	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
MAFB	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with MAFB

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002841	Hs_Ectoderm_Differentiation_WP2858_89329	wikipathways	56	137

Go term information of MAFB

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GO_term_name	GO_term_type	TF_name
GO_RESPIRATORY_GASEOUS_EXCHANGE	BP	MAFB
GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION	BP	MAFB
GO_SINGLE_ORGANISM_CELL_ADHESION	BP	MAFB
GO_THYMUS_DEVELOPMENT	BP	MAFB
GO_IMMUNE_SYSTEM_DEVELOPMENT	BP	MAFB
GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION	BP	MAFB
GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	MAFB
GO_REGULATION_OF_HEMOPOIESIS	BP	MAFB
GO_THYMOCYTE_AGGREGATION	BP	MAFB
GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS	BP	MAFB
GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	MAFB
GO_SEGMENTATION	BP	MAFB
GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION	BP	MAFB
GO_EAR_MORPHOGENESIS	BP	MAFB
GO_SEGMENT_SPECIFICATION	BP	MAFB
GO_LEUKOCYTE_CELL_CELL_ADHESION	BP	MAFB
GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION	BP	MAFB
GO_T_CELL_DIFFERENTIATION	BP	MAFB
GO_LYMPHOCYTE_DIFFERENTIATION	BP	MAFB
GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION	BP	MAFB
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	MAFB
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING	MF	MAFB

Survival analysis of MAFB

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of MAFB

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)