Cancer CRCdb

TF information

TF name:	HNF4A
TF family:	RXR-like
Ensembl gene ID:	ENSG00000101076
Ensembl protein ID:	ENSP00000315180, ENSP00000396216, ENSP00000476609, ENSP00000476310, ENSP00000410911, ENSP00000481331, ENSP00000312987, ENSP00000412111
Entrez gene ID:	3172

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of HNF4A in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_021	Cell line	Colon	V429	0.2306140098011
Sample_02_237	Cell line	Colon	V389	1
Sample_02_241	Cell line	Colon	V456	0.71218961625282
Sample_02_242	Cell line	Colon	V481	0.50621675318849
Sample_02_285	Cell line	Liver	HuH7_untreat	0.84320557491289
Sample_02_322	Cell line	Colon	Caco-2	1
Sample_02_424	Cell line	Colon	SW620	0.17391304347826

HNF4A distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_237	Colon	Cell line	V389
Sample_02_241	Colon	Cell line	V456
Sample_02_285	Liver	Cell line	HuH7_untreat
Sample_02_322	Colon	Cell line	Caco-2

HNF4A distribution in all CRCs

Genomic distribution of SEs associated with HNF4A

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Mutation of HNF4A

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HNF4A

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr20	43036102	43036102	C	T	exonic	HNF4A	synonymous	UCEC\|1\|248\|0.00403
rs761046168	chr20	42984468	42984468	C	T	exonic	HNF4A	synonymous	LUAD\|1\|543\|0.00184
-	chr20	43036075	43036075	C	G	exonic	HNF4A	nonsynonymous	UCEC\|1\|248\|0.00403
rs377476335	chr20	43042336	43042336	G	A	exonic	HNF4A	nonsynonymous	CESC\|1\|194\|0.00515
-	chr20	43052981	43052981	T	C	exonic	HNF4A	synonymous	ESCA\|1\|185\|0.00541
-	chr20	43057004	43057004	C	T	exonic	HNF4A	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs147342965	chr20	43042409	43042409	C	T	exonic	HNF4A	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,UCEC\|1\|248\|0.00403
-	chr20	43034798	43034798	C	T	exonic	HNF4A	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs754143633	chr20	43042421	43042421	C	T	exonic	HNF4A	nonsynonymous	UCEC\|1\|248\|0.00403
rs147552575	chr20	43034771	43034771	C	T	exonic	HNF4A	synonymous	UCEC\|1\|248\|0.00403
-	chr20	43052677	43052677	T	A	exonic	HNF4A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	43052726	43052726	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43043177	43043177	G	A	exonic	HNF4A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	43043227	43043227	G	A	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
rs757897768	chr20	43057088	43057088	G	A	exonic	HNF4A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	43034759	43034759	G	C	exonic	HNF4A	synonymous	LUSC\|1\|178\|0.00562
-	chr20	43036067	43036067	C	T	exonic	HNF4A	nonsynonymous	LIHC\|1\|373\|0.00268
rs760038979	chr20	43043174	43043174	G	A	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43058208	43058208	C	A	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43031251	43031251	A	T	exonic	HNF4A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs570058788	chr20	43034729	43034729	C	T	exonic	HNF4A	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,THCA\|1\|504\|0.00198
-	chr20	43043252	43043252	G	A	exonic	HNF4A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	43034755	43034755	C	T	exonic	HNF4A	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr20	43052955	43052955	A	G	exonic	HNF4A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	43052705	43052705	C	T	exonic	HNF4A	stopgain	SKCM\|1\|368\|0.00272
-	chr20	43043184	43043184	G	C	exonic	HNF4A	nonsynonymous	BLCA\|1\|396\|0.00253
rs142268325	chr20	43052848	43052848	C	T	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
-	chr20	43057097	43057097	T	A	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	42984471	42984471	G	C	exonic	HNF4A	synonymous	LUAD\|2\|543\|0.00368
rs757774160	chr20	43052674	43052674	C	T	exonic	HNF4A	synonymous	UCEC\|1\|248\|0.00403
-	chr20	43030114	43030114	G	A	exonic	HNF4A	synonymous	BLCA\|1\|396\|0.00253
-	chr20	43057001	43057001	C	A	exonic	HNF4A	nonsynonymous	ACC\|1\|90\|0.01111
-	chr20	43030051	43030051	C	T	exonic	HNF4A	synonymous	HNSC\|1\|512\|0.00195
rs779433584	chr20	43052754	43052754	C	T	exonic	HNF4A	nonsynonymous	UCEC\|1\|248\|0.00403
rs760091853	chr20	43056984	43056984	G	A	exonic	HNF4A	nonsynonymous	SKCM\|2\|368\|0.00543
rs748590780	chr20	43058239	43058239	C	T	exonic	HNF4A	synonymous	LUAD\|1\|543\|0.00184
-	chr20	43057040	43057040	G	A	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184,SARC\|1\|247\|0.00405
-	chr20	43056987	43056987	A	T	exonic	HNF4A	nonsynonymous	THCA\|1\|504\|0.00198
-	chr20	43057023	43057023	T	C	exonic	HNF4A	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr20	43043255	43043255	T	A	exonic	HNF4A	nonsynonymous	THCA\|1\|504\|0.00198
-	chr20	43034734	43034734	C	G	exonic	HNF4A	nonsynonymous	OV\|1\|469\|0.00213
rs557888367	chr20	43043173	43043173	C	T	exonic	HNF4A	synonymous	UCS\|1\|57\|0.01754
rs772959288	chr20	43042383	43042383	G	A	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
-	chr20	43056986	43056986	G	A	exonic	HNF4A	nonsynonymous	HNSC\|1\|512\|0.00195
rs376906221	chr20	43034754	43034754	G	A	exonic	HNF4A	nonsynonymous	CESC\|2\|194\|0.01031,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs150776703	chr20	43058189	43058189	C	T	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43034787	43034787	G	T	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43052774	43052775	CT	-	exonic	HNF4A	frameshift	PAAD\|5\|185\|0.02703,SKCM\|2\|368\|0.00543,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs550287415	chr20	43057096	43057096	G	A	exonic	HNF4A	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr20	43034711	43034711	A	G	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
-	chr20	43052891	43052891	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43034788	43034788	G	T	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43042402	43042402	A	T	exonic	HNF4A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr20	42984469	42984469	G	T	exonic	HNF4A	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355,LUAD\|1\|543\|0.00184
rs202073574	chr20	43057110	43057110	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43042351	43042351	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
rs537703038	chr20	43030034	43030034	G	A	exonic	HNF4A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	43047108	43047108	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43058177	43058177	C	T	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43034863	43034863	A	G	exonic	HNF4A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	43058205	43058205	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43048368	43048368	C	T	exonic	HNF4A	synonymous	DLBC\|1\|48\|0.02083
-	chr20	43034855	43034855	C	A	exonic	HNF4A	nonsynonymous	OV\|1\|469\|0.00213
-	chr20	43052897	43052897	C	T	exonic	HNF4A	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr20	42984463	42984463	C	T	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
rs753302065	chr20	43034816	43034816	C	T	exonic	HNF4A	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	43042392	43042392	C	T	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
-	chr20	43036091	43036091	T	C	exonic	HNF4A	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr20	43047076	43047076	C	T	exonic	HNF4A	synonymous	HNSC\|1\|512\|0.00195
rs377052026	chr20	43058230	43058230	G	A	exonic	HNF4A	synonymous	ESCA\|1\|185\|0.00541
-	chr20	43052831	43052831	C	T	exonic	HNF4A	stopgain	SKCM\|1\|368\|0.00272
-	chr20	43031282	43031282	G	A	exonic	HNF4A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr20	43057070	43057070	C	T	exonic	HNF4A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	43030068	43030068	T	C	exonic	HNF4A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	43058161	43058161	A	T	splicing	HNF4A	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	43043290	43043290	C	T	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
rs145902391	chr20	43052675	43052675	G	A	exonic	HNF4A	nonsynonymous	SKCM\|2\|368\|0.00543
rs141448616	chr20	43057087	43057087	C	T	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
-	chr20	43048412	43048412	G	A	exonic	HNF4A	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr20	43034712	43034712	G	C	exonic	HNF4A	nonsynonymous	HNSC\|1\|512\|0.00195
rs756553207	chr20	43030116	43030116	C	T	exonic	HNF4A	nonsynonymous	ESCA\|1\|185\|0.00541
rs780234320	chr20	43058278	43058278	G	A	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
-	chr20	43057024	43057024	G	A	exonic	HNF4A	synonymous	OV\|1\|469\|0.00213
-	chr20	42984464	42984464	C	T	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
rs753476712	chr20	43047092	43047092	G	A	exonic	HNF4A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	43030126	43030126	T	-	exonic	HNF4A	frameshift	SARC\|1\|247\|0.00405
-	chr20	43052918	43052918	C	T	exonic	HNF4A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs193922479	chr20	43052756	43052756	C	T	exonic	HNF4A	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,LUAD\|1\|543\|0.00184
-	chr20	43057090	43057090	A	G	exonic	HNF4A	synonymous	BLCA\|1\|396\|0.00253
-	chr20	43030116	43030116	C	A	exonic	HNF4A	nonsynonymous	LUSC\|1\|178\|0.00562
rs753027685	chr20	43052742	43052742	G	A	exonic	HNF4A	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr20	43036049	43036049	G	T	exonic	HNF4A	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr20	43043208	43043208	C	T	exonic	HNF4A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	43057089	43057089	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
rs754907741	chr20	43043207	43043207	G	A	exonic	HNF4A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	43058295	43058295	A	T	exonic	HNF4A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr20	43048506	43048506	C	A	exonic	HNF4A	nonsynonymous	UCEC\|2\|248\|0.00806
rs760173369	chr20	43048392	43048392	G	A	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
-	chr20	43030122	43030122	G	A	exonic	HNF4A	nonsynonymous	HNSC\|1\|512\|0.00195
rs748452860	chr20	43058294	43058294	G	A	exonic	HNF4A	nonsynonymous	SKCM\|3\|368\|0.00815
-	chr20	43048467	43048467	C	T	exonic	HNF4A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	43047093	43047093	A	T	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43052731	43052731	C	T	exonic	HNF4A	synonymous	BRCA\|1\|982\|0.00102
-	chr20	43036056	43036056	G	-	exonic	HNF4A	frameshift	LUAD\|1\|543\|0.00184
-	chr20	43034862	43034862	T	C	exonic	HNF4A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	43034831	43034831	C	T	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
rs146307320	chr20	43043164	43043164	C	T	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
-	chr20	43030050	43030050	C	T	exonic	HNF4A	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	43030037	43030037	G	A	exonic	HNF4A	nonsynonymous	UCEC\|1\|248\|0.00403
rs201749293	chr20	43043289	43043289	C	T	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43052967	43052967	C	T	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43058175	43058175	C	T	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43042366	43042366	C	T	exonic	HNF4A	stopgain	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr20	43034848	43034848	G	A	exonic	HNF4A	nonsynonymous	BLCA\|1\|396\|0.00253,SKCM\|1\|368\|0.00272
rs749375393	chr20	43057054	43057054	C	T	exonic	HNF4A	synonymous	UCEC\|1\|248\|0.00403
-	chr20	43058195	43058195	G	T	exonic	HNF4A	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr20	43052656	43052656	A	T	splicing	HNF4A	splicing	LIHC\|1\|373\|0.00268
-	chr20	43058204	43058204	G	-	exonic	HNF4A	frameshift	LUAD\|1\|543\|0.00184
-	chr20	43034763	43034763	G	C	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43047127	43047127	G	T	exonic	HNF4A	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr20	43048456	43048456	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43034773	43034773	G	T	exonic	HNF4A	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr20	43036067	43036067	C	G	exonic	HNF4A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr20	43043118	43043147	CAGCATTTTCTTCCCTGTATCTCTCGAAGA	-	exonic	HNF4A	frameshift	-
-	chr20	43057117	43057117	G	A	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
rs751922253	chr20	43052988	43052988	C	T	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43030112	43030112	T	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43043175	43043175	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	43048468	43048468	G	A	exonic	HNF4A	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr20	43056983	43056983	A	G	exonic	HNF4A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs776824742	chr20	43058237	43058237	G	A	exonic	HNF4A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	43058302	43058302	C	A	exonic	HNF4A	synonymous	LUAD\|2\|543\|0.00368
-	chr20	43057081	43057081	C	T	exonic	HNF4A	synonymous	ESCA\|1\|185\|0.00541
-	chr20	43034844	43034844	G	T	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43034730	43034730	G	A	exonic	HNF4A	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr20	43043249	43043249	G	A	exonic	HNF4A	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr20	43048493	43048493	A	C	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43056995	43056995	C	A	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43034856	43034856	C	A	exonic	HNF4A	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr20	43042431	43042431	G	C	exonic	HNF4A	synonymous	LUAD\|1\|543\|0.00184
-	chr20	43057109	43057109	C	T	exonic	HNF4A	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	43052943	43052943	G	C	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
rs768495780	chr20	43043163	43043163	C	G	exonic	HNF4A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	43058210	43058210	G	A	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43052704	43052704	C	T	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
-	chr20	43043180	43043180	A	C	exonic	HNF4A	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr20	43052875	43052875	-	C	exonic	HNF4A	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr20	43058194	43058194	A	T	exonic	HNF4A	synonymous	LUAD\|1\|543\|0.00184
-	chr20	43058182	43058182	G	A	exonic	HNF4A	synonymous	SKCM\|1\|368\|0.00272
rs767934753	chr20	43056985	43056985	C	T	exonic	HNF4A	synonymous	BLCA\|1\|396\|0.00253,PRAD\|1\|499\|0.00200
-	chr20	43057044	43057044	C	T	exonic	HNF4A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	43057043	43057043	A	G	exonic	HNF4A	nonsynonymous	CESC\|1\|194\|0.00515
-	chr20	43057079	43057079	C	T	exonic	HNF4A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	43047140	43047140	G	-	exonic	HNF4A	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	43036108	43036108	G	A	exonic	HNF4A	synonymous	BRCA\|1\|982\|0.00102
rs371827863	chr20	43043187	43043187	C	T	exonic	HNF4A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	43048461	43048461	G	A	exonic	HNF4A	synonymous	ESCA\|1\|185\|0.00541
-	chr20	43057118	43057118	G	A	exonic	HNF4A	nonsynonymous	SKCM\|1\|368\|0.00272
rs773633446	chr20	43034785	43034785	C	T	exonic	HNF4A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	43034745	43034745	G	T	exonic	HNF4A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	43052920	43052920	G	T	exonic	HNF4A	synonymous	LUAD\|1\|543\|0.00184
-	chr20	43052974	43052974	C	T	exonic	HNF4A	synonymous	BLCA\|1\|396\|0.00253

Disease information of HNF4A

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
HNF4A	Ulcerative Colitis	C06	Disease or Syndrome	CTD_human
HNF4A	Diabetes Mellitus, Non-Insulin-Dependent	C18;C19	Disease or Syndrome	CTD_human;UNIPROT
HNF4A	Hyperinsulinism	C18	Disease or Syndrome	GENOMICS_ENGLAND
HNF4A	Maturity onset diabetes mellitus in young	C18;C19	Disease or Syndrome	ORPHANET
HNF4A	Renal cysts and diabetes syndrome	C10;C12;C13;C18;C19	Disease or Syndrome	ORPHANET
HNF4A	INSULIN RESISTANCE, SUSCEPTIBILITY TO		Finding	UNIPROT
HNF4A	Maturity-Onset Diabetes of the Young, Type 1	C18;C19	Disease or Syndrome	CTD_human;UNIPROT
HNF4A	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
HNF4A	FANCONI RENOTUBULAR SYNDROME 4 WITH MATURITY-ONSET DIABETES OF THE YOUNG		Disease or Syndrome	CTD_human;UNIPROT
HNF4A	DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST		Finding	UNIPROT
HNF4A	Hyperinsulinism due to HNF4A deficiency		Disease or Syndrome	ORPHANET

Pathway associated with HNF4A

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000825	FOXA2 and FOXA3 transcription factor networks	pid	45	202
pathway0001021	HIF-1-alpha transcription factor network	pid	67	420
pathway0001534	Nuclear Receptor transcription pathway	reactome	51	284
pathway0001834	Regulation of gene expression in beta cells	reactome	17	54
pathway0001849	Regulation of nuclear SMAD2/3 signaling	pid	82	1072
pathway0002631	Maturity onset diabetes of the young	kegg	25	76

Go term information of HNF4A

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GO_term_name	GO_term_type	TF_name
GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION	BP	HNF4A
GO_ACYLGLYCEROL_HOMEOSTASIS	BP	HNF4A
GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION	BP	HNF4A
GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS	BP	HNF4A
GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION	BP	HNF4A
GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS	BP	HNF4A
GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND	BP	HNF4A
GO_REGULATION_OF_BODY_FLUID_LEVELS	BP	HNF4A
GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS	BP	HNF4A
GO_THIOESTER_METABOLIC_PROCESS	BP	HNF4A
GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION	BP	HNF4A
GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS	BP	HNF4A
GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS	BP	HNF4A
GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS	BP	HNF4A
GO_RESPONSE_TO_XENOBIOTIC_STIMULUS	BP	HNF4A
GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT	BP	HNF4A
GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS	BP	HNF4A
GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS	BP	HNF4A
GO_ESTABLISHMENT_OF_TISSUE_POLARITY	BP	HNF4A
GO_ANION_HOMEOSTASIS	BP	HNF4A
GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT	BP	HNF4A
GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS	BP	HNF4A
GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	HNF4A
GO_REGULATION_OF_GASTRULATION	BP	HNF4A
GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS	BP	HNF4A
GO_COENZYME_METABOLIC_PROCESS	BP	HNF4A
GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS	BP	HNF4A
GO_CARBOHYDRATE_HOMEOSTASIS	BP	HNF4A
GO_SEX_DIFFERENTIATION	BP	HNF4A
GO_REGULATION_OF_MICROVILLUS_ORGANIZATION	BP	HNF4A
GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY	BP	HNF4A
GO_NEGATIVE_REGULATION_OF_STAT_CASCADE	BP	HNF4A
GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT	BP	HNF4A
GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY	BP	HNF4A
GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN	BP	HNF4A
GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS	BP	HNF4A
GO_REGULATION_OF_STAT_CASCADE	BP	HNF4A
GO_REGULATION_OF_INTRACELLULAR_TRANSPORT	BP	HNF4A
GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS	BP	HNF4A
GO_REGULATION_OF_GLUCONEOGENESIS	BP	HNF4A
GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION	BP	HNF4A
GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT	BP	HNF4A
GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION	BP	HNF4A
GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS	BP	HNF4A
GO_FATTY_ACYL_COA_BINDING	MF	HNF4A
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING	MF	HNF4A
GO_COA_HYDROLASE_ACTIVITY	MF	HNF4A
GO_THIOLESTER_HYDROLASE_ACTIVITY	MF	HNF4A
GO_FATTY_ACID_BINDING	MF	HNF4A
GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	HNF4A
GO_PALMITOYL_COA_HYDROLASE_ACTIVITY	MF	HNF4A
GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	HNF4A
GO_COFACTOR_BINDING	MF	HNF4A
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	HNF4A
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	HNF4A

Survival analysis of HNF4A

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of HNF4A

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)